| Nader PRA et al. 200788 Nader PRA, Blandino VRPM, Maciel ELN. Características de abortamentos atendidos em uma maternidade pública do Município da Serra-ES. Rev Bras Epidemiol 2007; 10(4):615-624.. Quantitative/cross-sectional. Serra/ES. CAT I |
Describe the characteristics of abortion in a maternity |
83 hospitalised women |
25.3% of abortions were induced and misoprostol was used in more than 75% of the cases |
| Ramos KS et al. 201099 Ramos KS, Ferreira ALCG, Souza AI. Mulheres hospitalizadas por abortamento em uma Maternidade Escola na Cidade do Recife, Brasil. Rev Esc Enferm USP 2010; 44(3):605-610..Quantitative/cross-sectional. Recife/PE. CAT I |
Describe the sociodemographic and reproductive characteristics of women hospitalised from abortion |
160 hospitalised women |
The prevalent gestational age was lower than 12 weeks; most abortions were possibly induced; and the prevalent age group was between 20 and 29 years |
| Chaves JH et al. 201255 Chaves JHB, Pessini L, Bezerra AFSB, Guilhermina R, Nunes, Rui. A interrupção da gravidez na adolescência: aspectos epidemiológicos numa maternidade pública no nordeste do Brasil. Saude Soc 2012; 21(1):246-256.. Quantitative/survey. Maceió/AL. CAT I |
Describe sociodemographic/clinical aspects and the type of abortion in adolescents hospitalised in a maternity |
201 hospitalised adolescents |
Predominant age group was from 15 to 19 years; 85.98% of abortions occurred between 13th and 15th weeks; and 89.19% referred the use of misoprostol |
| Fonseca W et al. 19981010 Fonseca W, Misago C, Freitas P, Santos FL, Correia LL. Características sociodemográficas, reprodutivas e médicas de mulheres admitidas por aborto em hospital da Região Sul do Brasil. Cad Saude Publica 1998; 14(2):279-286.. Quantitative/survey. Florianópolis/SC. CAT I |
Investigate sociodemographic and reproductive characteristics of women hospitalised from abortion |
620 hospitalised women |
The majority of cases was classified as provoked abortion and used misoprostol, isolated or associated with other methods. Provoked abortion was most frequent in the age group between 20 and 24 years, with education level of five to eight years, and in married women or in a stable relationship |
| Fonseca W et al. 19961111 Fonseca W, Misago C, Correia LL, Parente JAM, Oliveira FC. Determinantes do aborto provocado entre mulheres admitidas em hospitais em localidade da região Nordeste do Brasil. Rev Saude Publica 1996; 30(1):13-18.. Quantitative/survey. Fortaleza/CE. CAT I |
Investigate determinants of abortion in women hospitalised from complications of pregnancy interruption |
4,359 hospitalised women |
48% of abortions were provoked, prevailing age group was between 20 and 29 years, 66% reported the use of misoprostol, isolated or associated to other methods |
| Diniz D et al. 20121212 Diniz D, Madeiro A. Cytotec e aborto: a polícia, os vendedores e as mulheres. Cien Saude Colet 2012; 17(7):1795-1804.. Qualitative/documentary research and interview. CAT V |
Analyse the history of women and suppliers of misoprostol denounced to the Public Prosecution Office |
6 police investigations, 4 criminal proceedings and 2 interviews |
Cytotec is commercialised in single envelopes, without a pack indicating the laboratory or information about the provenance. There is no guarantee about the quality of the medicament |
| Madeiro AP et al. 20151313 Madeiro AP, Diniz D. Induced abortion among Brazilian female sex workers: a qualitative study. Cien Saude Colet 2015; 20(2):587-593.. Qualitative/interview. Porto Alegre/RS, Teresina/PI and Belém/PA. CAT II |
Describe how female sex workers perform illegal abortion and its consequences for their health |
39 female sex workers |
The most common method was misoprostol. Doses were from one to eight tablets, introduced in the vagina and taken orally. Most women presented vaginal bleeding and/or abdominal pain |
| Leal OF. 20121414 Leal OF. "Levante a mão aqui quem nunca tirou criança!": revisitando dados etnográficos sobre a disseminação de práticas abortivas em populações de baixa-renda no Brasil. Cien Saude Colet 2012; 17(7):1689-1697. Qualitative/ethnography/interview. Rio de Janeiro RJ/Porto Alegre/RS. CAT II |
Establish a discussion about the dissemination of the practice of abortion |
9 women who aborted.
100 men and 100 women in reproductive age |
While there is no social recognition of pregnancy, methods are not seen as abortive but rather as a procedure to “get the menstruation down”. Despite the moral imperative to assume the child, certain conditions may turn tolerable the practice of abortion |
| Madeiro AP et al. 20121515 Madeiro AP, Rufino AC. Aborto induzido entre prostitutas: um levantamento pela técnica de urna em Teresina - Piauí. Cien Saude Colet 2012; 17(7):1735-1743.. Quantitative/survey. Teresina/PI. CAT II |
Describe the prevalence and the methods used for the interruption of pregnancy and associated factors |
310 women |
Most affirmed having practiced at least one abortion in life. “Cytotec” was the most common isolated method and in 9.2% of cases, it was associated with teas and catheter |
| Diniz D et al. 201233 Diniz D, Medeiros M. Itinerários e métodos do aborto ilegal em cinco capitais brasileiras. Cien Saude Colet 2012; 17(7):1671-1681.. Quantitative/survey. Belém/PA, Brasília/DF, Porto Alegre/RS, Rio de Janeiro/RJ and Salvador/BA. CAT II |
Present women’s trajectory to perform illegal abortion |
122 women |
The use of teas, liquids and herbs together with oral and vaginal misoprostol was evidenced, most commonly at eight gestational weeks. Half of the women concluded the abortion at a hospital unit |
| Arilha MM. 201277 Arilha MM. Misoprostol: percursos, mediações e redes sociais para o acesso ao aborto medicamentoso em contextos de ilegalidade no estado de São Paulo. Cien Saude Colet 2012; 17(7):1785-17947.. Qualitative/interview. São Paulo/SP. CAT II |
Apprehend elements of the experience of women who wish to perform an abortion |
4 women.
2 used misoprostol.
2 had contact about the commercialization of misoprostol |
Misoprostol represents an alternative due to price and safety. Its use places the user in a universe where the limits between legal and illegal are fragile. It circulates beyond health circuits, in the illegal commerce of urban areas |
| Porto RM et al. 20171616 Porto RM, Sousa CHD. "Percorrendo caminhos da angústia": itinerários abortivos em uma capital nordestina. Rev Estud Fem 2017; 25(2): 593-616.. Qualitative/interview. Natal/RN. CAT II |
Analyse the experiences of women who performed abortion in clandestinity |
2 women |
The study demonstrates the difficulty to find misoprostol and the lack of financial resources to buy it. There was also evidence of the difference in the care delivered in health services to women who induce abortion |
Diniz D et al. 20111717 Diniz D, Castro R. O comércio de medicamentos de gênero na mídia impressa brasileira: misoprostol e mulheres. Cad Saude Publica 2011; 27(1):94-102.. Quantitative and
Qualitative/documentary analysis. Brasil. CAT V |
Describe the context of illegal abortion from medicaments in the media |
524 news in general |
The commercialisation of misoprostol is a focus of police news, with sellers being mostly men. Women who practice abortion have their life story and imprisonment as focus of the news |
| Souza ZCS et al. 20101818 Souza ZCSN, Normélia MFD, Couto TM, Gesteira SMA. Trajetória de mulheres em situação de aborto provocado no discurso sobre clandestinidade. Acta Paul Enferm 2010; 23(6):732-736.. Qualitative/Interview. Salvador/BA. CAT II |
Analyse the clandestine trajectory of women in situation of provoked abortion |
17 women hospitalised |
Abortion induction was made with teas, misoprostol, injection and catheter to dilate the uterus. Gestation was interrupted due to fear of not being able to care for more than one child |
| FERRARI W et al. 20201919 Ferrari W, Peres S. Itinerários de solidão: aborto clandestino de adolescentes de uma favela da Zona Sul do Rio de Janeiro. Cad Saude Publica 2020; 36(Supl. 1): e00198318.. Qualitative/interviews. Rio de Janeiro/RJ. CAT II |
Discuss specificities of illegal abortion practice among adolescents |
10 female adolescents who practiced abortion |
Adolescents’ age varied from 12 to 17 years and abortions were made in clinics (inside the favela or outside) or using misoprostol, with financial resources hindrances to perform it |
| Zordo S. 20162020 Zordo S. The biomedicalisation of illegal abortion: the double life of misoprostol in Brazil. Hist Cienc Saude Manguinhos 2016; 23(1):19-36.. Qualitative/ethnography. Salvador/BA. CAT III |
Examine the impact of biomedicalisation of illegal abortion with misoprostol in the perspective of health professionals and poor women |
2 hospitals.
55 health professionals.
20 hospitalised women.
11 women in the community |
Distribution of contraceptives in health services is scarce. The effects of biomedicalisation vary according to the social context and despite greater safety using misoprostol for pregnancy interruption, the lack of post-abortion care contributes to greater risk |
| Kale P et al., 20182121 Kale PL, Jorge MHPM, Fonseca SC, Cascão AM, Silva KS, Reis AC, Taniguchi MT. Mortes de mulheres internadas para parto e por aborto e de seus conceptos em maternidades públicas. Cien Saude Colet 2018; 23(5):1577-1590.. Quantitative/cross-sectional. São Paulo/SP, Rio de Janeiro/RJ, Niterói/RJ. CAT III |
Analyse maternal obits, abortions, foetal and neonatal obits in maternities, in the cities of São Paulo, Rio de Janeiro and Niterói |
7,845 women hospitalised for birth delivery or abortion and their conceptuses
(N=7.898) |
One maternal obit occurred.
The abortion rate was of 6.3%. Misoprostol was the most common method used to provoke abortion. The proportion of provoked abortion in the city centre of Rio de Janeiro (11.9%) was circa 12 times higher than in the centre of São Paulo (1%) |
| Silva DFO et al. 201066 Silva DFO, Bedone AJ, Faúndes A, Fernandes MAS, Moura VGAL. Aborto provocado: redução da frequência e gravidade das complicações. Consequência do uso de misoprostol? Rev Bras Saude Mater Infant 2010; 10(4):441-447..Quantitative/cross-sectional. Campinas/SP.CAT III |
Evaluate the rate of severe complications from provoked abortion and their relation with the use of misoprostol |
543 hospitalised women |
48% of abortions were classified as possibly, probably or certainly induced. 25 women declared having induced abortion. Of these, 36% used misoprostol. 10% presented haemorrhagic complications and 13% signs of infection |
| Arcanjo FCN et al. 20112222 Arcanjo FCN, Ribeiro AS, Teles TG, Macena RHM, Carvalho FHC. Uso do misoprostol em substituição à curetagem uterina em gestações interrompidas precocemente. Rev Bras Ginecol Obstet 2011; 33(6):276-280.. Quantitative/clinical essay. Sobral/CE.CAT IV |
Evaluate the efficacy of the use of misoprostol 800mcg vaginal via for uterine emptying in interrupted pregnancies |
41 women |
Abortion was completed in 80.5% of women and the others (19.5%) needed uterine curettage. The lower the gestational age, the higher the efficacy of misoprostol in the uterine emptying |
| Bernardi P et al. 20102323 Bernardi P, Graziadio C, Rosa RFM, Pfeil JN, Zen PRG, Paskulin GA. Fibular dimelia and mirror polydactyly of the foot in a girl presenting additional features of the VACTERL association. Sao Paulo Med J 2010; 128(2):99-101.. Case report. Porto Alegre/RS. CAT IV |
Report the case of a baby-girl born at 7 gestational months, whose mother used misoprostol in the second gestational month |
1 baby-girl at 7 months old |
The evaluation of malformations suggests that they may be related to vascular alterations linked to the use of misoprostol; however, this association could be a mere coincidence |
| Opaleye ES et al. 20102424 Opaleye ES, Coelho HLL, Faccini LS, Almeida PC, Santos EC, Ribeiro AJV, Costa FS. Avaliação de riscos teratogênicos em gestações expostas ao misoprostol. Rev Bras Ginecol Obstet 2010; 32(1):19-35.. Quantitative/case-control. Fortaleza/CE. CAT IV |
Identify in malformed newborns and normal controls, the exposure to misoprostol consequences |
126 cases and
126 controls |
There has been exposure to misoprostol during the gestation of malformed newborns compared to the healthy ones (OR=3.65); however, without statistical significance |
| Assis PM 202125. Qualitative and quantitative. Brasil. CAT V |
Produce a databank on how Brazilian courts dealt with misoprostol in the past three decades |
331 juridical decisions |
In 77.6% of the cases, the crime associated to misoprostol was against public health. The crime of drug traffic corresponded to 9.9% of the cases. Smuggling was cited in 6.9% of the cases. The crime of abortion was associated to misoprostol in 8.4% of the cases |
| Duarte NIG et al. 20182626 Duarte NIG, Moraes LL, Andrade CB. A experiência do aborto na rede: análise de itinerários abortivos compartilhados em uma comunidade online. Cien Saude Colet 2018; 23(10):3337-3346.. Qualitative/virtual ethnography. Brasil. CAT II |
Analyse narratives about abortion experiences in an online community |
18 narratives |
In 13 stories, misoprostol is pointed as the main agent of abortion. The internet is an important source of information about abortion |
| Misago C et al. 19982727 Misago C, Fonseca W, Correia L, Fernandes LM, Campbell O. Determinants of abortion among women admitted to hospitals in Fortaleza, North Eastern Brazil. Int J Epidemiol 1998; 27(5):833-839.. Quantitative/cross-sectional. Fortaleza/CE. CAT I |
Present findings of medical determinants and characteristics of abortion in women admitted to hospitals |
4,359 hospitalised women |
Young women, with more than five years of education and single, presented higher risk of induced abortion. 48% of abortions were certainly induced and 66% used misoprostol for induction. |
| Nunes MD et al. 20122828 Nunes Md, Madeiro A, Diniz D. Histórias de aborto provocado entre adolescentes em Teresina, Piauí, Brasil. Cien Saude Colet 2013; 18(8):2311-2318.. Quantitative/cross-sectional and qualitative/interviews. Teresina/PI. CAT II |
Characterize methods, trajectory and support networks of adolescents for the interruption of pregnancy |
30 hospitalised adolescents |
The majority was less than 18 years old, single, brown or black, and urban. Misoprostol was used in 94% of the cases. The tablets were purchased in pharmacies in 43% of the cases, with prices varying between R$16 and R$60. Three adolescents had severe complications. They sought care by themselves or accompanied by mothers or girlfriends |
| Coelho HL et al. 19942929 Coêlho HL, Teixeira AC, Cruz Mde F, Gonzaga SL, Arrais PS, Luchini L, La Vecchia C, Tognoni G. Misoprostol: the experience of women in Fortaleza, Brazil. Contraception 1994; 49(2):101-110.. Quantitative/survey. Fortaleza/CE. CAT I/III |
Characterise the experience of a group of women who used misoprostol for abortion induction |
102 women with history of misoprostol use |
The majority was aged from 20 to 29 years, single and had less than eight years of education. The majority used four tablets introduced in the vagina and orally. 49 cases needed curettage.13% presented infection and 4% uterine perforation |
| Schuler L et al. 19993030 Schüler L, Pastuszak A, Sanseverino TV, Orioli IM, Brunoni D, Ashton-Prolla P, Silva da Costa F, Giugliani R, Couto AM, Brandao SB, Koren G. Pregnancy outcome after exposure to misoprostol in Brazil: a prospective, controlled study. Reprod Toxicol 1999; 13(2):147-151.. Quantitative/case-control. Porto Alegre/RS, São Paulo/SP, Rio de Janeiro/RJ. CAT IV |
Evaluate and compare the rate and type of congenital defects in pregnant women exposed to misoprostol |
86 control group
82 case group |
The study suggests that the use of misoprostol during pregnancy may increase the incidence of congenital anomalies. The magnitude of the increase is low |
| Araujo MCR et al. 20073131 Araújo MCR, Mochel EG. Aborto provocado: fatores associados em mulheres admitidas em maternidades públicas em São Luis/MA. Rev Paul Enferm 2007; 27(2):79-86.. Quantitative. Case study. São Luis/MA. CAT I/CAT III |
Identify the factors associated to provoked abortion in women admitted to hospital for complications resulting from abortion |
80 hospitalised women |
The average age was 21.6 years. 30% completed high school. 71.25% were single. 57.5% had income between one and three minimum wages. 56.25 % used misoprostol for abortion induction. The average period of hospitalisation was 2.5 days |
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