| IgA |
|
|
|
|
|
|
|
|
|
|
| ASSURE |
Ahmed et al. 2424. Ahmed F, Mursalin H, Alam MT, Amin R, Sekaran SD, Wang SM, et al. Evaluation of ASSURE(R) Dengue IgA Rapid Test using dengue-positive and dengue-negative samples. Diagn Microbiol Infect Dis 2010; 68:339-44. (2010) |
Bangladesh |
CC 1:1 |
424 (179) |
86.0 (80.1-90.8) |
99.2 (97.1-99.9) |
98.7 (95.2-99.6) |
90.7 (86.5-93.5) |
- |
ELISA NS1/IgM/IgG |
|
|
|
|
Conval. |
|
99.4 (96.9-99.9) |
92.0 (73.9-98.8) |
98.9 (96.1-99.8) |
95.8 (78.8-99.3) |
|
|
|
|
Tan et al. 2828. Tan YY, Sekaran SD, Wang SM, Ahmed F, Hossain A, Sil BK. Development of ASSURE Dengue IgA Rapid Test for the detection of anti-dengue IgA from dengue infected patients. J Glob Infect Dis 2011; 3:233-40. (2011) |
Singapore |
CC - |
914 (233) |
86.7 (81.7-90.8) |
86.1 (83.2-88.6) |
68.0 (62.4-73.3) |
94.9 (92.9-95.6) |
- |
ELISA IgM/IgG RT-PCR |
|
|
Hernández et al. 2626. Hernandez SIC, Gonzalez Mateos S, Flores Aguilar H, Lopez Martinez I, Alpuche Aranda C, Ludert JE, et al. Evaluation of a novel commercial rapid test for dengue diagnosis based on specific IgA detection. Diagn Microbiol Infect Dis 2012; 72:150-5. (2012) |
Mexico |
CS 5:1 (acute) |
225 (172) |
61.1 (53.6-68.0) |
86.8 (75.2-93.5) |
93.8 (88.4-96.7) |
40.7 (35.6-46.0) |
1 (103) 2 (69) |
RT-PCR ELISA NS1/IgM/IgG |
|
|
Naz et al. 2727. Naz A, Zahid D, Murky SN, Nadeem M, Sil BK, Shamsi TS. Evaluation of efficacy of various immunochromatographic rapid tests for dengue diagnosis. Pak J Med Sci 2014; 30:166-71. (2014) |
Pakistan |
CS 1:1 |
184 (142) |
85.2 (78.3-90.6) |
81.0 (65.9-91.4) |
93.8 (88.2-97.3) |
61.8 (47.7-74.6) |
- |
ELISA IgM/IgM |
| Dengue Rapid Test |
Hartono & Sari 2525. Hartono A, Sari SK. Diagnosis of dengue virus infection with IgA anti-dengue rapid tests. Int J Infect Dis 2012; 16 Suppl:e317-473. (2012) |
- |
CS - |
100 (70) |
82.9 (72.4-89.9) |
73.3 (55.6-85.8) |
87.9 (80.0-92.9) |
64.7 (51.3-76.1) |
- |
ELISA NS1/IgM/IgG |
| NS1 |
|
|
|
|
|
|
|
|
|
|
| Bio-Rad |
Dussart et al. 3232. Dussart P, Petit L, Labeau B, Bremand L, Leduc A, Moua D, et al. Evaluation of two new commercial tests for the diagnosis of acute dengue virus infection using NS1 antigen detection in human serum. PLoS Negl Trop Dis 2008; 2:e280. (2008) |
Guiana |
CC 1:0 |
320 (222) Read. 15’ |
76.1 (70.7-80.8) |
100.0 (92.6-100.0) |
100.0 (98.2-100.0) |
42.5 (33.2-52.1) |
1 (33) 2 (42) 3 (101) 4 (46) |
RT-PCR Viral isolation |
|
|
|
|
|
Read. 30’ |
77.6 (72.3-82.1) |
100.0 (92.6-100.0) |
100.0 (98.3-100.0) |
44.0 (34.5-53.9) |
|
|
|
|
Zainah et al. 4747. Zainah S, Wahab AH, Mariam M, Fauziah MK, Khairul AH, Roslina I, et al. Performance of a commercial rapid dengue NS1 antigen immunochromatography test with reference to dengue NS1 antigen-capture ELISA. J Virol Methods 2009; 155:157-60. (2009) |
Spain |
CC |
533 (314) |
90.4 (86.7-93.2) |
99.5 (97.5-99.9) |
99.6 (97.9-99,9) |
87.9 (83.2-91.3) |
- |
ELISA NS1/IgG Viral isolation RT-PCR |
|
|
Hang et al. 3535. Hang VT, Nguyet NM, Trung DT, Tricou V, Yoksan S, Dung NM, et al. Diagnostic accuracy of NS1 ELISA and lateral flow rapid tests for dengue sensitivity, specificity and relationship to viraemia and antibody responses. PLoS Negl Trop Dis 2009; 3:e360. (2009) |
Vietnam |
Cohort |
138 (125) |
72.8 (64.4-79.8) |
100.0 (77.2-100.0) |
100.0 (96.7-100.0) |
27.7 (15.6-42.6) |
1 (63) 2 (20) 3 (25) 4 (3) |
ELISA IgM/IgG RT-PCR |
|
|
Ramirez et al. 4444. Ramirez AH, Moros Z, Comach G, Zambrano J, Bravo L, Pinto B, et al. Evaluation of dengue NS1 antigen detection tests with acute sera from patients infected with dengue virus in Venezuela. Diagn Microbiol Infect Dis 2009; 65:247-53. (2009) |
Venezuela |
CC |
147 (87) |
67.8 (57.4-76.7) |
96.7 (88.6-99.1) |
96.7 (89.6-99.0) |
67.4 (60.4-73.8) |
1 (21) 2 (23) 3 (23) 4 (20) |
RT-PCR Viral isolation ELISA IgM |
|
|
Chaiyaratan et al. 3131. Chaiyaratana W, Chuansumrit A, Pongthanapisith V, Tangnararatchakit K, Lertwongrath S, Yoksan S. Evaluation of dengue nonstructural protein 1 antigen strip for the rapid diagnosis of patients with dengue infection. Diagn Microbiol Infect Dis 2009; 64:83-4. (2009) |
Marshall Islands |
CC |
104 (89) |
98.9 (96.8-100) |
90.6 (85.6-95.7) |
99.0 (96.2-99.7) |
90.5 (69.8-96.8) |
- |
ELISA NS1/IgM/IgG |
|
|
Shu et al. 4545. Shu PY, Yang CF, Kao JF, Su CL, Chang SF, Lin CC, et al. Application of the dengue virus NS1 antigen rapid test for on-site detection of imported dengue cases at airports. Clin Vaccine Immunol 2009; 16:589-91. (2009) (blood) |
8 Asian countries |
CS |
850 (22) |
77.3 (56.6-89.9) |
100.0 (99.5-100.0) |
100.0 |
99.4 |
1 (9) 2 (3) 3 (5) |
RT-PCR ELISA IgM/IgG |
|
|
Lima et al. 1010. Lima MRQ, Nogueira RM, Schatzmayr HG, dos Santos FB. Comparison of three commercially available dengue NS1 antigen capture assays for acute diagnosis of dengue in Brazil. PLoS Negl Trop Dis 2010; 4:e738. (2010) |
Brazil |
CC |
450 (220) |
89.6 (84,8-92.9) |
99.1 (96.9-99.8) |
99.0 (96.9-99.7) |
90.8 (87.1-93.6) |
1 (180) 2 (78) 3 (28) 4 (40) |
Viral isolation RT-PCR ELISA IgM/IgG |
|
|
Pok et al. 4343. Pok KY, Lai YL, Sng J, Ng LC. Evaluation of nonstructural 1 antigen assays for the diagnosis and surveillance of dengue in Singapore. Vector Borne Zoonotic Dis 2010; 10:1009-16. (2010) |
Singapore |
Cohort |
112 (52) |
76.9 (63.9-86.3) |
100.0 (94.0-100.0) |
100.0 |
83.3 |
1 (21) 2 (23) 3 (17) 4 (2) |
ELISA IgM/IgG Paired |
|
|
|
|
CS |
209 (109) |
78.9 (70.0-86.1) |
99.0 (94.6-99.9) |
98.9 (96.6-100) |
81.2 (73.1-88.2) |
- |
RNA viral |
|
|
Osorio et al. 4040. Osorio L, Ramirez M, Bonelo A, Villar LA, Parra B. Comparison of the diagnostic accuracy of commercial NS1-based diagnostic tests for early dengue infection. Virol J 2010; 7:361. (2010) |
Colombia |
CC |
310 (218) Read. 15’ |
57.7 (47.6-67.3) |
95.3 (84.2-99.4) |
96.8 (88.8-99.6) |
48.2 (37.3-59.3) |
1 (13) 2 (17) 3 (7) 4 (5) |
Viral isolation RT-PCR ELISA IgM |
|
|
|
|
|
Read. 30’ |
61.5 (51.5-70.9) |
93.3 (84.2-99.4) |
97.0 (89.5-99.6) |
50.6 (39.3-62) |
|
|
|
|
Tricou et al. 4646. Tricou V, Vu HT, Quynh NV, Nguyen CV, Tran HT, Farrar J, et al. Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses. BMC Infect Dis 2010; 10:142. (2010) |
Vietnam |
Cohort |
292 (245) |
61.6 (55.2-67.8) |
100.0 (93.8-100.0) |
100.0 (98.0-100.0) |
33.3 (25.6-41.8) |
1 (138) 2 (91) 3 (16) |
ELISA IgM/IgG RT-PCR |
|
|
Blacksell et al. 5050. Blacksell SD, Newton PN, Bell D, Kelley J, Mammen Jr. MP, Vaughn DW, et al. The comparative accuracy of 8 commercial rapid immunochromatographic assays for the diagnosis of acute dengue virus infection. Clin Infect Dis 2006; 42:1127-34. (2011) |
Sri Lanka |
CC |
259 (99) |
58.6 (48.2-68.4) |
98.8 (95.6-99.9) |
96.7 (88.5-99.6) |
79.4 (73.1-84.8) |
1 (1) 2 (16) 3 (47) 4 (2) |
RT-PCR ELISA IgM/IgG |
|
|
Najioullah et al. 3939. Najioullah F, Combet E, Paturel L, Martial J, Koulmann L, Thomas L, et al. Prospective evaluation of nonstructural 1 enzyme-linked immunosorbent assay and rapid immunochromatographic tests to detect dengue virus in patients with acute febrile illness. Diagn Microbiol Infect Dis 2011; 69:172-8. (2011) |
Caribbean |
CS |
537 (264) |
49.4 (43.2-55.6) |
100.0 (97.3-100.0) |
100.0 |
68.0 (63.4-72.6) |
2 (264) |
RT-PCR |
|
|
|
|
|
|
83.1 (76.2-88.3) |
99.7 (98.5-99.9) |
99.2 (85.2-99.8) |
93.6 (90.6-95.6) |
2 (156) |
ELISA NS1 |
|
|
Ferraz et al. 3333. Ferraz FO, Bomfim MR, Totola AH, Avila TV, Cisalpino D, Pessanha JE, et al. Evaluation of laboratory tests for dengue diagnosis in clinical specimens from consecutive patients with suspected dengue in Belo Horizonte, Brazil. J Clin Virol 2013; 58:41-6. (2013) |
Brazil |
CS |
189 (146) |
91.0 (81.8-95.8) |
100.0 (72.3-100.0) |
100.0 |
62.5 |
- |
ELISA NS1/IgM |
|
|
Pal et al. 4141. Pal S, Dauner AL, Mitra I, Forshey BM, Garcia P, Morrison AC, et al. Evaluation of dengue NS1 antigen rapid tests and ELISA kits using clinical samples. PLoS One 2014; 9:e113411. (2014) |
Peru/Honduras |
CC |
241 (200) |
79.1 (72.0-84.8) |
100.0 (91.2-100.0) |
100.0 |
55.6 |
1 (67) 2 (26) 3 (45) 4 (62) |
Viral isolation RT-PCR ELISA IgM |
| Panbio |
Blacksell et al. 5050. Blacksell SD, Newton PN, Bell D, Kelley J, Mammen Jr. MP, Vaughn DW, et al. The comparative accuracy of 8 commercial rapid immunochromatographic assays for the diagnosis of acute dengue virus infection. Clin Infect Dis 2006; 42:1127-34. (2011) |
Sri Lanka |
CC |
259 (99) |
58.6 (48.2-68.4) |
92.5 (87.3-96.1) |
82.9 (72.0-90.8) |
78.3 (71.7-84.0) |
1 (1) 2 (16) 3 (47) 4 (2) |
RT-PCR ELISA IgM/IgG |
|
|
Pan-ngum et al. 4242. Pan-ngum W, Blacksell SD, Lubell Y, Pukrittayakamee S, Bailey MS, de Silva HJ, et al. Estimating the true accuracy of diagnostic tests for dengue infection using bayesian latent class models. PLoS One 2013; 8:e50765. (2013) |
- |
CS |
549 (135) |
54.8 (43.5-65.7) |
95.1 (92.7-96.8) |
66.7 (54.3-77.6) |
92.1 (89.3-94.3) |
- |
ELISA IgM/IgG |
|
|
Ferraz et al. 3333. Ferraz FO, Bomfim MR, Totola AH, Avila TV, Cisalpino D, Pessanha JE, et al. Evaluation of laboratory tests for dengue diagnosis in clinical specimens from consecutive patients with suspected dengue in Belo Horizonte, Brazil. J Clin Virol 2013; 58:41-6. (2013) |
Brazil |
CS |
77 (67) |
88.1 (78.2-93.8) |
100.0 (72.3-100.0) |
100.0 |
55.6 |
- |
ELISA NS1/IgM |
|
|
Naz et al. 2727. Naz A, Zahid D, Murky SN, Nadeem M, Sil BK, Shamsi TS. Evaluation of efficacy of various immunochromatographic rapid tests for dengue diagnosis. Pak J Med Sci 2014; 30:166-71. (2014) |
Pakistan |
CS |
184 (142) |
64.1 (55.6-72.0) |
100.0 (91.6-100.0) |
100.0 (96.0-100.0) |
45.2 (34.8-55.8) |
2 (18) |
ELISA IgM/IgG |
|
|
Pal et al. 4141. Pal S, Dauner AL, Mitra I, Forshey BM, Garcia P, Morrison AC, et al. Evaluation of dengue NS1 antigen rapid tests and ELISA kits using clinical samples. PLoS One 2014; 9:e113411. (2014) |
Peru/Honduras |
CC |
241 (200) |
71.9 (64.3-78.4) |
95.0 (83.5-98.6) |
100.0 |
48.8 |
1 (67) 2 (26) 3 (45) 4 (62) |
Viral isolation RT-PCR ELISA IgM |
| Alere Dengue Earsly |
Fry et al. 3434. Fry SR, Meyer M, Semple MG, Simmons CP, Sekaran SD, Huang JX, et al. The diagnostic sensitivity of dengue rapid test assays is significantly enhanced by using a combined antigen and antibody testing approach. PLoS Negl Trop Dis 2011; 5:e1199. (2011) |
Vietnam |
CC |
298 (198) |
69.2 (62.5-75.2) |
96.0 (90.2-98.4) |
97.2 (93.2-98.8) |
61.1 (56.0-66.1) |
1 (83) 2 (24) 3 (29) |
RT-PCR ELISA NS1/IgM/IgG |
|
|
|
Malaysia |
CC |
293 (263) |
62.0 (56.0-67.6) |
96.7 (83.3-99.4) |
99.4 (97.1-99.0) |
22.5 (20.0-25.7) |
1 (101) 2 (21) 3 (23) 4 (16) |
RT-PCR ELISA NS1/IgM/IgG |
| Bioeasy |
Ferraz et al. 3333. Ferraz FO, Bomfim MR, Totola AH, Avila TV, Cisalpino D, Pessanha JE, et al. Evaluation of laboratory tests for dengue diagnosis in clinical specimens from consecutive patients with suspected dengue in Belo Horizonte, Brazil. J Clin Virol 2013; 58:41-6. (2013) |
Brazil |
CS |
77 (67) |
94.0 (85.6-97.7) |
100.0 (72.3-100.0) |
100.0 |
71.4 |
- |
ELISA NS1/IgM |
|
|
Buonora et al. 3030. Buonora SN, Passos SR, do Carmo CN, Quintela FM, de Oliveira DN, dos Santos FB, et al. Accuracy of clinical criteria and an immunochromatographic strip test for dengue diagnosis in a DENV-4 epidemic. BMC Infect Dis 2016; 16:37. (2016) |
Brazil |
CS |
325 (148) |
44.5 (36.4-53.3) |
97.8 (94.2-99.4) |
94.1 (85.6; 98.4 |
68.3 (62.1-74.0) |
4 (325) |
RT-PCR ELISA NS1 /IgM/IgG |
|
|
Mata et al. 3838. Mata VE, Passos SRL, Hökerberg YHM, Berardinelli GM, Dos Santos MAB, Fukuoka LVB, et al. Accuracy and reliability of an NS1 rapid immunochromatographic test for DENV-1 diagnosis at point of care and in the laboratory. BMC Infect Dis 2017; 17:594. (2017) |
Brazil |
CS 1:1 |
144 (120) Read. 15’ |
76.7 (68.0-84.1) |
87.0 (66.4-97.2) |
96.7 (90.8-99.3) |
42.6 (28.3-57.8) |
1 (105) |
RT-PCR ELISA NS1 (whole blood) |
|
|
|
|
|
Read. 30’ |
78.3 (69.9-85.3) |
87.5 (67.6-97.3) |
96.9 (91.2-99.4) |
44.7 (30.2-59.9) |
|
(whole blood) |
|
|
|
|
|
Read. 15’ |
82.2 (74.1-88.6) |
100.0 (85.8-100.0) |
100.0 (96.3-100.0) |
53.3 (37.9-68.3) |
|
(serum) |
|
|
|
|
|
Read. 30’ |
84.9 (77.2-90.8) |
95.8 (78.9-99.9) |
99.0 (95.4-99.8) |
56.1 (39.8-71.5) |
|
(serum) |
| Inbio |
Pal et al. 4141. Pal S, Dauner AL, Mitra I, Forshey BM, Garcia P, Morrison AC, et al. Evaluation of dengue NS1 antigen rapid tests and ELISA kits using clinical samples. PLoS One 2014; 9:e113411. (2014) |
Peru/Honduras |
CC |
241 (200) |
76.5 (65.1-85.0) |
97.4 (86.8-99.6) |
98.1 |
78.4 |
1 (67) 2 (26) 3 (45) 4 (62) |
Viral isolation RT-PCR ELISA IgM |
| Asan |
Lee et al. 3737. Lee H, Ryu JH, Park HS, Park KH, Bae H, Yun S, et al. Comparison of six commercial diagnostic tests for the detection of dengue virus non-structural-1 antigen and IgM/IgG antibodies. Ann Lab Med 2019; 39:566-71. (2019) |
Korea |
CC |
138 (75) |
41.3 (29.0-54.4) |
100.0 (95.2-100.0) |
100.0 (85.2-100.0) |
66.9 (62.2-71.4) |
- |
PCR-ELISA NS1/IgM/IgG |
| Asan Ag100 |
Lee et al. 3737. Lee H, Ryu JH, Park HS, Park KH, Bae H, Yun S, et al. Comparison of six commercial diagnostic tests for the detection of dengue virus non-structural-1 antigen and IgM/IgG antibodies. Ann Lab Med 2019; 39:566-71. (2019) |
Korea |
CC |
138 (75) |
42.9 (17.7-71.1) |
99.2 (95.6-99.9) |
85.7 (43.7-97.9) |
93.9 (90.7-96.0) |
- |
ELISA IgM |
| Boditech Med |
Lee et al. 3737. Lee H, Ryu JH, Park HS, Park KH, Bae H, Yun S, et al. Comparison of six commercial diagnostic tests for the detection of dengue virus non-structural-1 antigen and IgM/IgG antibodies. Ann Lab Med 2019; 39:566-71. (2019) |
Korea |
CC |
138 (75) |
85.7 (74.6-93.3) |
92.0 (83.4-97.0) |
90.0 (80.6-95.1) |
88.5 (80.7-93.4) |
- |
PCR-ELISA NS1/IgM/IgG |
| SD Bioline |
Jusoh & Shueb 3636. Jusoh TNAM, Shueb RH. Performance evaluation of commercial dengue diagnostic tests for early detection of dengue in clinical samples. J Trop Med 2017; 2017:4687182. (2017) |
- |
CC |
86 (36) |
88.9 (74.7-95.6) |
100.0 (92.9-100.0) |
100.0 |
92.6 |
1 (14) 2 (8) 3 (2) 4(1) |
RT-PCR ELISA NS1 |
|
|
Pal et al. 4141. Pal S, Dauner AL, Mitra I, Forshey BM, Garcia P, Morrison AC, et al. Evaluation of dengue NS1 antigen rapid tests and ELISA kits using clinical samples. PLoS One 2014; 9:e113411. (2014) |
Peru/Honduras |
CC |
241 (200) |
72.4 (64.8-78.9) |
100.0 (91.2-100) |
100.0 |
48.8 |
1 (67) 2 (26) 3 (45) 4 (62) |
Viral isolation RT-PCR ELISA IgM |
| IgM/IgG |
|
|
|
|
|
|
|
|
|
|
| SD Bioline |
Blacksell et al. 2929. Blacksell SD, Jarman RG, Bailey MS, Tanganuchitcharnchai A, Jenjaroen K, Gibbons RV, et al. Evaluation of six commercial point-of-care tests for diagnosis of acute dengue infections: the need for combining NS1 antigen and IgM/IgG antibody detection to achieve acceptable levels of accuracy. Clin Vaccine Immunol 2011; 18:2095-101. (2006) |
Thailand |
CC |
491 (326) |
21.8 (17.4-26.7) |
98.8 (95.7-99.9) |
97.3 (90.5-99.7) |
39.0 (34.3-43.9) |
- |
RT-PCR ELISA IgM/IgG |
| Panbio dengue IC |
Branch & Levett 5151. Branch SL, Levett PN. Evaluation of four methods for detection of immunoglobulin M antibodies to dengue virus. Clin Diagn Lab Immunol 1999; 6:555-7. (1999) |
- |
CS |
62 (36) |
83.9 (72.8-91.0) |
100.0 (88.7-100) |
75.0 |
100.0 |
- |
ELISA IgM |
| Panbio Dengue Duo |
Blacksell et al. 2929. Blacksell SD, Jarman RG, Bailey MS, Tanganuchitcharnchai A, Jenjaroen K, Gibbons RV, et al. Evaluation of six commercial point-of-care tests for diagnosis of acute dengue infections: the need for combining NS1 antigen and IgM/IgG antibody detection to achieve acceptable levels of accuracy. Clin Vaccine Immunol 2011; 18:2095-101. (2006) |
Thailand |
CC |
491 (326) |
65.3 (59.9-70.5) |
97.6 (93.9-99.3) |
98.2 (95.4-99.5) |
58.8 (52.7-64.7) |
- |
RT-PCR ELISA IgM/IgG |
|
|
Cohen et al. 5252. Cohen AL, Dowell SF, Nisalak A, Mammen Jr. MP, Petkanchanapong W, Fisk TL. Rapid diagnostic tests for dengue and leptospirosis: antibody detection is insensitive at presentation. Trop Med Int Health 2007; 12:47-51. (2007) |
|
CS (acute) |
723 (132) |
19.0 (14.2-24.9) |
96.0 (94.0-97.4) |
64.4 (52.3-75.0) |
75.6 (74.3-76.9) |
- |
ELISA IgM/IgG-HI |
|
|
|
|
Conval. |
|
59.0 (52.1-65.6) |
95.0 (92.8-96.6) |
81.9 (75.5-87.0) |
85.8 (83.7-87.8) |
- |
|
|
|
Congpuong et al. 5353. Congpuong K, Chuchan S, Kwangthong S, Kangchaingone Y, Darakapong A. Appropriate laboratory tests for the diagnosis of dengue infection at a general hospital in Southern Thailand. Asian Biomed (Res Rev News) 2008; 2:289-95. (2008) |
Thailand |
CS |
175 (100) |
23.0 (15.8-32.2) |
100.0 (95.1-100.0) |
100.0 |
55.0 |
1 (37) 2 (27) 3 (69) 4 (12) |
Real time PCR ELISA NS1/IgM/IgG |
|
|
Martínez-Vega et al. 5454. Martinez-Vega RA, Diaz-Quijano FA, Coronel-Ruiz C, Yebrail Gomez S, Villar-Centeno LA. Evaluation of PANBIO rapid immunochromatographic cassette for dengue diagnosis in a Colombian endemic area. Biomedica 2009; 29:616-24. (2009) |
Colombia |
CS (acute) |
100 (65) |
52.2 (40.3-64.2) |
84.8 (72.6-97.1) |
87.5 (77.3-97.7) |
46.7 (34.0-59.3) |
2 (29) |
ELISA IgM paired samples |
|
|
|
|
Conval. |
|
76.1 (65.9-86.3) |
75.8 (61.1-90.4) |
86.4 (77.7-95.2) |
61.0 (46.0-75.9) |
2 (29) |
ELISA IgM paired samples |
|
|
Naz et al. 2727. Naz A, Zahid D, Murky SN, Nadeem M, Sil BK, Shamsi TS. Evaluation of efficacy of various immunochromatographic rapid tests for dengue diagnosis. Pak J Med Sci 2014; 30:166-71. (2014) |
Pakistan |
CS |
184 (142) |
72.5 (64.4-79.7) |
69.1 (52.9-82.4) |
88.8 (81.6-93.9) |
42.7 (30.7-55.2) |
2 (18) |
ELISA IgM/IgG |
| Alere dengue duo |
Fry et al. 3434. Fry SR, Meyer M, Semple MG, Simmons CP, Sekaran SD, Huang JX, et al. The diagnostic sensitivity of dengue rapid test assays is significantly enhanced by using a combined antigen and antibody testing approach. PLoS Negl Trop Dis 2011; 5:e1199. (2011) |
Malaysia |
CC |
293 (263) |
72.5 (67.5-77.0) |
96.7 (83.3-99.4) |
99.5 (97.5-99.9) |
28.7 (24.6-33.3) |
1 (101) 2 (21) 3 (23) 4 (16) |
RT-PCR ELISA NS1/IgM/IgG |
| Dengue Fever |
Blacksell et al. 2929. Blacksell SD, Jarman RG, Bailey MS, Tanganuchitcharnchai A, Jenjaroen K, Gibbons RV, et al. Evaluation of six commercial point-of-care tests for diagnosis of acute dengue infections: the need for combining NS1 antigen and IgM/IgG antibody detection to achieve acceptable levels of accuracy. Clin Vaccine Immunol 2011; 18:2095-101. (2006) |
Thailand |
CC |
491 (326) |
9.5 (6.6-13.2) |
97.0 (93.0-99.0) |
86.1 (70.5-95.3) |
35.2 (30.8-39.8) |
- |
RT-PCR ELISA IgM/IgG |
| Dengue check-WB |
Blacksell et al. 2929. Blacksell SD, Jarman RG, Bailey MS, Tanganuchitcharnchai A, Jenjaroen K, Gibbons RV, et al. Evaluation of six commercial point-of-care tests for diagnosis of acute dengue infections: the need for combining NS1 antigen and IgM/IgG antibody detection to achieve acceptable levels of accuracy. Clin Vaccine Immunol 2011; 18:2095-101. (2006) |
Thailand |
|
|
6.4 (4.0-9.7) |
99.4 (96.9-99.9) |
95.5 (77.2-99.9) |
35.0 (30.7-39.5) |
|
|
| Core Dengue |
Blacksell et al. 2929. Blacksell SD, Jarman RG, Bailey MS, Tanganuchitcharnchai A, Jenjaroen K, Gibbons RV, et al. Evaluation of six commercial point-of-care tests for diagnosis of acute dengue infections: the need for combining NS1 antigen and IgM/IgG antibody detection to achieve acceptable levels of accuracy. Clin Vaccine Immunol 2011; 18:2095-101. (2006) |
Thailand |
|
|
22.9 (18.3-27.6) |
98.9 (95.7-99.9) |
97.4 (90.8-99.7) |
39.3 (34.6-44.2) |
|
|
| Diazyme Combo |
Blacksell et al. 2929. Blacksell SD, Jarman RG, Bailey MS, Tanganuchitcharnchai A, Jenjaroen K, Gibbons RV, et al. Evaluation of six commercial point-of-care tests for diagnosis of acute dengue infections: the need for combining NS1 antigen and IgM/IgG antibody detection to achieve acceptable levels of accuracy. Clin Vaccine Immunol 2011; 18:2095-101. (2006) |
Thailand |
|
|
17.8 (13.8-22.4) |
98.2 (94.7-99.4) |
95.1 (86.3-99.0) |
37.7 (33.1-42.4) |
|
|
| Smartcheck Globale Med |
Blacksell et al. 2929. Blacksell SD, Jarman RG, Bailey MS, Tanganuchitcharnchai A, Jenjaroen K, Gibbons RV, et al. Evaluation of six commercial point-of-care tests for diagnosis of acute dengue infections: the need for combining NS1 antigen and IgM/IgG antibody detection to achieve acceptable levels of accuracy. Clin Vaccine Immunol 2011; 18:2095-101. (2006) |
Thailand |
|
|
62.9 (57.4-68.1) |
69.1 (61.4-76.0) |
80.1 (74.7-84.8) |
48.5 (42.0-55.1) |
|
|
| Vscan (Minerva) |
Blacksell et al. 2929. Blacksell SD, Jarman RG, Bailey MS, Tanganuchitcharnchai A, Jenjaroen K, Gibbons RV, et al. Evaluation of six commercial point-of-care tests for diagnosis of acute dengue infections: the need for combining NS1 antigen and IgM/IgG antibody detection to achieve acceptable levels of accuracy. Clin Vaccine Immunol 2011; 18:2095-101. (2006) |
Thailand |
|
|
8.6 (5.8-12.2) |
100.0 (97.8-100.0) |
100.0 (87.7-100.0) |
35.6 (31.3-40.2) |
- |
RT-PCR ELISA IgM/IgG |
| Acon |
Yusuf et al. 5757. Yusuf NW, Kausar N, Akbar R, Iqbal N. Comparison of diagnostic efficacy of rapid diagnostic devices for dengue virus infection: a piolt study. J Ayub Med Coll Abbottabad 2008; 20:26-8. (2008) |
- |
CS |
50 (22) |
45.8 (31.6-60.7) |
100.0 (19.8-100.0) |
100.0 (81.5-100.0) |
71.0 (56.0-84.0) |
- |
ELISA |
| Dengue IgM/IgG |
Aikat et al. 4848. Aikat A, Sarkar A, Tudu N, Moitra S, Pal PP, Sarkar TK. Diagnostic dilemma of dengue fever: how much reliability are there in rapidity. J Indian Med Assoc 2011; 109:543-5. (2011) |
- |
CS |
158 (29) |
96.4 (85.2-99.4) |
98.4 (94.5-99.6) |
93.1 (77.6-97.7) |
99.2 (96.4-99.8) |
1 (1) 2 (16) 3 (47) 4 (2) |
ELISA IgM |
| IgM/IgG (only IgM) |
|
|
|
|
|
|
|
|
|
|
| SD Bioline |
Pun et al. 5656. Pun R, Shah Y, Gupta GP, Sherchand SP, Pandey BD. Prognostic value of rapid test for diagnosis of dengue in Nepalese patients during 2010 epidemic. Kathmandu Univ Med J (KUMJ) 2012; 10:7-10. (2012) |
Nepal |
CS |
131 (50) acute |
70.0 (55.5-81.5) |
76.5 (56.2-80.8) |
64.8 (51.5-76.1) |
80.5 (71.0-87.0) |
- |
ELISA IgM |
|
|
Nga et al. 5555. Nga TTT, Thai KTD, Phuong HL, Giao PT, Hung LQ, Binh TQ, et al. Evaluation of two rapid immunochromatographic assays for diagnosis of dengue among Vietnamese febrile patients. Clin Vaccine Immunol 2007; 14:799-801. (2007) |
Vietnam |
CS |
200 (162) |
10.6 (6.0-18.0) |
99.0 (94.3-99.8) |
91.7 (64.6-98.5) |
80.5 (43.5-57.6) |
- |
ELISA IgM/IgG |
| Panbio dengue duo |
Berry et al. 4949. Berry N, Chakravarti A, Gur R, Mathur MD. Serological investigation of a febrile outbreak in Delhi, India, using a rapid immunochromatographic test. J Clin Microbiol 1998; 36:2795-6. (1998) |
India |
CS |
43(31) |
41.7 (19.3-68.1) |
96.8 (83.8-99.4) |
83.0 (47.3-96.5) |
81.1 (72.4-87.5) |
- |
ELISA NS1/IgM |
|
|
Nga et al. 5555. Nga TTT, Thai KTD, Phuong HL, Giao PT, Hung LQ, Binh TQ, et al. Evaluation of two rapid immunochromatographic assays for diagnosis of dengue among Vietnamese febrile patients. Clin Vaccine Immunol 2007; 14:799-801. (2007) |
Vietnam |
CS Conval. |
200 (162) |
67.3 (59.7-74.0) |
92.1 (79.2-97.3) |
97.3 (92.9-99.0) |
39.8 (34.2-45.7) |
- |
ELISA IgM/IgG |
|
|
Blacksell et al. 5050. Blacksell SD, Newton PN, Bell D, Kelley J, Mammen Jr. MP, Vaughn DW, et al. The comparative accuracy of 8 commercial rapid immunochromatographic assays for the diagnosis of acute dengue virus infection. Clin Infect Dis 2006; 42:1127-34. (2011) |
Sri-Lanka |
CS |
259 (99) |
70.7 (60.7-79.4) |
80.0 (73.0-85.9) |
68.6 (58.7-77.5) |
81.5 (74.6-87.3) |
1 (1) 2 (16) 3 (47) 4 (2) |
MAC GAC ELISA paired samples |
|
|
Pan-ngum et al. 4242. Pan-ngum W, Blacksell SD, Lubell Y, Pukrittayakamee S, Bailey MS, de Silva HJ, et al. Estimating the true accuracy of diagnostic tests for dengue infection using bayesian latent class models. PLoS One 2013; 8:e50765. (2013) |
Sri-Lanka |
CS |
549 (135) |
50.0 (38.9-61.1) |
89.5 (86.3-92.1) |
46.2 (35.6-56.9) |
90.8 (87.8-93.3) |
- |
ELISA IgM/IgG |
|
|
Naz et al. 2727. Naz A, Zahid D, Murky SN, Nadeem M, Sil BK, Shamsi TS. Evaluation of efficacy of various immunochromatographic rapid tests for dengue diagnosis. Pak J Med Sci 2014; 30:166-71. (2014) |
Pakistan |
CS |
|
63.4 (54.9-71.3) |
76.2 (60.5-88.0) |
90.0 (82.4-95.1) |
38.1 (27.7-49.3) |
|
|
|
|
Garg et al. 6060. Garg A, Garg J, Singh DV, Dhole TN. Can rapid dengue diagnostic kits be trusted? A comparative study of commercially available rapid kits for serodiagnosis of dengue fever. J Lab Physicians 2019; 11:63-7. (2019) |
India |
CC |
152 (72) |
61.1 (48.8-72.3 |
95.1 (87.7-98.6) |
91.7 (80.0-97.6) |
91.7 (80.0-97.6) |
- |
RT-PCR ELISA NS1 IgM/IgG |
| Merlin dengue |
Blacksell et al. 5050. Blacksell SD, Newton PN, Bell D, Kelley J, Mammen Jr. MP, Vaughn DW, et al. The comparative accuracy of 8 commercial rapid immunochromatographic assays for the diagnosis of acute dengue virus infection. Clin Infect Dis 2006; 42:1127-34. (2011) |
Sri-Lanka |
CS |
259 (99) |
72.7 (62.9-81.2) |
73.8 (66.2-80.4) |
63.2 (53.2-72.0) |
81.4 (74.1-87.4) |
1 (1) 2 (16) 3 (47) 4 (2) |
RT-PCR ELISA IgM/IgG |
| Biosynex immunoquick |
|
|
|
259 (99) |
79.8 (70.5-87.2) |
46.3 (38.3-54.3) |
49.9 (40.1-55.8) |
78.7 (69.1-86.5) |
|
|
| Asan |
Lee et al. 3737. Lee H, Ryu JH, Park HS, Park KH, Bae H, Yun S, et al. Comparison of six commercial diagnostic tests for the detection of dengue virus non-structural-1 antigen and IgM/IgG antibodies. Ann Lab Med 2019; 39:566-71. (2019) |
|
CC |
138 (75) |
41.3 (29.0-54.4) |
100.0 (95.2-100.0) |
100.0 (85.2-100.0) |
66.9 (62.2-71.4) |
- |
PCR-ELISA NS1/IgM/IgG |
| Boditech Medichroma |
|
|
|
138 (75) |
85.7 (74.6-93.3) |
92.0 (83.4-97.0) |
90.0 (80.6-95.1) |
88.5 (80.7-93.4) |
|
|
| NS1/IgM/IgG |
|
|
|
|
|
|
|
|
|
|
| SD Bioline Dengue Duo |
Osorio et al. 4040. Osorio L, Ramirez M, Bonelo A, Villar LA, Parra B. Comparison of the diagnostic accuracy of commercial NS1-based diagnostic tests for early dengue infection. Virol J 2010; 7:361. (2010) |
Colombia |
CC |
310 (218) |
80.7 (75.0-85.4) |
89.1 (81.1-94.0) |
94.6 (90.8-96.9) |
66.1 (59.6-72.1) |
- |
Viral Isolation RT -PCR ELISA IgM |
|
|
Tricou et al. 4646. Tricou V, Vu HT, Quynh NV, Nguyen CV, Tran HT, Farrar J, et al. Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses. BMC Infect Dis 2010; 10:142. (2010) |
Vietnam |
Cohort (acute) |
292 (245) |
83.7 (78.4-88.1) |
97.9 (88.7-99.9) |
99.5 (97.3-100) |
53.5 (42.4-64.3) |
1 (138) 2 (91) 3 (16) |
RT-PCR ELISA IgM/IgG |
|
|
Andries et al. 5858. Andries AC, Duong V, Ngan C, Ong S, Huy R, Sroin KK, et al. Field evaluation and impact on clinical management of a rapid diagnostic kit that detects dengue NS1, IgM and IgG. PLoS Negl Trop Dis 2012; 6:e1993. (2012) |
|
Blood (hospital) |
157 (58) |
85.7 (78.4-91.3) |
83.9 (66.3-94.5) |
95.6 (90.0-98.5) |
59.1 (43.2-73.7) |
|
RT-PCR Viral Isolation IgM and HIA paired |
|
|
|
|
(laboratory) |
157 (57) |
94.4 (88.9-97.7) |
90.0 (73.5-97.9) |
97.5 (93.0-99.5) |
77.1 (59.9-89.6) |
|
|
|
|
Sanchez-Vargas et al. 7070. Sanchez-Vargas LA, Sanchez-Marce EE, Vivanco-Cid H. Evaluation of the SD BIOLINE Dengue Duo rapid test in the course of acute and convalescent dengue infections in a Mexican endemic region. Diagn Microbiol Infect Dis 2014; 78:368-72. (2014) |
Mexico |
CC 1:1.2 |
397 (310) |
90.7 (87.2-94.0) |
89.7 (82.7-96.6) |
96.9 (94.7-99.1) |
72.9 (64.0-81.8) |
- |
ELISA NS1/IgM/IgG |
|
|
Gan et al. 5959. Gan VC, Tan LK, Lye DC, Pok KY, Mok SQ, Chua RC, et al. Diagnosing dengue at the point-of-care: utility of a rapid combined diagnostic kit in Singapore. PLoS One 2014; 9:e90037. (2014) |
Singapore |
CS 1:1.1 |
197 (147) |
93.9 (83.9-97.1) |
92.0 (82.8-93.2) |
97.2 (75.4-90.0) |
83.2 (90.6-98.1) |
1 (22) 2 (89) 3 (1) |
RT-PCR ELISA IgM |
|
|
Carter et al. 7979. Carter MJ, Emary KR, Moore CE, Parry CM, Sona S, Putchhat H, et al. Rapid diagnostic tests for dengue virus infection in febrile Cambodian children: diagnostic accuracy and incorporation into diagnostic algorithms. PLoS Negl Trop Dis 2015; 9:e0003424. (2015) |
Cambodia |
CS < 16 years |
337 (71) |
57.8 (45.4-69.4) |
85.3 (80.3-89.5) |
52.6 (40.9-64.0) |
87.8 (83.0-91.0) |
- |
ELISA NS1 IgM |
|
|
Pal et al. 6969. Pal S, Dauner AL, Valks A, Forshey BM, Long KC, Thaisomboonsuk B, et al. Multicountry prospective clinical evaluation of two enzyme-linked immunosorbent assays and two rapid diagnostic tests for diagnosing dengue fever. J Clin Microbiol 2015; 53:1092-102. (2015) |
Peru/Venezuela/Cambodia/Thailand/USA |
Cohort 1:5 (4-14 days) |
1,108 (377) |
87.3 (84.1-90.2) |
86.8 (83.9-89.3) |
77.4 (73.9-80.6) |
93.0 (91.0-94.5) |
1 (88) 2 (103) 3 (24) 4 (32) |
PCR/Viral isolation In-house IgM/IgG PRNT |
|
|
Vickers et al. 7777. Vickers IE, Harvey KM, Brown MG, Nelson K, DuCasse MB, Lindo JF. The performance of the SD BIOLINE Dengue DUO(R) rapid immunochromatographic test kit for the detection of NS1 antigen, IgM and IgG antibodies during a dengue type 1 epidemic in Jamaica. J Biomed Sci 2015; 22:55. (2015) |
Jamaica |
CC 1:3 |
339 (309) |
97.5 (92.9-99.2) |
100.0 (86.3-100.0) |
100.0 (97.9-100.0) |
93.6 (79.3-98.2) |
NI |
ELISA NS1 IGM |
|
|
Jusoh & Shueb 3636. Jusoh TNAM, Shueb RH. Performance evaluation of commercial dengue diagnostic tests for early detection of dengue in clinical samples. J Trop Med 2017; 2017:4687182. (2017) |
Malaysa |
CC |
86 (36) |
88.9 (75.8-96.6) |
100.0 (92.9-100.0) |
- |
- |
1 (14) 2 (8) 3 (2) 4 (1) 1&2 (1) |
ELISA NS1 RT-PCR/viral isolation |
|
|
Lee et al. 3737. Lee H, Ryu JH, Park HS, Park KH, Bae H, Yun S, et al. Comparison of six commercial diagnostic tests for the detection of dengue virus non-structural-1 antigen and IgM/IgG antibodies. Ann Lab Med 2019; 39:566-71. (2019) |
|
CC |
138 (75) |
82.7 (72.2-90.4) |
100.0 (94.3-100.0) |
100.0 (93.9-100.0) |
82.9 (74.7-88.8) |
- |
PCR-ELISA NS1/IgM/IgG |
|
|
(at least one) |
|
CC |
138 (75) |
83.7 (78.4-88.1) |
97.9 (88.7-99.9) |
99.5 (97.3-100.0) |
53.5 (42.4-64.3) |
- |
PCR-ELISA NS1/IgM/IgG |
| ProDetect Dengue Duo (Mediven) |
Jusoh & Shueb 3636. Jusoh TNAM, Shueb RH. Performance evaluation of commercial dengue diagnostic tests for early detection of dengue in clinical samples. J Trop Med 2017; 2017:4687182. (2017) |
Malaysa |
CC |
86 (36) |
94.4 (81.9-98.5) |
96.0 (86.5-98.9) |
94.4 (83.3-98.3) |
96.0 (87.7-98.8) |
1 (14) 2 (8) 3 (2) 4 (1) 1&2 (1) |
ELISA NS1 RT-PCR/viral isolation |
| OneStep NS1 RapiDIP Instatest-Rapicard IgM/IgG |
Vickers et al. 7676. Vickers I, Harvey K, Nelson K, Brown M, Bullock-DuCasse M, Lindo J. Evaluation of OneStep Dengue NS1 RapiDip InstaTest and OneStep Dengue Fever IgG/IgM RapiCard InstaTest during the course of a dengue type 1 epidemic. Diagn Microbiol Infect Dis 2017; 89:271-5. (2017) (fever 4 days) |
Jamaica |
CC 1:1.1 |
339 (174) |
99.5 (97.1-99.9) |
100.0 (87.5-100.0) |
100.0 (98.0-100.0) |
96.4 (82.3-99.4) |
|
ELISA NS1 IgM |
| Asan |
Lee et al. 3737. Lee H, Ryu JH, Park HS, Park KH, Bae H, Yun S, et al. Comparison of six commercial diagnostic tests for the detection of dengue virus non-structural-1 antigen and IgM/IgG antibodies. Ann Lab Med 2019; 39:566-71. (2019) |
|
CC |
138 (75) |
77.3 (66.3-86.2) |
98.4 (91.5-99.9) |
98.3 (89.2-99.8) |
78.5 (70.6-84.7) |
- |
PCR-ELISA NS1/IgM/IgG |
| Boditech Med |
Lee et al. 3737. Lee H, Ryu JH, Park HS, Park KH, Bae H, Yun S, et al. Comparison of six commercial diagnostic tests for the detection of dengue virus non-structural-1 antigen and IgM/IgG antibodies. Ann Lab Med 2019; 39:566-71. (2019) |
|
CC |
138 (75) |
98.7 (92.8-99.9) |
90.5 (80.4-96.4) |
92.5 (85.2-96.4) |
98.3 (89.0-99.8) |
- |
PCR-ELISA NS1/IgM/IgG |
| NS1/IgM/IgG (only NS1) |
|
|
|
|
|
|
|
|
|
|
| SD Bioline Dengue Duo |
Osorio et al. 4040. Osorio L, Ramirez M, Bonelo A, Villar LA, Parra B. Comparison of the diagnostic accuracy of commercial NS1-based diagnostic tests for early dengue infection. Virol J 2010; 7:361. (2010) |
Colombia |
CC |
310 (218) |
51.0 (44.1-57.7) |
96.7 (90.8-99.3) |
97.4 (92.5-99.5) |
45.4 (38.3-52.7) |
1 (13) 2 (17) 3 (7) 4 (5) |
Viral isolation RT-PCR ELISA IgM |
|
|
Tricou et al. 4646. Tricou V, Vu HT, Quynh NV, Nguyen CV, Tran HT, Farrar J, et al. Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses. BMC Infect Dis 2010; 10:142. (2010) |
Vietnam |
Cohort |
292 (245) |
62.4 (56.1-68.5) |
100.0 (93.8-100.0) |
100.0 (98.1-100.0) |
33.8 (26.0-42.3) |
1 (138) 2 (91) 3 (16) |
ELISA IgM/IgG RT-PCR |
|
|
Blacksell et al. 5050. Blacksell SD, Newton PN, Bell D, Kelley J, Mammen Jr. MP, Vaughn DW, et al. The comparative accuracy of 8 commercial rapid immunochromatographic assays for the diagnosis of acute dengue virus infection. Clin Infect Dis 2006; 42:1127-34. (2011) |
Sri Lanka |
CC |
259 (99) |
48.5 |
99.4 |
98.0 |
75.7 |
1 (1) 2 (16) 3 (47) 4 (2) |
RT-PCR ELISA IgM/IgG |
|
|
Sandoval et al. 7171. Sandoval JJV, Amores DR, Ramudo SV, Gutiérrez NC, Tirado MGG. Evaluation of the SD Dengue Duo diagnosis system for detection of NS1 protein and IgM and IgG dengue antibodies. Rev Cubana Med Trop 2012; 64:27-34. (2011) |
Cuba |
CS |
161 (71) |
57.8 (45.6-69.9) |
98.9 (96.2-100.0) |
97.6 (86.8-99.4) |
74.8 (66.2-81.6) |
1 (53) 2 (21) 3 (1) |
ELISA NS1/IgM/IgG |
|
|
Tontulawat et al. 7575. Tontulawat P, Pongsiri P, Thongmee C, Theamboonlers A, Kamolvarin N, Poovorawan Y. Evaluation of rapid immunochromatographic NS1 test, anti-dengue IgM test, semi-nested PCR and IgM ELISA for detection of dengue virus. Southeast Asian J Trop Med Public Health 2011; 42:570-8. (2011) |
Thailand |
CS |
237 (126) |
70.3 (61.2-78.0) |
73.0 (64.7-80.0) |
69.6 (62.7-75.8) |
73.6 (67.3-79.1) |
- |
PCR semi-nested ELISA/IgM |
|
|
Andries et al. 5858. Andries AC, Duong V, Ngan C, Ong S, Huy R, Sroin KK, et al. Field evaluation and impact on clinical management of a rapid diagnostic kit that detects dengue NS1, IgM and IgG. PLoS Negl Trop Dis 2012; 6:e1993. (2012) |
Cambodia |
CS |
126 (31) (blood/hospital) |
44.4 (35.6-53.6) |
96.8 (83.3-99.9) |
98.2 (90.6-100.0) |
30.0 (21.2-40.0) |
- |
RT-PCR Viral isolation ELISA IgM |
|
|
|
|
|
(blood/laboratory) |
45.2 (36.4-54.3) |
96.6 (83.3-99.9) |
98.3 (92.0-99.7) |
30.3 (26.7-34.2) |
|
|
|
|
Parham et al. 6767. Parham LA, Sánchez C, López MJ, Lorenzana I. Evaluation of two parameters for dengue diagnosis in Honduran patients. Am J Trop Med Hyg 2014; 91(5 Suppl 1):429. (2013) |
Honduras |
CS |
61 (48) |
87.5 (75.3-94.1) |
15.4 (4.33-42.2) |
79.2 (74.3-83.4) |
25.0 (7.8-56.8) |
- |
RT-PCR |
|
|
Gan et al. 5959. Gan VC, Tan LK, Lye DC, Pok KY, Mok SQ, Chua RC, et al. Diagnosing dengue at the point-of-care: utility of a rapid combined diagnostic kit in Singapore. PLoS One 2014; 9:e90037. (2014) |
Singapore |
CS |
197 (147) |
81.6 (74.6-87.1) |
98.0 (89.5-99.7) |
99.2 (99.5-99.9) |
64.5 (53.3-74.3) |
1 (22) 2 (89) 3 (1) |
RT-PCR ELISA NS1 /IgM/IgG |
|
|
Sanchez-Vargas et al. 7070. Sanchez-Vargas LA, Sanchez-Marce EE, Vivanco-Cid H. Evaluation of the SD BIOLINE Dengue Duo rapid test in the course of acute and convalescent dengue infections in a Mexican endemic region. Diagn Microbiol Infect Dis 2014; 78:368-72. (2014) |
Mexico |
CC 139:171 |
397 (310) |
87.5 (81.6-93.43) |
94.6 (91.7-97.6) |
89.5 (83.9-95.1) |
93.6 (90.4-96.7) |
- |
ELISA NS1/IgM/IgG |
|
|
Krishnananthasivam et al. 6565. Krishnananthasivam S, Fernando AN, Tippalagama R, Tennekoon R, Man JD, Seneviratne D, et al. Evaluation of a commercial rapid test kit for detection of acute dengue infection. Southeast Asian J Trop Med Public Health 2015; 46:602-10. (2015) |
Sri Lanka |
CC |
143 (27) |
57.0 (47.1-65.7) |
86.7 (59.5-95.9) |
97.3 (90.7-99.6) |
19.1 (10.6-30.5) |
|
RT-PCR ELISA IgM IgG |
|
|
Hunsperger et al. 6262. Hunsperger EA, Sharp TM, Lalita P, Tikomaidraubuta K, Cardoso YR, Naivalu T, et al. Use of a rapid test for diagnosis of dengue during suspected dengue outbreaks in resource-limited regions. J Clin Microbiol 2016; 54:2090-5. (2016) |
|
CC |
1,678 (1,116) |
65.9 (62.2,69.4) |
80.9 (77.8,83.8) |
- |
- |
1 (31) 2 (188) 3 (89) 4 (430) |
RT-PCR |
|
|
|
Angola |
|
46 (43) |
92.9 (76.5-99.1) |
22.0 (6.4-47.6) |
- |
- |
1 (29) |
|
|
|
|
Marshall Island |
|
796 (430) |
66.8 (61.9-71.3) |
79.9 (74.3-84.7) |
- |
- |
4 (430) |
|
|
|
|
Fiji |
|
302 (148) |
84.4 (75.3-91.2) |
78.2 (71.8-83.7) |
- |
- |
3 (89) |
|
|
|
|
Yap Island |
|
534 (332) |
49.7 (42.0-57.4) |
89.0 (84.2-92.7) |
- |
- |
2 (175) |
|
|
|
Garg et al. 6060. Garg A, Garg J, Singh DV, Dhole TN. Can rapid dengue diagnostic kits be trusted? A comparative study of commercially available rapid kits for serodiagnosis of dengue fever. J Lab Physicians 2019; 11:63-7. (2019) |
India |
CC |
152 (72) |
100.0 (94.6-100.0.) |
100.0 (95.5-100.0) |
100.0 (94.6-100.0) |
100.0 (95.5-100.0) |
- |
|
|
|
Shih et al. 7272. Shih HI, Hsu HC, Wu CJ, Lin CH, Chang CM, Tu YF, et al. Applications of a rapid and sensitive Dengue DUO Rapid Immunochromatographic Test kit as a diagnostic strategy during a dengue type 2 epidemic in an urban city. PLoS One 2016; 11:e0158437. (2016) |
Taiwan |
CS (acute) Median 17 years |
1,607 (1,295) |
94.9 (92.1-96.7) |
70.9 (63.0-77.8) |
89.5 (86.9-91.7) |
84.0 (77.1-89.2) |
- |
|
|
|
Huits et al. 6161. Huits R, Soentjens P, Maniewski-Kelner U, Theunissen C, Van Den Broucke S, Florence E, et al. Clinical utility of the nonstructural 1 antigen rapid diagnostic test in the management of dengue in returning travelers with fever. Open Forum Infect Dis 2017; 4:ofw273. (2017) |
Belgium |
Cohort 4:1 |
308 (52) |
82.7 (74.4-93.0) |
99.6 (98.8-100) |
97.7 (89.6-99.5) |
96.6 (94.1-98.1) |
- |
|
|
|
Simonnet et al. 7474. Simonnet C, Okandze A, Matheus S, Djossou F, Nacher M, Mahamat A. Prospective evaluation of the SD BIOLINE Dengue Duo rapid test during a dengue virus epidemic. Eur J Clin Microbiol Infect Dis 2017; 36:2441-7. (2017) |
French Guiana |
Cohort (acute) |
3,347 (475) |
87.6 (84.3-90.2) |
98.1 (97.5-98.5) |
88.3 (85.3-90.8) |
97.9 (97.4-98.4) |
- |
|
|
|
Liu et al. 6868. Liu LT, Dalipanda T, Jagilly R, Wang YH, Lin PC, Tsai CY, et al. Comparison of two rapid diagnostic tests during a large dengue virus serotype 3 outbreak in the Solomon Islands in 2013. PLoS One 2018; 13:e0202304. (2018) |
Solomon Island |
CS 216:14 |
412 (242) |
90.9 (87.0-94.0) |
100.0 (98.0-100.0) |
100.0 (98.0-100.0) |
88.5 (83.0-93.0) |
3 (242) |
|
|
|
Kikuti et al. 6464. Kikuti M, Cruz JS, Rodrigues MS, Tavares AS, Paploski IAD, Silva MMO, et al. Accuracy of the SD BIOLINE Dengue Duo for rapid point-of-care diagnosis of dengue. PLoS One 2019; 14:e0213301. (2019) |
Brazil |
CC 45:199 |
500 (246) |
38.6 (32.5-45.0) |
98.2 (93.5-99.8) |
97.9 (93.2-99.4) |
58.8 (56.2-61.2) |
1 (18) 2 (113) 4 (49) |
|
|
|
Lee et al. 3737. Lee H, Ryu JH, Park HS, Park KH, Bae H, Yun S, et al. Comparison of six commercial diagnostic tests for the detection of dengue virus non-structural-1 antigen and IgM/IgG antibodies. Ann Lab Med 2019; 39:566-71. (2019) |
Korea |
CC |
138 (75) |
49.2 (36.4-62.1) |
98.7 (92.8-99.9) |
96.9 (81.3-99.5) |
69.8 (64.4-74.7) |
- |
PCR-ELISA NS1/IgM/IgG |
|
|
|
|
CC |
138 (75) |
57.1 (28.9-82.3) |
100.0 (97.1-100.0) |
100.0 (63.6-100.0) |
95.4 (91.9-97.4) |
- |
ELISA IgM |
|
|
Jang et al. 6363. Jang WS, Kwak SY, May WL, Yang DJ, Nam J, Lim CS. Comparative evaluation of three dengue duo rapid test kits to detect NS1, IgM, and IgG associated with acute dengue in children in Myanmar. PLoS One 2019; 14:e0213451. (2019) |
Myanmar |
CC 1:4 |
172 (109) |
48.6 (38.9-58.4) |
100.0 (94.3-100.0) |
100.0 |
52.9 |
|
qRT-PCR ELISA IgM/IgG |
| CTK Biotech |
Liu et al. 6868. Liu LT, Dalipanda T, Jagilly R, Wang YH, Lin PC, Tsai CY, et al. Comparison of two rapid diagnostic tests during a large dengue virus serotype 3 outbreak in the Solomon Islands in 2013. PLoS One 2018; 13:e0202304. (2018) |
Solomon Island |
CS 216:14 |
412 (242) |
92.6 (88.6-95.2) |
78.8 (72.1-84.3) |
86.2 (82.3-89.3) |
88.2 (82.7-92.1) |
3 (242) |
Real-time qRT-PCR |
| Dengucheck |
Garg et al. 6060. Garg A, Garg J, Singh DV, Dhole TN. Can rapid dengue diagnostic kits be trusted? A comparative study of commercially available rapid kits for serodiagnosis of dengue fever. J Lab Physicians 2019; 11:63-7. (2019) |
India |
CC |
152 (72) |
100.0 (94.6-100.0) |
100.0 (95.5-100.0) |
100.0 (94.6-100.0) |
100.0 (95.5-100.0) |
- |
RT-PCR ELISA NS1 IgM/IgG |
| Dengue day 1 |
|
|
|
|
94.4 (86.3-98.4) |
100.0 (98.5-100.0) |
100.0 |
95.2 (88.2-98.6) |
|
|
|
|
Shukla et al. 7373. Shukla MK, Singh N, Sharma RK, Barde PV. Utility of dengue NS1 antigen rapid diagnostic test for use in difficult to reach areas and its comparison with dengue NS1 ELISA and qRT-PCR. J Med Virol 2017; 89:1146-50. (2017) |
India |
CS |
249 (128) |
93.6 (87.8-96.7) |
91.1 (84.8-94.9) |
91.4 |
93.4 |
1 (79) 2 (85) 3 (85) |
RT-PCR |
| Humasis |
Jang et al. 6363. Jang WS, Kwak SY, May WL, Yang DJ, Nam J, Lim CS. Comparative evaluation of three dengue duo rapid test kits to detect NS1, IgM, and IgG associated with acute dengue in children in Myanmar. PLoS One 2019; 14:e0213451. (2019) |
Myanmar |
CC 1:4 |
172 (109) |
63.3 (53.5-72.3) |
100.0 (94.3-100.0) |
100.0 |
44.0 |
|
qRT-PCR ELISA IgM/IgG |
| Humasis NS1/IgM |
Kyaw et al. 6666. Kyaw AK, Ngwe Tun MM, Naing ST, Htet KKK, Htwe TT, Khaing YY, et al. Evaluation of commercially available three dengue rapid diagnostic test kits for diagnosis of acute dengue virus infection at the point-of-care setting in Myanmar. J Virol Methods 2019; 273:113724. (2019) |
Myanmar |
CS 1:1 |
202 (140) |
68.6 (60.2-76.1) |
90.3 (80.1-96.4) |
94.1 (87.6-97.8) |
56.0 (45.7-65.9) |
1 (57) 2 (7) 3 (6) 4 (10) |
ELISA IgM/IgG RT-PCR |
| CareUS |
Jang et al. 6363. Jang WS, Kwak SY, May WL, Yang DJ, Nam J, Lim CS. Comparative evaluation of three dengue duo rapid test kits to detect NS1, IgM, and IgG associated with acute dengue in children in Myanmar. PLoS One 2019; 14:e0213451. (2019) |
Myanmar |
CC 1:4 |
172 (109) |
79.8 (71.1-86.9) |
100.0 (94.3-100.0) |
100.0 |
74.1 |
|
qRT-PCR ELISA IgM/IgG |
| CareUs NS1/IgM |
Kyaw et al. 6666. Kyaw AK, Ngwe Tun MM, Naing ST, Htet KKK, Htwe TT, Khaing YY, et al. Evaluation of commercially available three dengue rapid diagnostic test kits for diagnosis of acute dengue virus infection at the point-of-care setting in Myanmar. J Virol Methods 2019; 273:113724. (2019) |
Myanmar |
CS 1:1 |
202 (140) |
72.1 (63.9-79.4) |
87.1 (76.1-94.3) |
92.7 (86.0-96.8) |
58.1 (47.4-68.2) |
1 (57) 2 (7) 3 (6) 4 (10) |
ELISA IgM/IgG RT-PCR |
| Wondfo NS1/IgM |
Kyaw et al. 6666. Kyaw AK, Ngwe Tun MM, Naing ST, Htet KKK, Htwe TT, Khaing YY, et al. Evaluation of commercially available three dengue rapid diagnostic test kits for diagnosis of acute dengue virus infection at the point-of-care setting in Myanmar. J Virol Methods 2019; 273:113724. (2019) |
Myanmar |
CS 1:1 |
202 (140) |
67.1 (58.7-74.8) |
91.9 (82.2-97.3) |
94.9 (88.6-98.3) |
55.3 (45.2-65.1) |
|
|
| SD Bioline duo |
Blacksell et al. 5050. Blacksell SD, Newton PN, Bell D, Kelley J, Mammen Jr. MP, Vaughn DW, et al. The comparative accuracy of 8 commercial rapid immunochromatographic assays for the diagnosis of acute dengue virus infection. Clin Infect Dis 2006; 42:1127-34. (2011) |
Sri Lanka |
CS |
259 (99) |
79.2 (70.5-87.2) |
89.4 (83.5-93.7) |
82.3 (73.2-89.3) |
87.7 (81.7-92.3) |
1 (1) 2 (16) 3 (47) 4 (2) |
RT-PCR ELISA IgM/IgG |
|
|
Parham et al. 6767. Parham LA, Sánchez C, López MJ, Lorenzana I. Evaluation of two parameters for dengue diagnosis in Honduran patients. Am J Trop Med Hyg 2014; 91(5 Suppl 1):429. (2013) |
|
CS |
61 (48) |
82.5 (70.6-90.2) |
87.5 (64.0-96.5) |
95.9 (87.8-98.7) |
58.3 (43.7-71.6) |
1 (50) 2 (50) 3 (58) |
RT-PCR |
|
|
Sanchez-Vargas et al. 7070. Sanchez-Vargas LA, Sanchez-Marce EE, Vivanco-Cid H. Evaluation of the SD BIOLINE Dengue Duo rapid test in the course of acute and convalescent dengue infections in a Mexican endemic region. Diagn Microbiol Infect Dis 2014; 78:368-72. (2014) |
Mexico |
CC 1:1.2 |
397 (310) |
60.5 (53.4-67.6) |
94.1 (90.6-97.6) |
90.8 (85.4-96.1) |
71.2 (65.5-76.8) |
- |
ELISA NS1/IgM/IgG |
|
|
Shih et al. 7272. Shih HI, Hsu HC, Wu CJ, Lin CH, Chang CM, Tu YF, et al. Applications of a rapid and sensitive Dengue DUO Rapid Immunochromatographic Test kit as a diagnostic strategy during a dengue type 2 epidemic in an urban city. PLoS One 2016; 11:e0158437. (2016) |
Taiwan |
CS |
1,607 (1,295) |
10.0 (7.3-13.5) |
66.0 (57.8-73.3) |
- |
- |
- |
RT-PCR |
|
|
Simonet et al. 7474. Simonnet C, Okandze A, Matheus S, Djossou F, Nacher M, Mahamat A. Prospective evaluation of the SD BIOLINE Dengue Duo rapid test during a dengue virus epidemic. Eur J Clin Microbiol Infect Dis 2017; 36:2441-7. (2017) |
French Guiana |
Cohort |
3,347 (475) |
44.8 (39.9-50.0) |
98.3 (97.8-98.7) |
75.9 (70.2-80.9) |
93.7 (93.1-94.2) |
- |
Dx select IgM |
| SD Bioline Dengue Duo |
Hunsperger et al. 6262. Hunsperger EA, Sharp TM, Lalita P, Tikomaidraubuta K, Cardoso YR, Naivalu T, et al. Use of a rapid test for diagnosis of dengue during suspected dengue outbreaks in resource-limited regions. J Clin Microbiol 2016; 54:2090-5. (2016) |
Angola |
CC |
46 (14) |
91.7 (61.5-99.8) |
85.3 (68.9-95.1) |
- |
- |
1 (29) |
ELISA IgM |
|
|
|
Marshall Island |
|
796 (53) |
80.0 (61.4-92.3) |
92.2 (88.9-94.8) |
- |
- |
4 (430) |
|
|
|
|
Fiji |
|
302 (38) |
55.3 (38.3-71.4) |
78.2 (96.2-99.6) |
- |
- |
3 (89) |
|
|
|
|
Yap Island |
|
534 (53) |
56.6 (42.3-70.2) |
93.1 (91.4-95.9) |
- |
- |
2 (175) |
|
|
|
Lee et al. 3737. Lee H, Ryu JH, Park HS, Park KH, Bae H, Yun S, et al. Comparison of six commercial diagnostic tests for the detection of dengue virus non-structural-1 antigen and IgM/IgG antibodies. Ann Lab Med 2019; 39:566-71. (2019) |
|
CC |
138 (75) |
49.2 (36.4-62.1) |
98.7 (92.8-99.9) |
96.9 (81.3-99.5) |
69.8 (64.4-74.7) |
- |
PCR-ELISA NS1/IgM/IgG |
|
|
Kikuti et al. 6464. Kikuti M, Cruz JS, Rodrigues MS, Tavares AS, Paploski IAD, Silva MMO, et al. Accuracy of the SD BIOLINE Dengue Duo for rapid point-of-care diagnosis of dengue. PLoS One 2019; 14:e0213301. (2019) |
Brazil |
CC 1:4.4 (acute) |
500 (246) |
13.8 (9.8-18.8) |
96.3 (90.8-99.0) |
89.5 (76.5-95.7) |
32.9 (31.5-34.3) |
1 (18) 2 (113) 4 (49) |
RT-PCR ELISA NS1/IgM paired/ IgG |
|
|
Garg et al. 6060. Garg A, Garg J, Singh DV, Dhole TN. Can rapid dengue diagnostic kits be trusted? A comparative study of commercially available rapid kits for serodiagnosis of dengue fever. J Lab Physicians 2019; 11:63-7. (2019) |
India |
CC |
152 (72) |
44.5 (32.7-56.6) |
100.0 (97.5-100.0) |
100.0 |
66.7 (57.4-75.1) |
- |
RT-PCR ELISA NS1 IgM/IgG |
|
|
Jang et al. 6363. Jang WS, Kwak SY, May WL, Yang DJ, Nam J, Lim CS. Comparative evaluation of three dengue duo rapid test kits to detect NS1, IgM, and IgG associated with acute dengue in children in Myanmar. PLoS One 2019; 14:e0213451. (2019) |
Myanmar |
CC 1:4 |
172 (109) |
60.6 (50.7-69.8) |
100.0 (94.3-100.0) |
100.0 |
59.4 |
|
qRT-PCR ELISA IgM/IgG |
| Dengucheck |
Garg et al. 6060. Garg A, Garg J, Singh DV, Dhole TN. Can rapid dengue diagnostic kits be trusted? A comparative study of commercially available rapid kits for serodiagnosis of dengue fever. J Lab Physicians 2019; 11:63-7. (2019) |
India |
CC |
152 (72) |
77.7 (66.4-86.7) |
50.0 (38.6-61.4) |
58.3 (47.8-68.3) |
71.4 (57.8-82.7) |
- |
RT-PCR ELISA NS1 IgM/IgG |
| Dengue day 1 |
Garg et al. 6060. Garg A, Garg J, Singh DV, Dhole TN. Can rapid dengue diagnostic kits be trusted? A comparative study of commercially available rapid kits for serodiagnosis of dengue fever. J Lab Physicians 2019; 11:63-7. (2019) |
India |
CC |
152 (72) |
27.8 (17.8-39.6) |
65.0 (53.5-75.3) |
41.6 (27.6-56.8) |
50.0 (40.0-60.0) |
- |
RT-PCR ELISA NS1 IgM/IgG |
| Humasis |
Jang et al. 6363. Jang WS, Kwak SY, May WL, Yang DJ, Nam J, Lim CS. Comparative evaluation of three dengue duo rapid test kits to detect NS1, IgM, and IgG associated with acute dengue in children in Myanmar. PLoS One 2019; 14:e0213451. (2019) |
Myanmar |
CC 1:4 |
172 (109) |
51.4 (41.6-61.1) |
98.2 (91.5-99.9) |
98.2 |
53.9 |
|
qRT-PCR ELISA IgM/IgG |
| CareUS |
Jang et al. 6363. Jang WS, Kwak SY, May WL, Yang DJ, Nam J, Lim CS. Comparative evaluation of three dengue duo rapid test kits to detect NS1, IgM, and IgG associated with acute dengue in children in Myanmar. PLoS One 2019; 14:e0213451. (2019) |
Myanmar |
CC 1:4 |
172 (109) |
89.9 (82.7-94.8) |
100.0 (94.3-100.0) |
100.0 |
85.1 |
|
qRT-PCR ELISA IgM/IgG |
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