C57BL/KsJdb/+mice |
Resveratrol at 10 mg/kg *d |
body weight↓; glucose↓; insulin sensitivity↑; G6P↓; AMPK signaling↑; p-AMPK/AMPK↑; p-HDAC4/HDAC4↓; |
Yao et al. (2015)Yao, L., Wan, J., Li, H., Ding, J., Wang, Y., Wang, X., & Li, M. (2015). Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK. Reproductive Biology and Endocrinology, 13(1), 118-125. http://dx.doi.org/10.1186/s12958-015-0114-0. PMid:26542478. http://dx.doi.org/10.1186/s12958-015-011...
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C57BL/KsJdb/+ mice |
Naringenin at 100 mg/kg *d |
body weight↓; GTT↑;ITT↑; FPG↓; HOMA-IR↓; APN↑; 2-Deoxyglucose↓; GLUT4↑; insulin sensitivity↑; IL-1β↓; IL-6↓; TNF-α↓; MCP-1↓; TLR2↓; TLR4↓; phorspho-JNK↓; phorspho-NF-κB p65↓; fetal birth weight↓; litter size↑; p-AMPK /AMPK↑; AMPK signaling↑ |
Li et al. (2019)Li, S., Zhang, Y., Sun, Y., Zhang, G., Bai, J., Guo, J., Su, X., Du, H., Cao, X., Yang, J., & Wang, T. (2019). Naringenin improves insulin sensitivity in gestational diabetes mellitus mice through AMPK. Nutrition & Diabetes, 9(1), 28. http://dx.doi.org/10.1038/s41387-019-0095-8. PMid:31591391. http://dx.doi.org/10.1038/s41387-019-009...
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C57BL/KsJ-Lepdb/+mice |
Naringenin at 50 mg/kg*d |
SOD↑; GSH↑; MDA↓; body weight↑; glucose↓; insulin↑; offspring(litter size↑;litter weight↓) |
Xing et al. (2016)Xing, B.-H., Yang, F.-Z., & Wu, X.-H. (2016). Naringenin enhances the efficacy of human embryonic stem cell-derived pancreatic endoderm in treating gestational diabetes mellitus mice. Journal of Pharmacological Sciences, 131(2), 93-100. http://dx.doi.org/10.1016/j.jphs.2016.04.014. PMid:27156928. http://dx.doi.org/10.1016/j.jphs.2016.04...
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C57BL/KsJdb/+mice |
Mangiferin at 50 mg/kg*d |
body weight↓; glucose↓; insulin↑; HOMA-IR↓; HOMA-β↑; TC↓; TG↓; HDL-C↑; LDL-C↓; atherogenic index↓; fetal survival rate↑; fetal weight↑; fetal crown-rump length↑; placenta(weight↑;SOD↓; GPX↓; GSH↓; CAT↓; IL-6↓;MCP-1↓; GRP78↓; p-IRE1α↓; p-eIF2α↓) |
Sha et al. (2019)Sha, H., Zeng, H., Zhao, J., & Jin, H. (2019). Mangiferin ameliorates gestational diabetes mellitus-induced placental oxidative stress, inflammation and endoplasmic reticulum stress and improves fetal outcomes in mice. European Journal of Pharmacology, 859, 172522. http://dx.doi.org/10.1016/j.ejphar.2019.172522. PMid:31276667. http://dx.doi.org/10.1016/j.ejphar.2019....
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C57BL/KsJdb/+mice |
Diosgenin at 10 and 20 mg/kg*d |
GTT↑; ITT↑; glucose↓; FPG↓; insulin↓; hepatic glycogen↑; liver |
Hua et al. (2016)Hua, S., Li, Y., Su, L., & Liu, X. (2016). Diosgenin ameliorates gestational diabetes through inhibition of sterol regulatory element-binding protein-1. Biomedicine and Pharmacotherapy, 84, 1460-1465. http://dx.doi.org/10.1016/j.biopha.2016.10.049. PMid:27810341. http://dx.doi.org/10.1016/j.biopha.2016....
|
(TBARS↑; GSH ↑; SOD↑; CAT↑; TC↓; TG↓;) plasma(TC↓; TG↓; LDL-C↓; HDL-C↑); Srebp-1↓; FAS↓; SCD-1↓; Acc↓ |
C57BL/KsJdb/+mice |
Mogroside IIIE at 20 mg/kg*d |
body weight↓; glucose↓; insulin↑; ITT↑; GTT↑; birth weight↓; litter size↑; IL-1β↓; IL-6 ↓; TNF-α↓;AMPK signaling↑; p-AMPK/AMPK↑; p-HDAC4/HDAC4↓; G6P↓ |
Zou et al. (2018)Zou, C., Zhang, Q., & Zhang, S. (2018). Mogroside IIIE attenuates gestational diabetes mellitus through activating of AMPK signaling pathway in mice. Journal of Pharmacological Sciences, 138(3), 161-166. http://dx.doi.org/10.1016/j.jphs.2018.09.008. PMid:30316692. http://dx.doi.org/10.1016/j.jphs.2018.09...
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C57BL/KsJ db/+mice |
Astaxanthin at 30 mg/kg *d |
glucose↓; insulin↑; GTT↑; ITT↑; TC↓; TG↓; HDL↑;LDL↓; MDA↑; atherogenic index↓; liver(GSH↑; SOD↑; CAT↑; MDA↑; GPX↑) |
Chen et al. (2020)Chen, Y., Tang, J., Zhang, Y., Du, J., Wang, Y., Yu, H., & He, Y. (2020). Astaxanthin alleviates gestational diabetes mellitus in mice through suppression of oxidative stress. Naunyn-Schmiedeberg’s Archives of Pharmacology, 393(12), 2517-2527. http://dx.doi.org/10.1007/s00210-020-01861-x. PMid:32279084. http://dx.doi.org/10.1007/s00210-020-018...
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C57BL/KsJdb/+mice |
Apocynin at 5,20 and 50 mg/kg*d |
body weight↑; glucose↓; insulin↑; HOMA-IR↑; HOMA-β↑; TG↓; TC↓; HDL↑; LDL↓;atherogenic index↓; fetal survival rate↑; fetal weight↑; crown-rump length↑; placenta weight↑; placental(MDA↑ ; SOD↑; GPx↑; GSH↑); IL-1β↓; IL-6↓; TNF-α↓; TLR4/NF-κB signaling↑ |
Liu et al. (2020)Liu, T., Zheng, W., Wang, L., Wang, L., & Zhang, Y. (2020). TLR4/NF-κB signaling pathway participates in the protective effects of apocynin on gestational diabetes mellitus induced placental oxidative stress and inflammation. Reproductive Sciences, 27(2), 722-730. http://dx.doi.org/10.1007/s43032-019-00078-5. PMid:32046403. http://dx.doi.org/10.1007/s43032-019-000...
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Leprdb/+ (db/+)mice |
Nobiletin at 50 mg/kg*d |
FPG↓; placenta(Cxcl1↓; Il1a↓); VAT(Ccl2 ↓; Il1a↓; d Il1b↓); subcutaneous adipose(Ccl2↓, Cxcl1↓, Il1a↓,Il1b↓; TNF-α↓); NF-κB↓; Akt↓; MAPK signaling↓ |
Nguyen-Ngo et al. (2020)Nguyen-Ngo, C., Salomon, C., Quak, S., Lai, A., Willcox, J. C., & Lappas, M. (2020). Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes. Clinical Science, 134(6), 571-592. http://dx.doi.org/10.1042/CS20191099. PMid:32129440. http://dx.doi.org/10.1042/CS20191099...
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C57BL/KsJdb/+mice |
Curcumin at 50 and 100 mg/kg*d |
insulin↓;FPG↓; GTT↑; ITT↓; liver(TBARS↓; GSH↑; SOD↑; CAT↑); AMPK signaling↑; p-AMPK/AMPK↑; p-HDAC4/HDAC4↓; G6P↓; hepatic glycogen↑; fetuse(birthweight↓; litter size↑) |
Lu et al. (2019)Lu, X., Wu, F., Jiang, M., Sun, X., & Tian, G. (2019). Curcumin ameliorates gestational diabetes in mice partly through activating AMPK. Pharmaceutical Biology, 57(1), 250-254. http://dx.doi.org/10.1080/13880209.2019.1594311. PMid:30957612. http://dx.doi.org/10.1080/13880209.2019....
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Wistar rats by STZ |
lotus leaf polysaccharides at 50 and 100 mg/kg*d |
FPG↓; FINS↓; TG↓; TC↓; HDL↑; LDL↓; hepatic glycogen↑; SOD↑CAT↑; GPX↑; GSH↑ |
Wang (2013)Wang, H. (2013). Preventive effects of ophiopogon-polysaccharide on apiponectin in gestational diabetes mellitus rat. Asian Pacific Journal of Tropical Medicine, 6(4), 296-299. http://dx.doi.org/10.1016/S1995-7645(13)60059-0. PMid:23608331. http://dx.doi.org/10.1016/S1995-7645(13)...
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Wistar rats by STZ |
lotus leaf selenium polysaccharide at 50 and 100 mg/kg*d |
FPG↓; FINS↓; TG↓; TC↓; HDL↑; LDL↓; hepatic glycogen↑; liver(SOD↑; GSH↑; GPX↑; CAT↑); fetal body weight↑; placental weight↑; prenatal body weight ↑ |
Zeng et al. (2017)Zeng, Z., Xu, Y., & Zhang, B. (2017). Antidiabetic activity of a lotus leaf selenium (Se)-polysaccharide in rats with gestational diabetes mellitus. Biological Trace Element Research, 176(2), 321-327. http://dx.doi.org/10.1007/s12011-016-0829-6. PMid:27580896. http://dx.doi.org/10.1007/s12011-016-082...
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Wistar rats by STZ |
pomegranate ellagic polyphenols at 50, 150 and 300 mg/kg*d |
serum(RBP4↓; Hcy↓; GA↓ ; FFA↓); prenatal body weight↑; fetal rats body weight↑; FPG↓; FINS↓; HOMA-IR↓;TG↓; TC↓; HDL↑; placenta(p-PI3K↓; p-AKT↓); PPARα↑; TRB3↑; AKT2↑; p-FOXO1↑; GLUT2↑; pancreas(TNF-α↓; IL-6↓; CRP↓; APN↓; Chemerin↓); 11β-hydroxy steroid dehydrogenase type 2 level↓; PPARα-TRB3-AKT2-p-FOXO1-GLUT2 signaling↓ |
Sun et al. (2019)Sun, Y.-L., Zhou, F.-M., & Wang, H.-R. (2019). Mechanism of pomegranate ellagic polyphenols reducing insulin resistance on gestational diabetes mellitus rats. American Journal of Translational Research, 11(9), 5487-5500. http://dx.doi.org/10.1113/JP278082. PMid:31632524. http://dx.doi.org/10.1113/JP278082...
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Sprague Dawley rats by STZ |
daily 0.5% vitamin E plus 1% vitamin C; daily 2% vitamin E and 4% vitamin C |
maternal bodyweight↑; maternal liverweight↑; glucose↓; plasma(vitaminE↑; vitaminC↑; TBARS↓); Liver(vitaminE↑; vitaminC↑;TBARS↓); fetal livers(ascorbic acid↑; a-tocopherol↑; carbonylated proteins to total protein amounts↓; dintrophenylated proteins.↓); malformations rate↓; fetal weight↑; fetal liver weight↑ |
Cederberg et al. (2001)Cederberg, J., Simán, C. M., & Eriksson, U. J. (2001). Combined Treatment with Vitamin E and Vitamin C Decreases Oxidative Stress and Improves Fetal Outcome in Experimental Diabetic Pregnancy. Pediatric Research, 49(6), 755-762. http://dx.doi.org/10.1203/00006450-200106000-00007. PMid:11385134. http://dx.doi.org/10.1203/00006450-20010...
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Wistar rats (Rattus norvegicus var. albinus) by STZ |
Lentinus edodes at 100 mg/kg*d |
GTT↑; insulin↓; lipase; glucose↓; red blood cells↑;hematocrit↓; leukocyte↓; hemoglobin; platelet↑;HDL↑; LDL↓;TG↓; TC↓; ALT↓; AST↓; CAT↑; GPX↑; GSH↓; TBARS↓; placenta(CAT↑; GPX↓; GSH↓; TBARS↓); uterus weight↑; ovary weight↓; placenta weight↓; fetal survival rate↑ |
Laurino et al. (2019)Laurino, L. F., Viroel, F. J., Caetano, E., Spim, S., Pickler, T. B., Rosa-Castro, R. M., Vasconcelos, E. A., Jozala, A. F., Hataka, A., Grotto, D., & Gerenutti, M. (2019). Lentinus edodes exposure before and after fetus implantation: materno-fetal development in rats with gestational diabetes mellitus. Nutrients, 11(11), 2720. http://dx.doi.org/10.3390/nu11112720. PMid:31717560. http://dx.doi.org/10.3390/nu11112720...
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Albino rats by STZ |
Cinnamal dehyde at 20 mg/kg*d |
body weight↓; glucose↓; insulin↑; leptin↓; hepatic glycogen↑; fructosamine↓; TC↓; TG↓; HDL-C↑; GTT↑; ITT↑; birth weight↓; litter size↑; IL-1β↓; IL-6 ↓; TNF-α↓ |
Hosni et al. (2017)Hosni, A. A., Abdel-Moneim, A. A., Abdel-Reheim, E. S., Mohamed, S. M., & Helmy, H. (2017). Cinnamaldehyde potentially attenuates gestational hyperglycemia in rats through modulation of PPARγ, proinflammatory cytokines and oxidative stress. Biomedicine and Pharmacotherapy, 88, 52-60. http://dx.doi.org/10.1016/j.biopha.2017.01.054. PMid:28092845. http://dx.doi.org/10.1016/j.biopha.2017....
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Albino Wistar rats by STZ |
A daily 6% olive oil supplemented diet |
maternal rat(TG↓;TC↓); male offspring(TG↓;TC↓;free fatty acids↓; phospholipids↑; PLIN2↓ ; PPARγ1↓; PPARγ2↓; PPARδ↓; PPARα↑; Srebp-1c↓; Acc1↓; Fasn↓; Aoo↓; Cpt1-L↓; Scd-1↓; Cpt1-L↓; PGC-1α↓; SRC-1↓); female offspring(TG↓; TC↑; free fatty acids↓; cholesterylesters↓; phospholipids↓; PLIN2↑; PPARγ1↑; PPARγ2↓; PPARδ↓; PPARα↑;Srebp-1c↑; Acc1↓; Fasn↓;Aoo↓; Cpt1-L↓; Scd-1↓; Cpt1-L↓; PGC-1α↑; SRC-1↓) |
Fornes et al. (2020)Fornes, D., Gomez Ribot, D., Heinecke, F., Roberti, S. L., Capobianco, E., & Jawerbaum, A. (2020). Maternal diets enriched in olive oil regulate lipid metabolism and levels of PPARs and their coactivators in the fetal liver in a rat model of gestational diabetes mellitus. The Journal of Nutritional Biochemistry, 78, 108334. http://dx.doi.org/10.1016/j.jnutbio.2019.108334. PMid:32004928. http://dx.doi.org/10.1016/j.jnutbio.2019...
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Albino Wistar rats by STZ |
A daily 6% olive oil supplemented diet |
maternal rat(glucose↓; weight↓; CTGF↓); offspring(glucose↑; weight↓); placenta(mTORC1 signaling↑; mTORC2signaling↑; PPARγ↓; 4EBP-1↑; lipoperoxidation↓; TBARS↓; CTGF↓; MMP2↓) |
Capobianco, et al. (2018b)Capobianco, E., Gomez Ribot, D., Fornes, D., Powell, T. L., Levieux, C., Jansson, T., & Jawerbaum, A. (2018b). Diet enriched with olive oil attenuates placental dysfunction in rats with gestational diabetes induced by intrauterine programming. Molecular Nutrition & Food Research, 62(19), 1800263. http://dx.doi.org/10.1002/mnfr.201800263. PMid:29939470. http://dx.doi.org/10.1002/mnfr.201800263...
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Albino Wistar rats by STZ |
6% safflflower oil Supplemented diet from day 1 to 14 of pregnancy,then 6% chia oil supplemented diet from day 14 to term |
maternal rat(glucose↓; TG↓; TC↓); offspring(glucose↓; TG↓; TC↓; body weight↓; lipoperoxidation↓); placenta(weight↓; mTORC2 signaling↓; mTORC1 signaling↓; PPARγ↑) |
Capobianco et al. (2018a)Capobianco, E., Fornes, D., Roberti, S. L., Powell, T. L., Jansson, T., & Jawerbaum, A. (2018a). Supplementation with polyunsaturated fatty acids in pregnant rats with mild diabetes normalizes placental PPARγ and mTOR signaling in female offspring developing gestational diabetes. The Journal of Nutritional Biochemistry, 53, 39-47. http://dx.doi.org/10.1016/j.jnutbio.2017.10.006. PMid:29190548. http://dx.doi.org/10.1016/j.jnutbio.2017...
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SD rats by STZ |
okra extract at 200 mg/kg*d |
prenatal body weight↑; fetal rats weight↑; placenta weight↑; HbA1c↓; TG↓; TC↓; FFA↓; FPG↓; HDL↑; LDL↓; FINS↓; Serum CP↓; hepatic glycogen↑; liver (SOD↑; CAT↑; GPX↑; GSH↑); pancreas(SOD↑; CAT↑; GPX↑; GSH↑) |
Tian et al. (2015)Tian, Z.-H., Miao, F.-T., Zhang, X., Wang, Q.-H., Lei, N., & Guo, L.-C. (2015). Therapeutic effect of okra extract on gestational diabetes mellitus rats induced by streptozotocin. Asian Pacific Journal of Tropical Medicine, 8(12), 1038-1042. http://dx.doi.org/10.1016/j.apjtm.2015.11.002. PMid:26706676. http://dx.doi.org/10.1016/j.apjtm.2015.1...
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Wistar rats by STZ |
A daily supplemented highly-pure-Cellulose-enriched-diet (10%cellulose) |
glucose↓; urea↓; creatinine↓; uric acid↓; albumine↓; TC↓; TG↓; HDL↑; LDL↓; VLDL-C↓; VLDL-TG↓; HDL-TG↓; LDL-TG↓; carbonyl proteins↓; MDA↓; CAT↑; SOD↑ |
Bensalah et al. (2018)Bensalah, M., Bouanane, S., Benyagoub, O., Merzouk, H., & Fatima, Z. (2018). Effects of highly-pure-enriched-cellulose diet on digestibility, lipid metabolism and redox status in obese offspring of streptozotocin-induced diabetic rats. Experimental And Clinical Endocrinology & Diabetes: Official Journal. German Society Of Endocrinology And German Diabetes Association, 126(2), 102-112. http://dx.doi.org/10.1055/s-0043-110014. http://dx.doi.org/10.1055/s-0043-110014...
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Wistar rats by STZ |
A daily 60% Omega-3 polyunsaturated fatty acids supplemented diet |
pancreas of offspring (TC↓; TG↓; CAT↑; GSH↑; MDA↓; SOD↑; TNF-α↓; IL-1β↓; IL-6↓; IL-10↑; pancreatic telomere length↑) |
Gao et al. (2019a)Gao, J., Huang, T., Li, J., Guo, X., Xiao, H., Gu, J., Tang, J., Cai, W., & Li, D. (2019a). Beneficial effects of n-3 polyunsaturated fatty acids on offspring’s pancreas of gestational diabetes rats. Journal of Agricultural and Food Chemistry, 67(48), 13269-13281. http://dx.doi.org/10.1021/acs.jafc.9b05739. PMid:31725275. http://dx.doi.org/10.1021/acs.jafc.9b057...
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Wistar rats by STZ |
A daily n−3 PUFAs (EPA and DHA) supplemented diet |
offspring(body weight↓; glucose↓; insulin↓; TG↓ ; TC↓; adipose tissue weight↓; adipose tissue lipid↓; liver lipid↓); liver fatty acid of offspring(C20:5n−3↑; C22:6n−3↑; C20:4n−6↓; SFA↓) |
Soulimane-Mokhtari et al. (2005)Soulimane-Mokhtari, N. A., Guermouche, B., Yessoufou, A., Saker, M., Moutairou, K., Hichami, A., Merzouk, H., & Khan, N. A. (2005). Modulation of lipid metabolism by n−3 polyunsaturated fatty acids in gestational diabetic rats and their macrosomic offspring. Clinical Science, 109(3), 287-295. http://dx.doi.org/10.1042/CS20050028. PMid:15898958. http://dx.doi.org/10.1042/CS20050028...
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Wistar rats by STZ |
Zuogui Wan(rhizome of adhesive Rehmannia, Rhizoma Dioscoreae, Barbary Wolfberry fruit, Cornus officinalis, China dodder, Colla Cornus Cervi, tortoise shell glue, and medicinal Cyathula root) |
body weight↓; FPG↓; 2hPG↓; fat weight↓;abdominal fat weight↓; TG↓; TC↓; HDL↓; LDL↓; insulin↓; leptin↓;APN↑;HOMA-IR↓ |
Wang et al. (2016)Wang, Y., Feng, Q., Niu, X., Xu, K., Wang, Y., Wang, J., Li, Q., Mao, Y., & Gao, S. (2016). The preventive effect of zuogui wan on offspring rats’ impaired glucose tolerance whose mothers had gestational diabetes mellitus. Evidence-Based Complementary and Alternative Medicine, 2016, 9417362. http://dx.doi.org/10.1155/2016/9417362. PMid:27034700. http://dx.doi.org/10.1155/2016/9417362...
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Wistar rats by STZ |
100 mg/kg*daqueous extract of Hibiscus rosa-sinensis from day 0 to 7 of pregnancy; 200 mg/kg*d from day 8 to 14 of pregnancy; 400 mg/kg*d from day 15 to term |
glucose↓; body weight gain↑; food intake↓; water intake↓; TG↓; TC↓; HDL↑; VLDL↓; CRI↓; liver(MDA↓; GSH↑; SOD↑; CAT↓); malformations rate↓ |
Afiune et al. (2017)Afiune, L. A. F., Leal-Silva, T., Sinzato, Y. K., Moraes-Souza, R. Q., Soares, T. S., Campos, K. E., Fujiwara, R. T., Herrera, E., Damasceno, D. C., & Volpato, G. T. (2017). Beneficial effects of Hibiscus rosa-sinensis L. flower aqueous extract in pregnant rats with diabetes. PLoS One, 12(6), e0179785. http://dx.doi.org/10.1371/journal.pone.0179785. PMid:28644857. http://dx.doi.org/10.1371/journal.pone.0...
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Rats by Alloxan |
grape seed and skin extract at 4 g/kg*d |
body weight↑; glycemia↓; insulinemia↓; prolactinemia↓; kidney index↓; kidney(TG↓; G6PDH↓; MDA↓; protein carbonylation↑; non protein thiols depletion↓; SOD↑; CAT↑);1/creatinine↓; proteinuria↓; uricemia↓; Kidney magnesium↑; plasma magnesium↑; urine magnesium↑;H2O2↓; AChE↑; calpain↑; Cu↓; Se↑; tyrosinase↑; GPx↑ |
Oueslati et al. (2016)Oueslati, N., Charradi, K., Bedhiafi, T., Limam, F., & Aouani, E. (2016). Protective effect of grape seed and skin extract against diabetes-induced oxidative stress and renal dysfunction in virgin and pregnant rat. Biomedicine and Pharmacotherapy, 83, 584-592. http://dx.doi.org/10.1016/j.biopha.2016.07.024. PMid:27459114. http://dx.doi.org/10.1016/j.biopha.2016....
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Sprague Dawley rats |
resveratrol at 147 mg/kg*d |
energy intake↓; food consumption↓; FPG↓;GTT↓;ITT↓; PTT↓; FINS↑; glucagon↑; TG↓; hepatic TG↓; Srebp1c↓; PPARα↑; lpl↑; g6p↑; pck1↓; offspring(food consumption↓; litter size↑; body weight ↓; body length ↑; TG↓; Srebp1c↓; PPARα↑; lpl↑; G6P↑; pck1↓) |
Brawerman et al. (2019)Brawerman, G. M., Kereliuk, S. M., Brar, N., Cole, L. K., Seshadri, N., Pereira, T. J., Xiang, B., Hunt, K. L., Fonseca, M. A., Hatch, G. M., Doucette, C. A., & Dolinsky, V. W. (2019). Maternal resveratrol administration protects against gestational diabetes-induced glucose intolerance and islet dysfunction in the rat offspring. The Journal of Physiology, 597(16), 4175-4192. http://dx.doi.org/10.1113/JP278082. PMid:31240717. http://dx.doi.org/10.1113/JP278082...
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Sprague Dawley rats |
A daily 10% oligofructose supplemented diet |
energy intake↓; offspring(GTT↑;ITT↓; AST↓; ALT↑; IL-1β↓;IL-6↓; MCP-1↓; body weight↓; body fat↓; insulin↓; glucose↓; body fat↓; leptin↓; PPAR-β↓; FABP4↓; PGC-1α↓); Bifidobacterium spp↑ |
Paul et al. (2019)Paul, H. A., Collins, K. H., Nicolucci, A. C., Urbanski, S. J., Hart, D. A., Vogel, H. J., & Reimer, R. A. (2019). Maternal prebiotic supplementation reduces fatty liver development in offspring through altered microbial and metabolomic profiles in rats. The FASEB Journal, 33(4), 5153-5167. http://dx.doi.org/10.1096/fj.201801551R. PMid:30629464. http://dx.doi.org/10.1096/fj.201801551R...
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ICR mice |
A daily 15% lactulose supplemented diet |
LDL↓; HDL↑; TG↓; TC↓; AST↓; ALT↓; estradiol↑; prolactin↑; luteinizing hormone↑; progesterone↑; trimethyl-amine N-oxide↓; immunoglobulin A↑; intestinal permeability↓; DAO activity↓; D-LA activity↓; ZO-1↑; Occludin↑; small intestines(villus height/crypt depth↑); colon(CD4+↑; CD8+↑; IgA↑; content pH↓); Bififidobacterium↑; Bacteroides↑ |
Zhang et al. (2019)Zhang, Z., Chen, X., Zhao, J., Tian, C., Wei, X., Li, H., Lin, W., Jiang, A., Feng, R., Yuan, J., & Zhao, X. (2019). Effects of a lactulose-rich diet on fecal microbiome and metabolome in pregnant mice. Journal of Agricultural and Food Chemistry, 67(27), 7674-7683. http://dx.doi.org/10.1021/acs.jafc.9b01479. PMid:31132256. http://dx.doi.org/10.1021/acs.jafc.9b014...
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human |
Lycium barbarum L. polysaccharides at 10 mg*d |
miR-33↓; ABCA1↑; Srebp1↓; TG↓; TC↓; HDL↑; LDL↓; MDA↓ |
Yang et al. (2018)Yang, S., Si, L., Fan, L., Jian, W., Pei, H., & Lin, R. (2018). Polysaccharide IV from Lycium barbarum L. improves lipid profiles of gestational diabetes mellitus of pregnancy by upregulating ABCA1 and downregulating sterol regulatory element-binding transcription 1 via miR-33. Frontiers in Endocrinology, 9, 49. http://dx.doi.org/10.3389/fendo.2018.00049. PMid:29527188. http://dx.doi.org/10.3389/fendo.2018.000...
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human |
250 mg*d magnesium oxide plus 400 IU*d vitamin E |
body weight↓; BMI↓; FPG↓; insulin↓; QUICKI↑; HOMA-IR↓; TG↓; TC↓; LDL↓; VLDL↓ |
Maktabi et al. (2018)Maktabi, M., Jamilian, M., Amirani, E., Chamani, M., & Asemi, Z. (2018). The effects of magnesium and vitamin E co-supplementation on parameters of glucose homeostasis and lipid profiles in patients with gestational diabetes. Lipids in Health and Disease, 17(1), 163. http://dx.doi.org/10.1186/s12944-018-0814-5. PMid:30025522. http://dx.doi.org/10.1186/s12944-018-081...
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human |
soybean oligosaccharides at 10 g*d |
HOMA-IR↓; SOD↑; GPx↑; CAT↑; TBARS↓; FPG↓; FINS↓; APN↑; HBCI ↓ |
Fei et al. (2014)Fei, B., Ling, L., Hua, C., & Ren, S.-y. (2014). Effects of soybean oligosaccharides on antioxidant enzyme activities and insulin resistance in pregnant women with gestational diabetes mellitus. Food Chemistry, 158, 429-432. http://dx.doi.org/10.1016/j.foodchem.2014.02.106. PMid:24731365. http://dx.doi.org/10.1016/j.foodchem.201...
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human |
5 g*d black garlic treated Lactobacillus bulgaricus |
1hPG↓; 2hPG↓; FPG↓; GTT↑; T-AOC↑; SOD↑; GSH-PX↑; MDA↓ |
Si et al. (2019)Si, L., Lin, R., Jia, Y., Jian, W., Yu, Q., Wang, M., & Yang, S. (2019). Lactobacillus bulgaricus improves antioxidant capacity of black garlic in the prevention of gestational diabetes mellitus: a randomized control trial. Bioscience Reports, 39(8), BSR20182254. http://dx.doi.org/10.1042/BSR20182254. PMid:31362999. http://dx.doi.org/10.1042/BSR20182254...
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human |
1000 mg*d omega-3 fatty acids plus 400IU*d vitamin E |
VLDL↓; LDL↓; HDL↑; TG↓; TC↓; HOMA-IR↓; HOMA-β↓; insulin sentivity↓ |
Taghizadeh et al. (2016)Taghizadeh, M., Jamilian, M., Mazloomi, M., Sanami, M., & Asemi, Z. (2016). A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids and vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes. Journal of Clinical Lipidology, 10(2), 386-393. http://dx.doi.org/10.1016/j.jacl.2015.12.017. PMid:27055970. http://dx.doi.org/10.1016/j.jacl.2015.12...
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human |
supplemented 40 mL extra virgin olive oil plus a handful of pistachios per day |
FPG↓; body weight gain↓; HOMA-IR↓; insulin↓; offspring(birth weight↑; body length↑; hypoglycemia↓) |
Assaf-Balut et al. (2017)Assaf-Balut, C., García de la Torre, N., Durán, A., Fuentes, M., Bordiú, E., Del Valle, L., Familiar, C., Ortolá, A., Jiménez, I., Herraiz, M. A., Izquierdo, N., Perez, N., Torrejon, M. J., Ortega, M. I., Illana, F. J., Runkle, I., de Miguel, M. P., Montañez, C., Barabash, A., Cuesta, M., Rubio, M. A., & Calle-Pascual, A. L. (2017). A Mediterranean diet with additional extra virgin olive oil and pistachios reduces the incidence of gestational diabetes mellitus (GDM): a randomized controlled trial: the St. Carlos GDM prevention study. PLoS One, 12(10), e0185873. http://dx.doi.org/10.1371/journal.pone.0185873. PMid:29049303. http://dx.doi.org/10.1371/journal.pone.0...
|
human |
A daily high-fibres diet |
VLDL↓; LDL↓; HDL↑; GlycA↓; LPS↓; Lachnospira↑ |
Röytiö et al. (2018)Röytiö, H., Mokkala, K., Vahlberg, T., & Laitinen, K. (2018). Dietary intake of fat and fibre according to reference values relates to higher gut microbiota richness in overweight pregnant women – CORRIGENDUM. British Journal of Nutrition, 120(5), 599-600. http://dx.doi.org/10.1017/S0007114518001940. PMid:30060769. http://dx.doi.org/10.1017/S0007114518001...
|
human |
oligosaccharide-sialic acid at 60g*d |
IL-1β↓; IL-6↓; IL-8↓; IL-10↓; TNF-α↓; CRP↓; VLDL↓; LDL↓; HDL↑; TG↓; TC↓; GTT↑; FPG↓ |
Wang et al. (2019)Wang, S., Peng, R., Qin, S., Liu, Y., Yang, H., & Ma, J. (2019). Effects of oligosaccharide-sialic acid (OS) compound on maternal-newborn gut microbiome, glucose metabolism and systematic immunity in pregnancy: protocol for a randomised controlled study. BMJ Open, 9(9), e026583. http://dx.doi.org/10.1136/bmjopen-2018-026583. PMid:31511279. http://dx.doi.org/10.1136/bmjopen-2018-0...
|
human |
A daily 2% myo-inositol supplemented diet |
TG↓; TC↓; LDL↓; HDL↑; FPG↓; birth weight↑; ponderal index↓ |
Plows et al. (2020)Plows, J. F., Ramos Nieves, J. M., Budin, F., Mace, K., Reynolds, C. M., Vickers, M. H., Silva-Zolezzi, I., Baker, P. N., & Stanley, J. L. (2020). The effects of myo-inositol and probiotic supplementation in a high-fat-fed preclinical model of glucose intolerance in pregnancy. British Journal of Nutrition, 123(5), 516-528. http://dx.doi.org/10.1017/S0007114519003039. PMid:31771683. http://dx.doi.org/10.1017/S0007114519003...
|
human |
Supplemented 2g myo-inositol *d |
Insulin↓; leptin↑; APN↑; fasting c-peptide↓; HOMA-IR↓; GTT↑; fasting glucose↓; 2hPG↓; birth weight↓; macrosomia rate↓ |
Amaefule et al. (2018)Amaefule, C. E., Drymoussi, Z., Dodds, J., Sweeney, L., Pizzo, E., Daru, J., Robson, J., Poston, L., Khalil, A., Myers, J., Harden, A., Hitman, G. A., Khan, K., Zamora, J., Huda, M. S. B., & Thangaratinam, S. (2018). Effectiveness and acceptability of myo-inositol nutritional supplement in the prevention of gestational diabetes (EMmY): a protocol for a randomised, placebo-controlled, double-blind pilot trial. BMJ Open, 8(9), e022831. http://dx.doi.org/10.1136/bmjopen-2018-022831. PMid:30249632. http://dx.doi.org/10.1136/bmjopen-2018-0...
|
human |
A daily Ca-rich low-fat diet (200 mg Ca) |
22% reduction in GDM risk |
Osorio-Yáñez et al. (2017)Osorio-Yáñez, C., Qiu, C., Gelaye, B., Enquobahrie, D. A., & Williams, M. A. (2017). Risk of gestational diabetes mellitus in relation to maternal dietary calcium intake. Public Health Nutrition, 20(6), 1082-1089. http://dx.doi.org/10.1017/S1368980016002974. PMid:27964774. http://dx.doi.org/10.1017/S1368980016002...
|
human |
A daily capsule (Lactobacillus acidophilus LA-5,BifidobacteriumBB-12,Streptococcus thermophilus STY-31 and Lactobacillus delbrueckii bulgaricus LBY-27) |
body weight gain↓; FPG↓; FINS↓; HOMA-IR↓ |
Dolatkhah et al. (2015)Dolatkhah, N., Hajifaraji, M., Abbasalizadeh, F., Aghamohammadzadeh, N., Mehrabi, Y., & Mesgari Abbasi, M. M. (2015). Is there a value for probiotic supplements in gestational diabetes mellitus? A randomized clinical trial. Journal of Health, Population and Nutrition, 33(1), 25-33. http://dx.doi.org/10.1186/s41043-015-0034-9. PMid:26825666. http://dx.doi.org/10.1186/s41043-015-003...
|
human |
A daily capsule (Lactobacillus acidophilus, Lactobacillus casei and Bififidobacterium bififidum) plus 800 mg inulin |
insulin↓; HOMA-IR↓; HOMA-B↓; TAG↓; VLDL↓; TC↓; LDL↓; HDL↓ |
Ahmadi et al. (2016)Ahmadi, S., Jamilian, M., Tajabadi-Ebrahimi, M., Jafari, P., & Asemi, Z. (2016). The effects of synbiotic supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes: a randomised, double-blind, placebo-controlled trial. British Journal of Nutrition, 116(8), 1394-1401. http://dx.doi.org/10.1017/S0007114516003457. PMid:27681077. http://dx.doi.org/10.1017/S0007114516003...
|
in vitro human placenta, adipose and skeletal muscle model of GDM |
Placental explants were incubated in 100 μM nobiletin;skeletal muscle explants and VAT explants were incubated in 200 μm nobiletin |
VAT(IκB-α↑); placenta(Akt ↓; MAPK ERK1/2↓) |
Nguyen-Ngo et al. (2020)Nguyen-Ngo, C., Salomon, C., Quak, S., Lai, A., Willcox, J. C., & Lappas, M. (2020). Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes. Clinical Science, 134(6), 571-592. http://dx.doi.org/10.1042/CS20191099. PMid:32129440. http://dx.doi.org/10.1042/CS20191099...
|
in vitro human placenta, omental and subcutaneous adipose tissue and skeletal muscle model of GDM |
incubated in 200 um resveratrol |
placenta/omental adipose/skeletal muscle (IL-1α↓; IL-1β↓; IL-6↓; IL-8↓; MCP-1↓); tyrosine phosphorylated PIRS-1/IRS-1↑; GLUT4↑; 2DG uptake↑ |
Tran et al. (2017)Tran, H. T., Liong, S., Lim, R., Barker, G., & Lappas, M. (2017). Resveratrol ameliorates the chemical and microbial induction of inflammation and insulin resistance in human placenta, adipose tissue and skeletal muscle. PLoS One, 12(3), e0173373. http://dx.doi.org/10.1371/journal.pone.0173373. PMid:28278187. http://dx.doi.org/10.1371/journal.pone.0...
|
in vitro human placental, amnion, and choriodecidua model of GDM |
incubated in 50, 100, and 200 uM resveratrol |
placenta(SIRT1↑; TNF↓; IL6↓; IL8↓; PTGS2↓; RELA↑; PGE2↓; PGF2α↓); amnion(SIRT1↑); choriodecidua(SIRT1↑) |
Lappas et al. (2011)Lappas, M., Mitton, A., Lim, R., Barker, G., Riley, C., & Permezel, M. (2011). SIRT1 is a novel regulator of key pathways of human labor. Biology of Reproduction, 84(1), 167-178. http://dx.doi.org/10.1095/biolreprod.110.086983. PMid:20844277. http://dx.doi.org/10.1095/biolreprod.110...
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