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Original Article • Food Sci. Technol 43 • 2023 • https://doi.org/10.1590/fst.124622   copy

Pomegranate punicalagin inhibits the foam cells formation in Raw264.7 macrophages

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

In order to reveal the inhibitory effect of pomegranate punicalagin on macrophage foam cell formation and its possible mechanism, Raw264.7 macrophages were as the experimental carrier to detect the effect of punicalagin on macrophage cholesterol accumulation and outflow, and evaluate the regulation of punicalagin on cholesterol accumulation related genes CD36, PPARγ and outflow related genes ABCA1/G1, LXRα by Western-Blot method. The results showed that punicalagin can inhibit the cholesterol accumulation in raw264.7 macrophages due to restraining the PPARγ-CD36 expression, and meanwhile it could also promote macrophage cholesterol efflux by regulating LXRα-ABCA1/G1 pathway.

Keywords:
pomegranate punicalagin; Raw264.7 macrophage; cholesterol efflux; foam cell; lipid accumulation

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