Application of silver nanoparticles in food packages: a review

SIMBINE, Emelda Orlando; RODRIGUES, Larissa da Cunha; LAPA-GUIMARÃES, Judite; KAMIMURA, Eliana Setsuko; CORASSIN, Carlos Humberto; OLIVEIRA, Carlos Augusto Fernandes de

doi:10.1590/fst.36318

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Food Science and Technology

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Review Article • Food Sci. Technol 39 (4) • Oct-Dec 2019 • https://doi.org/10.1590/fst.36318 copy

Application of silver nanoparticles in food packages: a review

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Silver nanoparticles (AgNPs) are antimicrobial agents that have a wide spectrum of action, including against pathogenic bacteria and spoilage fungi. However, their mechanism of action is not completely clarified. Nowadays, scientific interest on biological synthesis of AgNPs is growing, with emphasis in their extracellular biosynthesis by microbial cells, as it is the most reliable and ecologically correct method for production, yielding no toxic residues. AgNPs may be incorporated to biodegradable and non-biodegradable polymers for the production of food packages with antimicrobial properties, leading to greater safety and longer shelf life. However, it is important to carry out migration tests for new food packages incorporated with AgNPs, based on the effective levels for their inclusion in the packaging materials.

Keywords:
silver nanoparticles; antimicrobial activity; food packaging; polymers

Producer species	Particle size (nm)	Particle shape	Microbial species tested	MIC (mg/mL)	Reference
Acinetobacter calcoaceticus LRVP54	8-12	NI	P. aeruginosa and A. Baumannii	150-600	Singh et al. (2013a) Singh, D., Rathod, V., Ninganagouda, S., Herimath, J., & Kulkarni, P. (2013a). Biosynthesis of silver nanoparticle by endophytic fungi Pencillium sp. isolated from Curcuma longa (turmeric) and its antibacterial activity against pathogenic gram negative bacteria. Journal of Pharmacy Research, 7(5), 448-453. http://dx.doi.org/10.1016/j.jopr.2013.06.003. http://dx.doi.org/10.1016/j.jopr.2013.06...
Acinetobacter calcoaceticus LRVP54	8-12	NI	S. aureus and S. mutans	>1.000
Acid lactic bacteria	2-15	Spherical Triangular	P. aeruginosa, E. coli, Klebsiela pneumonia and L. monocytogenes	2	Kanmani & Lim (2013)Kanmani, P., & Lim, S. T. (2013). Synthesis and structural characterization of silver nanoparticles using bacterial exopolysaccharide and its antimicrobial activity against food and multidrug resistant pathogens. Process Biochemistry, 48(7), 1099-1106. http://dx.doi.org/10.1016/j.procbio.2013.05.011. http://dx.doi.org/10.1016/j.procbio.2013...
Acid lactic bacteria	2-15	Spherical Triangular	Aspergillus spp. and Penicillium spp	0.2-2
Bacillus spp. GP-23	7-21	Spherical	F. oxysporum	0.08	Gopinath & Velusamy (2013)Gopinath, V., & Velusamy, P. (2013). Extracellular biosynthesis of silver nanoparticles using Bacillus sp. GP-23 and evaluation of their antifungal activity towards Fusarium oxysporum. Spectrochimica Acta. Part A: Molecular and Biomolecular Spectroscopy, 106, 170-174. http://dx.doi.org/10.1016/j.saa.2012.12.087. PMid:23376272. http://dx.doi.org/10.1016/j.saa.2012.12....
Stenotrophomonas maltophilia (GenBank: JN247637.1)	93	Cubic	S. aureus, E. coli and S. marcescens	0.0125-0.05	Oves et al. (2013)Oves, M., Khan, M. S., Zaidi, A., Ahmed, A. S., Ahmed, F., Ahmad, E., Sherwani, A., Owais, M., & Azam, A. (2013). Antibacterial and cytotoxic efficacy of extracellular silver nanoparticles biofabricated from chromium reducing Novel OS4 Strain of Stenotrophomonas maltophilia. PLoS One, 8(3), e59140. http://dx.doi.org/10.1371/journal.pone.0059140. PMid:23555625. http://dx.doi.org/10.1371/journal.pone.0...
Nocardiopsis spp. MBRC-1	30-90	Spherical	B. subtilis ATCC 6633	0.007	Manivasagan et al. (2013)Manivasagan, P., Venkatesan, J., Senthilkumar, K., Sivakumar, K., & Kim, S. K. (2013). Biosynthesis, antimicrobial and cytotoxic effect of silver nanoparticles using a novel Nocardiopsis sp. MBRC-1. BioMed Research International, 2013, 287638. http://dx.doi.org/10.1155/2013/287638. PMid:23936787. http://dx.doi.org/10.1155/2013/287638...
			P. aeruginosa ATCC 27853 and C. albicans ATCC 10231	0.01
			E. coli ATCC 10536 13 and A. fumigatus ATCC 1022	0.013
			S. aureus ATCC 6538	0.014
			E. hirae ATCC 10541 and A. niger ATCC 1015	0.016
			S. flexneri ATCC 12022 and A. brasiliensis ATCC 16404	0.018
Streptomyces coelicolor	28-50	Irregular	methicillin-resistant S. aureus	0.03	Manikprabhu & Lingappa (2013)Manikprabhu, D., & Lingappa, K. (2013). Antibacterial activity of silver nanoparticles against methicillin-resistant staphylococcus aureus synthesized using model streptomyces sp. pigment by photo-irradiation method. Journal of Pharmacy Research, 6(2), 255-260. http://dx.doi.org/10.1016/j.jopr.2013.01.022. http://dx.doi.org/10.1016/j.jopr.2013.01...
Streptomyces parvulus SSNP11	1.7-11.7	Spherical	P. putida, S. typhi, B. subtilis and K. pnuemoniae	NI	Prakasham et al. (2014)Prakasham, R. S., Kumar, B. S., Kumar, Y. S., & Kumar, K. P. (2014). Production and Characterization of Protein Encapsulated Silver Nanoparticles by Marine Isolate Streptomyces parvulus SSNP11. Indian Journal of Microbiology, 54(3), 329-336. http://dx.doi.org/10.1007/s12088-014-0452-1. PMid:24891741. http://dx.doi.org/10.1007/s12088-014-045...
Streptomyces spp. SS2	67.9 ± 18.5	Spherical	E. coli (MTCC 1089), B. subtilis (MTCC 7164), S. epidermitis (MTCC 3615), V. cholerae (MTCC 3904), and S. aureus (MTCC 1144)	NI	Mohanta & Behera (2014)Mohanta, Y. K., & Behera, S. K. (2014). Biosynthesis, characterization and antimicrobial activity of silver nanoparticles by Streptomyces sp. SS2. Bioprocess and Biosystems Engineering, 37(11), 2263-2269. http://dx.doi.org/10.1007/s00449-014-1205-6. PMid:24842223. http://dx.doi.org/10.1007/s00449-014-120...
Bacillus licheniformis (NPs-3)	77-92	Triangular, hexagonal and spherical	E. coli, S. sonnei and K. pneumonia	0.0032	Elbeshehy et al. (2015)Elbeshehy, E. K. F., Elazzazy, A. M., & Aggelis, G. (2015). Silver nanoparticles synthesis mediated by new isolates of Bacillus spp., nanoparticle characterization and their activity against Bean Yellow Mosaic Virus and human pathogens. Frontiers in Microbiology, 6, 1-13. http://dx.doi.org/10.3389/fmicb.2015.00453. PMid:26029190. http://dx.doi.org/10.3389/fmicb.2015.004...
			P. aeruginosa	0.0063
			S. aureus	0.0125
			S. bovis	0.025
Pseudomonas aeruginosa ATCC 27853	33-300	Spherical	E. coli, S. aureus, P. aeruginosa, S. aureus, S. typhimurium, Acinetobacter and C. albicans	NI	Peiris et al. (2017)Peiris, M. K., Gunasekara, C. P., Jayaweera, P. M., Arachchi, N. D. H., & Fernando, N. (2017). Biosynthesized silver nanoparticles: Are they effective antimicrobials? Memorias do Instituto Oswaldo Cruz, 112(8), 537-543. http://dx.doi.org/10.1590/0074-02760170023. PMid:28767978. http://dx.doi.org/10.1590/0074-027601700...
Streptacidiphilus durhamensis	100-700	Spherical	S. aureus ATCC6338, B. subtilis PCM2021, E. coli ATCC8739, K. pneumoniae ATCC700603 and S. infantis	0.00625	Buszewski et al. (2018)Buszewski, B., Railean-Plugaru, V., Pomastowski, P., Rafińska, K., Szultka-Mlynska, M., Golinska, P., Wypij, M., Laskowski, D., & Dahm, H. (2018). Antimicrobial activity of biosilver nanoparticles produced by a novel Streptacidiphilus durhamensis strain. Journal of Microbiology, Immunology, and Infection, 51(1), 45-54. http://dx.doi.org/10.1016/j.jmii.2016.03.002. PMid:27103501. http://dx.doi.org/10.1016/j.jmii.2016.03...
			P. mirabilis	0.05
			P. aeruginosa ATCC10145	0.025
Bacillus spp. SBT8	1-20	Spherical and pseudo-spherical	L. monocytogenes S. aureus E. coli O157:H7 S. typhimurium P. aeruginosa	0.4 0.1 0.6 0.4 0.6	Yurtluk et al. (2018)Yurtluk, T., Akçay, F. A., & Avci, A. (2018). Biosynthesis of silver nanoparticles using novel Bacillus sp. SBT8. Preparative Biochemistry & Biotechnology, 48(2), 151-159. http://dx.doi.org/10.1080/10826068.2017.1421963. PMid:29313428. http://dx.doi.org/10.1080/10826068.2017....
Pseudomonas spp. THG-LS1.4	10-40	Irregular	B. cereus, S. aureus, C. tropicalis, V. parahaemolyticus, E. coli, P. aeruginosa and S. enterica	NI	Singh et al. (2018)Singh, H., Du, J., Singh, P., & Hoo, T. (2018). Extracellular synthesis of silver nanoparticles by Pseudomonas sp. THG-LS1.4 and their antimicrobial application. Journal of Pharmaceutical Analysis, 8(4), 258-264. https://doi.org/10.1016/j.jpha.2018.04.004. https://doi.org/10.1016/j.jpha.2018.04.0...
Streptomyces xinghaiensis OF1	5-20	Spherical and polydis persed	P. aeruginosa ATCC 10145 E. coli ATCC 8739 B. subtilis PCM 2021 K. pneumoniae ATCC 700603 S. aureus ATCC 6538 C. albicans ATCC 10231 M. furfur DSM 6170	0.016 0.064 0.256 0.032 0.032 0.032 0.032	Wypij et al. (2018)Wypij, M., Swiecimska, M., Czarnecka, J., Dahm, H., Rai, M., & Golinska, P. (2018). Antimicrobial and cytotoxic activity of silver nanoparticles synthesized from two haloalkaliphilic actinobacterial strains alone and in combination with antibiotics. Journal of Applied Microbiology, 124(6), 1411-1424. http://dx.doi.org/10.1111/jam.13723. PMid:29427473. http://dx.doi.org/10.1111/jam.13723...
B. brevis (NCIM 2533)	22-60	Spherical	S. aureus and S. typhi using	NI	Saravanan et al. (2018)Saravanan, M., Arokiyaraj, S., Lakshmi, T., & Pugazhendhi, A. (2018). Microbial pathogenesis synthesis of silver nanoparticles from Phenerochaete chrysosporium (MTCC- 787) and their antibacterial activity against human pathogenic bacteria. Microbial Pathogenesis, 117, 68-72. http://dx.doi.org/10.1016/j.micpath.2018.02.008. PMid:29427709. http://dx.doi.org/10.1016/j.micpath.2018...
E. coli	33.6	Spherical	E. coli, P. aeruginosa, K. pneumoniae and S. aureus	NI	Neihaya & Zaman (2018)Neihaya, H. Z., & Zaman, H. H. (2018). Investigating the effect of biosynthesized silver nanoparticles as antibiofilm on bacterial clinical isolates. Microbial Pathogenesis, 116, 200-208. http://dx.doi.org/10.1016/j.micpath.2018.01.024. PMid:29414608. http://dx.doi.org/10.1016/j.micpath.2018...
Pseudomonas aeruginosa ATCC 27853	33-300	Spherical	E. coli, S. aureus, P. aeruginosa, S. aureus, S. typhimurium, Acinetobacter and C. albicans	NI	Peiris et al. (2017)Peiris, M. K., Gunasekara, C. P., Jayaweera, P. M., Arachchi, N. D. H., & Fernando, N. (2017). Biosynthesized silver nanoparticles: Are they effective antimicrobials? Memorias do Instituto Oswaldo Cruz, 112(8), 537-543. http://dx.doi.org/10.1590/0074-02760170023. PMid:28767978. http://dx.doi.org/10.1590/0074-027601700...
Bacillus licheniformis (NPs-3)	77-92	Triangular, hexagonal and spherical	E. coli, S. sonnei and K. pneumonia P. aeruginosa S. aureus S. bovis	0.0032 0.0063 0.0125 0.025	Elbeshehy et al. (2015)Elbeshehy, E. K. F., Elazzazy, A. M., & Aggelis, G. (2015). Silver nanoparticles synthesis mediated by new isolates of Bacillus spp., nanoparticle characterization and their activity against Bean Yellow Mosaic Virus and human pathogens. Frontiers in Microbiology, 6, 1-13. http://dx.doi.org/10.3389/fmicb.2015.00453. PMid:26029190. http://dx.doi.org/10.3389/fmicb.2015.004...

Producer species	Particle size (nm)	Particle shape	Microbial species tested	MIC (mg/mL)	Reference
Aspergillus flavus	NI	NI	P. aeruginosa, E. coli and K. pneumonia	0.02	Ninganagouda et al. (2013)Ninganagouda, S., Rathod, V., Jyoti, H., Singh, D., Prema, K., & Manzoor-Ul-Haq, S. (2013). Aspergillus flavus and their antimicrobial activity. International Journal of Pharma and Bio Sciences, 4(2), 222-229. Retrieved from https://www.researchgate.net/publication/236943633%0AEXTRACELLULAR https://www.researchgate.net/publication...
Epicoccum nigrum	1-22	Spherical	C. tropocalis, F. solani and A. fumigatus	0.001	Qian et al. (2013)Qian, Y., Yu, H., He, D., Yang, H., Wang, W., Wan, X., & Wang, L. (2013). Biosynthesis of silver nanoparticles by the endophytic fungus Epicoccum nigrum and their activity against pathogenic fungi. Bioprocess and Biosystems Engineering, 36(11), 1613-1619. http://dx.doi.org/10.1007/s00449-013-0937-z. PMid:23463299. http://dx.doi.org/10.1007/s00449-013-093...
			C. neoformans and S. schenckii	0.00025
			A. flavus and C. albicans	0.0005
			C. parapsilosis and C. krusei	0.0000125
Cryptosporiopsis ericae PS4	2-15	Spherical	E. coli MTCC730 and S. enterica MTCC735	0.0015	Devi & Joshi (2014)Devi, L. S., & Joshi, S. R. (2014). Evaluation of the antimicrobial potency of silver nanoparticles biosynthesized by using an endophytic fungus, Cryptosporiopsis ericae PS4. Journal of Microbiology (Seoul, Korea), 52(8), 667-674. http://dx.doi.org/10.1007/s12275-014-4113-1. PMid:24994011. http://dx.doi.org/10.1007/s12275-014-411...
			S. aureus MTCC96 and E. faecalis MTCC2729	0.002
			C. albicans MTCC183	0.0001
Aspergillus tamarii	3.5 ± 3.3	Spherical	NI	NI	Devi & Joshi (2015)Devi, L. S., & Joshi, S. R. (2015). Ultrastructures of silver nanoparticles biosynthesized using endophytic fungi. Journal of Microscopy and Ultrastructure, 3(1), 29-37. http://dx.doi.org/10.1016/j.jmau.2014.10.004. PMid:30023179. http://dx.doi.org/10.1016/j.jmau.2014.10...
Aspergillus niger	8.7 ± 6
Penicllium ochrochloron	7.7 ± 4.3
Fusarium oxysporum	5-13	Spherical	E. coli and S. aureus	0.08	Husseiny et al. (2015)Husseiny, S. M., Salah, T. A., & Anter, H. A. (2015). Biosynthesis of size controlled silver nanoparticles by Fusarium oxysporum, their antibacterial and antitumor activities. Beni-Suef University Journal of Basic and Applied Sciences, 4(3), 225-231. http://dx.doi.org/10.1016/j.bjbas.2015.07.004. http://dx.doi.org/10.1016/j.bjbas.2015.0...
Guignardia spp.	5-30	Spherical	P. mirabilis, K. pneumoniae, P. aeruginosa and S. aureus	0.003	Balakumaran et al. (2015)Balakumaran, M. D., Ramachandran, R., & Kalaichelvan, P. T. (2015). Exploitation of endophytic fungus, Guignardia mangiferae for extracellular synthesis of silver nanoparticles and their in vitro biological activities. Microbiological Research, 178, 9-17. http://dx.doi.org/10.1016/j.micres.2015.05.009. PMid:26302842. http://dx.doi.org/10.1016/j.micres.2015....
			E. coli, S. epidermidis and B. subtilis	0.00625
			E. faecalis	0.000125
Cs-HK1 fungus (not specified)	30-40	-	E. coli	1.6	Chen et al. (2016)Chen, X., Yan, J. K., & Wu, J. Y. (2016). Characterization and antibacterial activity of silver nanoparticles prepared with a fungal exopolysaccharide in water. Food Hydrocolloids, 53, 69-74. http://dx.doi.org/10.1016/j.foodhyd.2014.12.032. http://dx.doi.org/10.1016/j.foodhyd.2014...
Penicillium aculeatum Su1	4-55	Spherical	E. coli ATCC-8739, P. aeruginosa, ATCC-15442, S. aureus ATCC, B. subtilis, ATCC-663, C. albicans ATCC-10231	0.05-0.2	Ma et al. (2017)Ma, L., Su, W., Liu, J. X., Zeng, X. X., Huang, Z., Li, W., Liu, Z. C., & Tang, J. X. (2017). Optimization for extracellular biosynthesis of silver nanoparticles by Penicillium aculeatum Su1 and their antimicrobial activity and cytotoxic effect compared with silver ions. Materials Science and Engineering C, 77, 963-971. http://dx.doi.org/10.1016/j.msec.2017.03.294. PMid:28532117. http://dx.doi.org/10.1016/j.msec.2017.03...
Alternaria spp.	10-30	Spherical	methicillin-resistant B. subtilis, S. aureus, E. coli and S. marcescens	NI	Singh et al. (2017)Singh, T., Jyoti, K., Patnaik, A., Singh, A., Chauhan, R., & Chandel, S. (2017). Biosynthesis, characterization and antibacterial activity of silver nanoparticles using an endophytic fungal supernatant of Raphanus sativus. Journal of Genetic Engineering and Biotechnology, 15(1), 31-39. http://dx.doi.org/10.1016/j.jgeb.2017.04.005. PMid:30647639. http://dx.doi.org/10.1016/j.jgeb.2017.04...
Fusarium oxysporum	34-44	NI	E. coli	11.1	Hamedi et al. (2017)Hamedi, S., Ghaseminezhad, M., Shokrollahzadeh, S., & Shojaosadati, S. A. (2017). Controlled biosynthesis of silver nanoparticles using nitrate reductase enzyme induction of filamentous fungus and their antibacterial evaluation. Artificial Cells, Nanomedicine, and Biotechnology, 45(8), 1588-1596. http://dx.doi.org/10.1080/21691401.2016.1267011. PMid:27966375. http://dx.doi.org/10.1080/21691401.2016....
Ganoderma enigmaticum and Trametes ljubarskyi	15	Spherical	B. subtilis MTCC 441, S. aureus MTCC 96, M. luteus KUCCC 4, Staphylococcus KUCC 7, E. coli MTCC 443, P. putida KUCCC 12, K. pneumoniae MTCC 109 and K. aerogenes MTCC 98	NI	Gudikandula et al. (2017)Gudikandula, K., Vadapally, P., & Singara Charya, M. A. (2017). OpenNano biogenic synthesis of silver nanoparticles from white rot fungi: their characterization and antibacterial studies. OpenNano, 2, 64-78. http://dx.doi.org/10.1016/j.onano.2017.07.002. http://dx.doi.org/10.1016/j.onano.2017.0...
Penicillium polonicum	10-15 > 30	Spherical and nonspherical polyhedral	Acinetobacter baumani,	0.156	Neethu et al. (2018)Neethu, S., Midhun, S. J., Radhakrishnan, E. K., & Jyothis, M. (2018). Green synthesized silver nanoparticles by marine endophytic fungus Penicillium polonicum and its antibacterial efficacy against biofilm forming, multidrug-resistant Acinetobacter baumanii. Microbial Pathogenesis, 116, 263-272. http://dx.doi.org/10.1016/j.micpath.2018.01.033. PMid:29366864. http://dx.doi.org/10.1016/j.micpath.2018...
Fusarium semitectum and Aspergillus niger	10-25	Spherical	E. coli (ATCC-8739), S. aureus (ATCC-6538) and P. aeruginosa (ATCC-15442)	NI	Madakka, Jayaraju, & Rajesh (2018)Madakka, M., Jayaraju, N., & Rajesh, N. (2018). Mycosynthesis of silver nanoparticles and their characterization. MethodsX, 5, 20-29. http://dx.doi.org/10.1016/j.mex.2017.12.003. PMid:30619720. http://dx.doi.org/10.1016/j.mex.2017.12....
Phenerochaete chrysosporium (MTCC- 787)	34-90	Spherical and oval	P. aeruginosa, K. pneumoniae, S. aureus and S. epidermidis	NI	Saravanan et al. (2018)Saravanan, M., Arokiyaraj, S., Lakshmi, T., & Pugazhendhi, A. (2018). Microbial pathogenesis synthesis of silver nanoparticles from Phenerochaete chrysosporium (MTCC- 787) and their antibacterial activity against human pathogenic bacteria. Microbial Pathogenesis, 117, 68-72. http://dx.doi.org/10.1016/j.micpath.2018.02.008. PMid:29427709. http://dx.doi.org/10.1016/j.micpath.2018...
Fusarium oxysporum	1-50	Spherical	E. coli and P. aeruginosa	0.01	Srivastava et al. (2019)Srivastava, S., Bhargava, A., Pathak, N., & Srivastava, P. (2019). Production, characterization and antibacterial activity of silver nanoparticles produced by Fusarium oxysporum and monitoring of protein- ligand interaction through in-silico approaches. Microbial Pathogenesis, 129, 136-145. http://dx.doi.org/10.1016/j.micpath.2019.02.013. PMid:30742948. http://dx.doi.org/10.1016/j.micpath.2019...

AgNP characteristics	Package	Food product	Storage conditions	Antimicrobial effect	Reference
Spherical (40-50 nm)	PVC	Minced beef	3 ± 1 °C for 14 days	Inhibitory effect on microbial growth after 7 days for mesophilic, total bacteria and S. aureus, and after 10 days for E. coli	Mahdi et al. (2012)Mahdi, S. S., Vadood, R., & Nourdahr, R. (2012). Study on the antimicrobial effect of nanosilver tray packaging of minced beef at refrigerator temperature. Global Veterinaria, 9(3), 284-289. http://dx.doi.org/10.5829/idosi.gv.2012.9.3.1827. http://dx.doi.org/10.5829/idosi.gv.2012....
Zinc oxide + AgNP	LDPE	Chicken breast cooked	4 °C for 21 days	Inhibitory effect on Enterobacteriaceae and mesophilic bacteria	Panea et al. (2014)Panea, B., Ripoll, G., González, J., Fernández-Cuello, Á., & Albertí, P. (2014). Effect of nanocomposite packaging containing different proportions of ZnO and Ag on chicken breast meat quality. Journal of Food Engineering, 123, 104-112. http://dx.doi.org/10.1016/j.jfoodeng.2013.09.029. http://dx.doi.org/10.1016/j.jfoodeng.201...
Pullulan + spherical (40-100 nm)	NI	Raw turkey breast, raw beef, and ready-to-eat turkey breast	4 °C for 21 days	Effectiveness against S. aureus, L. monocytogenes, E. coli O157:H7	Morsy et al. (2014)Morsy, M. K., Khalaf, H. H., Sharoba, A. M., El-Tanahi, H. H., & Cutter, C. N. (2014). Incorporation of Essential Oils and Nanoparticles in Pullulan Films to Control Foodborne Pathogens on Meat and Poultry Products. Journal of Food Science, 79(4), M675-M684. http://dx.doi.org/10.1111/1750-3841.12400. PMid:24621108. http://dx.doi.org/10.1111/1750-3841.1240...
Spherical (3-20 nm)	LDPE	Fresh pork sirloin	6 °C for 28 days	Decrease in viable counts of L. piscium, B. thermosphacta, H. alvei, L. sakei and C. divergens	Kuuliala et al. (2015)Kuuliala, L., Pippuri, T., Hultman, J., Auvinen, S. M., Kolppo, K., Nieminen, T., Karp, M., Björkroth, J., Kuusipalo, J., & Jääskeläinen, E. (2015). Preparation and antimicrobial characterization of silver-containing packaging materials for meat. Food Packaging and Shelf Life, 6, 53-60. http://dx.doi.org/10.1016/j.fpsl.2015.09.004. http://dx.doi.org/10.1016/j.fpsl.2015.09...
Spherical (10.10 + 0.60 nm)	LDPE	Chicken breast fillet	4 °C for 12 days	Changes in viable counts of psychrotrophic bacteria, Pseudomonas spp., lactic acid bacteria, B. thermosphacta, E. coli, and total coliforms	Azlin-Hasim et al. (2015)Azlin-Hasim, S., Cruz-Romero, M. C., Morris, M. A., Cummins, E., & Kerry, J. P. (2015). Effects of a combination of antimicrobial silver low density polyethylene nanocomposite films and modified atmosphere packaging on the shelf life of chicken breast fillets. Food Packaging and Shelf Life, 4, 26-35. http://dx.doi.org/10.1016/j.fpsl.2015.03.003. http://dx.doi.org/10.1016/j.fpsl.2015.03...
NI	Plastic	Fresh chicken meatballs	5 ± 1 °C for 7 days	Effectiveness against Enterobacteriaceae and Pseudomonas spp.	Gallocchio et al (2016)Gallocchio, F., Cibin, V., Biancotto, G., Roccato, A., Muzzolon, O., Carmen, L., Simone, B., Manodori, L., Fabrizi, A., Patuzzi, I., & Ricci, A. (2016). Testing nano-silver food packaging to evaluate silver migration and food spoilage bacteria on chicken meat. Food Additives and Contaminants - Part A, 33(6), 1063-1071. http://dx.doi.org/10.1080/19440049.2016.1179794. PMid:27147130. http://dx.doi.org/10.1080/19440049.2016....
Spherical (35 nm) + CuO (50 nm) + ZnO (50-30 nm)	LDPE	Ultra-filtrated cheese	4 ± 0.5 °C for 28 days	Decrease in the most probable number of coliforms	Beigmohammadi et al. (2016)Beigmohammadi, F., Peighambardoust, S. H., Hesari, J., Azadmard-Damirchi, S., Peighambardoust, S. J., & Khosrowshahi, N. K. (2016). Antibacterial properties of LDPE nanocomposite films in packaging of UF cheese. Lebensmittel-Wissenschaft + Technologie, 65, 106-111. http://dx.doi.org/10.1016/j.lwt.2015.07.059. http://dx.doi.org/10.1016/j.lwt.2015.07....
AgNPs	PVC	Walnut, hazelnut, pistachio almond	Room temperature, 24 months	Decrease total bacteria count and coliform	Tavakoli et al. (2017)Tavakoli, H., Rastegar, H., Taherian, M., Samadi, M., & Rostami, H. (2017). The effect of nano silver packaging in increasing the shelf life of nuts: an in vitro model. Italian Journal of Food Safety, 6(4), 6874. http://dx.doi.org/10.4081/ijfs.2017.6874. PMid:29564232. http://dx.doi.org/10.4081/ijfs.2017.6874...
TiO₂+Ag (10nm)	PLA	Yunnan cottage cheese	5 ± 1 °C for 25 days	Inhibitory effect against total bacteria count, yeasts and molds growth	Li et al. (2018)Li, W., Li, L., Zhang, H., Yuan, M., & Qin, Y. (2018). Evaluation of PLA nanocomposite films on physicochemical and microbiological properties of refrigerated cottage cheese. Journal of Food Processing and Preservation, 42(1), 1-9. http://dx.doi.org/10.1111/jfpp.13362. http://dx.doi.org/10.1111/jfpp.13362...
Bergamot essential oils + TiO₂ + AgNPS	PLA	Mangoes	Room temperature, 15 days	Effectiveness against total bacteria count	Chi et al. (2019)Chi, H., Song, S., Luo, M., Zhang, C., Li, W., Li, L., & Qin, Y. (2019). Effect of PLA nanocomposite films containing bergamot essential oil, TiO2 nanoparticles, and Ag nanoparticles on shelf life of mangoes. Scientia Horticulturae, 249, 192-198. http://dx.doi.org/10.1016/j.scienta.2019.01.059. http://dx.doi.org/10.1016/j.scienta.2019...

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[1] *Corresponding author: carlosaf@usp.br