Protective Effect of Victory Onion (<i>Allium victorialis</i> L.) Extract on Reproductive System Injury in Male Rats

LI, Fanzhu; ZHANG, Xian; AMEER, Kashif; EUN, Jong-Bang

doi:10.1590/fst.30220

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Food Science and Technology

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Original Article • Food Sci. Technol (Campinas) 41 (suppl 2) • 2021 • https://doi.org/10.1590/fst.30220 copy

Protective Effect of Victory Onion (Allium victorialis L.) Extract on Reproductive System Injury in Male Rats

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Aqueous and ethanol extracts of A. victorialis were obtained by reflux extraction. A model of kidney yang deficiency as established by injecting hydrocortisone into male Sprague-Dawley rats. The experimental groups (n=8 rats per group) consisted of blank group, kidney yang deficiency group, and Jingui Shenqi control group (oral administration of Jingui Shenqi herbal preparation). In the treated groups, A. victorialis aqueous or ethanol extract was applied at doses of 1000, 800, or 400 mg/kg. In the model group, kidney yang was associated with loss of appetite, increased drinking water consumption and urine output, and decreased range of activity. With a longer injection time, body weight slowly increased, the body temperature decreased, the response was slow, kyphosis was evident in the back of the bow, and body hair became sparse and lost luster in treated group.

Keywords:
A. victorialis extract; kidney yang deficiency; reproductive function

	Water Extract			Ethanol Extract
Group	Insert latency (s)	Number of insertions	Number of riding	Insert latency (s)	Number of insertions	Number of riding
Blank	157 ± 19.64^b	18.00 ± 2.53^a	22.83 ± 1.47^a	141.83 ± 21.38^d	12.5 ± 2.88^b	32.83 ± 7.11^a
Model group	257.67 ± 22.33^a	9.00 ± 1.27^d	11.33 ± 1.63^b	278.17 ± 17.44^a	7.00 ± 3.16^c	21.33 ± 2.25^c
Positve group	163.33 ± 24.93^b	14.00 ± 2.00^bc	24 ± 4.34^a	178.83 ± 39.94^c	18.17 ± 4.31^a	24.5 ± 2.81^bc
Low dose group	242.83 ± 14.93^a	11.67 ± 1.63^c	12.33 ± 1.75^b	248.33 ± 17.32^b	12.83 ± 1.47^b	21.33 ± 2.31^c
Medium dose group	251 ± 24.75^a	13.00 ± 1.41^bc	20.17 ± 3.43^a	234 ± 13.89^b	13.67 ± 2.50^b	27.5 ± 4.76^b
High dose group	178.83 ± 29.94^b	14.67 ± 2.58^b	22.5 ± 4.09^a	150.50 ± 31.95^d	15.67 ± 2.93^ab	35.5 ± 5.01^a

	Water Extract				Ethanol Extract
Group	Renal organ coefficient	Epididymis organ coefficient	Testicular organ coefficient	Seminal vesicle & prostate organ coefficient	Renal organ coefficient	Epididymis organ coefficient	Testicular organ coefficient	Seminal vesicle & prostate organ coefficient
Blank	0.756 ± 0.0320^a	0.316 ± 0.015^a	1.012 ± 0.020^b	0.694 ± 0.0108^b	0.722 ± 0.046^a	0.32 ± 0.024^ab	0.93 ± 0.077^a	0.65 ± 0.066^a
Model group	0.598 ± 0.0310^c	0.271 ± 0.012^b	0.851 ± 0.0391^d	0.516 ± 0.032^d	0.610 ± 0.041^b	0.287 ± 0.053^c	0.76 ± 0.067^c	0.516 ± 0.021^b
Positve group	0.671 ± 0.0183^b	0.308 ± 0.025^a	0.935 ± 0.072^c	0.696 ± 0.038^b	0.671 ± 0.0183^a	0.308 ± 0.025^bc	0.935 ± 0.072^a	0.696 ± 0.038^a
Low dose group	0.649 ± 0.0499^b	0.321 ± 0.037^a	0.995 ± 0.043^b	0.603 ± 0.029^c	0.701 ± 0.047^a	0.301 ± 0.018^c	0.83 ± 0.101^bc	0.637 ± 0.043^a
Medium dose group	0.663 ± 0.0241^b	0.328 ± 0.030^a	1.012 ± 0.044^b	0.622 ± 0.049^c	0.718 ± 0.053^a	0.322 ± 0.019^abc	0.88 ± 0.037^a	0.630 ± 0.077^a
High dose group	0.670 ± 0.0568^b	0.337 ± 0.029^a	1.074 ± 0.032^a	0.769 ± 0.072^a	0.720 ± 0.038^a	0.343 ± 0.023^a	0.96 ± 0.077^a	0.672 ± 0.049^a

	Water Extract	Ethanol Extract
Group	Testosterone content (pg/mL)	Testosterone content (pg/mL)
Blank	161.640 ± 3.340^a	146.066 ± 5.516^b
Model group	114.862 ± 5.000^d	115.660 ± 2.395^d
Positve group	147.957 ± 5.853^b	147.957 ± 5.853^b
Low dose group	138.387 ± 2.053^c	134.183 ± 4.970^c
Medium dose group	146.066 ± 5.516^b	145.266 ± 2.643^b
High dose group	147.353 ± 2.517^b	159.034 ± 3.560^a

	Water Extract			Ethanol Extract
Group	CRH(U/mL)	LH(U/mL)	GnRH(U/mL)	CRH(U/mL)	LH(U/mL)	GnRH(U/mL)
Blank	101.305 ± 0.750^a	26.641 ± 6.175^d	38.319 ± 4.733^a	82.695 ± 6.323^a	63.527 ± 7.490^d	40.128 ± 8.4629^a
Model group	67.090 ± 6.434^c	44.093 ± 2.491^a	17.970 ± 1.104^d	57.596 ± 1.875^c	109.183 ± 2.986^a	7.293 ± 1.636^d
Positve group	83.824 ± 7.477^b	29.324 ± 3.691^d	29.420 ± 2.969^b	83.824 ± 7.477^a	72.922 ± 7.422^c	38.319 ± 4.733^a
Low dose group	84.870 ± 3.554^b	36.475 ± 5.271^bc	19.613 ± 2.125^d	73.167 ± 5.434^b	83.264 ± 5.662^b	15.792 ± 2.525^c
Medium dose group	89.998 ± 2.020^b	37.202 ± 3.185^b	25.058 ± 4.773^c	74.993 ± 2.630^b	83.402 ± 6.232^b	14.243 ± 0.996^c
High dose group	96.575 ± 0.734^a	30.727 ± 2.631^dc	28.287 ± 8.996^b	77.251 ± 8.131^ab	74.492 ± 6.906^c	25.366 ± 2.190^b

	Water Extract		Ethanol Extract
Group	MDA (nmol/mL)	SOD vitality (U/mL)	MDA(nmol/mL)	SOD vitality (U/mL)
Blank	4.012 ± 0.626^d	124.415 ± 3.968^a	3.790 ± 0.505^c	151.486 ± 6.398^a
Model group	9.298 ± 0.626^a	84.309 ± 3.169^d	5.445 ± 0.312^a	107.994 ± 8.957^d
Positve group	4.432 ± 0.142^cd	128.697 ± 4.511^a	4.432 ± 0.142^b	128.697 ± 4.511^c
Low dose group	5.655 ± 0.283^b	92.872 ± 4.973^c	4.532 ± 0.464^b	126.522 ± 2.318^c
Medium dose group	4.845 ± 0.387^c	104.202 ± 1.780^c	4.121 ± 0508^bc	126.869 ± 3.645^c
High dose group	4.243 ± 0.330^cd	115.660 ± 2.395^b	3.722 ± 0.508^c	140.883 ± 2.662^b

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[1] *Corresponding author: jbeun@jnu.ac.kr