Oatp1a1 |
Uptake |
Down-regulation |
(Brcakova et al., 2009Brcakova, E., Fuksa, L., Cermanova, J., Kolouchova, G., Hroch, M., Hirsova, P., Martinkova, J., Staud, F., & Micuda, S. (2009). Alteration of methotrexate biliary and renal elimination during extrahepatic and intrahepatic cholestasis in rats. Biological & Pharmaceutical Bulletin, 32(12), 1978-1985. http://dx.doi.org/10.1248/bpb.32.1978. PMid:19952415. http://dx.doi.org/10.1248/bpb.32.1978...
; Donner et al., 2007Donner, M. G., Schumacher, S., Warskulat, U., Heinemann, J., & Haussinger, D. (2007). Obstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2. American Journal of Physiology. Gastrointestinal and Liver Physiology, 293(6), G1134-G1146. http://dx.doi.org/10.1152/ajpgi.00079.2007. PMid:17916651. http://dx.doi.org/10.1152/ajpgi.00079.20...
; Geier et al., 2007Geier, A., Dietrich, C. G., Trauner, M., & Gartung, C. (2007). Extrahepatic cholestasis downregulates Oatp1 by TNF-α signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver. Liver International, 27(8), 1056-1065. http://dx.doi.org/10.1111/j.1478-3231.2007.01523.x. PMid:17845533. http://dx.doi.org/10.1111/j.1478-3231.20...
; Slitt et al., 2007Slitt, A. L., Allen, K., Morrone, J., Aleksunes, L. M., Chen, C., Maher, J. M., Manautou, J. E., Cherrington, N. J., & Klaassen, C. D. (2007). Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Biochimica et Biophysica Acta - Biomembranes, 1768(3), 637-647. http://dx.doi.org/10.1016/j.bbamem.2006.10.008. PMid:17141734. http://dx.doi.org/10.1016/j.bbamem.2006....
; Yan et al., 2017Yan, J., Xie, G., Liang, C., Hu, Y., Zhao, A., Huang, F., Hu, P., Liu, P., Jia, W., & Wang, X. (2017). Herbal medicine Yinchenhaotang protects against α-naphthylisothiocyanate-induced cholestasis in rats. Scientific Reports, 7(1), 4211. http://dx.doi.org/10.1038/s41598-017-04536-5. PMid:28646179. http://dx.doi.org/10.1038/s41598-017-045...
; Zhang et al., 2012) |
Oatp1a4 |
Uptake |
Up-regulation |
(Gyamfi et al., 2009Gyamfi, M. A., Tanaka, Y., He, L., Klaassen, C. D., & Wan, Y. J. (2009). Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice. Toxicology and Applied Pharmacology, 234(2), 166-178. http://dx.doi.org/10.1016/j.taap.2008.09.022. PMid:18952117. http://dx.doi.org/10.1016/j.taap.2008.09...
; Slitt et al., 2007Slitt, A. L., Allen, K., Morrone, J., Aleksunes, L. M., Chen, C., Maher, J. M., Manautou, J. E., Cherrington, N. J., & Klaassen, C. D. (2007). Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Biochimica et Biophysica Acta - Biomembranes, 1768(3), 637-647. http://dx.doi.org/10.1016/j.bbamem.2006.10.008. PMid:17141734. http://dx.doi.org/10.1016/j.bbamem.2006....
) |
Oatp1b2 |
Uptake |
Down-regulation |
(Zhang et al., 2018Zhang, Y., Lickteig, A. J., Csanaky, I. L., & Klaassen, C. D. (2018). Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion. Toxicology and Applied Pharmacology, 338, 112-123. http://dx.doi.org/10.1016/j.taap.2017.11.014. PMid:29175453. http://dx.doi.org/10.1016/j.taap.2017.11...
) |
Oatp1a5 |
Uptake |
Down-regulation |
(Geier et al., 2007Geier, A., Dietrich, C. G., Trauner, M., & Gartung, C. (2007). Extrahepatic cholestasis downregulates Oatp1 by TNF-α signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver. Liver International, 27(8), 1056-1065. http://dx.doi.org/10.1111/j.1478-3231.2007.01523.x. PMid:17845533. http://dx.doi.org/10.1111/j.1478-3231.20...
; Slitt et al., 2007Slitt, A. L., Allen, K., Morrone, J., Aleksunes, L. M., Chen, C., Maher, J. M., Manautou, J. E., Cherrington, N. J., & Klaassen, C. D. (2007). Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Biochimica et Biophysica Acta - Biomembranes, 1768(3), 637-647. http://dx.doi.org/10.1016/j.bbamem.2006.10.008. PMid:17141734. http://dx.doi.org/10.1016/j.bbamem.2006....
) |
Mrp1 |
Efflux |
Up-regulation |
(Geier et al., 2007Geier, A., Dietrich, C. G., Trauner, M., & Gartung, C. (2007). Extrahepatic cholestasis downregulates Oatp1 by TNF-α signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver. Liver International, 27(8), 1056-1065. http://dx.doi.org/10.1111/j.1478-3231.2007.01523.x. PMid:17845533. http://dx.doi.org/10.1111/j.1478-3231.20...
; Slitt et al., 2007Slitt, A. L., Allen, K., Morrone, J., Aleksunes, L. M., Chen, C., Maher, J. M., Manautou, J. E., Cherrington, N. J., & Klaassen, C. D. (2007). Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Biochimica et Biophysica Acta - Biomembranes, 1768(3), 637-647. http://dx.doi.org/10.1016/j.bbamem.2006.10.008. PMid:17141734. http://dx.doi.org/10.1016/j.bbamem.2006....
) |
Mrp2 |
Efflux |
Up-regulation |
(Donner et al., 2007Donner, M. G., Schumacher, S., Warskulat, U., Heinemann, J., & Haussinger, D. (2007). Obstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2. American Journal of Physiology. Gastrointestinal and Liver Physiology, 293(6), G1134-G1146. http://dx.doi.org/10.1152/ajpgi.00079.2007. PMid:17916651. http://dx.doi.org/10.1152/ajpgi.00079.20...
; Geier et al., 2007Geier, A., Dietrich, C. G., Trauner, M., & Gartung, C. (2007). Extrahepatic cholestasis downregulates Oatp1 by TNF-α signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver. Liver International, 27(8), 1056-1065. http://dx.doi.org/10.1111/j.1478-3231.2007.01523.x. PMid:17845533. http://dx.doi.org/10.1111/j.1478-3231.20...
; Slitt et al., 2007Slitt, A. L., Allen, K., Morrone, J., Aleksunes, L. M., Chen, C., Maher, J. M., Manautou, J. E., Cherrington, N. J., & Klaassen, C. D. (2007). Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Biochimica et Biophysica Acta - Biomembranes, 1768(3), 637-647. http://dx.doi.org/10.1016/j.bbamem.2006.10.008. PMid:17141734. http://dx.doi.org/10.1016/j.bbamem.2006....
) |
Mrp3 |
Efflux |
Up-regulation |
(Cheng et al., 2016Cheng, Y., Freeden, C., Zhang, Y., Abraham, P., Shen, H., Wescott, D., Humphreys, W. G., Gan, J., & Lai, Y. (2016). Biliary excretion of pravastatin and taurocholate in rats with bile salt export pump (Bsep) impairment. Biopharmaceutics & Drug Disposition, 37(5), 276-286. http://dx.doi.org/10.1002/bdd.2011. PMid:27059119. http://dx.doi.org/10.1002/bdd.2011...
; Zhang et al., 2018Zhang, Y., Lickteig, A. J., Csanaky, I. L., & Klaassen, C. D. (2018). Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion. Toxicology and Applied Pharmacology, 338, 112-123. http://dx.doi.org/10.1016/j.taap.2017.11.014. PMid:29175453. http://dx.doi.org/10.1016/j.taap.2017.11...
) |
Mrp4 |
Efflux |
Up-regulation |
(Gyamfi et al., 2009Gyamfi, M. A., Tanaka, Y., He, L., Klaassen, C. D., & Wan, Y. J. (2009). Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice. Toxicology and Applied Pharmacology, 234(2), 166-178. http://dx.doi.org/10.1016/j.taap.2008.09.022. PMid:18952117. http://dx.doi.org/10.1016/j.taap.2008.09...
) |
Ntcp |
Uptake |
Down-regulation |
(Zhang et al., 2018Zhang, Y., Lickteig, A. J., Csanaky, I. L., & Klaassen, C. D. (2018). Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion. Toxicology and Applied Pharmacology, 338, 112-123. http://dx.doi.org/10.1016/j.taap.2017.11.014. PMid:29175453. http://dx.doi.org/10.1016/j.taap.2017.11...
) |
Ostβ |
Uptake |
Up-regulation |
(Penno et al., 2014Penno, C. A., Morgan, S. A., Rose, A. J., Herzig, S., Lavery, G. G., & Odermatt, A. (2014). 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice. Molecular Metabolism, 3(5), 554-564. http://dx.doi.org/10.1016/j.molmet.2014.04.008. PMid:25061560. http://dx.doi.org/10.1016/j.molmet.2014....
) |
Bsep |
Efflux |
Up-regulation |
(Donner et al., 2007Donner, M. G., Schumacher, S., Warskulat, U., Heinemann, J., & Haussinger, D. (2007). Obstructive cholestasis induces TNF-alpha- and IL-1 -mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2. American Journal of Physiology. Gastrointestinal and Liver Physiology, 293(6), G1134-G1146. http://dx.doi.org/10.1152/ajpgi.00079.2007. PMid:17916651. http://dx.doi.org/10.1152/ajpgi.00079.20...
; Geier et al., 2007Geier, A., Dietrich, C. G., Trauner, M., & Gartung, C. (2007). Extrahepatic cholestasis downregulates Oatp1 by TNF-α signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver. Liver International, 27(8), 1056-1065. http://dx.doi.org/10.1111/j.1478-3231.2007.01523.x. PMid:17845533. http://dx.doi.org/10.1111/j.1478-3231.20...
; Slitt et al., 2007Slitt, A. L., Allen, K., Morrone, J., Aleksunes, L. M., Chen, C., Maher, J. M., Manautou, J. E., Cherrington, N. J., & Klaassen, C. D. (2007). Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Biochimica et Biophysica Acta - Biomembranes, 1768(3), 637-647. http://dx.doi.org/10.1016/j.bbamem.2006.10.008. PMid:17141734. http://dx.doi.org/10.1016/j.bbamem.2006....
) |
ASBT |
Uptake |
Down-regulation |
(Yan et al., 2017Yan, J., Xie, G., Liang, C., Hu, Y., Zhao, A., Huang, F., Hu, P., Liu, P., Jia, W., & Wang, X. (2017). Herbal medicine Yinchenhaotang protects against α-naphthylisothiocyanate-induced cholestasis in rats. Scientific Reports, 7(1), 4211. http://dx.doi.org/10.1038/s41598-017-04536-5. PMid:28646179. http://dx.doi.org/10.1038/s41598-017-045...
) |
TGR5 |
Uptake |
Down-regulation |
(Yan et al., 2017Yan, J., Xie, G., Liang, C., Hu, Y., Zhao, A., Huang, F., Hu, P., Liu, P., Jia, W., & Wang, X. (2017). Herbal medicine Yinchenhaotang protects against α-naphthylisothiocyanate-induced cholestasis in rats. Scientific Reports, 7(1), 4211. http://dx.doi.org/10.1038/s41598-017-04536-5. PMid:28646179. http://dx.doi.org/10.1038/s41598-017-045...
) |
MDR2 |
Efflux |
Up-regulation |
(Donato et al., 2016Donato, M. T., Lopez-Riera, M., Castell, J. V., Gomez-Lechon, M. J., & Jover, R. (2016). Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: application to develop new predictive biomarkers for early drug development. Toxicology Letters, 263, 58-67. http://dx.doi.org/10.1016/j.toxlet.2016.10.008. PMid:27765674. http://dx.doi.org/10.1016/j.toxlet.2016....
) |
ABCG5 |
Efflux |
Up-regulation |
(Donato et al., 2016Donato, M. T., Lopez-Riera, M., Castell, J. V., Gomez-Lechon, M. J., & Jover, R. (2016). Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: application to develop new predictive biomarkers for early drug development. Toxicology Letters, 263, 58-67. http://dx.doi.org/10.1016/j.toxlet.2016.10.008. PMid:27765674. http://dx.doi.org/10.1016/j.toxlet.2016....
) |
ABCG8 |
Efflux |
Up-regulation |
(Donato et al., 2016Donato, M. T., Lopez-Riera, M., Castell, J. V., Gomez-Lechon, M. J., & Jover, R. (2016). Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: application to develop new predictive biomarkers for early drug development. Toxicology Letters, 263, 58-67. http://dx.doi.org/10.1016/j.toxlet.2016.10.008. PMid:27765674. http://dx.doi.org/10.1016/j.toxlet.2016....
) |