5 d 1x/d |
Hemato |
6100 mg/kg |
|
|
Commens, 1990Commens, C. A. (1990). Topical propylene glycol and hyperosmolality. The British Journal of Dermatology, 122(1), 77-80. http://dx.doi.org/10.1111/j.1365-2133.1990.tb08242.x. PMid:2297506. http://dx.doi.org/10.1111/j.1365-2133.19...
|
70 hr |
Resp Cardio Metab |
|
|
9000 M (acute respiratory acidosis) |
Fligner et al., 1985Fligner, C. L., Jack, R., Twiggs, G. A., & Raisys, V. A. (1985). Hyperosmolality induced by propylene glycol: a complication of silver sulfadiazine therapy. Journal of the American Medical Association, 253(11), 1606-1609. http://dx.doi.org/10.1001/jama.1985.03350350100031. PMid:3974044. http://dx.doi.org/10.1001/jama.1985.0335...
|
20-24 hr |
Dermal |
|
3.2% (irritation reaction) |
|
Hannuksela et al., 1975Hannuksela, M., Pirilä, V., & Salo, O. P. (1975). Skin reactions to propylene glycol. Contact Dermatitis, 1(2), 112-116. http://dx.doi.org/10.1111/j.1600-0536.1975.tb05336.x. PMid:233872. http://dx.doi.org/10.1111/j.1600-0536.19...
|
48 hr |
Dermal |
|
10 mg (50% solution, skin edema and erythema) |
|
Kinnunen & Hannuksela, 1989Kinnunen, T., & Hannuksela, M. (1989). Skin reactions to hexylene glycol. Contact Dermatitis, 21(3), 154-158. http://dx.doi.org/10.1111/j.1600-0536.1989.tb04728.x. PMid:2529099. http://dx.doi.org/10.1111/j.1600-0536.19...
|
7 d 2x/d |
Dermal |
104 M mg |
|
|
Trancik & Maibach, 1982Trancik, R. J., & Maibach, H. I. (1982). Propylene glycol: Irritation or sensitization? Contact Dermatitis, 8(3), 185-189. http://dx.doi.org/10.1111/j.1600-0536.1982.tb04180.x. PMid:7094572. http://dx.doi.org/10.1111/j.1600-0536.19...
|
48 hrs |
Dermal |
|
2.5% (erythema, induration, vesiculation) |
|
Warshaw & Herrmann, 1952Warshaw, T. G., & Herrmann, F. (1952). Studies of skin reactions to propylene glycol. The Journal of Investigative Dermatology, 19(6), 423-430. http://dx.doi.org/10.1038/jid.1952.118. PMid:13023015. http://dx.doi.org/10.1038/jid.1952.118...
|
48 hr |
Dermal |
15 mg M |
31 mg M (faint, patchy erythema with edema) |
|
Willis et al., 1988Willis, C. M., Stephens, C. J., & Wilkinson, J. D. (1988). Experimentally‐induced irritant contact dermatitis: determination of optimum irritant concentrations. Contact Dermatitis, 18(1), 20-24. http://dx.doi.org/10.1111/j.1600-0536.1988.tb05484.x. PMid:3349774. http://dx.doi.org/10.1111/j.1600-0536.19...
|
48 hr |
Dermal |
|
16 mg M ("basket weave" pattern to stratum corneum) |
|
Willis et al., 1988Willis, C. M., Stephens, C. J., & Wilkinson, J. D. (1988). Experimentally‐induced irritant contact dermatitis: determination of optimum irritant concentrations. Contact Dermatitis, 18(1), 20-24. http://dx.doi.org/10.1111/j.1600-0536.1988.tb05484.x. PMid:3349774. http://dx.doi.org/10.1111/j.1600-0536.19...
|