Abstract
To investigate the influence of neuropsychiatric manifestations and functional performance on quality of life (QOL) of AD patients and their caregivers/family members. Methods: The QOL-AD scale, Mini-Mental State Examination (MMSE), Geriatric Depression Scale (GDS), Cornell and Beck Scales for Depression, Physical and Instrumental-Self Maintenance scales (AIDL and ADL) and the Neuropsychiatric Inventory (NPI) were applied to 60 patients with probable AD, mild (n=30) or moderate (n=30) dementia, according to NINCDS-ADRDA and DSM-III-R criteria, respectively, and to their caregivers/family members. The total scores on the three QOL-AD versions were correlated with the measures previously mentioned. Results: The QOL-AD patients' version displayed significant correlations with GDS (-0.76 p<0.01), Cornell (-0.53 p<0.01) and NPI (-0.46 p<0.05) in the mild dementia subgroup. The caregivers' version about patients' QOL correlated with GDS (-0.48 p<0.01), Cornell (-0.57 p<0.01), NPI (-0.46 p<0.01) and AIDL (-0.36 p<0.05), while the caregivers' version about their own QOL was significantly correlated with NPI (-0.43 p<0.01), AIDL (-0.35 p<0.05) and Beck Depression (-0.67 p<0.01). In the moderate dementia subgroup, significant correlations were observed with GDS (-0.45 p<0.05) and Cornell (-0.46 p<0.01). For the caregivers' version about patients' QOL, significant correlations emerged with Cornell (-0.68 p<0.01), NPI (-0.67 p<0.01), AIDL (-0.41 p<0.05), ADL (-0.49, p<0.01) and Beck Depression (-0.33 p<0.05). For the caregivers' version about their own QOL, significant correlations with Beck Depression (-0.54 p<0.01) and ADL (-0.38, p<0.05) were found. Conclusion: The symptoms presented in AD affected the QOL in patients and caregivers/family members in both mild and moderate dementia.
Key words:
quality of life; Alzheimer's disease; neuropsychiatric symptoms; functional performance; caregivers
Resumo
Investigar avaliar a influência das manifestações neuropsiquiátricas e do desempenho funcional sobre a qualidade de vida dos pacientes com DA e de seus cuidadores/familiares. Métodos: A escala QdV-DA, Mini-exame do Estado Mental (MEM), Escala de Depressão Geriátrica (GDS), Inventário de Depressão de Beck e a Escala de Cornell para depressão, Escala de atividades de vida diária (ABVD e AIVD) de Lawton e Brody e o Inventário Neuropsiquiátrico (INP) foram administrados em uma amostra de 60 pacientes com DA provável, segundo os critérios do NINCDS-ADRDA , com gravidade de leve (n=30) a moderado (n-30) segundo os critérios do DMS-III-R. e a seus respectivos cuidadores/familiares. A pontuação total, das três versões da escala, foi correlacionada aos instrumentos previamente mencionados. Resultados: A versão de QV dos pacientes no grupo de demência leve apresentou correlações significativas com o GDS (-0,76 p<0,01), Cornell (-0,53 p<0,01) e INP (-0,46 p<0, 05). A versão do cuidador sobre a QV do paciente se correlacionou com: GDS (-0,48 p<0,01), Cornell (-0,57 p<0,01), INP (-0,62 p<0,01) e AIVD (-0,36 p<0,05) enquanto que a versão do cuidador sobre sua própria QV se correlacionou significativamente com NPI (-0,43 p<0,01), AIVD (-0,35 p<0,05) e GDS (-0,67 p<0,01). No grupo de pacientes moderados foram encontradas correlações significativas com GDS (-0,45 p<0,05) e a Escala de Cornell (-0,46 p<0,01). Para versão do cuidador sobre a QV do paciente as correlações significativas foram com: Cornell (-0,68 p<0,01), INP (-0,67 p<0,01), AIVD (-0,41 p<0,05), ABVD (-0,49 p<0,01), e Inventário de Depressão de Beck (-0,33 p<0,05). Para versão do cuidador sobre sua própria QV foram encontradas correlações significativas com: Inventário de Depressão Beck (-0,54 p<0,01) e ABVD (-0,38 p<0,05). Conclusão: Os sintomas da DA afetam a QV dos pacientes como também dos cuidadores/familiares tanto na fase leve como na fase moderada.
Palavras-chave:
qualidade de vida; doença de Alzheimer; sintomas neuropsiquiátricos; desempenho funcional; cuidadores
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Publication Dates
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Publication in this collection
Jan-Mar 2010
History
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Received
30 Oct 2008 -
Accepted
27 Jan 2010