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Views & Reviews • Dement. neuropsychol. 9 (4) • Oct-Dec 2015 • https://doi.org/10.1590/1980-57642015DN94000343   copy

PET and the multitracer concept in the study of neurodegenerative diseases

PET E O CONCEITO DE MULTITRAÇADOR NO ESTUDO DE DOENÇAS DEGENERATIVAS

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

The complexity of the pathological reactions of the brain to an aggression caused by an internal or external noxa represents a challenge for molecular imaging. Positron emission tomography (PET) can indicate in vivo,anatomopathological changes involved in the development of different clinical symptoms in patients with neurodegenerative disorders. PET and the multitracer concept can provide information from different systems in the brain tissue building an image of the whole disease. We present here the combination of 18F-flourodeoxyglucose (FDG) and N-[11C-methyl]-L-deuterodeprenyl (DED), FDG and N-[11C-methyl] 2-(4'-methylaminophenyl)-6-hydroxybenzothiazole (PIB), PIB and L-[11C]-3'4-Dihydrophenylalanine (DOPA) and finally PIB and [15O]H2O.

Key words:
PET; neurodegeneration; F-flourodeoxyglucose; PIB; Alzheimer's disease; Creutzfeldt-Jakob disease

Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento R. Vergueiro, 1353 sl.1404 - Ed. Top Towers Offices, Torre Norte, São Paulo, SP, Brazil, CEP 04101-000, Tel.: +55 11 5084-9463 | +55 11 5083-3876 - São Paulo - SP - Brazil
E-mail: revistadementia@abneuro.org.br | demneuropsy@uol.com.br
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