Chételat et al.5858. Chételat G, Villemagne VL, Pike KE, Ellis KA, Bourgeat P, Jones G, et al. Independent contribution of temporal beta-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer’s disease. Brain. 2011;134(Pt 3):798-807. https://doi.org/10.1093/brain/awq383 https://doi.org/https://doi.org/10.1093/...
|
93 |
PiB-PET |
N/A |
Gray matter, white matter, and CSF |
CVLT-II And RCFT |
EM involvement is related to Aβ deposition, especially in the temporal neocortex, and regardless of hippocampal atrophy |
4 |
15 |
Lim et al.5959. Lim YY, Ellis KA, Pietrzak RH, Ames D, Darby D, Harrington K, et al. Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults. Neurology. 2012;79(16):1645-52. https://doi.org/10.1212/WNL.0b013e31826e9ae6 https://doi.org/https://doi.org/10.1212/...
|
141 |
PiB-PET |
Blood exam |
Cerebellum |
CVLT-II and PAL |
High Aβ showed significantly greater decline in verbal and visual EM at 18 months |
5 |
15 |
Marchant et al.6060. Marchant NL, Reed BR, DeCarli CS, Madison CM, Weiner MC, Chui HC, et al. Cerebrovascular disease, β-amyloid, and cognition in aging. Neurobiol Aging. 2012;33(5):1006.e25-36. https://doi.org/10.1016/j.neurobiolaging.2011.10.001 https://doi.org/https://doi.org/10.1016/...
|
54 |
PiB-PET |
MRI and FLAIR |
CSF, WMH, frontal, parietal, and temporal cortex, posterior cingulate, and precuneus |
CVLT and MAS |
Aβ did not explain changes in EM |
5 |
16 |
Perrotin et al.6161. Perrotin A, Mormino EC, Madison CM, Hayenga AO, Jagust WJ. Subjective cognition and amyloid deposition imaging: a Pittsburgh Compound B positron emission tomography study in normal elderly individuals. Arch Neurol. 2012;69(2):223-9. https://doi.org/10.1001/archneurol.2011.666 https://doi.org/https://doi.org/10.1001/...
|
48 |
PiB-PET |
MRI |
Medial PFC/ACC, precuneus/PCC/ICC, and temporal lobe |
CVLT-II and WMS-R |
High Aβ performed worse than low Aβ just on the EM measure test CVLT |
5 |
15 |
Rodrigueet al.6262. Rodrigue KM, Kennedy KM, Devous MD, Rieck JR, Hebrank AC, Diaz-Arrastia R, et al. β-Amyloid burden in healthy aging. Neurology. 2012;78(6):387-95. https://doi.org/10.1212/WNL.0b013e318245d295 https://doi.org/https://doi.org/10.1212/...
|
137 |
F-florbetapir PET |
Blood exam |
– |
HVLT and CANTAB |
Aβ subgroup has no significant association with EM |
5 |
16 |
Adamczuk et al.6363. Adamczuk K, De Weer A-S, Nelissen N, Chen K, Sleegers K, Bettens K, et al. Polymorphism of brain derived neurotrophic factor influences β amyloid load in cognitively intact apolipoprotein E ε4 carriers. NeuroImage Clin. 2013;2:512-20. https://doi.org/10.1016/j.nicl.2013.04.001 https://doi.org/https://doi.org/10.1016/...
|
64 |
F-flutemetamol PET |
MRI |
Frontal, parietal, anterior cingulate, precuneus/posterior cingulate, and lateral temporal |
BNT, AVF, and RPM |
Aβ and EM were negatively correlated only in the BDNF group of met +ve/APOE ε 4 +ve |
5 |
14 |
Doré et al.6464. Doré V, Villemagne VL, Bourgeat P, Fripp J, Acosta O, Chetélat G, et al. Cross-sectional and longitudinal analysis of the relationship between Aβ deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease. JAMA Neurol. 2013;70(7):903-11. https://doi.org/10.1001/jamaneurol.2013.1062 https://doi.org/https://doi.org/10.1001/...
|
133 |
PiB-PET |
MRI |
Gray matter, white matter, CSF, and cerebellum |
CVLT-II and LMT-II |
No significant differences in EM between the Aβ- and Aβ+ groups. There was a significant reduction in the precuneus and hippocampus |
5 |
13 |
Ellis et al. 6565. Ellis KA, Lim YY, Harrington K, Ames D, Bush AI, Darby D, et al. Decline in cognitive function over 18 months in healthy older adults with high amyloid-β. J Alzheimers Dis. 2013;34(4):861-71. https://doi.org/10.3233/JAD-122170 https://doi.org/https://doi.org/10.3233/...
|
178 |
PiB-PET |
Blood exam |
Frontal, superior parietal, lateral temporal, lateral occipital, and anterior and posterior cingulate |
CVLT-II, LMR, and RCFT |
High Aβ showed greater decline in EM |
5 |
14 |
Hedden et al.6666. Hedden T, Mormino EC, Amariglio RE, Younger AP, Schultz AP, Becker JA, et al. Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults. J Neurosci. 2012;32(46):16233-42. https://doi.org/10.1523/JNEUROSCI.2462-12.2012 https://doi.org/https://doi.org/10.1523/...
|
168 |
PiB-PET |
MRI and FLAIR |
Frontal, lateral, parietal, temporal, and retrosplenial cortices |
FNAME, STSRT, and MCT |
Aβ burden and WMH had distinct cognitive profiles. Aβ was associated with a decline in EM |
5 |
14 |
Lim et al.6767. Lim YY, Ellis KA, Harrington K, Kamer A, Pietrzak RH, Bush AI, et al. Cognitive consequences of high Aβ amyloid in mild cognitive impairment and healthy older adults: implications for early detection of Alzheimer’s disease. Neuropsychology. 2013;27(3):322-32. https://doi.org/10.1037/a0032321 https://doi.org/https://doi.org/10.1037/...
|
234 |
PiB-PET |
Blood exam |
Cerebellar cortex, frontal, superior parietal, lateral temporal, lateral occipital, and anterior and posterior cingulate |
CVLT-II and RCFT |
No differences were observed between HC high and low Aβ groups |
4 |
15 |
Sperling et al.6868. Sperling RA, Johnson KA, Doraiswamy PM, Reiman EM, Fleisher AS, Sabbagh M, et al. Amyloid deposition detected with florbetapir F 18 (18F-AV-45) is related to lower episodic memory performance in clinically normal older individuals. Neurobiol Aging. 2013;34(3):822-31. https://doi.org/10.1016/j.neurobiolaging.2012.06.014 https://doi.org/https://doi.org/10.1016/...
|
78 |
Florbetapir F 18 PET |
MRI |
Grey matter, frontal, temporal, parietal cortices, anterior cingulate, and posterior cingulate |
WLM-I, WLM-D, and DSS |
The highest SUVr correlated with the lowest immediate memory |
8 |
16 |
Wirth et al.6969. Wirth M, Oh H, Mormino EC, Markley C, Landau SM, Jagust WJ. The effect of amyloid β on cognitive decline is modulated by neural integrity in cognitively normal elderly. Alzheimers Dement J Alzheimers Assoc. 2013;9(6):687-98.e1. https://doi.org/10.1016/j.jalz.2012.10.012 https://doi.org/https://doi.org/10.1016/...
|
38 |
PiB-PET |
FDG-PET and MRI |
Frontal, temporal, parietal, and anterior/posterior cingulate |
LMR and VRT |
PiB positivity was associated with nonmemory decline |
3 |
14 |
Lim et al.7070. Lim YY, Maruff P, Pietrzak RH, Ellis KA, Darby D, Ames D, et al. Aβ and cognitive change: examining the preclinical and prodromal stages of Alzheimer’s disease. Alzheimers Dement J Alzheimers Assoc. 2014;10(6):743-51.e1. https://doi.org/10.1016/j.jalz.2013.11.005 https://doi.org/https://doi.org/10.1016/...
|
225 |
PiB-PET |
Blood exam |
Cerebellar cortex |
CVLT-II |
High Aβ HC and MCI groups showed moderate decline in EM |
7 |
16 |
Lim et al.7171. Lim YY, Maruff P, Pietrzak RH, Ames D, Ellis KA, Harrington K, et al. Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer’s disease. Brain J Neurol. 2014;137(Pt 1):221-31. https://doi.org/10.1093/brain/awt286 https://doi.org/https://doi.org/10.1093/...
|
413 |
PiB-PET |
Blood exam |
Cerebellar cortex |
LMR, CVLT-II, RCFT, and COCLT |
Aβ+ showed greater decline on the verbal EM and visual EM |
7 |
16 |
Ossenkoppele et al. 7272. Ossenkoppele R, Madison C, Oh H, Wirth M, van Berckel BNM, Jagust WJ. Is verbal episodic memory in elderly with amyloid deposits preserved through altered neuronal function? Cereb Cortex N Y N 1991. 2014;24(8):2210-8. https://doi.org/10.1093/cercor/bht076 https://doi.org/https://doi.org/10.1093/...
|
81 |
PiB-PET |
FDG-PET and MRI |
Gray matter, posterior cingulate cortex, bilateral angular gyri, and bilateral inferior temporal gyri |
CVLT and VRT |
Aβ was associated with higher metabolic activity and lower visual episodic memory scores |
5 |
15 |
Villeneuve et al.99. Villeneuve S, Reed BR, Wirth M, Haase CM, Madison CM, Ayakta N, et al. Cortical thickness mediates the effect of β-amyloid on episodic memory. Neurology. 2014;82(9):761-7. https://doi.org/10.1212/WNL.0000000000000170 https://doi.org/https://doi.org/10.1212/...
|
67 |
PiB-PET |
MRI |
Right frontal, parietal, temporal, occipital, and precuneus |
MAS |
High Aβ was associated with cortical thinning and lower performance of EM |
5 |
16 |
Amariglio et al.7373. Amariglio RE, Mormino EC, Pietras AC, Marshall GA, Vannini P, Jonhson KA, et al. Subjective cognitive concerns, amyloid-β, and neurodegeneration in clinically normal elderly. Neurology. 2015;85(1):56-62. https://doi.org/10.1212/WNL.0000000000001712 https://doi.org/https://doi.org/10.1212/...
|
257 |
PiB-PET |
FDG-PET and MRI |
Hippocampal volume |
FNAME, STSRT, and MCT |
Aβ and ND biomarkers predict biggest changes in EM |
8 |
16 |
Aschenbrenner et al.7474. Aschenbrenner AJ, Balota DA, Fagan AM, Duchek JM, Benzinger TL, Morris JC. Alzheimer disease cerebrospinal fluid biomarkers moderate baseline differences and predict longitudinal change in attentional control and episodic memory composites in the adult children study. J Int Neuropsychol Soc. 2015;21(8):573-83. https://doi.org/10.1017/S1355617715000776 https://doi.org/https://doi.org/10.1017/...
|
238 |
PiB-PET |
Cerebrospinal fluid assessment |
Orbitofrontal, parietal, frontal, frontal, and temporal |
SRT |
EM was not correlated with levels of Aβ |
5 |
16 |
Lim et al. 7575. Lim YY, Pietrzak RH, Bourgeat P, Ames D, Ellis KA, Rembach A, et al. Relationships between performance on the cogstate brief battery, neurodegeneration, and Aβ accumulation in cognitively normal older adults and adults with MCI. Arch Clin Neuropsychol. 2015;30(1):49-58. https://doi.org/10.1093/arclin/acu068. https://doi.org/https://doi.org/10.1093/...
|
227 |
PiB-PET |
MRI |
Gray matter, white matter, cerebrospinal fluid, and hippocampus |
OCL |
Aβ+ CN and MCI groups showed decline on the EM measures |
6 |
15 |
Lim et al. 7676. Lim YY, Villemagne VL, Laws SM, Pietrzak RH, Snyder PJ, Ames D, et al. APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer’s disease. Mol Psychiatry. 2015;20(11):1322-8. https://doi.org/10.1038/mp.2014.123 https://doi.org/https://doi.org/10.1038/...
|
333 |
PiB-PET |
Blood exam |
Cerebellar cortex |
LMR, CVLT-II, RCFT, and COCLT |
Aβ+ ɛ4+ individuals showed cognitive decline across all domains. Aβ+ ɛ4− individuals showed faster decline only in verbal EM |
8 |
17 |
Mander et al.7777. Mander BA, Marks SM, Vogel JW, Rao V, Lu B, Saletin JM, et al. β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation. Nat Neurosci. 2015;18(7):1051-7. https://doi.org/10.1038/nn.4035 https://doi.org/https://doi.org/10.1038/...
|
26 |
PiB-PET |
fMRI and EEG |
Hippocampus and mPFC |
TWPT |
Aβ impairs sleep and has indirect implications for EM decline |
8 |
18 |
Mattsson et al.5252. Mattsson N, Insel PS, Aisen PS, Jagust W, Mackin S, Weiner M. Brain structure and function as mediators of the effects of amyloid on memory. Neurology. 2015;84(11):1136-44. https://doi.org/10.1212/WNL.0000000000001375 https://doi.org/https://doi.org/10.1212/...
|
743 |
Florbetapir PET |
FDG-PET and MRI |
Gray matter |
LMR and AVLT |
Aβ+ was associated with lower EM scores |
4 |
16 |
Pietrzak et al.7878. Pietrzak RH, Lim YY, Ames D, Harrington K, Restrepo C, Martins RN, et al. Trajectories of memory decline in preclinical Alzheimer’s disease: results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of ageing. Neurobiol Aging. 2015;36(3):1231-8. https://doi.org/10.1016/j.neurobiolaging.2014.12.015 https://doi.org/https://doi.org/10.1016/...
|
333 |
PiB-PET |
– |
– |
CVLT and LMR |
High Aβ was associated with a subtle decrease in EM |
8 |
16 |
Racine et al.7979. Racine AM, Koscik RL, Berman SE, Nicholas CR, Clark LR, Okonkwo OC, et al. Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife. Brain J Neurol. 2016;139(Pt 8):2261-74. https://doi.org/10.1093/brain/aww142 https://doi.org/https://doi.org/10.1093/...
|
175 |
Electrochemiluminescence |
MRI and FLAIR |
|
RAVLT and WMS-RLM |
High levels of Aβ and higher rates of decline in EM tests |
4 |
18 |
Wang et al.8080. Wang L, Benzinger TL, Hassenstab J, Blazey T, Owen C, Liu J, et al. Spatially distinct atrophy is linked to β-amyloid and tau in preclinical Alzheimer disease. Neurology. 2015;84(12):1254-60. https://doi.org/10.1212/WNL.0000000000001401 https://doi.org/https://doi.org/10.1212/...
|
188 |
CSF collection |
MRI |
Entorhinal cortex, fusiform gyrus, inferior, middle, and superior temporal gyri, superior and inferior parietal lobules, posterior cingulate gyrus, and precuneus |
N/A |
Reduced CSF Aβ42 was related to poorer performance on EM |
3 |
16 |
Wang et al.8181. Wang F, Gordon BA, Ryman DC, Ma S, Xiong C, Hassenstab J, et al. Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease. Neurology. 2015;85(9):790-8. https://doi.org/10.1212/WNL.0000000000001903 https://doi.org/https://doi.org/10.1212/...
|
263 |
PiB-PET |
Blood exam |
– |
LMIRD and WLIRD |
For asymptomatic carriers, Aβ burden was predictive of longitudinal decline in EM |
8 |
15 |
Bischof et al.8282. Bischof GN, Rodrigue KM, Kennedy KM, Devous MD, Park DC. Amyloid deposition in younger adults is linked to episodic memory performance. Neurology. 2016;87(24):2562-6. https://doi.org/10.1212/WNL.0000000000003425 https://doi.org/https://doi.org/10.1212/...
|
147 |
Florbetapir PET |
– |
– |
HVLT and CANTAB |
Higher Aβ may have an influence on EM, especially between 30 and 55 years of age |
7 |
16 |
Lim et al.8383. Lim YY, Laws SM, Villemagne VL, Pietrzak RH, Porter T, Ames D, et al. Aβ-related memory decline in APOE ε4 noncarriers: Implications for Alzheimer disease. Neurology. 2016;86(17):1635-42. https://doi.org/10.1212/WNL.0000000000002604 https://doi.org/https://doi.org/10.1212/...
|
423 |
PiB-PET |
Blood exam |
Cerebellar cortex |
CVLT, LMR, and RCFT |
Significantly increased decline in EM in Aβ+ APOE ε4 carriers |
7 |
17 |
Mielke et al.8484. Mielke MM, Machulda MM, Hagen CE, Christianson TJ, Roberts RO, Knopman DS, et al. Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort. Alzheimers Dement J Alzheimers Assoc. 2016;12(3):281-91. https://doi.org/10.1016/j.jalz.2015.09.010 https://doi.org/https://doi.org/10.1016/...
|
465 |
PiB-PET |
– |
– |
AVLT, WMS-RLM, WMS-RVR, and CogState |
High Aβ was not associated with changes in EM |
5 |
16 |
Song et al.8585. Song Z, McDonough IM, Liu P, Lu H, Park DC. Cortical amyloid burden and age moderate hippocampal activity in cognitively-normal adults. NeuroImage Clin. 2016;12:78-84. https://doi.org/10.1016/j.nicl.2016.05.013 https://doi.org/https://doi.org/10.1016/...
|
82 |
F18-AV-45-florbetapir PET |
MRI and fMRI |
– |
HVLT and CANTAB |
Aβ had no effects or interaction in EM |
4 |
14 |
Ayton et al.8686. Ayton S, Fazlollahi A, Bourgeat P, Raniga P, Ng A, Lim YY, et al. Cerebral quantitative susceptibility mapping predicts amyloid-β-related cognitive decline. Brain J Neurol. 2017;140(8):2112-9. https://doi.org/10.1093/brain/awx137 https://doi.org/https://doi.org/10.1093/...
|
117 |
PiB-PET |
|
Hippocampus |
CVLT and RCFT |
Aβ pathology and higher levels of quantitative susceptibility of the hippocampus predicted accelerated deterioration in EM |
6 |
17 |
Boots et al.8787. Boots EA, Schultz SA, Clark LR, Racine AM, Darst BF, Koscik RL, et al. BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer’s Prevention. Neurology. 2017;88(22):2098-106. https://doi.org/10.1212/WNL.0000000000003980 https://doi.org/https://doi.org/10.1212/...
|
140 |
PiB-PET |
– |
– |
RAVLT |
BDNF was associated with a decline in EM and was exacerbated by a greater Aβ load |
6 |
17 |
Farrell et al.8888. Farrell ME, Kennedy KM, Rodrigue KM, Wig G, Bischof GN, Rieck JR, et al. Association of longitudinal cognitive decline with amyloid burden in middle-aged and older adults: evidence for a dose-response relationship. JAMA Neurol. 2017;74(7):830-8. https://doi.org/10.1001/jamaneurol.2017.0892 https://doi.org/https://doi.org/10.1001/...
|
174 |
F-florbetapir PET |
– |
– |
– |
Aβ+ and the increase in baseline SUVR predicted an increasing decline in EM |
7 |
16 |
Lim et al.8989. Lim YY, Williamson R, Laws SM, Villemagne VL, Bourgeat P, Fowler C, et al. Effect of APOE genotype on amyloid deposition, brain volume, and memory in cognitively normal older individuals. J Alzheimers Dis. 2017;58(4):1293-302. https://doi.org/10.3233/JAD-170072 https://doi.org/https://doi.org/10.3233/...
|
989 |
PiB-PET |
Blood exam and MRI |
Hippocampus volume |
CVLT-II, LMR, and RCFT |
APOEɛ4 homozygotes (ɛ4/ɛ4) showed significantly worse EM and higher Aβ levels than heterozygous ɛ4 |
5 |
14 |
Lim et al.9090. Lim YY, Rainey-Smith S, Lim Y, Laws SM, Gupta V, Porter T, et al. BDNF Val66Met in preclinical Alzheimer’s disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. Int Psychogeriatr. 2017;29(11):1825-34. https://doi.org/10.1017/S1041610217001284 https://doi.org/https://doi.org/10.1017/...
|
446 |
PiB-PET |
Blood exam |
Hippocampus volume |
LMR, CVLT-II, and RCFT |
Aβ- Val and Aβ+ Val homozygotes showed a decline in EM |
4 |
17 |
Pietrzak et al.9191. Pietrzak RH, Laws SM, Lim YY, Bender SJ, Porter T, Doecke J, et al. Plasma cortisol, brain amyloid-β, and cognitive decline in preclinical alzheimer’s disease: a 6-year prospective cohort study. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017;2(1):45-52. https://doi.org/10.1016/j.bpsc.2016.08.006 https://doi.org/https://doi.org/10.1016/...
|
416 |
PiB-PET |
MRI |
Plasmatic cortisol |
CVLT-II, LMR, and RCFT |
Older Aβ+ adults experienced a faster decline in EM |
3 |
16 |
Vogel et al.9292. Vogel JW, Varga Doležalová M, La Joie R, Marks SM, Schwimmer HD, Landau SM, et al. Subjective cognitive decline and β-amyloid burden predict cognitive change in healthy elderly. Neurology. 2017;89(19):2002-9. https://doi.org/10.1212/WNL.0000000000004627 https://doi.org/https://doi.org/10.1212/...
|
136 |
PiB-PET |
– |
– |
N/A |
Decline in EM was observed only when cognitive decline and Aβ were present |
7 |
17 |
van Bergen et al.9393. van Bergen JMG, Li X, Quevenco FC, Gietl AF, Treyer V, Meyer R, et al. Simultaneous quantitative susceptibility mapping and Flutemetamol-PET suggests local correlation of iron and β-amyloid as an indicator of cognitive performance at high age. NeuroImage. 2018;174:308-16. https://doi.org/10.1016/j.neuroimage.2018.03.021 https://doi.org/https://doi.org/10.1016/...
|
116 |
Flutemetamol PET |
MRI |
– |
MMSE and VLMT |
Local correlation between iron and β-amyloid is related to levels of cognitive performance |
5 |
18 |
Bilgel et al.9494. Bilgel M, An Y, Helphrey J, Elkins W, Gomez G, Wong DF, et al. Effects of amyloid pathology and neurodegeneration on cognitive change in cognitively normal adults. Brain. 2018;141(8):2475-85. https://doi.org/10.1093/brain/awy150 https://doi.org/https://doi.org/10.1093/...
|
171 |
PiB-PET |
MRI |
Hippocampus |
CVLT and BVRT |
Amyloidosis or hippocampal atrophy had longitudinal declines in EM verbal and learning |
3 |
17 |
Farrell et al.9595. Farrell ME, Chen X, Rundle MM, Chan MY, Wig GS, Park DC. Regional amyloid accumulation and cognitive decline in initially amyloid-negative adults. Neurology. 2018;91(19):e1809-21. https://doi.org/10.1212/WNL.0000000000006469 https://doi.org/https://doi.org/10.1212/...
|
126 |
Florbetapir PET |
MRI |
Hippocampal and cortical volume |
HVLIR and CANTAB |
Decline in EM and increase in Aβ accumulation |
7 |
18 |
Jansen et al.9696. Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O, Klunk WE, et al. Association of cerebral amyloid-β aggregation with cognitive functioning in persons without dementia. JAMA Psychiatry. 2018;75(1):84-95. https://doi.org/10.1001/jamapsychiatry.2017.3391 https://doi.org/https://doi.org/10.1001/...
|
2,908 |
PiB-PET |
– |
– |
VWLT |
Aβ positivity was associated with low memory |
6 |
17 |
Leal et al.9797. Leal SL, Lockhart SN, Maass A, Bell RK, Jagust WJ. Subthreshold amyloid predicts tau deposition in aging. J Neurosci. 2018;38(19):4482-9. https://doi.org/10.1523/JNEUROSCI.0485-18.2018 https://doi.org/https://doi.org/10.1523/...
|
71 |
PiB-PET |
– |
– |
WMS - II and CVLT |
Higher levels of Aβ are associated with the decline of EM |
5 |
16 |
Lim et al.9898. Lim YY, Kalinowski P, Pietrzak RH, Laws SM, Burnham SC, Ames D, et al. Association of β-amyloid and apolipoprotein E ε4 with memory decline in preclinical alzheimer disease. JAMA Neurol. 2018;75(4):488-94. https://doi.org/10.1001/jamaneurol.2017.4325. https://doi.org/https://doi.org/10.1001/...
|
447 |
PiB-PET |
MRI |
– |
RAVLT |
Worsens in EM of Aβ+ than Aβ− and may exacerbate with age |
5 |
18 |
Mecca et al.9999. Mecca AP, Barcelos NM, Wang S, Brück A, Nabulsi N, Planeta-Wilson B, et al. Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer’s disease. Neurobiol Aging. 2018;61:207-14. https://doi.org/10.1016/j.neurobiolaging.2017.09.027 https://doi.org/https://doi.org/10.1016/...
|
45 |
PiB-PET |
MRI |
Gray matter |
N/A |
In middle-aged individuals, Aβ load does not affect EM performance |
6 |
18 |
Ko et al.100100. Ko H, Ihm J-J, Kim H-G. Cognitive profiling related to cerebral amyloid beta burden using machine learning approaches. Front Aging Neurosci. 2019;11:95. https://doi.org/10.3389/fnagi.2019.00095 https://doi.org/https://doi.org/10.3389/...
|
762 |
PiB-PET |
– |
– |
RAVLT and ADAS-Cog |
EM was a predictor for Aβ positivity |
6 |
17 |
Pothier et al.101101. Pothier K, Saint-Aubert L, Hooper C, Delrieu J, Payoux P, Barreto PS, et al. Cognitive changes of older adults with an equivocal amyloid load. J Neurol. 2019;266(4):835-43. https://doi.org/10.1007/s00415-019-09203-5 https://doi.org/https://doi.org/10.1007/...
|
65 |
F-florbetapir PET |
– |
– |
FCSRT |
Significant difference for EM over time, with better performance in Aβ- compared with Aβ+. |
8 |
19 |
Rabin et al.102102. Rabin JS, Perea RD, Buckley RF, Johnson KA, Sperling RA, Hedden T. Synergism between fornix microstructure and beta amyloid accelerates memory decline in clinically normal older adults. Neurobiol Aging. 2019;81:38-46. https://doi.org/10.1016/j.neurobiolaging.2019.05.005 https://doi.org/https://doi.org/10.1016/...
|
253 |
PiB-PET |
MRI |
Fornix |
WMS-RLM, FCSRT, and STSRT |
Elevated Aβ load has been associated with a faster decline in EM over time |
4 |
17 |
Rahayel et al.103103. Rahayel S, Bocti C, Sévigny Dupont P, Joannette M, Lavallée MM, Nikelski J, et al. Subcortical amyloid relates to cortical morphology in cognitively normal individuals. Eur J Nucl Med Mol Imaging. 2019;46(11):2358-69. https://doi.org/10.1007/s00259-019-04446-w https://doi.org/https://doi.org/10.1007/...
|
104 |
PiB-PET |
MRI |
– |
WMS - III and RAVLT |
Higher Aβ had worse episodic memory |
5 |
17 |
Yu et al.104104. Yu L, Petyuk VA, Tasaki S, Boyle P, Gaiteri C, Schneider JA, et al. Association of cortical β-amyloid protein in the absence of insoluble deposits with alzheimer disease. JAMA Neurol. 2019;76(7):818-26. https://doi.org/10.1001/jamaneurol.2019.0834 https://doi.org/https://doi.org/10.1001/...
|
148 |
SRM |
– |
– |
– |
Aβ is unrelated with decline in EM |
8 |
19 |
Dupont et al.105105. Dupont PS, Bocti C, Joannette M, Lavallée MM, Nikelski J, Vallet GT, et al. Amyloid burden and white matter hyperintensities mediate age-related cognitive differences. Neurobiol Aging. 2020;86:16-26. https://doi.org/10.1016/j.neurobiolaging.2019.08.025 https://doi.org/https://doi.org/10.1016/...
|
104 |
PiB-PET |
MRI |
WMHs |
LMT -II |
Deposition Aβ predicts weaker EM performance |
8 |
18 |
Joannette et al.106106. Joannette M, Bocti C, Dupont PS, Lavallée MM, Nikelski J, Vallet GT, et al. Education as a moderator of the relationship between episodic memory and amyloid load in normal aging. J Gerontol Ser A. 2020;75(10):1820-6. https://doi.org/10.1093/gerona/glz235 https://doi.org/https://doi.org/10.1093/...
|
104 |
PiB-PET |
MRI |
– |
RAVLT |
EM performance is associated with Aβ load |
6 |
18 |
Lim et al.107107. Lim YY, Maruff P, Kaneko N, Doecke J, Fowler C, Villemagne VL, et al. Plasma Amyloid-β Biomarker Associated with Cognitive Decline in Preclinical Alzheimer’s Disease. J Alzheimers Dis. 2020;77(3):1057-65. https://doi.org/10.3233/JAD-200475 https://doi.org/https://doi.org/10.3233/...
|
213 |
PiB-PET |
Blood exam |
– |
CVLT and RAVLT |
Aβ is related to the decline of EM |
7 |
16 |
Lindbergh et al.2323. Lindbergh CA, Casaletto KB, Staffaroni AM, Joie RL, Iaccarino L, Edwards L, et al. Sex-related differences in the relationship between β-amyloid and cognitive trajectories in older adults. Neuropsychology. 2020;34(8):835-50. https://doi.org/10.1037/neu0000696 https://doi.org/https://doi.org/10.1037/...
|
149 |
Florbetapir PET |
|
Gray matter |
RAVLT and RCFT |
Women with high Aβ are more vulnerable to declining EM than men |
6 |
18 |
Squarzoni et al.108108. Squarzoni P, Faria D de P, Yassuda MS, Porto FHG, Coutinho AM, Costa NA, et al. Relationship between PET-assessed amyloid burden and visual and verbal episodic memory performance in elderly subjects. J Alzheimers Dis. 2020;78(1):229-44. https://doi.org/10.3233/JAD-200758 https://doi.org/https://doi.org/10.3233/...
|
108 |
PiB-PET |
|
|
RAVLT |
Aβ load and poorer memory performance were detected only in stages + |
6 |
16 |
Busatto Filho et al.109109. Busatto Filho G, Duran FL de S, Squarzoni P, Coutinho AM, Rosa PG, Torralbo L, et al. Hippocampal subregional volume changes in elders classified using positron emission tomography-based Alzheimer’s biomarkers of β-amyloid deposition and neurodegeneration. J Neurosci Res. 2021;99(2):481-501. https://doi.org/https://doi.org/10.1002/jnr.24739 https://doi.org/https://doi.org/https://...
|
124 |
PiB-PET |
MRI and FDG-PET |
Hippocampal subregions |
AVLT and SCPT |
Subicular volumes were inversely correlated with the degree of Aβ deposition. Verbal EM scores were significantly lower in both (N)+ groups |
5 |
15 |
Han et al.110110. Han JW, Maillard P, Harvey D, Fletcher E, Martinez O, Johnson DK, et al. Association of vascular brain injury, neurodegeneration, amyloid, and cognitive trajectory. Neurology. 2020;95(19):e2622-34. https://doi.org/10.1212/WNL.0000000000010531 https://doi.org/https://doi.org/10.1212/...
|
154 |
PiB-PET |
MRI |
VL and WS |
SENAS |
Aβ influence retention in EM change |
6 |
19 |