*Sharab et al.22 Sharab LY, Morford LA, Dempsey J, Falcão-Alencar G, Mason A, Jacobson E, et al. Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia. Orthod Craniofac Res. 2015 Apr;18(Suppl 1):71-82. (2015) Orthodontics |
P2RX7 (rs208294, rs1718119, rs2230912) CASP1/ICE (rs580253, rs554344, rs530537 IL1-B (rs1143634) IL1-A (rs1800587) IL1RA (rs41959) |
P2RX7 (rs208294) |
P2RX7 (rs1718119, rs2230912) CASP1/ICE (rs580253, rs554344, rs530537 IL1-B (rs1143634) IL1-A (rs1800587) IL1RA (rs41959) |
*Al-Qawasmi et al.55 Al-Qawasmi RA, Hartsfield JK, Everett ET, Flury L, Liu L, Foroud TM, et al. Genetic predisposition to external apical root resorption. Am J Orthod Dentofacial Orthop. 2003 Mar;123(3):242-52. (2003) Orthodontics |
IL1-A (rs1143634) IL1-B (rs1143627) |
IL1-B (rs1143627) |
IL1-A (rs1143634) |
*Bastos Lages et al.66 Bastos Lages EM, Drummond AF, Pretti H, Costa FO, Lages EJP, Gontijo AI, et al. Association of functional gene polymorphism IL-1beta in patients with external apical root resorption. Am J Orthod Dentofacial Orthop. 2009 Oct;136(4):542-6. (2009) Orthodontics |
IL-1B (rs1143634) |
IL-1B (rs1143634) |
______ |
*Linhartova et al.77 Linhartova P, Cernochova P, Izakovicova Holla L. IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia. Oral Dis. 2013 Apr;19(3):262-70. (2013) Orthodontics |
IL1A (rs16347) IL1B (rs1143627) IL1RN (rs9005) |
IL1A (rs16347) IL1B (rs1143627) IL1RN (rs9005)/Short alleles |
IL1B (rs1143627) IL1RN (rs9005)/Long alleles |
*Iglesias-Linares et al.88 Iglesias-Linares A, Yañez-Vico RM, Ballesta S, Ortiz-Ariza E, Mendoza-Mendoza A, Perea E, et al. Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post-orthodontic root resorption in endodontic and their contralateral vital control teeth differently. Int Endod J. 2012 Nov;45(11):1018-26. (2012) Endodontics |
IL1A(rs1800587) IL1B (rs1143634) |
IL1B (rs1143634) |
IL1 (rs1800587) |
*Guo et al.99 Guo Y, He S, Gu T, Liu Y, Chen S. Genetic and clinical risk factors of root resorption associated with orthodontic treatment. Am J Orthod Dentofacial Orthop. 2016 Aug;150(2):283-9. (2016) Orthodontics |
IL-6 (rs1800796) IL1RN (rs419598) |
IL-6 (rs1800796) |
IL1RN (rs419598) |
Borges de Castilhos et al.1010 Castilhos BB, Souza CM, Fontana MLS, Pereira FA, Tanaka OM, Trevilatto PC. Association of clinical variables and polymorphisms in RANKL, RANK, and OPG genes with external apical root resorption. Am J Orthod Dentofacial Orthop. 2019 Apr;155(4):529-42. (2019) Orthodontics |
RANKL (rs1038434, rs3742257, rs931273, rs12585229) RANK (rs12455775) OPG (rs2875845, rs3102724, rs1032128, rs3102728) |
RANK (rs12455775) OPG (rs2875845, rs3102724, rs1032128, rs3102728) |
RANKL (rs1038434, rs3742257, rs931273, rs12585229) |
*Iglesias-Linares et al.1212 Iglesias-Linares A, Yañez-Vico R, Ballesta-Mudarra S, Ortiz-Ariza E, Ortega-Rivera H, Mendoza-Mendoza A, et al. Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations. Oral Dis. 2012 Mar;18(2):198-205. (2012) Orthodontics |
IL1A (rs1800587) IL1B (rs1143634) IL1RN (rs419598) |
IL1B (rs1143634) IL1RN (rs419598) |
IL1A (rs1800587) |
*Tomoyasu et al.1717 Tomoyasu Y, Yamaguchi T, Tajima A, Inoue I, Maki K. External apical root resorption and the interleukin-1B gene polymorphism in the Japanese population. Orthod Waves. 2009 Dec;68(4):152-7. (2009) Orthodontics |
IL-1B (rs1143634) |
______ |
IL-1B (rs1143634) |
*Pereira et al.1818 Pereira S, Lavado N, Nogueira L, Lopez M, Abreu J, Silva H. Polymorphisms of genes encoding P2X7R, IL-1B, OPG and RANK in orthodontic-induced apical root resorption. Oral Dis. 2014 Oct;20(7):659-67. (2014) Orthodontics |
OPG (rs3102735) RANK (rs1805034) IL-1B (rs1143634) P2RX7 (rs1718119) |
P2RX7 (rs1718119) |
OPG (rs3102735) RANK (rs1805034) IL-1B (rs1143634) |
*Borilova Linhartova et al.1919 Borilova Linhartova P, Cernochova P, Kastovsky J, Vrankova Z, Sirotkova M, Izakovicova Holla L. Genetic determinants and postorthodontic external apical root resorption in Czech children. Oral Dis. 2017 Jan;23(1):29-35. (2017) Orthodontics |
IL17A (rs2275913) P2RX7 (rs208294, rs1718119) SSP 1(rs9138, rs11730582) OPG (rs2073618, rs3102735) |
P2RX7 (rs208294, rs1718119) |
PPS 1 (rs9138, rs11730582) OPG (rs2073618, rs3102735) |
*Fontana et al.2020 Fontana MLSSN, Souza CM, Bernardino JF, Hoette F, Hoette ML, Thum L, et al. Association analysis of clinical aspects and vitamin D receptor gene polymorphism with external apical root resorption in orthodontic patients. Am J Orthod Dentofacial Orthop. 2012 Sep;142(3):339-47. (2012) Orthodontics |
Vitamin D receptor TaqI |
Vitamin D receptor TaqI |
______ |
*Iglesias-Linares et al.2121 Iglesias-Linares A, Yañez-Vico RM, Moreno-Fernández AM, Mendoza-Mendoza A, Orce-Romero A, Solano-Reina E. Osteopontin gene SNPs (rs9138, rs11730582) mediate susceptibility to external root resorption in orthodontic patients. Oral Dis. 2014 Apr;20(3):307-12. (2014) Orthodontics |
OPG (rs9138, rs11730582) |
OPG (rs9138, rs11730582) |
______ |
Urban and Mincik2222 Urban D, Mincik J. Monozygotic twins with idiopathic internal root resorption: A case report. Aust Endod J. 2010 Aug;36(2):79-82. (2010) Endodontics |
IL-1A IL-1B IL1RN |
IL-1B |
IL-1A IL1RN |
**Lee et al.2525 Lee YJ, Pak H, Hwang CJ, Choi YJ, Lee JH, Lee JH, et al. Targeted next-generation sequencing for comprehensive genetic analysis of external apical root resorption during orthodontic treatment with premolar extraction in the Korean population. Am J Orthod Dentofacial Orthop. 2022 Nov;162(5):668-679.e5. (2022) Orthodontics |
SPP1 (rs 4754, rs1126616, rs9138) SFRP2 (rs3810765) |
SPP1 (rs9138) SFRP2 (rs3810765) |
SPP1 (rs 4754,rs1126616) |
*Rutsch et al.2626 Rutsch F, MacDougall M, Lu C, Buers I, Mamaeva O, Nitschke Y, et al. A specific IFIH1 gain-of-function mutation causes Singleton-Merten syndrome. Am J Hum Genet. 2015 Feb;96(2):275-82. (2015) other areas of dental research |
MDA5 IFIH1 |
MDA5 IFIH1 |
______ |
*Al-Qawasmi et al.2727 Al-Qawasmi RA, Hartsfield JK, Everett ET, Flury L, Liu L, Foroud TM, et al. Genetic predisposition to external apical root resorption in orthodontic patients: linkage of chromosome-18 marker. J Dent Res. 2003 May;82(5):356-60. (2003) Orthodontics |
RANK (rs1805034) TNSALP (rs1256328) TNF-a (rs1799724) |
RANK (rs1805034) |
TNF-a (rs1799724) TNSALP (rs1256328) |
*Gülden et al.2828 Gülden N, Eggermann T, Zerres K, Beer M, Meinelt A, Diedrich P. Interleukin-1 polymorphisms in relation to external apical root resorption (EARR). J Orofac Orthop. 2009 Jan;70(1):20-38. (2009) Orthodontics |
IL1-A (-889) IL1-B (+3954) (rs1143634) |
IL1-A (-889) IL1-B (+3954) |
IL-1B (rs1143634) |
*Iglesias-Linares et al.2929 Iglesias-Linares A, Sonnenberg B, Solano B, Yañez-Vico RM, Solano E, Lindauer SJ, et al. Orthodontically induced external apical root resorption in patients treated with fixed appliances vs removable aligners. Angle Orthod. 2017 Jan;87(1):3-10. (2017) Orthodontics |
IL1-B (rs1143634) IL1RN (rs419598) SPP1 (rs9138, rs11730582) |
IL1RN (rs419598) |
IL1B (rs1143634) SPP1 (rs9138, rs11730582) |
*Pettersson et al.3030 Pettersson M, Bergendal B, Norderyd J, Nilsson D, Anderlid BM, Nordgren A, et al. Further evidence for specific IFIH1 mutation as a cause of Singleton-Merten syndrome with phenotypic heterogeneity. Am J Med Genet A. 2017 May;173(5):1396-9. (2017) Other areas of dental research |
MDA5 IFIH1 |
MDA5 IFIH1 |
______ |
Pereira et al.3131 Pereira S, Nogueira L, Canova F, Lopez M, Silva HC. IRAK1 variant is protective for orthodontic-induced external apical root resorption. Oral Dis. 2016 Oct;22(7):658-64. (2016) Orthodontics |
IL1B (rs1143634) IL1RN (rs315952) IRAK1 (rs1059703) |
IRAK1 (rs1059703) |
IL1B (rs1143634) IL1RN (rs315952) |
Bastos et al.3232 Bastos JV, Côrtes MIS, Silva JFC, Goulart EMA, Colosimo EA, Gomez RS, et al. A study of the interleukin-1 gene cluster polymorphisms and inflammatory external root resorption in replanted permanent teeth. Int Endod J. 2015 Sep;48(9):878-87. (2015) Other areas of dental research |
IL1A (rs 180058) IL1B (rs1143634) IL1RN (rs419598) |
______ |
IL1A (rs 180058) IL1B (rs1143634) IL1RN (rs419598) |
Ciurla et al.3333 Ciurla A, Marruganti C, Doldo T, Szymanska J. Association between polymorphisms in the IL-1ß, TNFRSF11B, CASP1, and IL-6 genes and orthodontic-induced external apical root resorption. J Clin Med. 2021 Sep;10(18):4166. (2021) Orthodontics |
IL-1B (rs1143634) TNFRSF11B (rs3102735) CASP1(rs530537) IL-6 (rs1800796) |
IL-1B (rs1143634) |
TNFRSF11B (rs3102735) CASP1(rs530537) IL-6 (rs1800796) |
Roskamp et al.3434 Roskamp L, Trevilatto PC, Souza CM, Silva Neto UX, Carneiro E, Fariniuk LF, et al. Types of external root resorption of replanted teeth: analysis of the clinical aspects and of interleukin-4 gene polymorphisms involvement. J Endod. 2017 Nov;43(11):1792-6. (2017) Endodontics |
IL4 (rs2227284, rs2243268) |
______ |
IL4 (rs2227284, rs2243268) |
Roskamp et al.3535 Roskamp L, Trevilatto PC, Souza CM, Silva Neto UX, Carneiro E, Fariniuk LF, et al. Analysis of the association of clinical factors and IL4 gene polymorphisms with root resorption in avulsed teeth after 1 year of replantation. Int Endod J. 2018 Jan;51(1):12-9. (2018) Endodontics |
IL4 (rs2227284, rs2243268) |
______ |
IL4(rs2227284, rs2243268) |
Behnaz et al.3636 Behnaz M, Mohammad-Rahimi H, Javaheri F, Omrani MD, Noroozi R, Taheri M, et al. The rs1143634 of IL-1ß gene is associated with external apical root resorption in Iranian population. Meta Gene. 2020 Jun;24:100711. (2020) Orthodontics |
IL-1A (rs1800587) IL-1B (rs1143634) |
IL-1B (rs1143634) |
IL-1A (rs1800587) |
Ciurla et al.3737 Ciurla A, Szymanska J, Plachno BJ, Bogucka-Kocka A. Polymorphisms of encoding genes IL1RN and P2RX7 in apical root resorption in patients after orthodontic treatment. Int J Mol Sci. 2021 Jan;22(2):777. (2021) Orthodontics |
P2RX7 (rs208294) IL1RN (rs419598) |
P2RX7 (rs208294) IL1RN (rs419598) |
______ |
Iber-díaz et al.3838 Iber-Díaz P, Senen-Carramolino R, Iglesias-Linares A, Fernández-Navarro P, Flores-Mir C, Yañez-Vico RM. GWAS of post-orthodontic aggressive external apical root resorption identified multiple putative loci at X-Y chromosomes. J Pers Med. 2020 Oct;10(4):169. (2020) Orthodontics |
Multiple putative loci and genes located at somatic chromosomes 2, 4, 8, 12, 18, and at sexual chromosomes X and Y |
STAG (rs151184635) RP1-30E17.2 (rs55839915) SSP1 (rs11730582) P2RX7 (rs1718119) TNFRSF11A (rs8086340) |
Other loci and genes located on somatic chromosomes 2, 4, 8, 12, 18 and on sex chromosomes X and Y analyzed |
Roskamp et al.3939 Roskamp L, Trevilatto PC, Souza CM, Ignácio SA, Lima GD, Pereira TM, et al. The role of polymorphism of the IL6 gene in tooth replantation. Aust Endod J. 2021 Aug;47(2):314-9. (2021) Other areas of dental research |
IL-6 (rs2069843) |
IL-6 (rs2069843) |
______ |
Bahirrah et al.4040 Bahirrah S, Lestari W, Zulhakim A, Suwandi A, Irfanita N. External root resorption (EARR) and interleukin-1ß (rs1143634) gene polymorphism in the Bataknese population: a pilot study. AIP Conf Proc. 2023 Feb;2682(1):050007. (2023) Orthodontics |
IL-IB (rs1143634) |
______ |
IL-IB (rs1143634) |
Marañón‐Vásquez et al.4141 Marañón-Vásquez G, Küchler EC, Hermann S, Paddenberg E, Schröder A, Baratto-Filho F, et al. Association between genetic variants in key vitamin-D-pathway genes and external apical root resorption linked to orthodontic treatment. Eur J Oral Sci. 2023 Apr;131(2):e12916. (2023) Orthodontics |
VDR (rs1544410, rs7975232, rs731236, rs2228570) GC (rs4588) P450CYP27B1 (rs4646536) P450 CYP24A1(rs921650) |
VDR (rs2228570) P450 CYP27B1 (rs4646536) P450 CYP24A1- less expressive |
VDR (rs1544410, rs7975232, rs731236) GC (rs4588) |
Silva et al.4242 Silva HC, Lavado N, Canova F, Lopez MG, Regateiro FJ, Pereira SA. Influence of clinical factors on the protective or deleterious impact of genetic variants in orthodontically induced external root resorption: an observational study. BMC Oral Health. 2022 Jul;22(1):270. (2022) Orthodontics |
TNFRSF11B gene, OPG (rs3102735) TNFRSF11A gene, RANK (rs1805034) IL-IB (rs1143634) P2RX7 (rs1718119) IL1RN (rs315952) |
TNFRSF11B gene, OPG (rs3102735) P2RX7 (rs1718119) IL1RN (rs315952) |
TNFRSF11A gene, encoding RANK (rs1805034) IL-IB (rs1143634) |
Roskamp et al.4343 Roskamp L, Souza CM, Ignácio SA, Perin CP, Mattos NHR, Sunye IR, et al. Influence of clinical factors, IL4 and IL6 genes polymorphisms in functional healing in late replantation. Braz Dent J. 2022;33(1):13-21. (2022) Other areas of dental research |
IL4(rs2227284/rs2243268) IL6(rs1524107/rs2069835/rs2069838/rs2069840/rs2069843/rs2069845) |
______ |
IL4(rs2243268) |
Baghaei et al.4444 Baghaei NN, Zhai G, Lamani E. Genetic and other factors contributing to external apical root resorption in orthodontic patients. Orthod Craniofac Res. 2023 Dec;26(Suppl 1):64-72. (2023) Orthodontics |
IL-1A (rs1800587) IL-1B (rs1143634) \ IL-1RN (rs419598) P2RX7 (rs1718119, rs2230912 IRAK1 (rs1059703) CASP1 (rs530537, rs580253, rs554344) |
IL-1A (rs1800587) |
IL-1B (rs1143634) IL-1RN (rs419598) P2RX7 (rs1718119, rs2230912), IRAK1 (rs1059703) CASP1 (rs530537, rs580253, rs554344) |
*Iglesias-Linares et al.4747 Iglesias-Linares A, Yañez-Vico RM, Ortiz-Ariza E, Ballesta S, Mendoza-Mendoza A, Perea E, et al. Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1ß polymorphism. J Endod. 2012 Mar;38(3):283-748. (2012) Endodontics and Orthodontics |
IL1A(rs1800587) IL1B (rs1143634) |
IL1B (rs1143634) |
IL1A (rs1800587) |
Iglesias-Linares et al.4848 Iglesias-Linares A, Yañez-Vico RM, Ballesta-Mudarra S, Ortiz-Ariza E, Mendoza-Mendoza A, Perea-Pérez E, et al. Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth. Histol Histopathol. 2013 Jun;28(6):767-73. (2013) Endodontics and Orthodontics |
IL1RN (rs419598) |
IL1RN (rs419598) |
_____ |
*Iglesias-Linares et al.4949 Iglesias-Linares A, Morford LA, Hartsfield JK Jr. Bone density and dental external apical root resorption. Curr Osteoporos Rep. 2016 Dec;14(6):292-309. (2016) Other areas of dental research |
IL-1B (rs1143634) IL1A (rs1800587) IL1RN (rs419598) IL-6 (rs1800796) P2RX7 (rs208294, rs1718119, rs2230912) TNFRSF11B (OPG) TNFRSF11A (rs3102735, rs1805034) RANKL (rs228769) |
IL-1B (rs1143634) IL1A (rs1800587) P2RX7 (rs208294) TNFRSF11B (OPG) TNFRSF11A (rs3102735, rs1805034) RANKL (rs228769) |
IL1RN (rs419598) P2RX7 (rs1718119, rs2230912) |