De Carlos F, et al44 . De Carlos F, Cobo J, Díaz-Esnal B, Arguelles J, Vijande M, Costales M. Orthodontic tooth movement after inhibition of cyclooxygenase-2. Am J Orthod Dentofacial Orthop. 2006;129(3):402-6.Spain, 2006 |
Case control |
Comparison of the effect of Diclofenac and Rofecoxib on the inhibition of dental movement in rats. |
42 male Wistar rats in 6 experimental groups: » 3 groups subjected to a 50-g coil-spring (Diclofenac, Rofecoxib, control) » 3 groups subjected to a 10-g coil-spring (Diclofenac, Rofecoxib, control) |
Both drugs significantly inhibit dental movement, partially in the case of Rofecoxib and totally in the case of Diclofenac. |
De Carlos F, et al55 . De Carlos F, Cobo J, Perillan C, Garcia MA, Arguelles J, Vijande M, et al. Orthodontic tooth movement after different coxib therapies. Eur J Orthod. 2007;29(6):596-9.Spain, 2007 |
Case control |
Comparison of the effect of Rofecoxib, Celecoxib, and Parecoxib on the inhibition of dental movement in rats. |
28 male Wistar rats in 4 groups subjected to 50-g force derived from a coil-spring: » 5 rats received Rofecoxib » 6 rats Celecoxib » 5 rats Parecoxib » 12 control rats |
Rofecoxib inhibit tooth movement while Celecoxib and Parecoxib do not affect orthodontic movement. |
Mermut S, et al3434 . Mermut S, Bengi AO, Akin E, Kürkçü M, Karaçay S. Effects of Interferon-Gamma on bone remodeling during experimental tooth movement. Angle Orthod. 2007;77(1):135-41.Ankara, Turkey 2007 |
Case control |
Determination of the effects of IFN- ɣ on bone during orthodontic tooth movement. |
30 male Sprague Dawley rats in five groups. (6 rats per group) » 0.01 µL IFN-ɣ dose » 0.02 µL IFN-ɣ dose » 0.05 µL IFN-ɣ dose » vehicle solution control group » only orthodontics control group |
IFN- ɣ seems involved in bone remodeling during orthodontic tooth movement, which strongly suppresses osteoclastogenesis. |
Gurton AU, et al3333 . Gurton AU, Akin E, Sagdic D, Olmez H. Effects of PGI2 and TxA2 analogs and inhibitors in orthodontic tooth movement. Angle Orthod. 2004;74(4):526-32.Ankara, Turkey 2004 |
Case control |
Comparison of the effects of PGI2 and TxA2 analogs and inhibitors on orthodontic tooth movement. |
150 male Sprague-Dawley rats in five equal groups, subdivided into three subgroups (SGs) depending on the concentration. » Iloprost (PGI2 analog) » indomethacin (PGI2 inhibitor), » U 46619 (TxA2 analog), » imidazole (TxA2 inhibitor) » control group |
Indomethacin and Imidazole decrease the rate of tooth movement at high concentration, although there is no statistically significant difference between their inhibitory effects. |
Chae HS3535 . Chae HS, Park HJ, Hwang HR, Kwon A, Lim WH, Yi WJ, et al. The effect of antioxidants on the production of pro-inflammatory cytokines and orthodontic tooth movement. Mol Cells. 2011;32(2):189-96. Seoul, Korea 2011 |
Case control |
Evaluation of the effects of antioxidants on the expression of pro-inflammatory cytokines in human periodontal ligament fibroblasts (PDLFs) Evaluation of the effects of these antioxidants on the rate of orthodontic tooth movement in rats. |
Two different assessments: Mechanical compression and induced hypoxia applied to human PDLFs exposed to 10 nM Resveratrol or 20 nM NAC orthodontic forces applied to 12 rats in a split-mouth design » 6 rats: experimental side treated with Resveratrol, contralateral side with vehicle solution » 6 rats: experimental side treated with NAC, contralateral side with vehicle solution |
Antioxidants decrease the expression of pro-inflammatory cytokines in human PDLFs induced by mechanical compression and hypoxia in vitro. NAC delays orthodontic tooth movement in rats. Antioxidants may have the potential to retard orthodontic tooth movement. |