Auperh, 1997 |
67 |
Chidren |
Solid neoplasm + febrife neutropenia |
Yes |
Severe CKD |
10 mg/kg BID for 3 doses, than OD |
10 mg/kg every 6hs |
Moderate renal faibre |
Charboneau, 1994 |
56 |
Adults |
Severe Gram-positive infections |
Yes |
Cr > 2.3 mg/dL |
6 mg/kg BID for 3 doses, than OD |
24 mg/kg/day in 3 or 4 doses |
Increase in serum Cr >0.5 mg/dL |
Choi, 1992 |
44 |
>15 years |
Hematological malignancies + febrile neutropenia |
Yes |
Cr > 1.5 mg/dL or CrCl < 60 mL/min OD |
400mg BID for 2 doses, than OD |
500 mg every 8hs |
NS |
Chow, 1993 |
53 |
Adults |
Hickman catheter + febrile neutropenia |
Yes |
Cr > 2.5 mg/dL |
6 mg/kg BID for 3 doses, than OD |
14 mg/kg BID |
Cr > 1.24 mg/dL |
Cony-Makhoul, 1990 |
65 |
Adults |
Hematologic malignancies + febrile neutropenia |
No |
NA |
6 mg/kg BID for 3 doses, than OD |
15 mg/kg BID |
NS |
Pham Dang, 2001 |
30 |
Adults |
Joint or bone infection |
No |
HA |
400 mg BID for 3 doses, than OD, IM |
Continuous infusion to obtain serum levels between 20-30 mg/L |
Increase in serum Cr or anuria |
D’Antonio, 2004 |
154 |
Adults |
Hematologic malignancies + febrile neutropenia |
Yes |
Cr > 3.0 mg/dL |
6 mg/kg BID for 2 days, than OD |
15 mg/kg BID |
reversible renal toxicity |
Figuera, 1996 |
149 |
Adults |
Hematologic malignancies or BMT + febrile neutropenia |
Yes |
Cr > 2.5 mg/dL |
400mg BID for 3 doses, than OD |
lg BID |
Cr > 1.5 mg/dL |
Fortun, 2001 |
23 |
Adults |
MRSA right-side endocarditis |
Yes |
Cr > 2.5 mg/dL |
24mg/kg OD in the 1st day, than 12 mg/kg OD |
500 mg every 6hs |
Moderate increase in SCr |
Hedström, 1995 |
80 |
Adults |
Suspected or proven Gram-positive infection |
Yes |
CCr < 40 mL/min |
400mg BID for 3 doses, than OD |
lg BID |
Increase in Cr |
MMD-09-1992 |
242 |
Adults |
Catheter-associated bloodstream infection |
Unknown |
NA |
6 mg/kg BID for 3 doses, than OD |
15 mg/kg BID |
Rise of 0.5 mg/dL or more if baseline SCr< 3mg/dL or rise of 1 mg/dL if baseline Cr > 3 mg/dL. |
MMD-14-1992 |
106 |
Adults |
Vascular-access-associated bacteremia |
Unknown |
NA |
3 schemes: A) 6 mg/kg BID for 3 doses, than OD; B) 6 mg/kg BID for 9 doses than 6-10 mg/kg OD;C) 10 mg/kg BID. |
15 mg/kg BID |
Rise of 0.5 mg/dL or more if baseline SCr< 3mg/dL or rise of 1 mg/dL if baseline Cr > 3 mg/dL. |
MMD-19-1992 |
132 |
Adults |
Bacteremia and endocarditis |
Unknown |
NA |
2 schemess: A) For Staphylococcus aureus 30 mg/ kg BID for 3 doses, than OD; B) For Streptococcus sp 6mg/ kg OD |
15 mg/kg BID |
Rise of 0.5 mg/dL or more if baseline SCr< 3mg/dL or rise of 1 mg/dL if baseline Cr > 3 mg/dL. |
Liu, 1996 |
45 |
Adults |
MRSA bacteremia |
Yes |
Cr > 2.5mg/dL |
400mg BID for 3 doses, than OD |
500 mg every 6hs |
Increase in Cr > 50% |
Menichetti, 1994 |
635 |
Adults |
Hematologic malignancies + febrile neutropenia |
Yes |
Cr > 1.4mg/dL |
8 mg/kg loading dose, than 6mg/kg OD |
15 mg/kg BID |
Rise in Cr above normal range |
Neville, 1995 |
56 |
Adults |
Suspected or proven Gram-positive infection |
Yes |
Cr > 1.7mg/dL |
400 mg OD (some patients 200 mg OD after 2nd day) |
1g BID |
Increase in Cr > 100% |
Nucci, 1998 |
106 |
Adults |
BMT + febrile neutropenia |
No |
NA |
6 mg/kg BID for 3 doses, than OD |
40 mg/kg/d in 1h infusion |
Increase in Cr > 0.5 mg/dL or dcrease in CrCl > 50% |
Rolston, 1994 |
64 |
Adults |
Solid neoplasm with suspected or proven Gram-positive bacteremia |
Yes |
Cr >3.0mg/dL |
6 mg/kg BID for 3 doses, than OD |
15 mg/kg BID |
Increase in Cr |
Rolston, 1999 |
64 |
Adults |
Catheter-associated infection with suspected or proven Gram-positive |
Yes |
Cr >3.0 mg/dL |
6 mg/kg BID for 3 doses, than OD |
15 mg/kg BID |
Increase in Cr |
Sidi, 2000 |
20 |
Children |
Gram-positive bacteremia + febrile neutropenia |
No |
NA |
10 mg/kg BID for 3 doses, than OD |
40 mg/kg/d divided in 3 doses |
Increase in Cr > 0.5 mp/dL |
Smith, 1989 |
72 |
Adults |
Hickman catheter-associated infection + hematological malignancies |
No |
NA |
First 11 episodes 400 mg on day 1 than 200 mg OD; thereafter 800 mg on day 1 than 400 mg OD |
1g BID |
Increase in Cr > 0.5 mg/dL |
Van der Auwera, 1991 |
74 |
Adults |
Solid neoplasm + suspected of proven Gram-positive infection |
Yes |
Cr> 2.0 mg/dL |
First 21 patients 400 mg OD first 3 days than 200 mgOD; thereafter 400mg BID 1st day than 400 mg OD |
1g BID |
Increase in Cr > 0.5 mg/dL |
Van Laethem, 1988 |
21 |
Adults |
MRSA infection |
Yes |
Cr> 2.0 mg/dL |
400 mg OD |
1g BID |
NS |
Vazquez, 1999 |
76 |
Adults |
Hematological malignancies + febrile neutropenia |
Yes |
Cr >1.5mg/dL |
400 mg BID for 3 doses, than OD |
According to serum levels |
NS |