Almeida et al.,(99 Almeida L, Schmauch A, Bergström S. A randomised study on the impact of peroral amoxicillin in women with prelabour rupture of membranes preterm. Gynecol Obstet Invest. 1996;41(2):82-4.) |
AX 750mg 8/8 hours VO |
NR |
NR |
NR |
Amon et al.,(1010 Amon E, Lewis SV, Sibai BM, Villar MA, Arheart KL. Ampicillin prophylaxis in preterm premature rupture of the membranes: a prospective randomized study. Am J Obstet Gynecol. 1988;159(3):539-43.) |
A 1g 6/6 hours IV for 24 hours + A 500mg 6/6 hours VO until delivery |
SN |
Yes |
Until birth |
Camli et al.,(1111 Camli L, Mavunagacioglu S, Bostanci A, Camli S, Soylu F. Antibiotherapy in preterm premature rupture of membrane. Does it affect the latent period and infectious morbidity? Jinekoloji Ve Obstetrik Dergisi. 1997;11(2):138-42.) |
A 1g 6/6 hours IV |
NR |
No |
NR |
Christmas et al.,(1212 Christmas JT, Cox SM, Andrews W, Dax J, Leveno KJ, Gilstrap LC. Expectant management of preterm ruptured membranes: effects of antimicrobial therapy. Obstet Gynecol. 1992;80(5):759-62.) |
AGC (A 2g 6/6 hours IV + G 60-90mg 8/8 hours IV + C 900mg 8/8 hours IV) 1 day, AXC 500 + 125mg 8/8 hours 7 days VO |
No |
No |
7 days |
Cox et al.,(1313 Cox SM, Leveno KJ, Sherman ML, Travis L, De Plama R. Ruptured membranes at 24 to 29 weeks: a randomized double blind trial of antimicrobials versus placebo [abstract]. Am J Obstet Gynecol. 1995;172(1 PT2):P412.) |
AS 1+2g 6/6 hours 4 doses IV, AXC 500 + 125mg 6/6 hours VO for 5 days |
NR |
NR |
5 days |
August Fuhr et al.,(1414 August Fuhr N, Becker C, van Baalen A, Bauer K, Hopp H. Antibiotic therapy for preterm premature rupture of membranes: results of a multicenter study. J Perinat Med. 2006;34(3):203-6.) |
MZ 2g 8/8 hours IV 7 days |
Yes |
Yes |
7 days |
Garcia-Burguillo et al.,(1515 Garcia-Burguillo A, Hernandez-Garcia JM, de la Fuente P. Profilaxis con eritromicina en gestaciones pretermino con rotura prematura de las membranas amnioticas. Clinica Investigacion Ginecol Obstetricia. 1995;23(3):96-100.) |
E 500mg 6/6 hours VO until birth |
No |
No |
Until birth |
Grable et al.,(1616 Grable IA, Garcia PM, Perry D, Socol ML. Group B streptococcus and preterm premature rupture of membranes: a randomized, double-blind clinical trial of antepartum ampicillin. Am J Obstet Gynecol. 1996;175(4 Pt 1):1036-42.) |
A 2g 6/6 hours IV (1 day) + A 500mg 6/6 hours VO until birth |
NR |
NR |
Until birth |
Johnston et al.,(1717 Johnston MM, Sanchez-Ramos L, Vaughan AJ, Todd MW, Benrubi GI. Antibiotic therapy in preterm premature rupture of membranes: a randomized, prospective, double- blind trial. Am J Obstet Gynecol. 1990;163(3):743-7.) |
MZ por 2 days + A VO |
No |
No |
Until birth |
Kenyon et al.,(1818 Kenyon SL, Taylor DJ, Tarnow-Mordi W. Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE Collaborative Group. Lancet. 2001;357(9261):979-88.) |
AXC 250 + 125mg 8/8 hours VO + E 250mg VO AXC 250 + 125mg 8/8 hours VO E 250mg |
SN |
SN |
Until birth |
Kurki et al.,(1919 Kurki T, Hallman M, Zilliacus R, Teramo K, Ylikorkala O. Premature rupture of the membranes; effect of penicillin prophylaxis and long-term outcome of the children. Am J Perinatol. 1992;9(1):11-6.) |
P 5000mUI 2 doses IV |
NR |
Yes |
1 day |
Lockwood et al.,(2020 Lockwood CJ, Costigan K, Ghidini A, Wein R, Chien D, Brown BL, et al. Double-blind; placebo-controlled trial of piperacillin prophylaxis in preterm membrane rupture. Am J Obstet Gynecol. 1993;169(4):970-6.) |
PP 3g 6/6 hours IV 72 hours |
SN |
SN |
3 days |
Lovett et al.,(2121 Lovett SM, Weiss JD, Diogo MJ, Williams PT, Garite TJ. A prospective, double-blind, randomized, controlled clinical trial of ampicillin-sulbactam for preterm premature rupture of membranes in women receiving antenatal corticosteroid therapy. Am J Obstet Gynecol. 1997;176(5):1030-8.) |
AS 1.5g 6/6 hours IV 72 hours + AXC 500+125mg 8/8 hours A 2g IV 72 hours + AXC 500+125mg 8/8 hours |
SN |
Yes |
Until birth |
Magwali et al.,(2222 Magwali TL, Chipato T, Majoko F, Rusakaniko S, Mujaji C. Prophylactic augmentin in prelabour preterm rupture of the membranes. Int J Gynaecol Obstet. 1999;65(3):261-5.) |
AXC VO 5 days |
SN |
NR |
5 days |
McCaul et al.,(2323 McCaul JF, Perry KG Jr, Moore JL Jr, Martin RW, Bucovaz ET, Morrison JC. Adjunctive antibiotic treatment of women with preterm rupture of membranes or preterm labor. Int J Gynecol Obstet. 1992;38(1):19-24.) |
A 2g IV + A 500mg 6/6 hours 7 days |
No |
No |
7 days |
McGregor et al.,(2424 McGregor JA, French JI. Use of antibiotics for preterm premature rupture of membranes. Rationales and results. Obstet Gynecol Clin North Am. 1992;19(2):327-38.) |
E 333mg 8/8 hours |
No |
No |
NR |
Mercer et al.,(2525 Mercer BM, Moretti ML, Prevost RR, Sibai BM. Erythromycin therapy in preterm premature rupture of the membranes: a prospective, randomized trial of 220 patients. Am J Obstet Gynecol. 1992;166(3):794-802.) |
E 333mg 8/8 hours |
SN |
SN |
NR |
Mercer,(2626 Mercer B. The NICHD-MFMU antibiotic treatment of PPRPM study: evaluation of factors associated with successful outcome [abstract]. Am J Obstet Gynecol. 1997;176(1 Pt 2):S8.) |
A 2g 6/6 hours + E 250mg 6/6 hours IV AX 250mg 8/8 hours VO + E 333mg 8/8 hours VO 5 days |
No |
No |
5 days |
Morales et al.,(2727 Morales WJ, Angel JL, O’Brien WF, Knuppel RA. Use of ampicillin and corticosteroids in premature rupture of membranes: a randomized study. Obstet Gynecol. 1989;73(5 Pt 1):721-6.) |
A 2g 6/6 hours |
No |
No |
NR |
Ovalle et al.,(2828 Ovalle A, Martínez MA, Kakarieka E, Gómez R, Rubio R, Valderrama O, et al. Antibiotic administration in patients with preterm premature rupture of membranes reduces the rate of histological chorioamnionitis: a prospective, randomized, controlled study. J Matern Fetal Neonatal Med. 2002;12(1):35-41.) |
CG (C 600mg 6/6 hours IV + G 4mg/kg/day 48 hours) and CG (C 300mg 6/6 hours + G 2mg/kg/day 12/12 hours) IM |
NR |
NR |
5 days |
Svare et al.,(2929 Svare J. Preterm delivery and subclinical uro-genital infection [thesis]. Denmark: University of Copenhagen; 1997.) |
A 2g 6/6 hours IV (1 day) and M 500mg 8/8 hours IV (1 day) + PVM (PV 500mg 8/8 hours 7 days + M 400mg 8/8 hours) VO |
NR |
NR |
7 days |