Emotional Impact of breast cancerrelated genetic mutation diagnosis: a systematic review

Visintin, Carolina Del Negro; Ribeiro, Letícia Jóia; Vicensotti, Stephanie Aragão Lusoli; Granato, Tânia Mara Marques

doi:10.1590/1982-0275202441e220115

Acessibilidade / Reportar erro

Brasil

Estudos de Psicologia (Campinas)

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

THEORETICAL ARTICLE | Health Psychology • Estud. psicol. 41 • 2024 • https://doi.org/10.1590/1982-0275202441e220115 copy

Emotional Impact of breast cancerrelated genetic mutation diagnosis: a systematic review

Impacto Emocional do diagnóstico de mutação genética relacionada ao câncer de mama: uma revisão sistemática

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Objective

Based on the premise that the diagnosis of a genetic mutation related to breast cancer causes emotional distress for the patient and their family members, a systematic literature review was conducted to clarify this relationship commonly observed in oncologic clinical practice.

Method

In total, 18 articles confirmed through bias analysis were reviewed. The articles were retrieved from the PubMed, Cochrane Wiley, SciELO, and APA-PsycInfo databases.

Results

These studies confirmed the hypothesis that a positive result in the genetic test triggers significant distress for both the patient and their family members, although each individual reacts in a unique way. The researchers recommend that the diagnosis should not be considered the sole factor for the studied outcome. It should be related to personal or family history of illness, previous experiences, and previous mental health.

Conclusion

We conclude, by a slight tendency, to include qualitative studies as a way to evaluate experiences in a more in-depth manner.

Keywords
Breast cancer; Emotional impact; Hereditary cancer; Psychology

Programa de Pós-Graduação em Psicologia, Pontifícia Universidade Católica de Campinas Editora Splendet, Pontifícia Universidade Católica de Campinas, Campus I, Rua Prof. Dr. Euryclides de Jesus Zerbini, 1516, Pq. Rural Fazenda Santa Cândida, Telefone: (55 19) 3343-7223. - Campinas - SP - Brazil
E-mail: psychologicalstudies@puc-campinas.edu.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Correspondence to: C. D. N. VISINTIN. E-mail: carolina.visintin@gmail.com.

Title	Author/ Year	Study Type	Bias scale	Note
Associations Between Relationship Support and Psychological Reactions of Participants and Partners to BRCA1 and BRCA2 Testing in a Clinic-Based Sample.	ManneManne, S., Audrain, J., Schwartz, M., Main, D., Finch, C., & Lerman, C. (2004). Associations between relationship support and psychological reactions of participants and partners to BRCA1 and BRCA2 testing in a clinic-based sample. Annals of Behavioral Medicine, 28(3), 211-225. https://doi.org/10.1207/s15324796abm2803_10 https://doi.org/10.1207/s15324796abm2803... et al. (2004)Manne, S., Audrain, J., Schwartz, M., Main, D., Finch, C., & Lerman, C. (2004). Associations between relationship support and psychological reactions of participants and partners to BRCA1 and BRCA2 testing in a clinic-based sample. Annals of Behavioral Medicine, 28(3), 211-225. https://doi.org/10.1207/s15324796abm2803_10 https://doi.org/10.1207/s15324796abm2803...	Cohort	NOS-Cohort	7/9
BRCA1 2 testing in hereditary breast and ovarian cancer families: effectiveness of problem-solving training as a counseling intervention.	McInerney-LeoMcInerney-Leo, A., Biesecker, B. B., Hadley, D. W., Kase, R. G., Giambarresi, T. R., Johnson, E., Lerman, C., & Struewing, J. P. (2004). BRCA1/2 testing in hereditary breast and ovarian cancer families: Effectiveness of problem-solving training as a counseling intervention. American Journal of Medical Genetics, 130A(3), 221-227. https://doi.org/10.1002/ajmg.a.30265 https://doi.org/10.1002/ajmg.a.30265... et al. (2004)McInerney-Leo, A., Biesecker, B. B., Hadley, D. W., Kase, R. G., Giambarresi, T. R., Johnson, E., Lerman, C., & Struewing, J. P. (2004). BRCA1/2 testing in hereditary breast and ovarian cancer families: Effectiveness of problem-solving training as a counseling intervention. American Journal of Medical Genetics, 130A(3), 221-227. https://doi.org/10.1002/ajmg.a.30265 https://doi.org/10.1002/ajmg.a.30265...	ECR	RoB2	Low risk
Distress and the parenting dynamic among BRCA1 2 tested mothers and their partners.	MaysMays, D., DeMarco, T. A., Luta, G., Peshkin, B. N., Patenaude, A. F., Schneider, K. A., Garber, J. E., & Tercyak, K. P. (2014). Distress and the parenting dynamic among BRCA1/2 tested mothers and their partners. Health Psychology, 33(8), 765-773. https://doi.org/10.1037/a0033418 https://doi.org/10.1037/a0033418... et al. (2014)Mays, D., DeMarco, T. A., Luta, G., Peshkin, B. N., Patenaude, A. F., Schneider, K. A., Garber, J. E., & Tercyak, K. P. (2014). Distress and the parenting dynamic among BRCA1/2 tested mothers and their partners. Health Psychology, 33(8), 765-773. https://doi.org/10.1037/a0033418 https://doi.org/10.1037/a0033418...	Longitudinal	NOS-CS	7/10
Distress in couples approached for genetic counseling and BRCA1 2 testing during adjuvant radiotherapy.	Schlich-BakkerSchlich-Bakker, K. J., ten Kroode, H. F. J., Wárlám Rodenhuis, C. C., Ausems, M. G. E. M., & van den Bout, J. (2009). Distress in couples approached for genetic counseling and BRCA1/2testing during adjuvant radiotherapy. Psycho-Oncology, 18(9), 965-973. https://doi.org/10.1002/pon.1446 https://doi.org/10.1002/pon.1446... et al. (2009)Schlich-Bakker, K. J., ten Kroode, H. F. J., Wárlám Rodenhuis, C. C., Ausems, M. G. E. M., & van den Bout, J. (2009). Distress in couples approached for genetic counseling and BRCA1/2testing during adjuvant radiotherapy. Psycho-Oncology, 18(9), 965-973. https://doi.org/10.1002/pon.1446 https://doi.org/10.1002/pon.1446...	Longitudinal	NOS-CS	8/10
Effects of coping style and BRCA1 and BRCA2 test results on anxiety among women participating in genetic counseling and testing for breast and ovarian cancer risk.	Tercyak, LemanTercyak, K. P., Hughes, C., Main, D., Snyder, C., Lynch, J. F., Lynch, H. T., & Lerman, C. (2001). Parental communication of BRCA1/2 genetic test results to children. Patient Education and Counseling, 42(3), 213-224. https://doi.org/10.1016/s0738-3991(00)00122-1 https://doi.org/10.1016/s0738-3991(00)00... et al. (2001)Tercyak, K. P., Hughes, C., Main, D., Snyder, C., Lynch, J. F., Lynch, H. T., & Lerman, C. (2001). Parental communication of BRCA1/2 genetic test results to children. Patient Education and Counseling, 42(3), 213-224. https://doi.org/10.1016/s0738-3991(00)00122-1 https://doi.org/10.1016/s0738-3991(00)00...	Longitudinal	NOS-CS	10/10
Experience of parental cancer in childhood is a risk factor for psychological distress during genetic cancer susceptibility testing.	van Oostromvan Oostrom, I., Meijers-Heijboer, H., Duivenvoorden, H. J., Bröcker-Vriends, A. H. J. T., van Asperen, C. J., Sijmons, R. H., Seynaeve, C., Van Gool, A. R., Klijn, J. G. M., & Tibben, A. (2006). Experience of parental cancer in childhood is a risk factor for psychological distress during genetic cancer susceptibility testing. Annals of Oncology, 17(7), 1090-1095. https://doi.org/10.1093/annonc/mdl069 https://doi.org/10.1093/annonc/mdl069... et al. (2006)van Oostrom, I., Meijers-Heijboer, H., Duivenvoorden, H. J., Bröcker-Vriends, A. H. J. T., van Asperen, C. J., Sijmons, R. H., Seynaeve, C., Van Gool, A. R., Klijn, J. G. M., & Tibben, A. (2006). Experience of parental cancer in childhood is a risk factor for psychological distress during genetic cancer susceptibility testing. Annals of Oncology, 17(7), 1090-1095. https://doi.org/10.1093/annonc/mdl069 https://doi.org/10.1093/annonc/mdl069...	Longitudinal	NOS-CS	9/10
Italian Men Tested for BRCA1 2 Mutation Psychological Distress during 6-Month Follow-Up.	PelliniPellini, F., Mirandola, S., Granuzzo, E., Urbani, S., Piccinni Leopardi, G., & Pollini, G. P. (2020). Italian men tested for BRCA1/2 mutation: Psychological distress during 6-month follow-up. Journal of Oncology, 2020, 1–5. https://doi.org/10.1155/2020/3987935 https://doi.org/10.1155/2020/3987935... et al. (2020)Pellini, F., Mirandola, S., Granuzzo, E., Urbani, S., Piccinni Leopardi, G., & Pollini, G. P. (2020). Italian men tested for BRCA1/2 mutation: Psychological distress during 6-month follow-up. Journal of Oncology, 2020, 1–5. https://doi.org/10.1155/2020/3987935 https://doi.org/10.1155/2020/3987935...	Longitudinal	NOS-CS	7/10
Parental communication of BRCA1 2 genetic test results to children.	Tercyak, HughesTercyak, K. P., Hughes, C., Main, D., Snyder, C., Lynch, J. F., Lynch, H. T., & Lerman, C. (2001). Parental communication of BRCA1/2 genetic test results to children. Patient Education and Counseling, 42(3), 213-224. https://doi.org/10.1016/s0738-3991(00)00122-1 https://doi.org/10.1016/s0738-3991(00)00... et al. (2001)Tercyak, K. P., Hughes, C., Main, D., Snyder, C., Lynch, J. F., Lynch, H. T., & Lerman, C. (2001). Parental communication of BRCA1/2 genetic test results to children. Patient Education and Counseling, 42(3), 213-224. https://doi.org/10.1016/s0738-3991(00)00122-1 https://doi.org/10.1016/s0738-3991(00)00...	Longitudinal	NOS-CS	7/10
Predictive genetic testing for hereditary breast and ovarian cancer: psychological distress and illness representations 1 year following disclosure.	ClaesClaes, E., Evers-Kiebooms, G., Denayer, L., Decruyenaere, M., Boogaerts, A., Philippe, K., & Legius, E. (2005). Predictive genetic testing for hereditary breast and ovarian cancer: Psychological distress and illness representations 1 year following disclosure. Journal of Genetic Counseling, 14(5), 349-363. https://doi.org/10.1007/s10897-005-1371-4 https://doi.org/10.1007/s10897-005-1371-... et al. (2005)Claes, E., Evers-Kiebooms, G., Denayer, L., Decruyenaere, M., Boogaerts, A., Philippe, K., & Legius, E. (2005). Predictive genetic testing for hereditary breast and ovarian cancer: Psychological distress and illness representations 1 year following disclosure. Journal of Genetic Counseling, 14(5), 349-363. https://doi.org/10.1007/s10897-005-1371-4 https://doi.org/10.1007/s10897-005-1371-...	Cohort	NOS-Cohort	7/9
Preliminary report of the relationship between experience of death of a relative, illness perception, and psychological outcome among BRCA carriers.	Samama (2013)Samama, D., Hasson-Ohayon, I., Perry, S., Morag, O., & Goldzweig, G. (2013). Preliminary report of the relationship between experience of death of a relative, illness perception, and psychological outcome among BRCA carriers. Psychology, Health & Medicine, 19(6), 698-704. https://doi.org/10.1080/13548506.2013.861600 https://doi.org/10.1080/13548506.2013.86...	Cross-sectional	NOS-CS	3/10
Prognostic factors for distress after genetic testing for hereditary cancer.	Voorwinden and Jaspers (2015)Voorwinden, J. S., & Jaspers, J. P. C. (2015). Prognostic Factors for Distress After Genetic Testing for Hereditary Cancer. Journal of Genetic Counseling, 25(3), 495-503. https://doi.org/10.1007/s10897-015-9894-9 https://doi.org/10.1007/s10897-015-9894-...	Longitudinal	NOS-CS	9/10
Psychological distress and quality of life associated with genetic testing for breast cancer risk.	SmithSmith, A. W., Dougall, A. L., Posluszny, D. M., Somers, T. J., Rubinstein, W. S., & Baum, A. (2008). Psychological distress and quality of life associated with genetic testing for breast cancer risk. Psycho-Oncology, 17(8), 767-773. https://doi.org/10.1002/pon.1291 https://doi.org/10.1002/pon.1291... et al. (2008)Smith, A. W., Dougall, A. L., Posluszny, D. M., Somers, T. J., Rubinstein, W. S., & Baum, A. (2008). Psychological distress and quality of life associated with genetic testing for breast cancer risk. Psycho-Oncology, 17(8), 767-773. https://doi.org/10.1002/pon.1291 https://doi.org/10.1002/pon.1291...	Cross-sectional	NOS-CS	7/10
Psychological distress related to BRCA testing in ovarian cancer patients.	Bjørnslett et al. (2015)Bjørnslett, M., Dahl, A. A., Sørebø, Ø., & Dørum, A. (2015). Psychological distress related to BRCA testing in ovarian cancer patients. Familial Cancer, 14(4), 495-504. https://doi.org/10.1007/s10689-015-9811-2 https://doi.org/10.1007/s10689-015-9811-...	Cross-sectional	NOS-CS	7/10
Psychological responses to BRCA1 mutation testing Preliminary findings.	Croyle et al. (1997)Croyle, R. T., Smith, K. R., Botkin, J. R., Baty, B., & Nash, J. (1997). Psychological responses to BRCA1 mutation testing: Preliminary findings. Health Psychology, 16(1), 63-72. https://doi.org/10.1037/0278-6133.16.1.63 https://doi.org/10.1037/0278-6133.16.1.6...	Cross-sectional	NOS-CS	7/10
Psychosocial impact of BRCA testing in young Black breast cancer survivors.	Gonzalez et al. (2018)Gonzalez, B. D., Hoogland, A. I., Kasting, M. L., Cragun, D., Kim, J., Ashing, K., Holt, C. L., Hughes Halbert, C., Pal, T., & Vadaparampil, S. T. (2018). Psychosocial impact of BRCA testing in young Black breast cancer survivors. Psycho-Oncology, 27(12), 2778-2785. https://doi.org/10.1002/pon.4887 https://doi.org/10.1002/pon.4887...	Longitudinal	NOS-CS	8/10
Sisters in hereditary breast and ovarian cancer families Communal coping, social integration, and psychological well-being.	KoehlyKoehly, L. M., Peters, J. A., Kuhn, N., Hoskins, L., Letocha, A., Kenen, R., Loud, J., & Greene, M. H. (2008). Sisters in hereditary breast and ovarian cancer families: Communal coping, social integration, and psychological well-being. Psycho-Oncology, 17(8), 812-821. https://doi.org/10.1002/pon.1373 https://doi.org/10.1002/pon.1373... et al. (2008)Koehly, L. M., Peters, J. A., Kuhn, N., Hoskins, L., Letocha, A., Kenen, R., Loud, J., & Greene, M. H. (2008). Sisters in hereditary breast and ovarian cancer families: Communal coping, social integration, and psychological well-being. Psycho-Oncology, 17(8), 812-821. https://doi.org/10.1002/pon.1373 https://doi.org/10.1002/pon.1373...	Cross-sectional	NOS-CS	8/10
Communication processes about predictive genetic testing within high-risk breast cancer families: a two-phase study design.	BlomenBlomen, C. L., Pott, A., Volk, A. E., Budäus, L., & Witzel, I. (2021). Communication processes about predictive genetic testing within high-risk breast cancer families: a two-phase study design. Scientific Reports, 11(1), e20178. https://doi.org/10.1038/s41598-021-98737-8 https://doi.org/10.1038/s41598-021-98737... et al. (2021Blomen, C. L., Pott, A., Volk, A. E., Budäus, L., & Witzel, I. (2021). Communication processes about predictive genetic testing within high-risk breast cancer families: a two-phase study design. Scientific Reports, 11(1), e20178. https://doi.org/10.1038/s41598-021-98737-8 https://doi.org/10.1038/s41598-021-98737...	Longitudinal	NOS-CS	8/10
Participants diagnosed with ATM and CHECK2 genetic mutations underwent qualitative interviews. How participants make meaning of “moderate risk” genetic results in a population breast cancer screening trial.	JamesJames, J. E., Riddle, L., Caruncho, M., Koenig, B. A., & Joseph, G. (2022). A qualitative study of unaffected ATM and CHEK2 carriers: How participants make meaning of “moderate risk” genetic results in a population breast cancer screening trial. Journal of Genetic Counseling, 31(6), 1421-1433. https://doi.org/10.1002/jgc4.1617 https://doi.org/10.1002/jgc4.1617... et al. (2022)James, J. E., Riddle, L., Caruncho, M., Koenig, B. A., & Joseph, G. (2022). A qualitative study of unaffected ATM and CHEK2 carriers: How participants make meaning of “moderate risk” genetic results in a population breast cancer screening trial. Journal of Genetic Counseling, 31(6), 1421-1433. https://doi.org/10.1002/jgc4.1617 https://doi.org/10.1002/jgc4.1617...	Cross-sectional	NOS-CS	9/10