This research assessed the reaction of six corn (Zea mays) hybrids (AG 9012, C 808, P 3041, C 901, XL 212 and X 9403), from different germplasms, to inoculation of Diplodia maydis. The hybrid X 9403 had the lowest incidence of infected grains and the highest kernel yield. The hybrid XL 212 showed intermediate incidence and yield. These two materials have dent grain texture. The hybrids P 3041, AG 9012, and C 808, which have flint grain texture, showed variable reaction to D. maydis and D. macrospora in grains and had lower kernel yields than the dent grain materials. Results from this research show differences among corn hybrids regarding their reactions to D. maydis. This suggests the utilization of artificial inoculation to increase disease pressure through artificial inoculation.