ABSTRACT
The Retrogenesis Theory (RT) describes the declines presented in Alzheimer’s disease (AD) based on the stages of Piaget’s neuropsychomotor development. The objective of this cross-sectional study was to evaluate and describe psychomotor and cognitive aspects, falls and the dependency relations between these variables according to RT in healthy older women and with probable Alzheimer’s Disease (AD). Composed of 45 older women (27 healthy and 18 with mild AD), residing in São Paulo from 2016 to 2017. Anamnesis, Geriatric Depression Scale Yesavage (GDS-30), Montreal Cognitive Assessment (MoCA), Cambridge were used for evaluation Revised Cognitive Exam (CAMCOG-R), Berg Balance Scale (BBS), timed up and go test (TUGT) and Direct Functional Status Assessment (DAFS-BR). The Mann-Whitney U tests, Spearman correlation and multiple regression analysis were used with p <0.05. A loss order similar to that suggested by RT was observed in both groups. The lower the CAMCOG-R index, the greater the number of falls (p=0.03). Praxia items (p<0.00) and executive functions (p<0.00) of CAMCOG-R highly correlated with TUGT and BBS. A dependency relation between functionality/cognition is suggested; balance/cognition and correlation between risk of falling and cognitive performance in both groups. The observed losses are in line with what the RT proposes, but with different intensities between the groups. Longitudinal studies are necessary, with the use of imaging tests to validate RT in the loss patterns in older people with and without AD.
Keywords |
Aging; Retrogenesis Theory; Alzheimer’s Disease
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