Ryan et al.(2005)1717. Ryan CM, Usui K, Floras JS, Bradley TD. Effect of continuous positive airway pressure on ventricular ectopy in heart failure patients with obstructive sleep apnoea. Thorax. 2005;60(9):781-5. doi: 10.1136/thx.2005.040972. https://doi.org/10.1136/thx.2005.040972...
|
10; 8; IG: 57,6 (2,2); CG: 60,3 (4,1) |
6 hours |
IG: Ideal drug treatment for HF+nocturnal CPAP (average of 8.0±0.5 cmH2O) |
Cardiac Effects+Respiratory Effects |
VPB: IG<CG |
1 month |
CG: Drug treatment for HF (digoxin, diuretic, ACE inhibitors, β-blockers) |
UNE: IG<CG |
LVEF: IG>CG |
HR: IG<CG |
SBP: IG<CG |
DBP: IG<CG |
AHI: IG<CG |
AFSH: IG<CG |
Kaneko et al. (2003)1818. Kaneko Y, Floras JS, Usui K, Plante J, Tkacova R, et al. Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. N Engl J Med. 2003;348(13):1233-41. doi: 10.1056/NEJMoa022479. https://doi.org/10.1056/NEJMoa022479...
|
12; 12; IG: 55.9 (2.5); CG: 55.2 (3.6) |
6 hours |
IG: Ideal drug treatment for HF+nocturnal CPAP (an average of 8.9±0.7 cmH2O) |
Cardiac Effects+Respiratory Effects+AFSH |
LVEF: IG>CG |
1 month |
CG: Drug treatment for HF (digoxin, diuretics, ACE inhibitors, hydralazine, nitrates, β-blockers) |
HR: IG>CG |
SBP: IG<CG |
DBP: IG<CG |
AHI: IG<CG |
SaO2: IG>CG |
AFSH: IG<CG |
Gilman et al. (2008)1919. Gilman MP, Floras JS, Usui K, Kaneko Y, Leung RS, et al. Continuous positive airway pressure increases heart rate variability in heart failure patients with obstructive sleep apnoea. Clin Sci (Lond). 2008;114(3):243-9. doi: 10.1042/CS20070172. https://doi.org/10.1042/CS20070172...
|
12; 7; IG: 56.7 (8.0); CG: 58.1 (7.1) |
>6 hours |
IG: Ideal drug treatment for HF+nocturnal CPAP (average pressure of 8.8±2.4 cmH2O) |
Cardiac Effects+Respiratory Effects+AFSH |
HF-HRV: IG>CG |
1 month |
CG: Drug treatment for HF (digoxin, diuretics, ACE inhibitors, hydralazine, nitrates, β-blockers) |
LVEF: IG>CG |
AHI: IG<CG |
SaO2: IG>CG |
AFSH: IG<CG |
Ferrier et al. (2008)2020. Ferrier KA, Neill AM, O'Meeghan T, Richards M, Campbell AJ. Continuous positive airway pressure in heart failure patients with obstructive sleep apnoea. Intern Med J. 2008;38(11):829-36. doi: 10.1111/j.1445-5994.2007.01585.x. https://doi.org/10.1111/j.1445-5994.2007...
|
19; 7; IG: 58.5 (11.2); CG: 60.3 (4.3) |
Participants were instructed to use every night for as long as possible. Average adherence was 4.2 hours per night (range of 0-7.9 hours per night) |
IG: Ideal drug treatment for HF+CPAP that was manually titrated with polysomnography. Participants received an educational video and were contacted by phone after one night. After two and four weeks, the results were reviewed by a sleep technician to assess the side effects of CPAP, mask adjustment, and the need for humidification |
Cardiac effects+Respiratory effects+AFSH+Catecholamines+Quality of life (SF-36)+Exercise capacity+ESS |
LVEF: IG>CG*
|
6 months |
CG: Drug treatment for HF ( β-blocker, ACE or AT II inhibitor, spironolactone, loop diuretics, digoxin, calcium antagonist, nitrate) |
SBP: IG<CG |
CG*
|
AHI: IG<CG*
|
ESS: IG<CG*
|
Mansfield et al. (2004)2121. Mansfield DR, Gollogly NC, Kaye DM, Richardson M, Bergin P, et al. Controlled trial of continuous positive airway pressure in obstructive sleep apnea and heart failure. Am J Respir Crit Care Med. 2004;169(3):361-6. doi: 10.1164/rccm.200306-752OC. https://doi.org/10.1164/rccm.200306-752O...
|
28; 27; IG: 57.2 (1.7); CG: 57.5 (1.6) |
Average time from 5.6 to 0.4 hours |
IG: nocturnal nasal CPAP (average pressure of 8.8 to 1.4 mmHg) |
Cardiac effects+Respiratory effects+AFSH+ESS+Quality of life (SF-36) |
UNE: IG<CG |
3 months |
CG: No intervention |
LVEF: IG>CG |
AHI: IG<CG |
SaO2(%): IG>CG |
ESS: IG<CG |
Quality of life (SF-36): IG>CG |
Smith et al. (2007)2222. Smith LA, Vennelle M, Gardner RS, McDonagh TA, Denvir MA, et al. Auto-titrating continuous positive airway pressure therapy in patients with chronic heart failure and obstructive sleep apnoea: a randomized placebo-controlled trial. Eur Heart J. 2007;28(10):1221-7. doi: 10.1093/eurheartj/ehm131. https://doi.org/10.1093/eurheartj/ehm131...
|
12; 11; 61±8 |
6 hours |
IG: auto-titrated nocturnal CPAP (adjusts pressure according to upper airway obstruction). The average CPAP pressure applied was 7±2 cmH2O) |
Cardiac effects+Quality of life (SF-36)+Exercise capacity |
ESS: IG<CG |
6 weeks |
CG: simulated CPAP (1 cmH2O) |