Carocin D |
DNase |
His-Me_finger (CL0263) |
- |
Pectobacterium carotovorum
|
Roh et al., 2010Roh E, Park T-H, Kim M-i, Lee S, Ryu S, Oh C-S, Rhee S, Kim D-H, Park B-S and Heu S (2010) Characterization of a new bacteriocin, Carocin D, from Pectobacterium carotovorum subsp. carotovorum Pcc21. Appl Environ Microbiol 76:7541-7549.
|
Carocin S1 |
DNase |
- |
- |
Pectobacterium carotovorum
|
Chuang et al., 2007Chuang D-y, Chien Y-c and Wu H-P (2007) Cloning and expression of the Erwinia carotovora subsp. carotovora gene encoding the low-molecular-weight bacteriocin carocin S1. J Bacteriol 189:620-626.
|
Carocin S3 |
DNase |
- |
- |
Pectobacterium carotovorum
|
Wang et al., 2020Wang J-W, Derilo RC, Lagitnay RBJS, Wu H-P, Chen K-I and Chuang D-Y (2020) Identification and characterization of the bacteriocin Carocin S3 from the multiple bacteriocin producing strain of Pectobacterium carotovorum subsp. carotovorum. BMC Microbiol 20:273.
|
Colicin E2 |
DNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Escherichia coli W3110
|
Schaller and Nomura, 1976Schaller K and Nomura M (1976) Colicin E2 is DNA endonuclease. Proc Natl Acad Sci U S A 73:3989-3993.
|
Colicin E7 |
DNase RNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Escherichia coli K317
|
Males and Stocker, 1980Males BM and Stocker B (1980) Escherichia coli K317, formerly used to define colicin group E2, produces colicin E7, is immune to colicin E2, and carries a bacteriophage-restricting conjugative plasmid. J Bacteriol 144:524-531.; Chak et al., 1991Chak KF, Kuo W-S and James R (1991) Cloning and characterization of the ColE7 plasmid. Microbiology 137:91-100.; Hsia et al., 2004Hsia K-C, Chak K-F, Liang P-H, Cheng Y-S, Ku W-Y and Yuan HS (2004) DNA binding and degradation by the HNH protein ColE7. Structure 12:205-214.
|
Colicin E8 |
DNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Escherichia coli J
|
Cooper and James 1984Cooper PC and James R (1984) Two new E colicins, E8 and E9, produced by a strain of Escherichia coli. Microbiology 130:209-215.; Toba et al., 1988Toba M, Masaki H and Ohta T (1988) Colicin E8, a DNase which indicates an evolutionary relationship between colicins E2 and E3. J Bacteriol 170:3237-3242.
|
Colicin E9 |
DNase RNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Escherichia coli J
|
Cooper and James 1984Cooper PC and James R (1984) Two new E colicins, E8 and E9, produced by a strain of Escherichia coli. Microbiology 130:209-215.; Chak et al., 1991Chak KF, Kuo W-S and James R (1991) Cloning and characterization of the ColE7 plasmid. Microbiology 137:91-100.; Garinot-Schneider et al., 1996Garinot-Schneider C, Pommer AJ, Moore GR, Kleanthous C and James R (1996) Identification of putative active-site residues in the DNase domain of colicin E9 by random mutagenesis. J Mol Biol 260:731-742.; Pommer et al., 1998Pommer AJ, Wallis R, Moore GR, James R and Kleanthous C (1998) Enzymological characterization of the nuclease domain from the bacterial toxin colicin E9 from Escherichia coli. Biochem J 334:387-392.
|
Klebicin A |
DNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Klebsiella pneumoniae
|
Cooper and James, 1985Cooper PC and James R (1985) Three immunity types of klebicins which use the cloacin DF13 receptor of Klebsiella pneumoniae. Microbiology 131:2313-2318.; James et al., 1987James R, Schneider J and Cooper PC (1987) Characterization of three group A klebicin plasmids: localization of their E colicin immunity genes. Microbiology 133:2253-2262.
|
Klebicin B |
DNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Klebsiella pneumoniae
|
Riley et al., 2001Riley MA, Pinou T, Wertz JE, Tan Y and Valletta CM (2001) Molecular characterization of the klebicin B plasmid of Klebsiella pneumoniae. Plasmid 45:209-221.
|
Pyocin AP41 |
DNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Pseudomonas aeruginosa
|
Sano and Kageyama, 1981Sano Y and Kageyama M (1981) Purification and properties of an S-type pyocin, pyocin AP41. J Bacteriol 146:733-739.; Sano et al., 1993Sano Y, Matsui H, Kobayashi M and Kageyama M (1993) Molecular structures and functions of pyocins S1 and S2 in Pseudomonas aeruginosa. J Bacteriol 175:2907-2916.
|
Pyocin S1 |
DNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Pseudomonas aeruginosa
|
Sano et al., 1993Sano Y, Matsui H, Kobayashi M and Kageyama M (1993) Molecular structures and functions of pyocins S1 and S2 in Pseudomonas aeruginosa. J Bacteriol 175:2907-2916.
|
Pyocin S2 |
DNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Pseudomonas aeruginosa
|
Ohkawa et al., 1973Ohkawa I, Kageyama M and Egami F (1973) Purification and properties of pyocin S2. J Biochem 73:281-289.; Sano et al., 1993Sano Y, Matsui H, Kobayashi M and Kageyama M (1993) Molecular structures and functions of pyocins S1 and S2 in Pseudomonas aeruginosa. J Bacteriol 175:2907-2916.
|
Pyocin S3 |
DNase |
- |
- |
Pseudomonas aeruginosa
|
Duport et al., 1995Duport C, Baysse C and Michel-Briand Y (1995) Molecular characterization of pyocin S3, a novel S-type pyocin from Pseudomonas aeruginosa. J Biol Chem 270:8920-8927.
|
Pyocin S8 |
DNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Pseudomonas aeruginosa
|
Turano et al., 2017Turano H, Gomes F, Barros-Carvalho GA, Lopes R, Cerdeira L, Soares Netto LE, Gales AC and Lincopan N (2017) Tn 6350, a novel transposon carrying pyocin S8 genes encoding a bacteriocin with activity against carbapenemase-producing Pseudomonas aeruginosa. Antimicrob Agents Ch 61:e00100-00117.; Turano et al., 2020Turano H, Gomes F, Domingos RM, Degenhardt MF, Oliveira CL, Garratt RC, Lincopan N and Soares Netto LE (2020) Molecular structure and functional analysis of pyocin S8 from Pseudomonas aeruginosa reveals the essential requirement of a glutamate residue in the HNH motif for DNase activity. J Bacteriol 202:e00346-00320.
|
Pyocin S9 |
DNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Pseudomonas aeruginosa
|
Ghequire and De Mot, 2014Ghequire MGK and De Mot R (2014) Ribosomally encoded antibacterial proteins and peptides from Pseudomonas. FEMS Microbiol Rev 38:523-568.
|
Usp |
DNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Escherichia coli
|
Kurazono, 2000Kurazono H, Yamamoto S, Nakano M, Nair G, Terai A, Chaicumpa W and Hayashi H (2000) Characterization of a putative virulence island in the chromosome of uropathogenic Escherichia coli possessing a gene encoding a uropathogenic-specific protein. Microb Pathog 28:183-189.; Nipic et al., 2013Nipič D, Podlesek Z, Budič M, Črnigoj M and Žgur-Bertok D (2013) Escherichia coli uropathogenic-specific protein, Usp, is a bacteriocin-like genotoxin. J Infect Dis 208:1545-1552.; Zaw et al., 2013Yajima S, Nakanishi K, Takahashi K, Ogawa T, Hidaka M, Kezuka Y, Nonaka T, Ohsawa K and Masaki H (2004) Relation between tRNase activity and the structure of colicin D according to X-ray crystallography. Biochem Biophys Res Commun 322:966-973.
|
Carocin S2 |
tRNase |
Colicin D/E5 (CL0640) |
Colicin_D (PF11429) |
Pectobacterium carotovorum
|
Chan et al., 2011Chan Y-C, Wu J-L, Wu H-P, Tzeng K-C and Chuang D-Y (2011) Cloning, purification, and functional characterization of Carocin S2, a ribonuclease bacteriocin produced by Pectobacterium carotovorum. BMC Microbiol 11:99.
|
Colicin E5 |
tRNase |
Colicin D/E5 (CL0640) |
Colicin_E5 (PF12106) |
Shigella sonnei 101BM
|
Males and Stocker, 1982Males B and Stocker B (1982) Colicins E4, E5, E6 and A and properties of btuB+ colicinogenic transconjugants. Microbiology 128:95-106.; Ogawa et al., 1999Ogawa T, Tomita K, Ueda T, Watanabe K, Uozumi T and Masaki H (1999) A cytotoxic ribonuclease targeting specific transfer RNA anticodons. Science 283:2097-2100.; Masaki and Ogawa, 2002Masaki H and Ogawa T (2002) The modes of action of colicins E5 and D, and related cytotoxic tRNases. Biochimie 84:433-438.
|
Colicin D |
tRNase |
Colicin D/E5 (CL0640) |
Colicin_D (PF11429) |
Escherichia coli K-12 W1485
|
Timmis and Hedges, 1972Timmis K and Hedges AJ (1972) The killing of sensitive cells by colicin D. Biochim Biophys Acta 262:200-207.; Tomita et al., 2000Tomita K, Ogawa T, Uozumi T, Watanabe K and Masaki H (2000) A cytotoxic ribonuclease which specifically cleaves four isoaccepting arginine tRNAs at their anticodon loops. Proc Natl Acad Sci U S A 97: 8278-8283.; Masaki and Ogawa, 2002Masaki H and Ogawa T (2002) The modes of action of colicins E5 and D, and related cytotoxic tRNases. Biochimie 84:433-438.
|
Klebicin D |
tRNase |
Colicin D/E5 (CL0640) |
Colicin_D (PF11429) |
Klebsiella pneumoniae
|
Chavan et al., 2005Chavan M, Rafi H, Wertz J, Goldstone C and Riley MA (2005) Phage associated bacteriocins reveal a novel mechanism for bacteriocin diversification in Klebsiella. J Mol Evol 60:546-556.
|
Pyocin S4 |
tRNase |
Colicin D/E5 (CL0640) |
Colicin_E5 (PF12106) |
Pseudomonas aeruginosa
|
Parret and De Mot, 2000Parret A and De Mot R (2000) Novel bacteriocins with predicted tRNase and pore‐forming activities in Pseudomonas aeruginosa PAO1. Mol Microbiol 35:472-473.
|
Pyocin S6 |
rRNase |
- |
E3 rRNase (PF09000) |
Pseudomonas aeruginosa
|
Dingermans et al., 2016Dingemans J, Ghequire MG, Craggs M, De Mot R and Cornelis P (2016) Identification and functional analysis of a bacteriocin, pyocin S6, with ribonuclease activity from a Pseudomonas aeruginosa cystic fibrosis clinical isolate. Microbiologyopen 5:413-423.
|
Cloacin DF13 |
rRNase |
- |
E3 rRNase (PF09000) |
Enterobacter cloacae
|
De Graaf et al., 1973De Graaf F, Niekus H and Klootwijk J (1973) Inactivation of bacterial ribosome in vivo and in vitro by cloacin DF13. FEBS Lett 35:161-165.
|
Colicin E3 |
rRNase |
- |
E3 rRNase (PF09000) |
Escherichia coli CA38 Pseudomonas spp.
|
Senior and Holland, 1971Senior B and Holland I (1971) Effect of colicin E3 upon the 30S ribosomal subunit of Escherichia coli. Proc Natl Acad Sci U S A 68:959-963.; Bowman et al., 1971Bowman C, Dahlberg J, Ikemura T, Konisky J and Nomura M (1971) Specific inactivation of 16S ribosomal RNA induced by colicin E3 in vivo. Proc Natl Acad Sci U S A 68:964-968.; Lasater et al., 1989Lasater L, Cann P and Glitz DG (1989) Localization of the site of cleavage of ribosomal RNA by colicin E3: Placement on the small ribosomal subunit by electron microscopy of antibody-complementary oligodeoxynucleotide complexes. J Biol Chem 264:21798-21805.;Ogawa et al., 1999Ogawa T, Tomita K, Ueda T, Watanabe K, Uozumi T and Masaki H (1999) A cytotoxic ribonuclease targeting specific transfer RNA anticodons. Science 283:2097-2100.
|
Colicin E4 |
rRNase |
- |
E3 rRNase (PF09000) |
Citrobacter 20-78
|
Horak, 1975Horak V (1975) Typing of Shigella sonnei colicins by means of specific indicators. Zentralbl Bakteriol Orig A 233:58-63.; Smarda et al., 1988Šmarda J, Uher P, Osecký P and Šmarda J (1988) Modes of action of colicins E4-E7: Rates of basic biosyntheses inhibition. Zentralbl Bakteriol Mikrobiol Hyg A 269:7-14.; Smarda et al., 2002; Hirao et al., 2004Hirao I, Harada Y, Nojima T, Osawa Y, Masaki H and Yokoyama S (2004) In vitro selection of RNA aptamers that bind to colicin E3 and structurally resemble the decoding site of 16S ribosomal RNA. Biochemistry 43:3214-3221. |
Colicin E6 |
rRNase |
- |
E3 rRNase (PF09000) |
Shigella sonnei
|
Males and Stocker, 1982Males B and Stocker B (1982) Colicins E4, E5, E6 and A and properties of btuB+ colicinogenic transconjugants. Microbiology 128:95-106.; Sharma et al., 2002Sharma S, Waterfield N, Bowen D, Rocheleau T, Holland L, James R and Ffrench-Constant R (2002) The lumicins: novel bacteriocins from Photorhabdus luminescens with similarity to the uropathogenic-specific protein (USP) from uropathogenic Escherichia coli. FEMS Microbiol Lett 214:241-249.; Hirao et al., 2004Hirao I, Harada Y, Nojima T, Osawa Y, Masaki H and Yokoyama S (2004) In vitro selection of RNA aptamers that bind to colicin E3 and structurally resemble the decoding site of 16S ribosomal RNA. Biochemistry 43:3214-3221.
|
Klebicin C |
rRNase |
- |
E3 rRNase (PF09000) |
Klebsiella pneumoniae
|
Chavan et al., 2005Chavan M, Rafi H, Wertz J, Goldstone C and Riley MA (2005) Phage associated bacteriocins reveal a novel mechanism for bacteriocin diversification in Klebsiella. J Mol Evol 60:546-556.
|
Microcin B17 |
DNA gyrase |
- |
- |
Escherichia coli Pseudomonas spp.
|
Baquero and Moreno, 1984; Moreno and Baquero 1986; Heddle et al., 2001 |
T4SS
|
Smlt4382 |
DNAse |
His-Me_finger (CL0263) |
AHH (PF14412) |
Stenotrophomonas maltophilia
|
Bayer-Santos et al., 2019Bayer-Santos E, Cenens W, Matsuyama BY, Oka GU, Di Sessa G, Mininel IDV, Alves TL and Farah CS (2019) The opportunistic pathogen Stenotrophomonas maltophilia utilizes a type IV secretion system for interbacterial killing. PLoS Pathogens 15:e1007651.
|
XAC3266 |
DNAse |
His-Me_finger (CL0263) |
AHH (PF14412) |
Xanthomonas citri
|
Souza et al., 2015Souza DP, Oka GU, Alvarez-Martinez CE, Bisson-Filho AW, Dunger G, Hobeika L, Cavalcante NS, Alegria MC, Barbosa LR and Salinas RK (2015) Bacterial killing via a type IV secretion system. Nat Commun 6:6453.
|
T5SS
|
CdiA-CT3937-2
|
DNase |
- |
- |
Dickeya dadantii
|
Aoki et al., 2010Aoki SK, Diner EJ, de Roodenbeke CtK, Burgess BR, Poole SJ, Braaten BA, Jones AM, Webb JS, Hayes CS and Cotter PA (2010) A widespread family of polymorphic contact-dependent toxin delivery systems in bacteria. Nature 468:439-442.
|
CdiA2-CT |
DNase |
PD-(D/E)XK (CL0236) |
Tox-REase 7 (PF15649) |
Acinetobacter baumannii
|
Roussin et al., 2019Roussin M, Rabarioelina S, Cluzeau L, Cayron J, Lesterlin C, Salcedo SP and Bigot S (2019) Identification of a contact-dependent growth inhibition (CDI) system that reduces biofilm formation and host cell adhesion of Acinetobacter baumannii DSM30011 strain. Front Microbiol 10:2450.
|
CdiA-CTGN05224
|
RNase |
EndoU (CL0695) |
EndoU_bacteria (PF14436) |
Klebsiella aerogenes GN05224
|
Michalska et al., 2018Michalska K, Quan Nhan D, Willett JL, Stols LM, Eschenfeldt WH, Jones AM, Nguyen JY, Koskiniemi S, Low DA and Goulding CW (2018) Functional plasticity of antibacterial EndoU toxins. Mol Microbiol 109:509-527.
|
CdiA-CTSTECO31
|
tRNase |
EndoU (CL0695) |
EndoU_bacteria (PF14436) |
Escherichia coli STEC_O31
|
Michalska et al., 2018Michalska K, Quan Nhan D, Willett JL, Stols LM, Eschenfeldt WH, Jones AM, Nguyen JY, Koskiniemi S, Low DA and Goulding CW (2018) Functional plasticity of antibacterial EndoU toxins. Mol Microbiol 109:509-527.
|
CdiA-CTII Bp1026b
|
tRNase |
PD-(D/E)XK (CL0236) |
CdiA_C (PF18451) |
Burkholderia pseudomallei
|
Morse et al., 2012Morse RP, Nikolakakis KC, Willett JL, Gerrick E, Low DA, Hayes CS and Goulding CW (2012) Structural basis of toxicity and immunity in contact-dependent growth inhibition (CDI) systems. Proc Natl Acad Sci U S A 109:21480-21485.
|
CdiA-CTE479
|
tRNase |
PD-(D/E)XK (CL0236) |
CdiA_C_tRNase (PF18664) |
Burkholderia pseudomallei
|
Nikolakakis et al., 2012Nikolakakis K, Amber S, Wilbur JS, Diner EJ, Aoki SK, Poole SJ, Tuanyok A, Keim PS, Peacock S and Hayes CS (2012) The toxin/immunity network of Burkholderia pseudomallei contact‐dependent growth inhibition (CDI) systems. Mol Microbiol 84:516-529.
|
CdiA-CTEC869
|
tRNase |
Colicin D/E5 (CL0640) |
- |
Escherichia coli EC869
|
Jones et al., 2017Jones AM, Garza-Sánchez F, So J, Hayes CS and Low DA (2017) Activation of contact-dependent antibacterial tRNase toxins by translation elongation factors. Proc Natl Acad Sci U S A 114:E1951-E1957.
|
CdiA-CTEC3006
|
tRNase |
Colicin D/E5 (CL0640) |
Colicin_D (PF11429) |
Escherichia coli EC3006
|
Willett et al., 2015Willett JL, Gucinski GC, Fatherree JP, Low DA and Hayes CS (2015) Contact-dependent growth inhibition toxins exploit multiple independent cell-entry pathways. Proc Natl Acad Sci U S A 112:11341-11346.; Gucinski et al., 2019Gucinski GC, Michalska K, Garza-Sánchez F, Eschenfeldt WH, Stols L, Nguyen JY, Goulding CW, Joachimiak A and Hayes CS (2019) Convergent evolution of the Barnase/EndoU/Colicin/RelE (BECR) fold in antibacterial tRNase toxins. Structure 27:1660-1674.e1665.
|
CdiA-CTKp342
|
tRNase |
Colicin D/E5 (CL0640) |
Colicin_D (PF11429) |
Klebsiella pneumoniae 342
|
Gucinski et al., 2019Gucinski GC, Michalska K, Garza-Sánchez F, Eschenfeldt WH, Stols L, Nguyen JY, Goulding CW, Joachimiak A and Hayes CS (2019) Convergent evolution of the Barnase/EndoU/Colicin/RelE (BECR) fold in antibacterial tRNase toxins. Structure 27:1660-1674.e1665.
|
CdiA-CTK96243
|
tRNase |
Colicin D/E5 (CL0640) |
Colicin_E5 (PF12106) |
Burkholderia pseudomallei
|
Nikolakakis et al., 2012Nikolakakis K, Amber S, Wilbur JS, Diner EJ, Aoki SK, Poole SJ, Tuanyok A, Keim PS, Peacock S and Hayes CS (2012) The toxin/immunity network of Burkholderia pseudomallei contact‐dependent growth inhibition (CDI) systems. Mol Microbiol 84:516-529.
|
CdiA-CTE478
|
tRNase |
Colicin D/E5 (CL0640) |
Colicin_E5 (PF12106) |
Burkholderia pseudomallei
|
Nikolakakis et al., 2012Nikolakakis K, Amber S, Wilbur JS, Diner EJ, Aoki SK, Poole SJ, Tuanyok A, Keim PS, Peacock S and Hayes CS (2012) The toxin/immunity network of Burkholderia pseudomallei contact‐dependent growth inhibition (CDI) systems. Mol Microbiol 84:516-529.
|
CdiA-CTUPEC536
|
tRNase |
- |
Ntox28 (PF15605) |
Escherichia coli UPEC536
|
Aoki et al., 2010Aoki SK, Diner EJ, de Roodenbeke CtK, Burgess BR, Poole SJ, Braaten BA, Jones AM, Webb JS, Hayes CS and Cotter PA (2010) A widespread family of polymorphic contact-dependent toxin delivery systems in bacteria. Nature 468:439-442.; Diner et al., 2012 |
CdiA-CTo1 EC93
|
tRNase |
- |
Ntox28 (PF15605) |
Escherichia coli EC93
|
Poole et al., 2011 |
CdiA-CTECL
|
rRNase |
- |
E3 rRNase (PF09000) |
Enterobacter cloacae
|
Beck et al., 2014Beck CM, Morse RP, Cunningham DA, Iniguez A, Low DA, Goulding CW and Hayes CS (2014) CdiA from Enterobacter cloacae delivers a toxic ribosomal RNase into target bacteria. Structure 22:707-718.
|
CdiA-CTEC16
|
rRNase |
- |
E3 rRNase (PF09000) |
Dickeya chrysanthemi
|
Beck et al., 2014Beck CM, Morse RP, Cunningham DA, Iniguez A, Low DA, Goulding CW and Hayes CS (2014) CdiA from Enterobacter cloacae delivers a toxic ribosomal RNase into target bacteria. Structure 22:707-718.
|
CdiA-CT49162
|
rRNase |
- |
E3 rRNase (PF09000) |
Enterobacter hormaechei
|
Beck et al., 2014Beck CM, Morse RP, Cunningham DA, Iniguez A, Low DA, Goulding CW and Hayes CS (2014) CdiA from Enterobacter cloacae delivers a toxic ribosomal RNase into target bacteria. Structure 22:707-718.
|
CdiA-CT0038
|
rRNase |
- |
E3 rRNase (PF09000) |
Pseudomonas viridiflava
|
Beck et al., 2014Beck CM, Morse RP, Cunningham DA, Iniguez A, Low DA, Goulding CW and Hayes CS (2014) CdiA from Enterobacter cloacae delivers a toxic ribosomal RNase into target bacteria. Structure 22:707-718.
|
T6SS
|
ET4 |
DNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Escherichia coli PE086
|
Ma et al., 2017Ma J, Pan Z, Huang J, Sun M, Lu C and Yao H (2017) The Hcp proteins fused with diverse extended-toxin domains represent a novel pattern of antibacterial effectors in type VI secretion systems. Virulence 8:1189-1202.
|
Hcp-ET1 |
DNase |
His-Me_finger (CL0263) |
HNH (PF01844) |
Escherichia coli STEC004
|
Ma et al., 2017Ma J, Pan Z, Huang J, Sun M, Lu C and Yao H (2017) The Hcp proteins fused with diverse extended-toxin domains represent a novel pattern of antibacterial effectors in type VI secretion systems. Virulence 8:1189-1202.
|
RhsA |
DNase |
His-Me_finger (CL0263) |
Endonuclea_NS_2 (PF13930) |
Dickeya dadantii
|
Koskiniemi et al., 2013Koskiniemi S, Lamoureux JG, Nikolakakis KC, de Roodenbeke CtK, Kaplan MD, Low DA and Hayes CS (2013) Rhs proteins from diverse bacteria mediate intercellular competition. Proc Natl Acad Sci U S A 110:7032-7037.
|
RhsB |
DNase |
His-Me_finger (CL0263) |
HNH (PF01844) |
Dickeya dadantii
|
Koskiniemi et al., 2013Koskiniemi S, Lamoureux JG, Nikolakakis KC, de Roodenbeke CtK, Kaplan MD, Low DA and Hayes CS (2013) Rhs proteins from diverse bacteria mediate intercellular competition. Proc Natl Acad Sci U S A 110:7032-7037.
|
Rhs2 |
DNase |
His-Me_finger (CL0263) |
HNH (PF01844) |
Serratia marcescens
|
Alcoforado-Diniz and Coulthurst, 2015Alcoforado-Diniz J, Coulthurst SJ (2015) Intraspecies competition in Serratia marcescens is mediated by type VI-secreted Rhs effectors and a conserved effector-associated accessory protein. J Bacteriol 197:2350-2360.
|
Rhs2 |
DNase |
His-Me_finger (CL0263) |
AHH (PF14412) |
Acinetobacter baumannii
|
Fitzsimons et al., 2018Fitzsimons TC, Lewis JM, Wright A, Kleifeld O, Schittenhelm RB, Powell D, Harper M and Boyce JD (2018) Identification of novel Acinetobacter baumannii type VI secretion system antibacterial effector and immunity pairs. Infect Immun 86:e00297-18.
|
TseI |
DNase |
His-Me_finger (CL0263) |
Tox-HNH-EHHH (PF15657) |
Aeromonas dhakensis
|
Pei et al., 2020Pei T-T, Li H, Liang X, Wang Z-H, Liu G, Wu L-L, Kim H, Xie Z, Yu M and Lin S (2020) Intramolecular chaperone-mediated secretion of an Rhs effector toxin by a type VI secretion system. Nat Commun 11:1865.
|
Tse7 (PA0099) |
DNase |
His-Me_finger (CL0263) |
Tox-GHH2 (PF15635) |
Pseudomonas aeruginosa
|
Hachani et al., 2014Hachani A, Allsopp LP, Oduko Y and Filloux A (2014) The VgrG proteins are “a la carte” delivery systems for bacterial type VI effectors. J Biol Chem 289:17872-17884.; Pissaridou et al., 2018Pissaridou P, Allsopp LP, Wettstadt S, Howard SA, Mavridou DA and Filloux A (2018) The Pseudomonas aeruginosa T6SS-VgrG1b spike is topped by a PAAR protein eliciting DNA damage to bacterial competitors. Proc Natl Acad Sci U S A 115:12519-12524.
|
Tke2 |
DNase RNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Pseudomonas putida
|
Bernal et al., 2017Bernal P, Allsopp LP, Filloux A and Llamas MA (2017) The Pseudomonas putida T6SS is a plant warden against phytopathogens. ISME J 11:972-987.
|
Tke4 |
DNase RNase |
His-Me_finger (CL0263) |
Tox-SHH (PF15652) |
Pseudomonas putida
|
Bernal et al., 2017Bernal P, Allsopp LP, Filloux A and Llamas MA (2017) The Pseudomonas putida T6SS is a plant warden against phytopathogens. ISME J 11:972-987.
|
Txe1 |
DNase |
His-Me_finger (CL0263) |
- |
Pseudomonas plecoglossicida
|
Li et al., 2022Li Y, Yan X and Tao Z (2022) Two type VI secretion DNase effectors are utilized for interbacterial competition in the fish pathogen Pseudomonas plecoglossicida. Front Microbiol 13:869278.
|
Txe2 |
DNase |
His-Me_finger (CL0263) |
AHH (PF14412) |
Pseudomonas plecoglossicida
|
Li et al., 2022Li Y, Yan X and Tao Z (2022) Two type VI secretion DNase effectors are utilized for interbacterial competition in the fish pathogen Pseudomonas plecoglossicida. Front Microbiol 13:869278.
|
Txe4 |
DNase |
His-Me_finger (CL0263) |
Tox-SHH (PF15652) |
Pseudomonas plecoglossicida
|
Li et al., 2022Li Y, Yan X and Tao Z (2022) Two type VI secretion DNase effectors are utilized for interbacterial competition in the fish pathogen Pseudomonas plecoglossicida. Front Microbiol 13:869278.
|
VP1415 |
DNase |
His-Me_finger (CL0263) |
AHH (PF14412) |
Vibrio parahaemolyticus
|
Salomon et al., 2014Salomon D, Kinch LN, Trudgian DC, Guo X, Klimko JA, Grishin NV, Mirzaei H and Orth K (2014) Marker for type VI secretion system effectors. Proc Natl Acad Sci U S A 111:9271-9276.
|
Hcp-ET3 |
DNase |
- |
- |
Escherichia coli UT189
|
Ma et al., 2017Ma J, Pan Z, Huang J, Sun M, Lu C and Yao H (2017) The Hcp proteins fused with diverse extended-toxin domains represent a novel pattern of antibacterial effectors in type VI secretion systems. Virulence 8:1189-1202.
|
VgrG-NucSe1 |
DNase |
His-Me_finger (CL0263) |
HNH (PF01844) |
Salmonella arizonae
|
Blondel et al., 2009Blondel CJ, Jiménez JC, Contreras I and Santiviago CA (2009) Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes. BMC Genomics 10:354.; Ho et al., 2017Ho BT, Fu Y, Dong TG and Mekalanos JJ (2017) Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells. Proc Natl Acad Sci U S A 114:9427-9432.
|
VPA1263 |
DNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Vibrio parahaemolyticus
|
Salomon et al., 2014Salomon D, Kinch LN, Trudgian DC, Guo X, Klimko JA, Grishin NV, Mirzaei H and Orth K (2014) Marker for type VI secretion system effectors. Proc Natl Acad Sci U S A 111:9271-9276.; Fridman et al., 2022Fridman CM, Jana B, Ben-Yaakov R, Bosis E and Salomon D (2022) A DNase type VI secretion system effector requires its MIX domain for secretion. Microbiol Spectr:e02465-02422.
|
PT1 |
DNase |
- |
- |
Escherichia marmotae
|
Nachmias et al., 2022Nachmias N, Dotan N, Fraenkel R, Rocha MC, Kluzek M, Shalom M, Rivitz A, Shamash-Halevy N, Cahana I and Deouell N et al. (2022) Systematic discovery of antibacterial and antifungal bacterial toxins. bioRxiv:2021.2010.2019.465003.
|
IdrD |
DNase |
PD-(D/E)XK (CL0236) |
- |
Proteus mirabilis
|
Sirias et al., 2020Sirias D, Utter DR and Gibbs KA (2020) A family of contact-dependent nuclease effectors contain an exchangeable, species-identifying domain. bioRxiv:2020.02.20.956912.
|
PoNe |
DNase |
PD-(D/E)XK (CL0236) |
- |
Vibrio parahaemolyticus
|
Jana et al., 2019Jana B, Fridman CM, Bosis E and Salomon D (2019) A modular effector with a DNase domain and a marker for T6SS substrates. Nat Commun 10:3595.
|
RhsB |
DNase |
PD-(D/E)XK (CL0236) |
- |
Acidovorax citrulli
|
Pei et al., 2022Pei T-T, Kan Y, Wang ZH, Tang MX, Li H, Yan S, Cui Y, Zheng HY, Luo H and Liang X (2022) Delivery of an Rhs‐family nuclease effector reveals direct penetration of the gram‐positive cell envelope by a type VI secretion system in Acidovorax citrulli. mLife 1:66-78.
|
TseT |
DNase |
PD-(D/E)XK (CL0236) |
Tox-REase-5 (PF15648) |
Pseudomonas aeruginosa
|
Burkinshaw et al., 2018Burkinshaw BJ, Liang X, Wong M, Le AN, Lam L and Dong TG (2018) A type VI secretion system effector delivery mechanism dependent on PAAR and a chaperone-co-chaperone complex. Nat Microbiol 3:632-640.; Wen et al., 2021Wen H, Liu G, Geng Z, Zhang H, Li Y, She Z and Dong Y (2021) Structure and SAXS studies unveiled a novel inhibition mechanism of the Pseudomonas aeruginosa T6SS TseT-TsiT complex. Int J Biol Macromol 188:450-459.
|
TseTBg |
DNase RNase |
PD-(D/E)XK (CL0236) |
Tox-REase-5 (PF15648) |
Burkholderia gladioli
|
Yadav et al., 2021Yadav SK, Magotra A, Ghosh S, Krishnan A, Pradhan A, Kumar R, Das J, Sharma M and Jha G (2021) Immunity proteins of dual nuclease T6SS effectors function as transcriptional repressors. EMBO Rep 22:e51857.
|
TseV |
DNase |
PD-(D/E)XK (CL0236) |
VRR_NUC (PF08774) |
Pseudomonas aeruginosa
|
Wang et al., 2021Wang S, Geng Z, Zhang H, She Z and Dong Y (2021) The Pseudomonas aeruginosa PAAR2 cluster encodes a putative VRR‐NUC domain‐containing effector. FEBS J 288:5755-5767.
|
TseV2/TseV3 |
DNase |
PD-(D/E)XK (CL0236) |
VRR_NUC (PF08774) |
Salmonella bongori
|
Hespanhol et al., 2022Hespanhol JT, Sanchez-Limache DE, Nicastro GG, Mead L, Llontop EE, Chagas-Santos G, Farah CS, de Souza RF, da Silva Galhardo R, Lovering A et al. (2022) Antibacterial T6SS effectors with a VRR-Nuc domain are structure-specific nucleases. Elife 11:e82437.
|
Tce1 |
DNase |
- |
toxin_43/Ntox15 (PF15604) |
Pseudomonas putida
|
Song et al., 2021Song L, Pan J, Yang Y, Zhang Z, Cui R, Jia S, Wang Z, Yang C, Xu L and Dong TG (2021) Contact-independent killing mediated by a T6SS effector with intrinsic cell-entry properties. Nat Commun 12:423.
|
Tde1/2 |
DNase |
- |
toxin_43/Ntox15 (PF15604) |
Agrobacterium tumefaciens
|
Ma et al., 2014; Bondage et al., 2016Bondage DD, Lin J-S, Ma L-S, Kuo C-H and Lai E-M (2016) VgrG C terminus confers the type VI effector transport specificity and is required for binding with PAAR and adaptor-effector complex. Proc Natl Acad Sci U S A 113:E3931-E3940. |
SED_RS01930 |
RNase |
- |
Ntox47 (PF15540) |
Salmonella enterica Dublin |
Amaya et al., 2022 |
Tre23 |
ADP-ribosyltranferase |
- |
Tox-ART-HYD1 (PF15633) |
Photorhabdus laumondii
|
Jurenas et al., 2021Jurėnas D, Payelleville A, Roghanian M, Turnbull KJ, Givaudan A, Brillard J, Hauryliuk V and Cascales E (2021) Photorhabdus antibacterial Rhs polymorphic toxin inhibits translation through ADP-ribosylation of 23S ribosomal RNA. Nucleic Acids Res 49:8384-8395.
|
RhsP2 |
ADP-ribosyltranferase |
- |
- |
Pseudomonas aeruginosa
|
Bullen et al., 2022Bullen NP, Sychantha D, Thang SS, Culviner PH, Rudzite M, Ahmad S, Shah VS, Filloux A, Prehna G and Whitney JC (2022) An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs. Mol Cell 82:3484-3498.e3411.
|
DddA |
Deamination |
Cytidine deaminase-like (CL0109) |
DddA-like (PF14428) |
Burkholderia cenocepacia
|
Mok et al., 2020Mok BY, de Moraes MH, Zeng J, Bosch DE, Kotrys AV, Raguram A, Hsu F, Radey MC, Peterson SB and Mootha VK (2020) A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing. Nature 583:631-637.; Moraes et al., 2021de Moraes MH, Hsu F, Huang D, Bosch DE, Zeng J, Radey MC, Simon N, Ledvina HE, Frick JP and Wiggins PA (2021) An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations. Elife 10:e62967.
|
SsdA |
Deamination |
Cytidine deaminase-like (CL0109) |
DYW_deaminase (PF14432) |
Pseudomonas syringae
|
Moraes et al., 2021de Moraes MH, Hsu F, Huang D, Bosch DE, Zeng J, Radey MC, Simon N, Ledvina HE, Frick JP and Wiggins PA (2021) An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations. Elife 10:e62967.
|
T7SS
|
EsaD/EssD |
DNase |
His-Me_finger (CL0263) |
Endonuclea_NS_2 (PF13930) |
Staphylococcus aureus
|
Cao et al., 2016Cao Z, Casabona MG, Kneuper H, Chalmers JD and Palmer T (2016) The type VII secretion system of Staphylococcus aureus secretes a nuclease toxin that targets competitor bacteria. Nat Microbiol 2:16183.; Ohr et al., 2017Ohr RJ, Anderson M, Shi M, Schneewind O and Missiakas D (2017) EssD, a nuclease effector of the Staphylococcus aureus ESS pathway. J Bacteriol 199:e00528-00516.
|
YeeF |
DNase |
His-Me_finger (CL0263) |
Endonuclea_NS_2 (PF13930) |
Bacillus subtilis
|
Holberger et al., 2012Holberger LE, Garza-Sánchez F, Lamoureux J, Low DA and Hayes CS (2012) A novel family of toxin/antitoxin proteins in Bacillus species. FEBS Lett 586:132-136.; Kaundal et al., 2020Kaundal S, Deep A, Kaur G and Thakur KG (2020) Molecular and biochemical characterization of YeeF/YezG, a polymorphic toxin-immunity protein pair from Bacillus subtilis. Front Microbiol 11:95.
|
PT7 |
DNase |
- |
- |
Bacillus cereus BAG3X2-1
|
Nachmias et al., 2022Nachmias N, Dotan N, Fraenkel R, Rocha MC, Kluzek M, Shalom M, Rivitz A, Shamash-Halevy N, Cahana I and Deouell N et al. (2022) Systematic discovery of antibacterial and antifungal bacterial toxins. bioRxiv:2021.2010.2019.465003.
|
YobL |
rRNase |
His-Me_finger (CL0263) |
LHH (PF14411) |
Bacillus subtilis
|
Holberger et al., 2012Holberger LE, Garza-Sánchez F, Lamoureux J, Low DA and Hayes CS (2012) A novel family of toxin/antitoxin proteins in Bacillus species. FEBS Lett 586:132-136.
|
YxiD |
rRNase |
His-Me_finger (CL0263) |
- |
Bacillus subtilis
|
Holberger et al., 2012Holberger LE, Garza-Sánchez F, Lamoureux J, Low DA and Hayes CS (2012) A novel family of toxin/antitoxin proteins in Bacillus species. FEBS Lett 586:132-136.
|
YqcG |
RNase |
His-Me_finger (CL0263) |
GH-E (PF14410) |
Bacillus subtilis
|
Holberger et al., 2012Holberger LE, Garza-Sánchez F, Lamoureux J, Low DA and Hayes CS (2012) A novel family of toxin/antitoxin proteins in Bacillus species. FEBS Lett 586:132-136.
|
BC_0920 |
RNase |
EndoU (CL0695) |
EndoU_bacteria (PF14436) |
Bacillus cereus
|
Holberger et al., 2012Holberger LE, Garza-Sánchez F, Lamoureux J, Low DA and Hayes CS (2012) A novel family of toxin/antitoxin proteins in Bacillus species. FEBS Lett 586:132-136.
|
OME
|
SitA1 |
DNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Myxococcus xanthus
|
Vassallo et al., 2017Vassallo CN, Cao P, Conklin A, Finkelstein H, Hayes CS and Wall D (2017) Infectious polymorphic toxins delivered by outer membrane exchange discriminate kin in myxobacteria. Elife 6:e29397.
|
SitA2 |
DNase |
His-Me_finger (CL0263) |
Colicin DNase (PF12639) |
Myxococcus xanthus
|
Vassallo et al., 2017Vassallo CN, Cao P, Conklin A, Finkelstein H, Hayes CS and Wall D (2017) Infectious polymorphic toxins delivered by outer membrane exchange discriminate kin in myxobacteria. Elife 6:e29397.
|
SitA3 |
tRNase |
PD-(D/E)XK (CL0236) |
CdiA_C (PF18451) |
Myxococcus xanthus
|
Vassallo et al., 2017Vassallo CN, Cao P, Conklin A, Finkelstein H, Hayes CS and Wall D (2017) Infectious polymorphic toxins delivered by outer membrane exchange discriminate kin in myxobacteria. Elife 6:e29397.
|
Nanotube
|
WapA-CT168
|
tRNase |
unknown |
- |
Bacillus subtilis
|
Koskiniemi et al., 2013Koskiniemi S, Lamoureux JG, Nikolakakis KC, de Roodenbeke CtK, Kaplan MD, Low DA and Hayes CS (2013) Rhs proteins from diverse bacteria mediate intercellular competition. Proc Natl Acad Sci U S A 110:7032-7037.
|
WapA-CTnatto
|
tRNase |
unknown |
- |
Bacillus subtilis
|
Koskiniemi et al., 2013Koskiniemi S, Lamoureux JG, Nikolakakis KC, de Roodenbeke CtK, Kaplan MD, Low DA and Hayes CS (2013) Rhs proteins from diverse bacteria mediate intercellular competition. Proc Natl Acad Sci U S A 110:7032-7037.
|
WapA-CTT-UB-10
|
tRNase |
unknown |
- |
Bacillus subtilis
|
Koskiniemi et al., 2013Koskiniemi S, Lamoureux JG, Nikolakakis KC, de Roodenbeke CtK, Kaplan MD, Low DA and Hayes CS (2013) Rhs proteins from diverse bacteria mediate intercellular competition. Proc Natl Acad Sci U S A 110:7032-7037.
|
WapA-CT PY79
|
tRNase |
unknown |
- |
Bacillus subtilis
|
Stempler et al., 2017Stempler O, Baidya AK, Bhattacharya S, Malli Mohan GB, Tzipilevich E, Sinai L, Mamou G and Ben-Yehuda S (2017) Interspecies nutrient extraction and toxin delivery between bacteria. Nat Commun 8:315.
|
OMV
|
MafBMGI-1NEM8013
|
RNase |
EndoU (CL0695) |
EndoU_bacteria (PF14436) |
Neisseria meningitidis
|
Jamet et al., 2015Jamet A, Jousset AB, Euphrasie D, Mukorako P, Boucharlat A, Ducousso A, Charbit A and Nassif X (2015) A new family of secreted toxins in pathogenic Neisseria species. PLoS Pathogens 11:e1004592.
|
Antibiotic
|
Bleomycin, Phleomycin, Tallysomycin, Zorbamycin |
DNase |
Glycopeptides |
Bleomycins |
Streptomyces verticillus
|
Umezawa et al., 1966Umezawa H, Maeda K, Takeuchi T and Okami Y (1966) New antibiotics, bleomycin A and B. J Antibiot (Tokyo) 19:200-209.; Takeshita et al., 1978Takeshita M, Grollman AP, Ohtsubo E and Ohtsubo H (1978) Interaction of bleomycin with DNA. Proc Natl Acad Sci U S A 75:5983-5987.; Kross et al., 1982Kross J, Henner WD, Hecht SM and Haseltine WA (1982) Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin, and tallysomycin. Biochemistry 21:4310-4318.; Hecht, 2000Hecht SM (2000) Bleomycin: new perspectives on the mechanism of action. J Nat Prod 63:158-168.
|
Calicheamicin |
DNase |
- |
Enediynes |
Micromonospora echinospora ssp. calichensis
|
Zein et al., 1988Zein N, Sinha AM, McGahren WJ and Ellestad GA (1988) Calicheamicin γ1I: an antitumor antibiotic that cleaves double-stranded DNA site specifically. Science 240:1198-1201.
|
Daunorubicin |
DNase |
- |
Anthracyclines |
Streptomyces peucetius
|
Marco et al., 1975Marco AD, Arcamone F and Zunino F (1975) Daunomycin (daunorubicin) and adriamycin and structural analogues: biological activity and mechanism of action. In: Corcoran JW, Hahn FE, Snell JF and Arora KL (eds) Mechanism of action of antimicrobial and antitumor agents. Springer, Berlin, pp 101-128.
|
Kibdelomycin |
DNA gyrase |
- |
- |
Kibdelosporangium sp. (MA7385)
|
Philips et al., 2011Phillips JW, Goetz MA, Smith SK, Zink DL, Polishook J, Onishi R, Salowe S, Wiltsie J, Allocco J and Sigmund J (2011) Discovery of kibdelomycin, a potent new class of bacterial type II topoisomerase inhibitor by chemical-genetic profiling in Staphylococcus aureus. Chem Biol 18:955-965.
|
Amycolamicin |
DNA gyrase |
- |
- |
Amycolatopsis sp. (MK575-fF)
|
Sawa et al., 2012Sawa R, Takahashi Y, Hashizume H, Sasaki K, Ishizaki Y, Umekita M, Hatano M, Abe H, Watanabe T and Kinoshita N (2012) Amycolamicin: a novel broad‐spectrum antibiotic inhibiting bacterial topoisomerase. Chemistry 18: 15772-15781.
|
Coumarin |
DNA gyrase |
- |
- |
Streptomyces spp.
|
Maxwell and Lawson, 2003Maxwell A and Lawson DM (2003) The ATP-binding site of type II topoisomerases as a target for antibacterial drugs. Curr Top Med Chem 3:283-303.; Oblak et al., 2007Oblak M, Kotnik M and Solmajer T (2007) Discovery and development of ATPase inhibitors of DNA gyrase as antibacterial agents. Curr Med Chem 14:2033-2047.
|
Cyclothialidine |
DNA gyrase |
- |
- |
Streptomyces filipinensis NR0484
|
Goetschi et al., 1993Goetschi E, Angehrn P, Gmuender H, Hebeisen P, Link H, Masciadri R and Nielsen J (1993) Cyclothialidine and its congeners: a new class of DNA gyrase inhibitors. Pharmacol Ther 60:367-380.; Oblak et al., 2007Oblak M, Kotnik M and Solmajer T (2007) Discovery and development of ATPase inhibitors of DNA gyrase as antibacterial agents. Curr Med Chem 14:2033-2047.
|
Rifamycin |
RNA polymerase |
Macrolides |
Ansamycin |
Amycolatopsis rifamycinica
|
Sensi et al., 1959Sensi P (1959) Rifamycin, a new antibiotic, preliminary report. Farmaco Ed Sci 14:146-147.; Campbell et al., 2001Dé E, Baslé A, Jaquinod M, Saint N, Malléa M, Molle G and Pagès JM (2001) A new mechanism of antibiotic resistance in Enterobacteriaceae induced by a structural modification of the major porin. Mol Microbiol 41:189-198.; Floss and Yu, 2005Floss HG and Yu T-W (2005) Rifamycin mode of action, resistance, and biosynthesis. Chem Rev 105:621-632.
|
Fidaxomicin |
RNA polymerase |
Macrolides |
Lipiarmycin |
Dactylosporangium aurantiacum subsp. hamdenensis
|
Theriault et al, 1987Theriault RJ, Karwowski JP, Jackson M, Girolami RL, Sunga GN, Vojtko CM and Coen LJ (1987) Tiacumicins, a novel complex of 18-membered macrolide antibiotics I. Taxonomy, fermentation and antibacterial activity. J Antibiot (Tokyo) 40:567-574.; Artsimovitch et al., 2012Artsimovitch I, Seddon J and Sears P (2012) Fidaxomicin is an inhibitor of the initiation of bacterial RNA synthesis. Clin Infect Dis 55:S127-S131.
|
Gentamicin, Streptomycin, Hygromycin, Neomycin, Paromomycin, Kanamycin, Spectinomycin, Kasugamycin, Spectinomycin |
16S rRNA |
Aminoglycoside |
- |
Actinomycetes
|
Schatz et al., 1944Schatz A, Bugle E and Waksman SA (1944) Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria. Clin Orthop Relat Res 437:3-6.; Waksman and Lechevalier, 1949Waksman SA and Lechevalier HA (1949) Neomycin, a new antibiotic active against streptomycin-resistant bacteria, including tuberculosis organisms. Science 109:305-307.; Umezawa et al., 1957Umezawa H, Ueda M, Maeda K, Yagishita K, Kondō S, Okami Y, Utahara R, Ōsato Y, Nitta K and Takeuchi T (1957) Production and isolation of a new antibiotic, kanamycin. J Antibiot (Tokyo) 10:181-188.; Mann and Bromer, 1958Mann RL and Bromer W (1958) The isolation of a second antibiotic from Streptomyces hygroscopicus. J Am Chem Soc 80:2714-2716.; Mason et al., 1961Mason D, Dietz A and Smith R (1961) Actino-spectacin, a new antibiotic. I. Discovery and biological properties. Antibiot Chemother (Northfield) 11:118-122.; Weinstein et al., 1963Weinstein M, Luedemann G, Oden E, Wagman G, Rosselet J, Marquez J, Coniglio C and Herzog H (1963) Gentamicin, a new antibiotic complex from Micromonospora. J Med Chem 6:463-464.; Wilson, 2009Wilson DN (2009) The A-Z of bacterial translation inhibitors. Crit Rev Biochem Mol Biol 44:393-433.
|
Tetracycline |
16S rRNA |
Tetracyclines |
- |
Streptomyces aureofaciens
|
Putnam et al., 1953Putnam L, Hendricks F and Welch H (1953) Tetracycline, a new antibiotic. Antibiot Chemother 3:1183-1186.; Brodersen et al., 2000Brodersen DE, Clemons WMJr, Carter AP, Morgan-Warren RJ, Wimberly BT and Ramakrishnan V (2000) The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell 103:1143-1154.; Pioletti et al., 2001Pioletti M, Schlünzen F, Harms J, Zarivach R, Glühmann M, Avila H, Bashan A, Bartels H, Auerbach T and Jacobi C (2001) Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3. EMBO J 20:1829-1839.
|
Pactamycin |
16S rRNA |
- |
Aminocyclopentitol |
Streptomyces pactum
|
Bhuyan, 1962Bhuyan B (1962) Pactamycin production by Streptomyces pactum. Appl Microbiol 10:302-304.; Brodersen et al., 2000Brodersen DE, Clemons WMJr, Carter AP, Morgan-Warren RJ, Wimberly BT and Ramakrishnan V (2000) The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell 103:1143-1154.
|
Edeine |
16S rRNA |
- |
Edeine |
Brevibacillus brevis
|
Kurylo-Borowska, 1959Kurylo-borowska Z (1959) Isolation and properties of pure edeine, an antibiotic of the strain. Bacillus brevis Vm4 Bull Inst Marine Med Gdansk 10:151-163.; Pioletti et al., 2001Pioletti M, Schlünzen F, Harms J, Zarivach R, Glühmann M, Avila H, Bashan A, Bartels H, Auerbach T and Jacobi C (2001) Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3. EMBO J 20:1829-1839.
|
Erythromycin |
23S rRNA |
Macrolides |
- |
Actinomycetes
|
Schlünzen et al., 2001Schlünzen F, Zarivach R, Harms J, Bashan A, Tocilj A, Albrecht R, Yonath A and Franceschi F (2001) Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature 413:814-821.; Reviewed by Vázquez-Laslop and Mankin, 2018Vázquez-Laslop N and Mankin AS (2018) How macrolide antibiotics work. Trends in biochemical sciences 43:668-684.; |
Lincomycin |
23S rRNA |
- |
Lincosamides |
Streptomyces lincolnensis
|
Mason et al., 1962Mason D, Dietz A and DeBoer C (1962) Lincomycin, a new antibiotic. I. Discovery and biological properties. Antimicrob Agents Ch 1962:554-559.
|
Blasticidin S |
23S rRNA |
- |
Aminoacyl nucleoside |
Streptomyces griseochromogenes
|
Takeuchi et al., 1958Takeuchi S, Hirayama K, Ueda K, Sakai H and Yonehara H (1958) Blasticidin S, a new antibiotic. J Antibiot (Tokyo) 11:1-5.; Hansen et al., 2003Hansen JL, Moore PB and Steitz TA (2003) Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit. J Mol Biol 330:1061-1075.
|
Viomycin/Capreomycin |
16S rRNA 23S rRNA |
Cyclic peptides |
Tuberactinomycins |
Streptomyces puniceus
|
Finlay et al., 1951Finlay A, Hobby G, Hochstein F, Lees T, Lenert T, Means J, P’an S, Regna P, Routien J and Sobin B (1951) Viomycin, a new antibiotic active against mycobacteria. Am Rev Tuberc 63:1-3.; Herr and Redstone, 1966Herr EBJr and Redstone MO (1966) Chemical and physical characterization of capreomycin. Ann N Y Acad Sci 135:940-946.; Johansen et al, 2006Johansen SK, Maus CE, Plikaytis BB and Douthwaite S (2006) Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2′-O-methylations in 16S and 23S rRNAs. Mol Cell 23:173-182.
|