Medications
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Thalidomide |
Case series |
Description of three cases of TE occurred in Brazil after 2005. |
Schuler-Faccini et al., 2007Schuler-Faccini L, Soares RCF, Sousa ACM, Maximino C, Luna E, Schwartz IVD, Waldman C and Castilla EE (2007) New cases of thalidomide embryopathy in Brazil. Birth Defects Res A Clin Mol Teratol 79:671–672.
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Pharmacovigilance |
Hospital-based epidemiological surveillance. |
Vianna et al., 2011Vianna FSL, Lopez-Camelo JS, Leite JCL, Sanseverino MTV, Dutra MDG, Castilla EE and Schüler-Faccini L (2011) Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil. PLoS One: 6:e21735.
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Case series |
Description of two cases of TE in regions with a high prevalence of leprosy and the development of a checklist for recognition of TE phenotypes. |
Vianna et al., 2013Vianna FSL, Schuler-Faccini L, Leite JCL, Sousa SHC, Costa LMM, Dias MF, Morelo EF, Doriqui MJR, Maximino CM and Sanseverino MTV (2013) Recognition of the phenotype of thalidomide embryopathy in countries endemic for leprosy. Clin Dysmorphol 22:59-63.
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Case series |
Follow-up of TE cases born between 1959 and 2010. |
Kowalski et al., 2015Kowalski TW, Sanseverino MTV, Schüler-Faccini L and Vianna FSL (2015) Thalidomide embryopathy: Follow-up of cases born between 1959 and 2010. Birth Defects Res A Clin Mol Teratol 104:794-803.
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Pharmacovigilance |
Hospital-based epidemiological surveillance. |
Vianna et al., 2015Vianna FSL, Oliveira MZ, Sanseverino MTV, Morelo EF, Rabello Neto DL, Lopez-Camelo J, Camey AS and Schuler-Faccini L (2015) Pharmacoepidemiology and thalidomide embryopathy surveillance in Brazil. Reprod Toxicol 53:63-67.
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Molecular |
Analyses of genetic variants related to TE. |
Vianna et al., 2013Vianna FSL, Schuler-Faccini L, Leite JCL, Sousa SHC, Costa LMM, Dias MF, Morelo EF, Doriqui MJR, Maximino CM and Sanseverino MTV (2013) Recognition of the phenotype of thalidomide embryopathy in countries endemic for leprosy. Clin Dysmorphol 22:59-63.; Vianna et al., 2016; Kowalski et al., 2015Kowalski TW, Sanseverino MTV, Schüler-Faccini L and Vianna FSL (2015) Thalidomide embryopathy: Follow-up of cases born between 1959 and 2010. Birth Defects Res A Clin Mol Teratol 104:794-803.; Kowalski et al., 2017Kowalski TW, Fraga LR, Tovo-Rodrigues L, Sanseverino MT, Hutz MH, Schuler-Faccini L and Vianna FS (2017) Angiogenesis-related genes and thalidomide teratogenesis in humans: an approach on genetic variation and review of past in vitro studies. Reprod Toxicol 70:133-140.; |
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Review |
History of thalidomide use in Brazil and the occurrence of new cases of TE. |
Vianna et al., 2017Vianna FSL, Kowalski TW, Fraga LR, Sanseverino MT and Schuler-Faccini L (2017) The impact of thalidomide use in birth defects in Brazil. Eur J Med Genet 60:12-15.
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Misoprostol |
Case-control |
Misoprostol associated to the occurrence of Moebius sequence in newborns exposed to the medication during pregnancy. |
Pastuszak et al., 1998Pastuszak LA, Schuler-Faccini L, Speck-Martins CE, Coelho S, Cordello D, Schwartz IVD, Larrandaburu M and Koren G (1998) Use of misoprostol during pregnancy and Möbius’ syndrome in infants. N Engl J Med 338:1881-1885.
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Case-control |
Misoprostol associated to the occurrence of defects of vascular disruption in newborns. |
Vargas et al., 2000Vargas FR, Schuler-Faccini L, Brunoni D, Kim C, Meloni VF, Sugayama SM, Albano L, Llerena Jr JC, Almeida JC, Duarte A et al. (2000) Prenatal exposure to misoprostol and vascular disruption defects: A case-control study. Am J Med Genet 95:302–306.
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Venlafaxine |
Prospective multicentre cohort |
No evidences of increased risk for major malformations. |
Einarson et al., 2001Einarson A, Fatoye B, Sarkar M, Lavigne SV, Borchu J, Chambers CD, Mastroiacovo P, Addis A, Matsui D, Schüler-Faccini L et al. (2001) Pregnancy outcome following gestational exposure to venlafaxine: A multicentre prospective controlled study. Am J of Psych 158:1728-1730.
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Loratadine |
Prospective multicentre cohort |
No association for increased risk for major malformations. |
Moretti et al., 2003Moretti M, Caprara D, Coutinho C, Baroz B, Berkovitch M, Addis A, Jovanovski E, Schuler-Faccini L and Koren G (2003) Fetal safety of loratadine use in the first trimester of pregnancy: A multicenter study. J Allerg Clin Immunol 111:479-483.
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Infections and Vaccines
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Rubella Vaccine |
Prospective cohort |
Vaccine safety during pregnancy, presenting no risk for congenital anomalies. |
Minussi et al., 2008Minussi L, Mohrdieck R, Bercini M, Ranieri T, Sanseverino MTV, Momino W, Callegari-Jacques SM and Schuler-Faccini L (2008) Prospective evaluation of women vaccinated against rubella in southern Brazil. Reprod Toxicol 25:120-123.
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H1N1 virus and oseltamivir |
Prospective cohort |
No increased risk for major anomalies in exposures to H1N1 or oseltamivir. |
Silva et al., 2014Silva AA, Ranieri TMS, Torres FD, Vianna FSL, Paniz GR, Sanseverino PB, Picon PD, Azevedo PB, Costa MH, Schüler-Faccini L and Sanseverino MTV (2014) Impact on pregnancies in South Brazil from the influenza A (H1N1) pandemic: Cohort Study. PLoS One 9:e88624.
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Zika Virus |
Case series |
Suggestion of a possible association between maternal infection by Zika virus and congenital microcephaly. |
Schuler-Faccini et al., 2016aSchuler-Faccini L, Ribeiro EM, Feitosa IML, Horovitz DDG, Cavalcanti DP, Pessoa A, Doriqui MJR, Neri JI, Pina Neto JM, Wanderley HYC et al. (2016a) Possible association between Zika virus infection and microcephaly — Brazil, 2015. Morb Mortal Wkly Rep 65:59–62.
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Critical Review |
Discussion and confirmation of Zika virus as a new human teratogen. |
Schuler-Faccini et al., 2016bSchuler-Faccini L, Sanseverino M, Vianna F, Silva AA, Larrandaburu M, Marcolongo-Pereira C and Abeche AM (2016b) Zika virus: A new human teratogen? Implications for women of reproductive age. Clin Pharmacol Ther 100:28-30.
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Case series |
Description of 1501 newborns with congenital microcephaly in Brazil. |
França et al., 2016França GV, Schuler-Faccini L, Oliveira WK, Henriques CMP, Carmo EH, Pedi VD, Nunes ML, Castro MC, Serruya S, Silveira MF et al. (2016) Congenital Zika virus syndrome in Brazil?: A case series of the first 1501 livebirths with complete investigation. Lancet 388:891–897.
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Critical Review |
Contribution in the definition of criteria for notification of microcephaly in Brail. |
Victora et al., 2016Victora CG, Schuler-Faccini L, Matijasevich A, Ribeiro E, Pessoa A and Barros FC (2016) Microcephaly in Brazil: How to interpret reported numbers? Lancet 13:621-624.
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Case series |
Description of the phenotype of Zika virus embryopathy. |
Del Campo et al., 2017Del Campo M, Feitosa IM, Ribeiro EM, Horovitz DD, Pessoa AL, França GV, García-Alix A, Doriqui MJ, Wanderley HY, Sanseverino MV et al. (2017) Zika Embryopathy Task Force-Brazilian Society of Medical Genetics ZETF-SBGM. The phenotypic spectrum of congenital Zika syndrome. Am J Med Genet A 173:841-857.
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Environmental
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Hospital-based |
No association for increased risk for major malformations. |
Leite et al., 2001Leite JCL and Schüler-Faccini L (2001) Defeitos congênitos em uma região de mineração de carvão. Rev Saúde Publ 35:136-141.
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Hospital-based |
No association for increased risk for major malformations and other adverse outcomes. |
Oliveira et al., 2002Oliveira LM, Stein N, Sanseverino MTV, Vargas VMF, Fachel JMG and Schüler L (2002) Reproductive outcomes in an area adjacent to a petrochemical plant in southern Brazil. Rev Saúde Publ 36:81-87.
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Teratogens in general
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Case-control |
Association between maternal alcohol use during pregnancy and criminal behavior |
Momino et al., 2012Momino W, Félix TM, Abeche AM, Zandoná DI, Scheibler GG, Chambers C, Jones KL, Flores RZ and Schuler-Faccini L (2012) Maternal drinking behavior and Fetal Alcohol Spectrum disorders in adolescents with criminal behavior in southern Brazil. Genet Mol Biol 35:960–965.
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Review |
Evaluation of teratogens in the Brazilian population. |
Schüler-Faccini et al., 2002Schüler-Faccini L, Leite JCL, Sanseverino MTV and Peres RM (2002) Avaliação de teratógenos potenciais na população brasileira. Ciênc Saúde Coletiva 7:65-71.; Momino et al., 2003Momino W, Minussi L, Woffchuck D, Palmero EI, Sanseverino MT, Guimarães Fachel JM and Schüler-Faccini L (2003) Reproductive risk factors related to socioeconomic status in pregnant women in southern Brazil. Community Genet 6:77-83.; Garcias and Schuler-Faccini, 2004Garcias GDL and Schüler-Faccini L (2004) The beliefs of mothers in southern Brazil regarding risk-factors associated with congenital abnormalities. Genet Mol Biol 27:147–153.
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Review and evaluation of congenital anomalies in Brazil |
Integrative approach of the principles of teratogenesis, teratogenic mechanisms, and other aspects. |
Mazzu-Nascimento et al., 2017Mazzu-Nascimento T, Melo DG, Morbioli GG, Carrilho E, Vianna FSL, Silva AAD and Schuler-Faccini L (2017) Teratogens: A public health issue - a Brazilian overview. Genet Mol Biol. 40:387-397.
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