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Genetics of Microorganisms • Genet. Mol. Biol. 21 (1) • Mar 1998 • https://doi.org/10.1590/S1415-47571998000100004 linkcopy

Open-access OppA Escherichia coli mutants have osmodependent resistance to aminoglycoside antibiotics

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    The oligopeptide permease (OppA) protein was found to be missing in the periplasmic fractions of Escherichia coli kanamycin-resistant mutants selected under high osmotic conditions. The growth behavior of one mutant in media containing kanamycin or the toxic peptide triornithine suggests that OppA and another cell envelope component contribute to the osmolarity-dependent aminoglycoside resistance of E. Coli.

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