rs2781659 (A>G) rs2781667 (C>T) rs2246012 (T>A) rs17599586 (C>T) |
Brazilian |
Erectile dysfunction |
Sildenafil |
No significant associations |
(Lacchini et al., 2018Lacchini R, Muniz JJ, Nobre YTDA, Cologna AJ, Martins ACP and Tanus-Santos JE (2018) Influence of arginase polymorphisms and arginase levels/activity on the response to erectile dysfunction therapy with sildenafil. Pharmacogenomics J 18:238-244.) |
rs2781659 (A>G) rs2781667 (C>T) rs2246012 (T>A) rs17599586 (C>T) |
Brazilian |
Colonoscopy |
Propofol |
Ni affect on the propofol-induced changes in blood pressure and heart rate |
(Oliveira-Paula et al., 2021Oliveira-Paula GH, Coeli-Lacchini FB, Ferezin LP, Ferreira GC, Pinheiro LC, Paula-Garcia WN, Garcia LV, Tanus-Santos JE and Lacchini R (2021) Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability. Eur J Clin Pharmacol 77:869-877.) |
rs2781659 (A>G) rs2781663 (T>A) rs2781665 (A>T) rs2749935 (A>C) |
Non-Hispanic white Non-Hispanic black Hispanics Other |
Asthma |
Bronchodilator (BD) β 2 agonist Glucocorticoid |
rs22781659 significantly associated with BD response |
(Litonjua et al., 2008Litonjua AA, Lasky-Su J, Schneiter K, Tantisira KG, Lazarus R, Klanderman B, Lima JJ, Irvin CG, Peters SP, Hanrahan JP et al. (2008) ARG1 is a novel bronchodilator response gene: Screening and replication in four asthma cohorts. Am J Respir Crit Care Med 178:688-694.) |
rs2781667 (C>T) rs2781668 (C>T) rs17599586 (C>T) |
Europeans |
|
|
T-allele of rs2781667 associated with a significantly decreased response to β 2 agonist |
(Vonk et al., 2010Vonk JM, Postma DS, Maarsingh H, Bruinenberg M, Koppelman GH and Meurs H (2010) Arginase 1 and arginase 2 variations associate with asthma asthma severity and beta2 agonist and steroid response. Pharmacogenet Genomics 20:179-186.) |
rs2781659 (A>G) rs2781663 (T>A) rs2781665 (A>T) rs60389358 (C>T) |
Non-Hispanic whites African Americans Hispanics |
|
|
Haplotype ATAC carriers were more likely to have higher response BD |
(Duan et al., 2011Duan QL, Gaume BR, Hawkins GA, Himes BE, Bleecker ER, Klanderman B, Irvin CG, Peters SP, Meyers DA, Hanrahan JP et al. (2011) Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. Am J Respir Crit Care Med 183:449-454.) |
rs2781659 (A>G) |
Caucasian |
|
|
No significant association |
(Scaparrotta et al., 2019Scaparrotta A, Franzago M, Marcovecchio ML, Di Pillo S, Chiarelli F, Mohn A and Stuppia L (2019) Role of THRB, ARG1, and ADRB2 genetic variants on bronchodilators response in asthmatic children. J Aerosol Med Pulm Drug Deliv 32:164-173.) |
rs2781667(C>T) |
Russians Tatars Bashkirs |
|
|
No significant associations |
(Savelieva et al., 2020Savelieva ON, Karunas AS, Fedorova YY, Murzina RR, Savelieva AN, Gatiyatullin RF, Etkina EI and Khusnutdinova EK (2020) The role of polymorphic variants of arginase genes (ARG1 ARG2) involved in beta-2-agonist metabolism in the development and course of asthma. Vavilovskii Zhurnal Genet Selektsii 24:391-398.) |