Mouse embryos |
MNNG, menadione |
Protective (knockout increased cell death) |
- |
- |
Koh et al., 2004Koh DW, Lawler AM, Poitras MF, Sasaki M, Wattler S, Nehls MC, Stöger T, Poirier GG, Dawson VL and Dawson TM (2004) Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality. Proc Natl Acad Sci U S A 101:17699-17704.
|
MEFs |
H2O2
|
Protective (knockdown increased cell death |
- |
- |
Blenn et al., 2006Blenn C, Althaus FR and Malanga M (2006) Poly(ADP-ribose) glycohydrolase silencing protects against H2O2-induced cell death. Biochem J 396:419-429.
|
Cortical neurons |
NMDA |
Protective (overexpression reduced cell death |
- |
- |
Andrabi et al., 2006Andrabi SA, Kim NS, Yu SW, Wang H, Koh DW, Sasaki M, Klaus JA, Otsuka T, Zhang Z, Koehler RC et al. (2006) Poly(ADP-ribose) (PAR) polymer is a death signal. Proc Natl Acad Sci U S A 103:18308-18313.
|
Mice |
middle cerebral artery occlusion (MCAO) |
Protective (heterozygous KO increased tissue damage; overexpression reduced tissue damage) |
- |
- |
Andrabi et al., 2006Andrabi SA, Kim NS, Yu SW, Wang H, Koh DW, Sasaki M, Klaus JA, Otsuka T, Zhang Z, Koehler RC et al. (2006) Poly(ADP-ribose) (PAR) polymer is a death signal. Proc Natl Acad Sci U S A 103:18308-18313.
|
Cortical neurons |
MNNG |
Protective (overexpression prevented glycolytic defect) |
- |
- |
Andrabi et al., 2014Andrabi SA, Umanah GK, Chang C, Stevens DA, Karuppagounder SS, Gagné JP, Poirier GG, Dawson VL and Dawson TM (2014 ) Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis. Proc Natl Acad Sci U S A 111:10209-10214.
|
MEFs |
MNNG |
No effect |
- |
- |
Blenn et al., 2006Blenn C, Althaus FR and Malanga M (2006) Poly(ADP-ribose) glycohydrolase silencing protects against H2O2-induced cell death. Biochem J 396:419-429.
|
HK-2 cells |
TGHQ |
No effect |
- |
- |
Munoz et al., 2017Munoz FM, Zhang F, Islas-Robles A, Lau SS and Monks TJ (2017) ROS-induced store-operated Ca2+ entry coupled to PARP-1 hyperactivation is independent of PARG activity in necrotic cell death. Toxicol Sci 158:444-453.
|
Mice and rats |
splanchnic artery occlusion (SAO) shock |
Detrimental (knockout and inhibition protected tissues) |
- |
- |
Cuzzocrea et al., 2005Cuzzocrea S, Di Paola R, Mazzon E, Cortes U, Genovese T, Muià C, Li W, Xu W, Li JH, Zhang J et al. (2005) PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion. FASEB J 19:558-566.
|
Glioblastoma cells |
MNNG |
Detrimental (knockdown prevented ATP depletion and glycolytic defect) |
- |
- |
Fouquerel et al., 2014Fouquerel E, Goellner Eva M, Yu Z, Gagné J-P, Barbi de Moura M, Feinstein T, Wheeler D, Redpath P, Li J, Romero G et al. (2014) ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ Depletion. Cell Rep 8:1819-1831.
|
Glioblastoma cells |
MMS |
Protective (knockdown increased cell death) |
No |
- |
Tang et al., 2010Tang JB, Goellner EM, Wang XH, Trivedi RN, St Croix CM, Jelezcova E, Svilar D, Brown AR and Sobol RW (2010) Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage. Mol Cancer Res 8:67-79.
|
Pancreatic cancer cells |
ZZW-115 (NUPR1 inhibitor) |
Protective (inhibition increased cell death) |
No |
- |
Santofimia-Castaño et al., 2022Santofimia-Castaño P, Huang C, Liu X, Xia Y, Audebert S, Camoin L, Peng L, Lomberk G, Urrutia R, Soubeyran P et al. (2022) NUPR1 protects against hyperPARylation-dependent cell death. Commun Biol 5:732.
|
Trophoblast stem cells |
UV |
Protective (knockout increased cell death) |
Yes |
- |
Zhou et al., 2011Zhou Y, Feng X and Koh DW (2011) Activation of cell death mediated by apoptosis-inducing factor due to the absence of poly(ADP-ribose) glycohydrolase. Biochemistry 50:2850-2859.
|
MEFs |
H2O2
|
Detrimental (knockdown reduced cell death) |
Yes |
- |
Mashimo et al., 2013Mashimo M, Kato J and Moss J (2013) ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose) degradation and cell death during oxidative stress. Proc Natl Acad Sci U S A 110:18964-18969.
|
Rat fibroblasts |
MNNG |
- |
Yes |
- |
Yu et al., 2002Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM and Dawson VL (2002) Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 297:259-263.
|
Neurons |
NMDA |
- |
Yes |
- |
Yu et al., 2006Yu S-W, Andrabi SA, Wang H, Kim NS, Poirier GG, Dawson TM and Dawson VL (2006) Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci U S A 103:18314-18319.
|
MEFs |
H2O2
|
- |
Yes |
- |
Kolthur-Seetharam et al., 2006Kolthur-Seetharam U, Dantzer F, McBurney MW, de Murcia G and Sassone-Corsi P (2006) Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage. Cell Cycle 5:873-877.
|
MEFs |
MNNG |
- |
Yes |
- |
Wang et al., 2009Wang Y, Kim NS, Li X, Greer PA, Koehler RC, Dawson VL and Dawson TM (2009) Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos). J Neurochem 110:687-696.
|
Cortical neurons |
NMDA |
- |
Yes |
- |
Wang et al., 2011Wang Y, Kim NS, Haince JF, Kang HC, David KK, Andrabi SA, Poirier GG, Dawson VL and Dawson TM (2011) Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos), Sci Signal 4:ra20.
|
Glioma cells |
DPT |
- |
Yes |
- |
Ma et al., 2016Ma D, Lu B, Feng C, Wang C, Wang Y, Luo T, Feng J, Jia H, Chi G, Luo Y et al. (2016) Deoxypodophyllotoxin triggers parthanatos in glioma cells via induction of excessive ROS. Cancer Lett 371:194-204.
|
SH-SY5Y cells |
MNNG |
- |
Yes |
- |
Zhong et al., 2018Zhong H, Song R, Pang Q, Liu Y, Zhuang J, Chen Y, Hu J, Hu J, Liu Y, Liu Z et al. (2018) Propofol inhibits parthanatos via ROS-ER-calcium-mitochondria signal pathway in vivo and vitro. Cell Death Dis 9:932.
|
HK-2 cells |
TGHQ |
- |
No |
- |
Zhang et al., 2014Zhang F, Xie R, Munoz FM, Lau SS and Monks TJ (2014) PARP-1 hyperactivation and reciprocal elevations in intracellular Ca2+ during ROS-induced nonapoptotic cell death. Toxicol Sci 140:118-134.
|
Retinal cells |
H2O2
|
- |
No |
- |
Jang et al., 2017Jang KH, Do YJ, Son D, Son E, Choi JS and Kim E (2017) AIF-independent parthanatos in the pathogenesis of dry age-related macular degeneration. Cell Death Dis 8:e2526.
|
Mouse bone-marrow derived macrophages |
H2O2
|
- |
No |
- |
Regdon et al., 2019Regdon Z, Robaszkiewicz A, Kovács K, Rygielska Ż, Hegedűs C, Bodoor K, Szabó É and Virág L (2019) LPS protects macrophages from AIF-independent parthanatos by downregulation of PARP1 expression, induction of SOD2 expression, and a metabolic shift to aerobic glycolysis. Free Radic Biol Med 131:184-196.
|
HEK293 expressing recombinant TRPM2 |
H2O2
|
- |
- |
Increased |
Fonfria et al., 2004Fonfria E, Marshall ICB, Benham CD, Boyfield I, Brown JD, Hill K, Hughes JP, Skaper SD and McNulty S (2004) TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase. Br J Pharmacol 143:186-192.
|
Rat striatal neurons |
H2O2 and amyloid β-peptide(1-42) |
- |
- |
Increased |
Fonfria et al., 2005Fonfria E, Marshall IC, Boyfield I, Skaper SD, Hughes JP, Owen DE, Zhang W, Miller BA, Benham CD and McNulty S (2005) Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures. J Neurochem 95:715-723.
|
Rat cardiomyocytes |
H2O2
|
- |
- |
Increased (apoptosis markers also present) |
Yang et al., 2006Yang KT, Chang WL, Yang PC, Chien CL, Lai MS, Su MJ and Wu ML (2006) Activation of the transient receptor potential M2 channel and poly(ADP-ribose) polymerase is involved in oxidative stress-induced cardiomyocyte death. Cell Death Differ 13:1815-1826.
|
Mice |
MCAO |
- |
- |
Increased infarct volumes (also androgen signalling-dependent) |
Shimizu et al., 2013Shimizu T, Macey TA, Quillinan N, Klawitter J, Perraud AL, Traystman RJ and Herson PS (2013) Androgen and PARP-1 regulation of TRPM2 channels after ischemic injury. J Cereb Blood Flow Metab 33:1549-1555.
|
RIN-5F (rat pancreatic β-cells) |
H2O2
|
- |
- |
Increased |
Ishii et al., 2014Ishii M, Hagiwara T, Mori Y and Shimizu S (2014) Involvement of TRPM2 and L-type Ca²⁺ channels in Ca²⁺ entry and cell death induced by hydrogen peroxide in rat β-cell line RIN-5F. J Toxicol Sci 39:199-209.
|
Mouse hippocampal neurons |
H2O2
|
- |
- |
Increased (death is also partly Zn2+ dependent) |
Li et al., 2017Li X, Yang W and Jiang LH (2017) Alteration in intracellular Zn(2+) homeostasis as a result of TRPM2 channel activation contributes to ROS-induced hippocampal cell death. Front Mol Neurosci 10:414.
|
SH-SY5Y overexpressing TRPM2 |
H2O2
|
- |
- |
Increased |
An et al., 2019An X, Fu Z, Mai C, Wang W, Wei L, Li D, Li C and Jiang LH (2019) Increasing the TRPM2 channel expression in human neuroblastoma SH-SY5Y cells augments the susceptibility to ROS-Induced Cell Death. Cells 8:28.
|