Beta Thalassemia |
Pinto et al. Italy |
57/M |
TDT |
Splenectomy Severe pulmonary arterial hypertension Chronic heart failure |
+ |
Dessaturation |
CT: bilateral ground glass |
Yes |
Yes |
Yes |
RBC |
Antibiotics Antivirals HCQ |
Recovered |
Motta et al. Italy |
49/F |
NTDT |
Obesity Hyperparathyroidism |
+ |
Fever, cough, anosmia, ageusia pain, fatigue, diarrhea, headache |
X-r: thickening |
No |
low-intensity |
No |
NA |
HCQ |
Recovered |
Motta et al. Italy |
48/F |
TDT |
Splenectomy |
+ |
Fever, cough, anosmia, ageusia pain, fatigue |
X-r: thickening |
No |
low-intensity |
No |
No |
No drugs |
Recovered |
Motta et al. Italy |
31/M |
TDT |
Cardiomyopathy, chronic hepatopathy, diabetes, Hypothyroidism, Osteoporosis, Hypogonadism |
+ |
Fever, cough, anosmia, ageusia, pain, fatigue, headache, neutropenia |
CT: thickening |
No |
No |
Yes |
RBC |
No drugs |
Recovered |
Motta et al. Italy |
42/M |
TDT |
Splenectomy, asthma, hypogonadism |
+ |
Fever, cough, pain, diarrhea |
X-r: thickening |
No |
No |
No |
No |
No drugs |
Recovered |
Motta et al. Italy |
33/F |
TDT |
Splenectomy Hypothyroidism |
+ |
Cough, pain, diarrhea |
Not done |
No |
No |
No |
No |
No drugs |
Recovered |
Motta et al. Italy |
59/F |
TDT |
Splenectomy, cardiomyopathy, renal impairment, chronic hepatopathy, diabetes, hypothyroidism, osteoporosis, hypogonadism, previous NHL |
+ |
Fever, cough, difficulty breathing |
X-r: thickening |
No |
High-intensity |
Yes |
No |
Canaquinumab HCQ |
Hospitalized |
Motta et al. Italy |
32/M |
TDT |
Splenectomy, osteoporosis, previous ALL |
+ |
Fever, cough, anosmia, ageusia, fatigue, headache |
X-r: normal |
No |
No |
No |
No |
No drugs |
Recovered |
Motta et al. Italy |
61/F |
TDT |
Splenectomy, respiratory disease, cardiomyopathy, renal impairment, chronic hepatopathy, diabetes, osteoporosis, hypogonadism, sarcoidosis |
+ |
Pain, fatigue difficult breathing |
X-r and CT: thickening |
No |
low-intensity |
No |
No |
No drugs |
Recovered |
Motta et al. Italy |
56/M |
TDT |
Splenectomy, cardiomyopathy, chronic hepatopathy, osteoporosis, hypogonadism, pulmonary arterial hypertension |
+ |
Fever, cough, pain, difficult breathing |
X-r and CT: thickening |
No |
low-intensity |
Yes |
No |
Antivirals HCQ |
Recovered |
Motta et al. Italy |
40/F |
TDT |
Splenectomy, cardiomyopathy, chronic hepatopathy, hypothyroidism, hypoparathyroidism, hypogonadism |
+ |
Fever, cough, anosmia, ageusia, pain, fatigue |
Not done |
No |
No |
No |
No |
No drugs |
Recovered |
Motta et al. Italy |
36/M |
TDT |
Hypothyroidism |
+ |
Fever, cough, anosmia, ageusia, pain, fatigue |
X-r: thickening |
No |
low-intensity |
No |
No |
No drugs |
Recovered |
Data from April 29th 2020 Karimi et al. Iran |
Mean age: 36 (22-66) 39 (30-54): suspected COVID-19 14 M/9F |
18 TDT 5 NTDT |
16 Splenectomy 17 comorbidities |
15 + |
Fever, shortness of breath, fatigue, dry cough |
CT: SARS-CoV-2 pneumonia |
NA |
NA |
NA |
NA |
Antivirals HCQ |
17 recovered 6 deaths - 26% (2 TDT; 4 NTDT) |
Sickle cell disease |
Alisson et al. USA |
27/M |
HbSC |
-- |
+ |
VOC ACS |
X-r: bilateral SARS-CoV-2 pneumonia |
Yes |
Yes |
Yes |
ET |
Analgesics Antibiotics Corticosteroids HCQ Tocilizumab |
Recovered |
Nur et al. NL |
24/M |
HbSS |
Minor pain episodes |
+ |
VOC ACS |
CT: double-sided infiltrates in the lower lobes |
No |
No |
Yes |
No |
Analgesics Antibiotics |
Recovered |
Nur et al. NL |
20/F |
HbSS |
VOC |
+ |
VOC |
CT: normal |
No |
No |
No |
No |
Analgesics |
Recovered |
Beerkens et al. USA |
21/M |
HbSβ0
|
Hydroxyurea Avascular necrosis |
+ |
Severe anemia (Hb 2 g/dL) |
X-r: ground glass |
No |
No |
Yes |
RBC ET |
Analgesics Antibiotics HCQ |
Recovered |
Hussain et al. USA |
32/M |
HbSS |
VOC ACS Extremity ulcers |
+ |
VOC |
X-r: pneumonia |
No |
Yes |
MV |
RBC ET |
Analgesics Antibiotics HCQ |
Recovered |
Hussain et al. USA |
37/F |
HbSβ+
|
VOC Venous thromboembolism |
+ |
VOC |
X-r: normal |
No |
No |
No |
No |
Analgesics |
Recovered |
Hussain et al. USA |
22/F |
HbSS |
ACS, VOC Asthma |
+ |
VOC |
Not done |
No |
No |
No |
No |
Analgesics Antibiotics |
Recovered |
Hussain et al. USA |
41/M |
HbSC |
Avascular Necrosis Pulmonary embolism |
+ |
VOC |
Not done |
No |
No |
No |
No |
Analgesics |
Recovered |
McCloskey et al. UK |
Mean age: 36 (23-57) 8M/2F |
9 HbSS or HbSβ0 1 HbSC |
1 stroke 1 nephropathy 6 VOC |
6 + |
80% VOC |
5 X-r and/or CT: infiltrates |
Yes (all) |
No |
10 |
3 RBC |
Antibiotics |
9 recovered 1 death (10%) |
De Luna et al. France |
45/M |
HbSS |
Nephropathy Retinopathy Priapism Cardiac remodeling |
+ |
VOC |
CT: Ground glass |
No |
No |
Yes |
RBC |
Antibiotics HCQ Tocilizumab |
Recovered |
Chakravorty et al. UK |
36/M |
HbSS |
ACS Chronic pain |
+ |
VOC |
NA |
Yes |
No |
No |
No |
Antibiotics |
Recovered |
Chakravorty et al. UK |
38/F |
HbSS |
Recurrent leg ulcers |
+ |
VOC |
NA |
Yes |
No |
Yes |
RBC |
Antibiotics |
Recovered |
Chakravorty et al. UK |
34/F |
HbSS |
Stroke |
+ |
VOC |
NA |
Yes |
No |
No |
No |
Antibiotics |
Recovered |
Chakravorty et al. UK |
46/F |
HbSS |
Renal disease Hemodialysis Chronic pain Asthma |
+ |
VOC |
NA |
No |
No |
No |
No |
Antibiotics |
Recovered (Not admitted) |
Chakravorty et al. UK |
37/M |
HbSS |
Stroke |
+ |
VOC |
NA |
No |
No |
No |
No |
Antibiotics |
Recovered (Not admitted) |
Chakravorty et al. UK |
52/F |
HbSS |
Hydroxyurea Chronic shoulder pain |
+ |
VOC |
NA |
No |
No |
No |
No |
Antibiotics |
Recovered (Not admitted) |
Chakravorty et al. UK |
25/M |
HbSS |
Recurrent TIA |
+ |
VOC |
NA |
No |
No |
No |
No |
Antibiotics |
Recovered (Not admitted) |
Chakravorty et al. UK |
35/F |
HbSS |
Hydroxyurea Chronic hip pain |
+ |
VOC |
NA |
No |
No |
No |
No |
Antibiotics |
Recovered (Not admitted) |
Chakravorty et al. UK |
54/F |
HbSS |
Hyperhaemolysis, asthma, Avascular necrosis |
+ |
VOC |
NA |
Yes |
Yes |
Yes |
No |
Antibiotics |
Died (10%) |
Chakravorty et al. UK |
44/F |
HbSS |
ACS Stroke |
+ |
VOC |
NA |
Yes |
No |
No |
RBC |
Antibiotics |
Recovered |
Justino et al. Brazil |
35/F |
HbSS |
28 weeks pregnant. |
+ |
Myalgia Fever Cough Dyspnea Hypoxia |
CT: Ground glass |
No |
Yes |
Yes |
RBC |
Antibiotics |
Recovered |
Sickle cell disease (already described in Table 2) |
Appiah-Kubi et al. USA |
20/F |
HbSS |
Hallucinations Hydroxyurea |
+ |
Hypoxia, Psychosis |
NA |
Yes |
No |
No |
No |
Anakinra Antibiotics HCQ |
Recovered |
Appiah-Kubi et al. USA |
20/F |
HbSS |
Asthma Hydroxyurea |
+ |
VOC |
NA |
Yes |
No |
No |
RBC |
Analgesics Antibiotics HCQ |
Recovered |