Red cells with cytoplasmic projections, resembling pincer-like cells, also known as mushroom- shaped red blood cells, as Figures 1 and 2, are usually associated with erythrocyte disorders, such as congenital dyserthropoietic anemias, hereditary spherocytosis associated with Banda-3 protein deficiency, disseminated intravascular coagulation, hemo-lytic-uremic syndrome, thrombotic thrombocytopenic purpura, kidney disease, microangiopathic hemolytic anemia, erythroleukemia and, more rarely, oxidative drug-induced hemolysis. However, a recent study have demonstrated a relationship between these cells and infection caused by Sars-CoV-2 in a pathophysiologic mechanism that possibly involves the occurrence of oxidative stress, which triggers progressive cascade of inflammation, known as citokines storm, that leads to red blood cell damage.11 Gerard D, Ben Brahim S, Lesesve JF, Perrin J. Are mushroom-shaped erythrocytes an indicator of COVID-19? Br J Haematol. 2021(2):230.. https://doi.org/10.1111/bjh.17127. 192 Epub 2021 Jan 5. PMID: 33399215.
https://doi.org/10.1111/bjh.17127...
, 22 Lesesve JF. Mushroom-shaped red blood cells in protein band-3 deficiency. Am J Hematol. 2011;86(8):694.. https://doi.org/10.1002/ajh.21962. PMID: 21761435.
https://doi.org/10.1002/ajh.21962...
, 33 McCann SR, Firth R, Murray N, Temperley IJ. Congenital dyserythropoietic anaemia type II (HEMPAS): a family study. J Clin Pathol. 1980;33(12):1197–201. https://doi.org/10.1136/jcp.33.12.1197. PMID: 7451666; PMCID: PMC1146375.
https://doi.org/10.1136/jcp.33.12.1197...
REFERENCES
-
1Gerard D, Ben Brahim S, Lesesve JF, Perrin J. Are mushroom-shaped erythrocytes an indicator of COVID-19? Br J Haematol. 2021(2):230.. https://doi.org/10.1111/bjh.17127 192 Epub 2021 Jan 5. PMID: 33399215.
» https://doi.org/10.1111/bjh.17127 -
2Lesesve JF. Mushroom-shaped red blood cells in protein band-3 deficiency. Am J Hematol. 2011;86(8):694.. https://doi.org/10.1002/ajh.21962 PMID: 21761435.
» https://doi.org/10.1002/ajh.21962 -
3McCann SR, Firth R, Murray N, Temperley IJ. Congenital dyserythropoietic anaemia type II (HEMPAS): a family study. J Clin Pathol. 1980;33(12):1197–201. https://doi.org/10.1136/jcp.33.12.1197 PMID: 7451666; PMCID: PMC1146375.
» https://doi.org/10.1136/jcp.33.12.1197
Publication Dates
-
Publication in this collection
10 Oct 2022 -
Date of issue
Jul-Sep 2022
History
-
Received
12 Feb 2021 -
Accepted
20 May 2021 -
Published
09 July 2021