El-Aziz Awad et al., Egypt [22]22 El-Aziz Awad M-D, Amin SM, Abdou SM. Assessment of diagnostic and therapeutic approaches of Helicobacter pylori-associated iron deficiency and anemia in children with dyspeptic symptoms. J Egypt Soc Parasitol. 2014;44(3):695-708.
|
Children |
H. pylori serum IgG antibodies |
Group (A): Anti H. pylori and Oral iron (n = 20) Group (B): Anti H. pylori (n = 20) Group (C): oral iron (n = 20) |
Improvement of iron parameters were significantly greater in groups of children who received anti-HP therapy either combined with iron or alone |
Nashaat et al., Egypt [25]25 Nashaat EH, Mansour GM. Helicobacter pylori and anemia with pregnancy. Arch Gynecol Obstet. 2014;289(6):1197-202.
|
Pregnant women |
H. pylori serum IgG antibodies |
All patients received oral iron (n = 100) after 1 month H. pylori positive cases (n = 50) received anti H. pylori and oral iron |
Hb in cases negative to H. pylori was higher than those positive to H. pylori. It was found that rise of Hb was higher after treatment than before eradication of H. pylori. |
Kotb et al., Egypt [26]26 Kotb NA, Bedewy MM, Soliman HH, Nagy HM, Hasby EA. The impact of H. pylori eradication on response to oral iron therapy in patients with iron deficiency anemia. Egypt J Immunol. 2012;19(1):11-8.
|
IDA adults |
Gastric biopsy for H. pylori
|
20 patients received sequential eradication therapy for followed by oral iron therapy. |
Improvement in hematological parameters and serum iron profile was observed post successful H. eradication and oral iron therapy. |
Xia et al., China [27]27 Xia W, Zhang X, Wang JJ, Sun CH, Wu LJ. Survey of anaemia and Helicobacter pylori infection in adolescent girls in Suihua, China and enhancement of iron intervention effects by H. pylori eradication. Br J Nutr. 2012;108(2):357-62.
|
Adolescent girls |
Serum H. pylori IgG antibodies and stool antigen EIA |
Group (A): oral iron and anti H. pylori (n = 32) Group (B): oral iron (n = 42) |
Treatment of H. pylori infection is associated with a more rapid response to oral Fe therapy |
Malik et al., India [28]28 Malik R, Guleria K, Kaur I, Sikka M, Radhakrishnan G. Effect of Helicobacter pylori eradication therapy in iron deficiency anaemia of pregnancy – a pilot study. Indian J Med Res. 2011;134:224-31.
|
Pregnant women |
H. pylori stool antigen |
Group (A): anti H. pylori and oral iron and folic acid (n = 19) Group (B): oral iron and folic acid (n = 19) |
Eradication therapy resulted in significantly better response to oral iron supplementation among H. pylori infected pregnant women with IDA. |
Cardenas et al., Texas [29]29 Cardenas VM, Prieto-Jimenez CA, Mulla ZD, Rivera JO, Dominguez DC, Graham DY, et al. Helicobacter pylori eradication and change in markers of iron stores among non-iron deficient children in El Paso, Texas: an etiologic intervention study. J Pediatr Gastroenterol Nutr. 2011;52(3):326-32.
|
Children (3-10) years |
Urine H. pylori IgG antibody and l3C-Iabeled urea breath tests |
Group (A): Both anti H. pylori and oral iron (n = 32). Group (B): anti H. pylori sequential (n = 29) Group (C): oral Iron (n = 23) Group (D): Placebo only (n = 26) |
They found that those who had their infection eradicated had a 3-fold increased average change from baseline serum ferritin compared with that of children who remained infected |
Sarker et al., Bangladesh [23]23 Sarker SA, Mahmud H, Davidsson L, Alam NH, Ahmed T, Alam N, et al. Causal relationship of Helicobacter pylori with iron-deficiency anemia or failure of iron supplementation in children. Gastroenterology. 2008;135(5):1534-42.
|
Children (2-5) years |
l3C-Iabeled urea breath tests |
Group (A): anti H. pylori and oral iron (n = 50). Group (B): anti H. pylori (n = 50). Group (C): oral iron (n = 49) Group (D): Placebos only (n = 51) |
H. pylori is neither a cause of IDA/ID nor a reason for treatment failure of iron supplementation in young Bangladeshi children |
Vijayan et al., India [30]30 Vijayan G, Sundaram RC, Bobby Z, Hamide A, Selvaraj N, Dasse NR. Increased plasma malondialdehyde and fructosamine in anemic H. pylori infected patients: effect of treatment. World J Gastroenterol. 2007;13(5):796-800.
|
13 years or older |
Rapid urease test and histology |
Group (A): anti H. pylori and oral iron (n = 11) Group (B): oral iron (n = 11) |
Treatment for both anemia and H. pylori infections is required for lowering the levels of lipid peroxides in those patients. |
Chen and Luo, China [31]31 Chen LH, Luo HS. Effects of H. pylori therapy on erythrocytic and iron parameters in iron deficiency anemia patients with H. pylori-positive chronic gastritis. World J Gastroenterol. 2007;13(40):5380-3.
|
IDA adults |
l3C-Iabeled urea breath tests |
Group (A): anti H. pylori and oral iron (n = 43) Group (B): Oral iron (n = 43) |
Successful H. pylori eradication resulted in a significant post-treatment an increase in the peripheral complete blood count and serum iron. |
Gessner et al., USA [32]32 Gessner BD, Baggett HC, Muth PT, Dunaway E, Gold BD, Feng Z, et al. A controlled, householdrandomized, open-label trial of the effect that treatment of Helicobacter pylori infection has on iron deficiency in children in rural Alaska. J Infect Dis. 2006;193(4):537-46.
|
Children (7-11) years |
l3C-Iabeled urea breath tests |
Group (A): anti H. pylori and oral iron (n = 79) Group (B): oral iron (n = 113) |
In a high-prevalence population, treatment and resolution of H. pylori infection did not improve isolated iron deficiency or mild anemia up to 14 months after treatment initiation. |
Choe et al., South Korea [33]33 Choe YH, Kwon YS, Jung MK, Kang SK, Hwang TS, Hong YC. Helicobacter pylori-associated iron-deficiency anemia in adolescent female athletes. J Pediatr. 2001;139(1):100-4.
|
Adolescent female athletes |
Rapid urease test and histology |
Group (A): anti H. pylori (n = 12) Group (B): oral iron (n = 9) |
Significant increases in iron parameters after H. pylori eradication while no significant changes in subjects who were treated orally with iron alone |
Choe et al., South Korea [34]34 Choe YH, Kim SK, Son BK, Lee DH, Hong YC, Pai SH. Randomized placebo-controlled trial of Helicobacter pylori eradication for iron deficiency anemia in preadolescent children and adolescents. Helicobacter. 1999;4(2):135-9.
|
Preadolescent children and adolescents |
Rapid urease test and histology |
Group A: anti H. pylori and oral iron. Group B: only anti H. pylori. Group C: only oral iron. |
Treatment of H. pylori infection was associated with a more rapid response to oral iron treatment than the use of iron alone |