Sasahira et al
3131 Sasahira T, Kirita T, Bhawal UK, et al. The expression of receptor for advanced glycation end products is associated with angiogenesis in human oral squamous cell carcinoma. Virchows Arch 2007; 450(3):287-295
|
RAGE (OSCC) |
IHC and ELISA |
• Lower in T1-T2 stages than T3-T4 (p= 0.0408).• Correlated with MVD (p= 0.0123) and VEGF expression (p= 0.0344).• No correlation with N stage, age, sex, histological differentiation, LVD. |
Sasahira et al
3535 Sasahira T, Kirita T, Oue N, et al. High mobility group box-1inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma. Cancer Sci 2008;99(9):1806-1812
|
HMGB1 (OSCC) |
IHC |
• High expression in cancer cell nuclei and nodal metastatic foci.• Correlated with VEGF-C and VEGF-D expression (p< 0.001) |
Wu et al
3636 Wu D, Ding Y, Wang S, Zhang Q, Liu L. Increased expression of high mobility group box 1 (HMGB1) is associated with progression and poor prognosis in human nasopharyngeal carcinoma. J Pathol 2008;216(2):167-175
|
HMGB1 (NPC) |
IHC |
• Detected in 53.6% of cases, higher in malignant tissue.• Correlated with T classification (p= 0.01), N classification (p= 0.003), distant metastasis (p= 0.046), clinical stage (p< 0.001), initial radiotherapy response (p= 0.034), overall survival (p< 0.001), and disease-free survival (p< 0.001). |
Landesberg et al
3232 Landesberg R, Woo V, Huang L, et al. The expression of the receptor for glycation endproducts (RAGE) in oral squamous cell carcinomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 105(5):617-624
|
RAGE (OSCC) |
IHC and Western blot |
• Expression was significantly different by tumor differentiation (p< 0.05): 100% of well-differentiated, 75% of well-to-moderately differentiated, 14% of moderate-to-poorly differentiated, 0% of poorly differentiated.• RAGE was highest in normal tissue and trended toward decreased levels with less tumor differentiation. |
Tsuji et al
3333 Tsuji A, Wakisaka N, Kondo S, Murono S, Furukawa M, Yoshizaki T. Induction of receptor for advanced glycation end products by EBV latent membrane protein 1 and its correlation with angiogenesis and cervical lymph node metastasis in nasopharyngeal carcinoma. Clin Cancer Res 2008;14(17):5368-5375
|
RAGE (NPC) |
IHC |
• Tumor expression correlated with MVD (p= 0.0049), suggestive of the important role of RAGE in angiogenesis.• Expression was higher with lymph node metastasis (p= 0.0005). |
Liu et al
3737 Liu Y, Xie C, Zhang X, et al. Elevated expression of HMGB1 in squamous-cell carcinoma of the head and neck and its clinical significance. Eur J Cancer 2010;46(16):3007-3015
|
HMGB1 (HNSCC) |
IHC |
• Expressed in 88.3% of primary tumor samples and 43.7% in adjacent normal tissue (p< 0.001).• Correlated with tumor T classification (p= 0.001), advanced stage (p< 0.001), lymph node metastasis (p< 0.001) recurrence (p< 0.001), disease-free survival (p< 0.001), and overall survival (p< 0.001).• Was not correlated with age, alcohol intake, smoking, tumor grade, and tumor site. |
Wild et al
3838 Wild CA, Brandau S, Lotfi R, et al. HMGB1 is overexpressed in tumor cells and promotes activity of regulatory T cells in patients with head and neck cancer. Oral Oncol 2012;48(5):409-416
|
HMGB1 (HNSCC) |
IF, real-time PCR, and ELISA |
• Expressed more strongly in tumor tissue than tumor-adjacent stroma (p= 0.005).• HMGB1 levels were higher in sera of HNSCC patients than controls (p= 0.002). |
Qiu et al
3939 Qiu G, Li Y, Liu Z, Wang M, Ge J, Bai X. Clinical value of serum HMGB1 in diagnosis and prognosis of laryngeal squamous cell carcinoma. Med Oncol 2014;31(12):316
|
HMGB1 (LSCC) |
ELISA |
• Associated with T classification (p= 0.005), N classification (p= 0.002), and clinical stage (p= 0.001).• High HMGB1 (cutoff 4.80 ng/mL) was associated with poorer overall survival rate (p= 0.036).• Diagnosis of LSCC: 42.0% sensitive, 88.3% specific, positive predictive value of 52.9% (cutoff 4.80 ng/mL) |
Hanakawa et al
4040 Hanakawa H, Orita Y, Sato Y, et al. Does HMGB1 predict occult neck lymph node metastasis in early tongue carcinoma? A case-control study of 26 patients. J Laryngol Otol 2014;128(10):926-931
|
HMGB1 (Tongue SCC) |
IHC |
• Expression is not significantly associated with late neck metastases. |
Supic et al
4141 Supic G, Kozomara R, Zeljic K, et al. HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients. Oral Dis 2015;21(4):536-543
|
HMGB1 (OSCC) |
TaqMan genotyping |
HMGB1 G/C polymorphism analysis:• 1177GG genotype had higher prevalence of advance tumor stage III (p= 0.016) and significantly lower RFS (p= 0.000).• 3814CC genotype had higher prevalence of nodal metastasis and advance tumor stage III (p= 0.019). |
Su et al
3434 Su S, Chien M, Lin C, Chen M, Yang S. RAGE gene polymorphism and environmental factor in the risk of oral cancer. J Dent Res 2015 ; 94(3):403-411
|
RAGE (OSCC) |
TaqMan genotyping |
• -429TC genotype was associated with oral cancer incidence (OR, 1.870; 95% CI, 1.323–2.644) and late stage tumors (OR, 1.644; 95% CI, 1.083 to 2.493). |