1 |
Cavanagh et al.77 Cavanagh JF, Kumar P, Mueller AA, Richardson SP, Mueen A. Diminished EEG habituation to novel events effectively classifies Parkinson’s patients. Clin Neurophysiol 2018;129(02):409-418
|
2018 |
SG: 25 individuals with PD (age: 69.69 ± 8.73 years; 16 M). DD: 5,4 ± 4,09. CG: 25 healthy controls (age: 69.32 ± 9.58 years; 16 M) |
MMSE, NAART, BDI, UPDRS. |
The P300 component trended toward being larger in the PD group than in the CG. |
These findings identify a systemic alteration in an obligatory neural mechanism that may contribute to higherlevel cognitive dysfunction in PD. |
2 |
Lei et al.88 Lei J, Conradi N, Abel C, et al. Cognitive effects of rhythmic auditory stimulation in Parkinson’s disease: A P300 study. Brain Res 2019;1716:70-79
|
2019 |
SG: 23 individuals with PD (age: 61 ± 9 years; 11 M). DD: 7 ± 5 years. CG: 23 healthy controls (age: 61 ± 8 years; 11 M). |
CERAD-Plus, NAI stroop test, FAB, BDI, GDS, ERP. |
The patients showed larger P300 amplitudes for periodic versus random tones for sitting and pedalling conditions, and the controls showed a timing effect only for the sitting condition. A correlation between P300 amplitudes and motor variability in the periodic pedaling condition was only obtained in control participants. |
RAS facilitates the attentional processing of temporally predictable external events in PD patients as well as in healthy controls. |
3 |
Silva Lopes et al.99 Silva Lopes Md, Souza Melo Ad, Nóbrega AC. Delayed latencies of auditory evoked potential P300 are associated with the severity of Parkinson’s disease in older patients. Arq Neuropsiquiatr 2014;72 (04):296-300
|
2014 |
SG: 44 individuals with PD (age: 48-81 years; 24 M). DD: 7 years. CG: 33 healthy controls (age: 48-81 years; 5 M). |
MMSE, UPDRS, PTA, ABR. |
There was correlation between latencies and non-motor clinical features. Subjects older than 65, in advanced stages, presented a significant increase in latencies. |
There was an association between PD severity and P300 prolonged latencies among subjects 65 years old or older. This prolongation is more emphasized in individuals in advanced stages of the disease. |
4 |
Maidan et al.1111 Maidan I, Fahoum F, Shustak S, et al. Changes in event-related potentials during dual task walking in aging and Parkinson’s disease. Clin Neurophysiol 2019;130(02):224-230
|
2019 |
SG: 10 individuals with PD (age: 60.5 ± 3.6 years; 6 M). DD 2.9 ± 0.5 years. CGI: 11 healthy young adults (age: 32 ± 1.8 years; 7 M). CGII: 10 healthy older adults (age: 67.1 ± 1.7 years; 4 M). |
MoCA, CTT, UPDRS. |
Prolonged P300 latency during walking is more pronounced in aging and PD. There is an association between P300 latency and reduced cognitive function. Reduced P300 amplitude during walking was found only in patients with PD. |
The physiological recruitment of attentional networks during walking and their impact by aging and disease. |
5 |
Naskar et al.1616 Naskar S, Sood SK, Goyal V. Effect of acute deep brain stimulation of the subthalamic nucleus on auditory event-related potentials in Parkinson’s disease. Parkinsonism Relat Disord 2010;16(04): 256-260
|
2010 |
SG: 10 individuals with idiopathic PD (age: 52.5 ± 5.17 years; 6 M). DD: 9.5 ± 2.4years. |
HY, hearing test and MMSE. |
Neither amplitudes nor areas of the ERP components changed significantly. There was no significant change in the latency of the P300 potential when the target stimulus was applied. |
DBS may also worsen the orientation response as reflected by the increase in the N100 latency after the DBS electrode is turned on. |
6 |
Pauletti et al.1212 Pauletti C, Mannarelli D, Locuratolo N, Currà A, Marinelli L, Fattapposta F. Central fatigue and attentional processing in Parkinson’s disease: An event-related potentials study. Clin Neurophysiol 2019;130(05):692-700
|
2019 |
SC I: 11 individuals with PDF (age: 68.3 ± 9.8 years; 9 M). DD:5.6 ± 4.5 years. SC II: 24 individuals with PDnF (age: 65.2 ± 6.8 years; 18 M). DD: 3.8 ± 2.8 years. CG: 32 healthy controls (age: 62.8 ± 9.3 years; 20 M). |
MMSE, HY, UPDRS, PDQ-39, PSQI, STAI, BDI. |
P300 latency was significantly longer in the PDF and PDnF groups than in the controls. P3a latency and P3a amplitude were respectively significantly longer and lower in the PDF group than in either the PDnF group or the controls. |
PDF patients exhibited a difficulty in attentional orienting to salient novel stimuli. |
7 |
Sarikaya et al.1010 Sarikaya S, Yoldas TK, Yavasoglu NG. Evaluation of cognitive functions in Parkinson’s patients without dementia with auditory event related potential (P300). Dusunen Adam 2014;27(02): 132-137
|
2014 |
SG: 38 individuals with PD (age: 58.8 years; 25 M). CG: 39 healthy patients (age: 63.5 years; 25 M). |
SMMT, UPDRS, HY, HAM-D. |
P300 latencies in PD patients were significantly prolonged compared with the control group. There was a decrease in P300 amplitude values with increasing HAM-D. |
P300 latency reflects the rate of stimuli classification by mental process, attention, and cognitive processing. There is a dysfunction in these functions, and it can be demonstrated by the P300 test. |
8 |
Solís-Vivanco et al.66 Solís-Vivanco R, Rodríguez-Violante M, Rodríguez-Agudelo Y, Schilmann A, Rodríguez-Ortiz U, Ricardo-Garcell J. The P3a wave: A reliable neurophysiological measure of Parkinson’s disease duration and severity. Clin Neurophysiol 2015;126(11): 2142-2149
|
2015 |
SCI: 28 individuals with PD at stage1 of the HY (age: 56.2 ± 8.8 years; 16 M). DD 3.0 ± 2.1 years. SCII: 14 individuals with PD at stage2 of the HY (age: 57.2 ± 8.5 years; 12 M). DD 5.3 ± 3.9 years. SCIII: 13 subjects diagnosed with PD at stage 3 of the HY(age: 64.9 ± 8.3 years; 5 M). DD 10.0 ± 4.8 years. CG: 24 healthy subjects (age: 51.6 ± 7.8 years, 12 M). |
HY, BDI, MMSE, MMN, RON. |
The P300 amplitude was significantly lower in all PD groups compared with the control group, especially for stages 2 and 3. The disease duration inversely predicted the P300. |
The P300 could be a potential, well suited cognitive biomarker of progression in mild-tomoderate PD. |
9 |
Solís-Vivanco et al.1313 Solís-Vivanco R, Ricardo-Garcell J, Rodríguez-Camacho M, et al. Involuntary attention impairment in early Parkinson’s disease: an event-related potential study. Neurosci Lett 2011;495(02):144-149
|
2011 |
SC I: 25 medicated individuals with PD (age: 55.1 ± 7.6 years; 15 M). DD: 4.9 ± 3.1 years. SC II: 17 non-medicated individuals PD (age: 56.9 ± 7.2 years; 13 M). DD: 2.4 ± 2.2 years CG: 20 healthy controls (age: 51.7 ± 7.6 years; 10 M). |
MMSE, BDI, HY. |
A significant lower P300 amplitude in the medicated group compared with the control group. |
There were no significant differences in the latencies of any of the waves among the groups. The main finding of this study was the reduction in the IA in early PD. |
10 |
Tang et al.1414 Tang H, Huang J, Nie K, et al. Cognitive profile of Parkinson’s disease patients: a comparative study between early-onset and late-onset Parkinson’s disease. Int J Neurosci 2016;126(03):227-234
|
2016 |
SGI: 76 EOPD (age: 50 years). DD 11.96 ± 7.12 years. SG II: 166 LOPD (age: > 50 years). DD: 3.63 ± 4.29 years. |
UPDRS, HY, MMSE, MoCA, WAIS-RC, WMS-RC. |
P300 latencies were markedly delayed, and P300 amplitudes were reduced, in the LOPD group. In addition, the amplitudes of P3 at Cz and Pz in the LOPD group were significantly reduced compared with those observed in the EOPD group. |
Cognitive dysfunction progressed more slowly in the EOPD group. Although the LOPD patients exhibited shorter disease durations, their cognitive abilities, including executive function, visuospatial function and attention, may have been impaired. |
11 |
Tokic et al.1515 Tokic K, Titlic M, Beganovic-Petrovic A, Suljic E, Romac R, Silic S. P300 Wave Changes in Patients with Parkinson’s Disease. Med Arh 2016;70(06):453-456
|
2016 |
SC: 21 individuals with PD (age: 70.38 years; 12 M). |
— |
Patients with PD have prolonged P300 targeted and frequent stimulus latency compared with reference value for healthy population. |
The p300 findings in PD patients indicate the presence of cognitive dysfunction in these patients. |
12 |
Yilmaz et al.44 Yilmaz FT, Özkaynak SS, Barçin E. Contribution of auditory P300 test to the diagnosis of mild cognitive impairment in Parkinson’s disease. Neurol Sci 2017;38(12):2103-2109
|
2017 |
SG 1: 20 individuals with PD and MCI (age: 61.3 ± 7.8 years; 11 M). DD: 4.0 years. SC 2: 21 individuals with PD without cognitive impairment (age: 60.6 ± 7.8 years; 13 M). DD: 3.0. CG: 20 healthy subjects (age: 59.3 ± 5.7 years; 11 M). |
WMS, OVMPT, DST, JOT, BFRT, VFT, CDT, BNT, GAT-2, audiometric threshold of 1,000Hz. |
P300 latencies were significantly longer in the PD-MCI group than in the PD-Normal and the control group. The P300 amplitude recorded from the Fz was significantly lower in PD-MCI group than in the other groups. |
P300 provides a diagnostic tool to detect MCI in PD, and the prolongation of the P300 potential could be used as supportive parameters in this diagnosis. |