Feres et al., 2021 (77 Feres O, Feitosa MR, Ribeiro da Rocha JJ, Miranda JM, Dos Santos LE, Féres AC, et al. Hyperbaric oxygen therapy decreases mortality due to Fournier’s gangrene: a retrospective comparative study. Med Gas Res. 2021; 11:18-23.) |
Retrospective |
With Hyperbaric Oxygen Therapy |
48.2 (10 – 81) |
HBOT was administered once daily for a total of 15 sessions (2.4 atmospheric oxygen, for 2 hours) |
29 (36.7) |
28 (35.4) |
27 (34.1) |
24 (30.3) |
NR |
|
|
Without Hyperbaric Oxygen Therapy |
46.6 (1 – 82) |
33 (27.9) |
35 (29.6) |
33 (27.9) |
30 (25.4) |
NR |
Creta et al., 2020 (1010 Creta M, Longo N, Arcaniolo D, Giannella R, Cai T, Cicalese A, et al. Hyperbaric oxygen therapy reduces mortality in patients with Fournier’s Gangrene. Results from a multi-institutional observational study. Minerva Urol Nefrol. 2020; 72:223-8.) |
Retrospective |
With Hyperbaric Oxygen Therapy |
64.3 (16.1) |
HBOT given twice a day for 4-7 days (2.4 – 2.8 atmospheric oxygen, for 50 – 90 minutes) |
NR |
NR |
NR |
NR |
9.0 ± 4.8 |
|
|
Without Hyperbaric Oxygen Therapy |
68.3 (14.2) |
NR |
NR |
NR |
NR |
8.0 ± 4.0 |
Tutino et al., 2020 (1818 Tutino R, Colli F, Rizzo G, Cocorullo G, Gulotta G. Which is the role of hyperbaric oxygen therapy (hbot) in the treatment of fournier’s gangrene? Techniques in Coloproctology. 2020; 24:652.) |
Retrospective |
With Hyperbaric Oxygen Therapy |
NR |
HBOT was offered to 13 (56.5%) patients using a scheduled session of 60 minutes daily. |
11 (55) |
4 (15) |
NR |
11 (50) |
NR |
|
|
Without Hyperbaric Oxygen Therapy |
|
Anheuser et al., 2018 (1414 Anheuser P, Mühlstädt S, Kranz J, Schneidewind L, Steffens J, Fornara P. Significance of Hyperbaric Oxygenation in the Treatment of Fournier’s Gangrene: A Comparative Study. Urol Int. 2018; 101:467-71.) |
Retrospective |
With Hyperbaric Oxygen Therapy |
58 |
NR |
9 (52.9) |
5 (29.4) |
NR |
NR |
NR |
|
|
Without Hyperbaric Oxygen Therapy |
|
60 |
23 (50) |
14 (31.1) |
NR |
NR |
NR |
Ferretti et al., 2017 (1212 Ferretti M, Saji AA, Phillips J. Fournier’s Gangrene: A Review and Outcome Comparison from 2009 to 2016. Adv Wound Care (New Rochelle). 2017; 6:289-95.) |
Retrospective |
With Hyperbaric Oxygen Therapy |
56 (19-74) |
NR |
3(16) |
NR |
NR |
0 (0) |
4.3 (3-6) |
|
|
Without Hyperbaric Oxygen Therapy |
|
|
10 (53) |
|
|
3(16) |
8.3 (2-19) |
Hung et al., 2016 (1717 Hung MC, Chou CL, Cheng LC, Ho CH, Niu KC, Chen HL, et al. The role of hyperbaric oxygen therapy in treating extensive Fournier’s gangrene. Urological Science 2016, 27, 3, 148-53.) |
Retrospective |
With Hyperbaric Oxygen Therapy |
59.6 ± 14.5 |
NR |
44(73) |
NR |
25 (41) |
NR |
NR |
|
|
Without Hyperbaric Oxygen Therapy |
|
Li et al., 2015 (1111 Li C, Zhou X, Liu LF, Qi F, Chen JB, Zu XB. Hyperbaric Oxygen Therapy as an Adjuvant Therapy for Comprehensive Treatment of Fournier’s Gangrene. Urol Int. 2015; 94:453-8.) |
Retrospective |
With Hyperbaric Oxygen Therapy |
46.13±13.11 |
HBOT given twice daily for 5-7 days (2.5 units of atmospheric oxygen, 90-120 minutes per session at 10 hours intervals) |
NR |
NR |
NR |
NR |
7.38±3.20 |
|
|
Without Hyperbaric Oxygen Therapy |
48.42±15.31 |
NR |
NR |
NR |
NR |
7.42±3.20 |
Mindrup et al., 2005 (1313 Mindrup SR, Kealey GP, Fallon B. Hyperbaric oxygen for the treatment of fournier’s gangrene. J Urol. 2005; 173:1975-7.) |
Retrospective |
With Hyperbaric Oxygen Therapy |
57 ±14 |
HBOT given 1-3 times (2.4-3 units of atmospheric oxygen, 30-90 minutes) |
19 (73) |
6 (23) |
4 (15) |
19 (73) |
NR |
|
|
Without Hyperbaric Oxygen Therapy |
57 ±15 |
10 (63) |
5 (31) |
2 (13) |
10 (63) |
NR |
Ayan et al., 2005 (1515 Ayan F, Sunamak O, Paksoy SM, Polat SS, As A, Sakoglu N, et al. Fournier’s gangrene: a retrospective clinical study on forty-one patients. ANZ J Surg. 2005; 75:1055-8.) |
Retrospective |
With Hyperbaric Oxygen Therapy |
57.3 (35-74) |
Hyperbaric Oxygen (HBO) using 2.5 atmospheric pressure for 90 min/day was applied to 18 patients (43.9%) for three to 10 days. |
17 (41.4) |
5 (12.1) |
NR |
NR |
NR |
|
|
Without Hyperbaric Oxygen Therapy |
|
Hollabaugh et al., 1998 (1616 Hollabaugh RS Jr, Dmochowski RR, Hickerson WL, Cox CE. Fournier’s gangrene: therapeutic impact of hyperbaric oxygen. Plast Reconstr Surg. 1998; 101:94-100.) |
Retrospective |
With Hyperbaric Oxygen Therapy |
57 (26-87) |
HBOT was offered to 14 (54%) patients, The dive parameters were 90 min at 2.4 atmospheres absolute/45 feet sea water. Duration of therapy averaged 12 days. |
10 (38) |
9 (35) |
NR |
NR |
NR |
|
|
Without Hyperbaric Oxygen Therapy |
|