Silvia Ceccanti 1 1 Pediatric Surgery Unit, Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Azienda Ospedaliero Universitaria Policlinico Umberto I, Rome, Italy , Giuseppe Migliara 2 2 Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy , Corrado De Vito 2 2 Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy , Denis A Cozzi 3 3 Pediatric Surgery Unit, Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Azienda Ospedaliero Universitaria Policlinico Umberto I, Rome, Italy.
J Pediatr Surg. 2021 Jul 13;S0022-3468(21)00494-2.
COMMENT
Gastroschisis is a paraumbilical abdominal wall defect associated with protrusion of the abdominal content through a defect which cause is not completely elucidated, but there is evidence of an abnormality in the formation and development of the ventral body wall during embryogenesis, resulting in bowel herniation (11 Opitz JM, Feldkamp ML, Botto LD. An evolutionary and developmental biology approach to gastroschisis. Birth Defects Res. 20191;111:294-311.). Patients with gastroschisis are associated with malformations outside the gastrointestinal tract in around 10% of the cases, and with abnormalities related to the gastrointestinal tract in up to 25% of cases (22 Prefumo F, Izzi C. Fetal abdominal wall defects. Best Pract Res Clin Obstet Gynaecol. 2014;28:391-402., 33 Logsdon NT, Sampaio FJB, Favorito LA. The role of intra-abdominal pressure in human testicular migration. Int Braz J Urol. 2021;47:36-44.). The association of gastroschisis and undescended testis probably occurs by mechanical factors rather than prematurity (44 Logsdon NT, Gallo CM, Favorito LA, Sampaio FJ. Investigation of a connection between abdominal wall defects and severity of the herniation in fetuses with gastroschisis and omphalocele. Sci Rep. 2021;11:27.).
Undescended testis is associated with abdominal wall defects around 30 to 40% of the cases and in these patients the spontaneous testicular descent occurs in about in 50% of the cases (55 Yardley IE, Bostock E, Jones MO, Turnock RR, Corbett HJ, Losty PD. Congenital abdominal wall defects and testicular maldescent––a 10-year single-center experience. J Pediatr Surg. 2012;47:1118-22.). In this interesting systematic review published in Journal of Pediatric Surgery in 2021, the authors confirmed that cryptorchidism in gastroschisis appears to occur more frequently than in the normal population with an unfavorable presentation which is represented by originally intrabdominal or prolapsed testis in the majority of cases. This a very interesting paper to pediatric urology.
REFERENCES
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1Opitz JM, Feldkamp ML, Botto LD. An evolutionary and developmental biology approach to gastroschisis. Birth Defects Res. 20191;111:294-311.
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2Prefumo F, Izzi C. Fetal abdominal wall defects. Best Pract Res Clin Obstet Gynaecol. 2014;28:391-402.
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3Logsdon NT, Sampaio FJB, Favorito LA. The role of intra-abdominal pressure in human testicular migration. Int Braz J Urol. 2021;47:36-44.
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4Logsdon NT, Gallo CM, Favorito LA, Sampaio FJ. Investigation of a connection between abdominal wall defects and severity of the herniation in fetuses with gastroschisis and omphalocele. Sci Rep. 2021;11:27.
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5Yardley IE, Bostock E, Jones MO, Turnock RR, Corbett HJ, Losty PD. Congenital abdominal wall defects and testicular maldescent––a 10-year single-center experience. J Pediatr Surg. 2012;47:1118-22.
Publication Dates
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Publication in this collection
11 Mar 2022 -
Date of issue
Mar-Apr 2022