Arora, et al. 2010 (1111. Arora M, Weuve J, Fall K, Pedersen NL, Mucci LA. An exploration of shared genetic risk factors between periodontal disease and cancers: a prospective co-twin study. Am J Epidemiol. 2010; 171:253-9.) |
The Swedish Twin Registry |
Prospective cohort (1963-2004) |
Sweden |
15.333 (604) |
38-77 |
27 |
Self-report |
Unreported |
Age, education, employment, number of siblings, smoking status, smoking status of partner, alcohol status, body mass index, and diabetes |
PD |
Dizdar, et al. 2017 (1212. Dizdar O, Hayran M, Guven DC, Yılmaz TB, Taheri S, Akman AC, et al. Increased cancer risk in patients with periodontitis. Curr Med Res Opin. 2017; 33:2195-2200.) |
The Hacettepe University Dentistry and Oncology hospitals in Ankara |
Retrospective cohort (2001-2010) |
Turkey |
1.250 (3 cases with CP) |
49.6 |
12 |
Clinical and radiographic parameters |
Included |
Age |
CP (moderate or severe) |
Güven, et al. 2019 (1313. Güven DC, Dizdar Ö, Akman AC, Berker E, Yekedüz E, Ceylan F, et al. Evaluation of cancer risk in patients with periodontal diseases. Turk J Med Sci. 2019; 49:826-31.) |
The Hacettepe University Dentistry and Oncology hospitals in Ankara |
Retrospective cohort (2007-2012) |
Turkey |
5.199 (40 cases with PD) |
57.7 |
7.2 |
Clinical and radiographic parameters |
Unreported |
Age |
PD |
Hujoel, et al. 2003 (2020. Hujoel PP, Drangsholt M, Spiekerman C, Weiss NS. An exploration of the periodontitis-cancer association. Ann Epidemiol. 2003; 13:312-6.) |
The NHANES I Epidemiologic Follow-up Study (NHEFS) |
Prospective cohort (1971/1975-1992) |
USA |
11.328 (67) |
25-74 |
10 |
Clinical diagnosis |
Unreported |
Age, poverty index, education, race, smoking, vitamin A and C consumption, and alcohol consumption |
Periodontitis Gingivitis |
Hwang, et al. 2014 (2121. Hwang IM, Sun LM, Lin CL, Lee CF, Kao CH. Periodontal disease with treatment reduces subsequent cancer risks. QJM. 2014; 107:805-12.) |
Taiwan National Health Insurance (NHI) system |
Retrospective cohort (1996-2010) |
Taiwan |
38.902 (250 cases with PD) |
43.1±13.6 |
NA |
Clinical diagnosis |
Unreported |
Age, occupation, type 2 diabetes mellitus, hypertension, and hyperlipidemia |
PD |
Lee, et al. 2017 (2222. Lee JH, Kweon HH, Choi JK, Kim YT, Choi SH. Association between Periodontal disease and Prostate cancer: Results of a 12-year Longitudinal Cohort Study in South Korea. J Cancer. 2017; 8:2959-65.) |
National Health Insurance Service-Health Examinee Cohort (NHIS-HEC) |
Retrospective cohort (2002-2013) |
Korea |
187.934 (934) |
≥40 |
NA |
Clinical and radiographic parameters |
Unreported |
Age, household income, insurance status, residence area, hypertension, diabetes mellitus, cerebral infarction, angina pectoris, myocardial infarction, smoking status, alcohol intake, and regular exercise |
PD Current smokers |
Michaud, et al. 2016 (2323. Michaud DS, Kelsey KT, Papathanasiou E, Genco CA, Giovannucci E. Periodontal disease and risk of all cancers among male never smokers: an updated analysis of the Health Professionals Follow-up Study. Ann Oncol. 2016; 27:941-7.) |
The Health Professionals Follow-up Study (HPFS) |
Prospective cohort (1986-2012) |
USA |
19.933 (696) |
40-75 |
26 |
Self-report |
Unreported |
Age, race, alcohol use, physical activity, history of diabetes, body mass index, geographical location, height, and NSAID use |
PD |
Michaud, et al. 2018 (2424. Michaud DS, Lu J, Peacock-Villada AY, Barber JR, Joshu CE, Prizment AE, et al. Periodontal Disease Assessed Using Clinical Dental Measurements and Cancer Risk in the ARIC Study. J Natl Cancer Inst. 2018; 110:843-54.) |
Atherosclerosis Risk in Communities study cohort (ARIC) |
Prospective cohort (1987-2012) |
USA |
7.466 (375) |
44-66 |
14.7 |
Self-report |
Included |
Age, field center, education level, smoking status, smoking duration, drinking status, body mass index, and diabetes status |
Periodontitis (Moderate) |
Wen, et al. 2014 (2525. Wen BW, Tsai CS, Lin CL, Chang YJ, Lee CF, Hsu CH, et al. Cancer risk among gingivitis and periodontitis patients: a nationwide cohort study. QJM. 2014; 107:283-90.) |
Taiwan National Health Insurance (NHI) system |
Retrospective cohort (1997-2010) |
Taiwan |
153.566 (384) |
45.2± 14.8 |
NA |
Clinical diagnosis |
Included |
Age, diabetes, hypertension and hyperlipidemia |
PD |