Randomized Clinical Trials
|
Robinson et al. (2009) (1313 Robinson JW, Donnelly BJ, Siever JE, Saliken JC, Ernst SD, Rewcastle JC, et al. A randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancer: quality of life outcomes. Cancer. 2009;115:4695-704.) |
Group 1 |
117 |
Cryoblation |
69.4 |
8.1 |
- |
- |
- |
9/34 |
10/34 |
Erections sufficient for sexual intercourse |
- |
- |
- |
Moderate quality |
Group 2 |
114 |
Radiotherapy |
68.6 |
9.0 |
- |
- |
- |
24/30 |
18/30 |
Erections sufficient for sexual intercourse |
- |
- |
- |
Donelly et al. (2010) (1414 Donnelly BJ, Saliken JC, Brasher PM, Ernst SD, Rewcastle JC, Lau H, et al. A randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancer. Cancer. 2010;116:323-30.) |
Group 1 |
117 |
Cryoblation |
69.4 |
8.1 |
20/117 |
29/117 |
PSA nadir+ 2 ng/dL |
- |
14/56 |
Erections sufficient for sexual intercourse |
- |
- |
- |
Moderate quality |
Group 2 |
114 |
Radiotherapy |
68.9 |
9.0 |
15/114 |
29/114 |
PSA nadir+ 2 ng/dL |
- |
15/57 |
Erections sufficient for sexual intercourse |
- |
- |
- |
Chin et al. (2012) (1515 Chin JL, Al-Zahrani AA, Autran-Gomez AM, Williams AK, Bauman G. Extended followup oncologic outcome of randomized trial between cryoablation and external beam therapy for locally advanced prostate cancer (T2c-T3b). J Urol. 2012;188:1170-5.) |
Group 1 |
31 |
Cryoblation |
70.4 |
11.1 |
17/31 |
22/31 |
PSA nadir+ 2 ng/dL |
- |
- |
- |
- |
- |
- |
Moderate quality |
Group 2 |
31 |
Radiotherapy |
70.5 |
8.6 |
6/31 |
7/31 |
PSA nadir+ 2 ng/dL |
- |
- |
- |
- |
- |
- |
Retrospective Studies
|
Albissini et al. (2017) (1616 Albisinni S, Aoun F, Bellucci S, Biaou I, Limani K, Hawaux E, et al. Comparing High-Intensity Focal Ultrasound Hemiablation to Robotic Radical Prostatectomy in the Management of Unilateral Prostate Cancer: A Matched-Pair Analysis. J Endourol. 2017;31:14-9.) |
Group 1 |
55 |
HIFU (hemigland) |
73.0 |
6.9 |
7/55 |
- |
PSA nadir+ 2 ng/dL |
24/30 |
- |
Erections sufficient for sexual intercourse |
52/55 |
52/55 |
0 pads |
Moderate quality |
Group 2 |
55 |
Radical Prostatectomy |
63 |
6.5 |
6/55 |
- |
PSA ≥ 0.2 ng/dL |
27/48 |
- |
Erections sufficient for sexual intercourse |
48/55 |
50/55 |
0 pads |
Chinevovo et al. (2018) (1717 Chinenov DV, Rapoport LM, Shpot EV, Enikeev DV, Chernov YN, Taratkin MS, et al. Comparative results of cryoablation and laparoscopic radical prostatectomy in the treatment of localized prostate cancer. Urologia. 2018;85:68-72.) |
Group 1 |
42 |
cryoablation |
69.0 |
6.5 |
- |
- |
- |
- |
- |
- |
42/42 |
- |
0 pads |
Moderate quality |
Group 2 |
42 |
Radical Prostatectomy |
65.0 |
6.7 |
- |
- |
- |
- |
- |
- |
45/42 |
- |
0 pads |
Garcia-Barreras et al. (2018) (1818 Garcia-Barreras S, Sanchez-Salas R, Sivaraman A, Barret E, Secin F, Nunes-Silva I, et al. Comparative Analysis of Partial Gland Ablation and Radical Prostatectomy to Treat Low and Intermediate Risk Prostate Cancer: Oncologic and Functional Outcomes. J Urol. 2018;199:140-6.) |
Group 1 |
236 |
HIFU and cryoablation |
68.2 |
7.12 |
21/336 |
- |
PSA nadir+ 2 ng/dL |
145/160 |
- |
Erections sufficient for sexual intercourse |
208/236 |
- |
0 pads |
Moderate quality |
Group 2 |
472 |
Radical Prostatectomy |
65.1 |
6.99 |
29/472 |
- |
PSA ≥ 0.2 ng/dL |
94/344 |
- |
Erections with or without PDE5i |
300/472 |
- |
0 pads |
Rosenhammer et al. (2019) (1919 Rosenhammer B, Ganzer R, Zeman F, Näger T, Fritsche HM, Blana A, et al. Oncological long-term outcome of whole gland HIFU and open radical prostatectomy: a comparative analysis. World J Urol. 2019;37:2073-80.) |
Group 1 |
365 |
HIFU |
67.5 |
7.1 |
45/365 |
62/365 |
PSA nadir+ 2 ng/dL |
- |
- |
- |
- |
- |
- |
Low quality |
Group 2 |
394 |
Radical Prostatectomy |
62.8 |
9.2 |
37/394 |
52/394 |
PSA ≥ 0.2 ng/dL |
- |
- |
- |
- |
- |
- |
Shah et al. (2021) (2020 Shah TT, Reddy D, Peters M, Ball D, Kim NH, Gomez EG, Miah S, Evans DE, Guillaumier S, van Rossum PSN, Van Son MJ, Hosking-Jervis F, Dudderidge T, Hindley R, Emara A, McCracken S, Greene D, Nigam R, McCartan N, Valerio M, Minhas S, Afzal N, Lewi H, Ogden C, Persad R, Virdi J, Moore CM, Arya M, Emberton M, Ahmed HU, Winkler M. Focal therapy compared to radical prostatectomy for non-metastatic prostate cancer: a propensity score-matched study. Prostate Cancer Prostatic Dis. 2021;24:567-74.) |
Group 1 |
246 |
HIFU and cryoablation |
63.3 |
7.9 |
22/246 |
34/246 |
Gleason ≤7 in biopsy |
- |
- |
- |
- |
- |
- |
Moderate quality |
Group 2 |
246 |
Radical Prostatectomy |
63.4 |
7.9 |
24/246 |
44/246 |
PSA ≥ 0.2 ng/dL |
- |
- |
- |
- |
- |
- |