ABSTRACT
Introduction and Objective:
Upper tract urothelial carcinoma (UTUC) represents 5% of all urothelial malignancies (11 Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017; 67:7-30.–33 Sharma G, Yadav AK, Pareek T, Kaundal P, Tyagi S, Devana SK, et al. Impact of pathological factors on survival in patients with upper tract urothelial carcinoma: a systematic review and meta-analysis. Int Braz J Urol. 2021; 47. Epub ahead of print.). Accurate pathologic diagnosis is key and may direct treatment decisions. Current ureteroscopic biopsy techniques include cold-cup, backloaded cold-cup and stone basket (44 Breda A, Territo A, Sanguedolce F, Basile G, Subiela JD, Reyes HV, et al. Comparison of biopsy devices in upper tract urothelial carcinoma. World J Urol. 2019; 37:1899-905.–66 Lama DJ, Safiullah S, Patel RM, Lee TK, Balani JP, Zhang L, et al. Multi-institutional Evaluation of Upper Urinary Tract Biopsy Using Backloaded Cup Biopsy Forceps, a Nitinol Basket, and Standard Cup Biopsy Forceps. Urology. 2018; 117:89-94.). The study objective was to compare a standard cold-cup biopsy technique to a novel cold-cup biopsy technique and evaluate histopathologic results.
Materials and Methods:
We developed a novel UTUC biopsy technique termed the “form tackle” biopsy. Ureteroscope is passed into ureter/renal collecting system. Cold-cup forceps are opened and pressed into the lesion base (to engage the urothelial wall/submucosal tissue) then closed. Ureteroscope/forceps are advanced forward 3-10mm and then extracted from the patient. We compared standard versus novel upper tract biopsy techniques in a series of patients with lesions ≥1cm. In each procedure, two standard and two novel biopsies were obtained from the same lesion. The primary study aim was diagnosis of malignancy. IRB approved: 21-006907.
Results:
Fourteen procedures performed on 12 patients between June 2020 and March 2021. Twenty-eight specimens sent (14 standard, 14 novel) (Two biopsies per specimen). Ten procedures with concordant pathology. In 4 procedures the novel biopsy technique resulted in a diagnosis of UTUC (2 high-grade, 2 low-grade) in the setting of a benign standard biopsy. Significant difference in pathologic diagnoses was detected between standard and novel upper tract biopsy techniques (p=0.008).
Conclusions:
The “form tackle” upper tract ureteroscopic biopsy technique provides higher tissue yield which may increase diagnostic accuracy. Further study on additional patients required. Early results are encouraging.
REFERENCES
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1Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017; 67:7-30.
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2Roupret M, Babjuk M, Comperat E, Zigeuner R, Sylvester RJ, Burger M, et al. European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2017 Update. Eur Urol. 2018; 73:111-22.
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3Sharma G, Yadav AK, Pareek T, Kaundal P, Tyagi S, Devana SK, et al. Impact of pathological factors on survival in patients with upper tract urothelial carcinoma: a systematic review and meta-analysis. Int Braz J Urol. 2021; 47. Epub ahead of print.
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4Breda A, Territo A, Sanguedolce F, Basile G, Subiela JD, Reyes HV, et al. Comparison of biopsy devices in upper tract urothelial carcinoma. World J Urol. 2019; 37:1899-905.
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5Kleinmann N, Healy KA, Hubosky SG, Margel D, Bibbo M, Bagley DH. Ureteroscopic biopsy of upper tract urothelial carcinoma: comparison of basket and forceps. J Endourol. 2013; 27:1450-4.
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6Lama DJ, Safiullah S, Patel RM, Lee TK, Balani JP, Zhang L, et al. Multi-institutional Evaluation of Upper Urinary Tract Biopsy Using Backloaded Cup Biopsy Forceps, a Nitinol Basket, and Standard Cup Biopsy Forceps. Urology. 2018; 117:89-94.
Publication Dates
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Publication in this collection
11 Mar 2022 -
Date of issue
Mar-Apr 2022
History
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Received
28 June 2021 -
Accepted
14 July 2021 -
Published
10 Sept 2021