Kaswick et al. (1313. Kaswick JA, Waisman J, Goodwin WE. Nephrogenic metaplasia (adenomatoid tumors) of bladder. Urology. 1976;8:283-6.) |
1976 |
2 |
No |
Hematuria Incontinence |
History of prior urosurgery History of UTI |
1 recurrence |
-treatment with TUR, antibiotics -monitor for recurrence |
Molland et al. (1515. Molland EA, Trott PA, Paris AM, Blandy JP. Nephrogenic adenoma: a form of adenomatous metaplasia of the bladder. A clinical and electron microscopical study. Br J Urol. 1976;48:453-62.) |
1976 |
3 patients |
No |
Unknown |
Unknown |
Unknown |
Malignant transformation to adenocarcinoma in one patient |
Ford et al. (44. Ford TF, Watson GM, Cameron KM. Adenomatous metaplasia (nephrogenic adenoma) of urothelium. An analysis of 70 cases. Br J Urol. 1985;57:427-33.) |
1985 |
70 (35 within bladder) |
7 patients with TCC |
Incidental findings |
History of prior urosurgery |
15 patients |
No malignancy in 12 year follow up |
Oliva et al. (55. Oliva E, Young RH. Nephrogenic adenoma of the urinary tract: a review of the microscopic appearance of 80 cases with emphasis on unusual features. Mod Pathol. 1995;8:722-30.) |
1995 |
80 (42 within bladder) |
No |
N/A |
Prior urosurgery nephrolithiasis infection |
N/A |
NA with bland cytologic features |
Peeker et al. (66. Peeker R, Aldenborg F, Fall M. Nephrogenic adenoma--a study with special reference to clinical presentation. Br J Urol. 1997;80:539-42.) |
1997 |
31 (24 within bladder) |
7 patients with UCC |
Hematuria Urinary frequency Bladder Pain |
History of renal transplant (1) History of prior urosurgery History of UTI |
7 patients |
-Trauma to urothelial mucosa may lead to NA - TUR as method of management |
Tse et al. (1818. Tse V, Khadra M, Eisinger D, Mitterdorfer A, Boulas J, Rogers J. Nephrogenic adenoma of the bladder in renal transplant and non-renal transplant patients: a review of 22 cases. Urology. 1997;50:690-6.) |
1997 |
22 |
6 patients with TCC |
Hematuria Urinary frequency Incidental |
History of renal transplant (7) Recurrent UTI History of prior urosurgery |
6 patients |
With association to TCC, NA should be taken seriously and followed up |
Porcaro et al. (1212. Porcaro AB, D'Amico A, Ficarra V, Balzarro M, Righetti R, Martignoni G, et al. Nephrogenic adenoma of the urinary bladder: our experience and review of the literature. Urol Int. 2001;66:152-5.) |
2001 |
8 |
3 patients with TCC |
Hematuria Irritative voiding symptoms |
History of prior urosurgery |
5 patients |
-Features of NA nonspecific but TUR will diagnose & treat -high recurrence rate requiring follow up |
Chen et al. (1111. Chen CS, Cheng CL. Nephrogenic adenoma of the urinary bladder: clinical experience and review of the literature. J Chin Med Assoc. 2006;69:166-8.) |
2006 |
8 |
No |
Hematuria Urinary frequency |
History of urosurgery History of catheterization History of UTI |
3 patients (median relapse 7 months) |
-NA is a benign lesion -recurrence is high |
Hungerhuber et al. (1919. Hungerhuber E, Bach E, Hartmann A, Frimberger D, Stief C, Zaak D. Adenocarcinoma of the bladder following nephrogenic adenoma: a case report. J Med Case Rep. 2008;2:164.) |
2008 |
1 |
Progression to adenocarcinoma |
Hematuria |
History of urosurgery |
Yes |
NA may have malignant potential and warrants follow up |
Dhaliwal et al. (1010. Dhaliwal CA, Fineron PW. The progression of nephrogenic metaplasia of the urinary bladder to clear cell adenocarcinoma: a case report. Curr Urol. 2012;6:106-8.) |
2012 |
1 |
Progression to Clear cell adenocarcinoma |
Hematuria Proteinuria |
History of urosurgery |
No |
Malignant transformation can occur with NA |
Kuzaka et al. (33. Kuzaka B, Pudełko P, Powała A, Górnicka B, Radziszewski P. Nephrogenic adenoma of the urinary bladder: a report of three cases and a review of the literature. Ann Transplant. 2014;19:153-6.) |
2014 |
3 |
1 patient with TCC |
Hematuria |
History of recurrent UTI History of prior urosurgery |
2 patients (5 and 9 months) |
-NA is a benign lesion -Recurrence is high |
Gordetsky et al. (77. Gordetsky J, Gennaro KH, Selph JP, Rais-Bahrami S. Nephrogenic Adenoma: Clinical Features, Management, and Diagnostic Pitfalls. Urology. 2016;95:29-33.) |
2016 |
31 (26 within bladder) |
12 patients with UCC |
Hematuria Urinary incontinence Hydronephrosis Asymptomatic |
History of renal transplant (1) History of DM (8 patients) |
1 patient |
-NA is a benign lesion |