1 |
Aleluia MM et al. (2017) |
Brazil |
Association of classical markers and establishment of the dyslipidemic subphenotype of sickle cell anemia |
99 HbSS patients in steady state |
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HDL-C levels greater than 40.0 mg/dL were associated with an improvement in hematological parameters (red blood cell count, Hb, and Ht), in addition to an increase in HbF. |
2 |
Ataga KI et al. (2015) |
USA |
Association of pro-inflammatory high-density lipoprotein cholesterol with clinical and laboratory variables in sickle cell disease |
117 patients with sickle cell disease: (91 HbSS; 13 HbSC; 5 HbSβ0-thalassemia and 8 HbSβ+ -thalassemia) in addition to 11 healthy patients (control) |
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Pro-HDL was increased in patients with suspected pulmonary hypertension and decreased in patients with history of priapism.
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TC was reduced in patients with suspected pulmonary hypertension. There was a trend towards lower TC levels in patients with history of priapism and ulcers in the lower limbs.
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HDL was also decreased in patients with history of priapism.
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3 |
Akinlade KS et al. (2014) |
Nigeria |
Defective lipid metabolism in sickle cell anaemia subjects in vaso-occlusive crisis |
58 HbSS adults (30 in steady state and 28 in vaso-occlusive crisis) in addition to 24 healthy adults (control) |
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TC, LDL, TG, and TG/HDL were significantly reduced while HDL was increased in patients in vaso-occlusive crisis when compared to patients in a stable disease state. |
4 |
Adegoke SA et al. (2016) |
Nigeria |
Electrocardiographic abnormalities and dyslipidaemic syndrome in children with sickle cell anaemia |
62 HbSS children and 40 healthy people of the same age group |
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5 |
Rissatto-Lago MR et al. (2018) |
Brazil |
Hidden hearing loss in children and adolescents with sickle cell anemia |
37 HbSS patients in steady state and 44 healthy controls (all 6-18 years of age) |
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No association was observed between lipid profile and increased acoustic reflex thresholds. |
6 |
Teixeira RS et al. (2019) |
Brazil |
Higher TG/HDL-cholesterol ratios hallmark disease severity in children and adolescents with sickle cell anemia |
55 HbSS patients in steady state and 41 healthy controls (all 6-18 years of age) |
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Elevated TG/HDL in patients with SCA was associated with more episodes of acute chest syndrome and vaso-occlusive crises.
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TG/HDL also had a positive correlation with LDH, WBC count, and flow velocity in the right and left cerebral arteries, in addition to a negative correlation with Hb levels.
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7 |
Guarda CC et al. (2020) |
Brazil |
Investigation of Lipid Profile and Clinical Manifestations in SCA Children |
126 HbSS patients in steady state |
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Patients with history of pneumonia had increased levels of TC and LDL-C. Previous history of lower limb ulcers was associated with reduced LDL-C levels. Individuals with history of pain crises presented elevated HDL-C levels. |
8 |
Seixas MO et al. (2010) |
Brazil |
Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease |
152 HbSS children in steady state and 132 healthy children |
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Decreased HDL-C levels were associated with a history of cardiac abnormalities, pneumonia, and need for blood transfusion.
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Elevated levels of TC, LDL-C, VLDL-C, and TG were associated with the occurrence of cholelithiasis.
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9 |
Zorca S et al. (2010) |
USA |
Lipid levels in sickle-cell disease associated with haemolytic severity, vascular dysfunction and pulmonary hypertension |
328 adults with SCA in a stable state (250 SS or Sβ0 and 78 SC or Sβ+) and 39 healthy controls |
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TC, HDL-C, and LDL-C were inversely correlated with anemia severity, but not with markers of pulmonary hypertension (NT-proBNP and TRV).
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Serum TG levels were positively correlated with markers of pulmonary hypertension.
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10 |
Lalanne-Mistrih ML et al. (2018) |
Guadalupe (France) |
Lipid profiles in French West Indies sickle cell disease cohorts, and their general population |
159 adults with SCA in steady state (97 HbSS and 62 HbSC) |
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Patients with elevated TG showed history of acute chest syndrome more frequently.
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Acute chest syndrome, vaso-occlusive crises, and osteonecrosis were not affected by TC, HDL-C, and LDL-C levels.
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11 |
Lamarre Y et al. (2013) |
Guadalupe (France) |
Male Gender, Increased Blood Viscosity, Body Mass Index and Triglyceride Levels Are Independently Associated with Systemic Relative Hypertension in Sickle Cell Anemia |
97 HbSS adults in steady state |
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Elevated TG levels could increase the risk of developing relative hypertension (BP ≥ 120/70 mmHg and < 140/90 mmHg) in SCA.
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Patients with borderline/elevated TG levels had history of acute chest syndrome and vaso-occlusive crises more frequently.
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12 |
Ephraim RKD et al. (2016) |
Gana |
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Normal Non-HDL Cholesterol, Low Total Cholesterol, and HDL Cholesterol Levels in Sickle Cell Disease Patients in the Steady State:
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A Case-Control Study of Tema Metropolis
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50 patients with SCA (12 HbSS and 38 HbSC) in a stable state and 50 healthy controls |
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TC
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HDL-C
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LDL-C
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VLDL-C
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Non-HDL
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TG
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TG/HDL
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Increased VLDL was inversely correlated with systolic blood pressure and positively correlated with diastolic blood pressure. |
13 |
Valente-Frossard TNS et al. (2020) |
Brazil |
Polymorphisms in genes that affect the variation of lipid levels in a Brazilian pediatric population with sickle cell disease: rs662799 APOA5 and rs964184 ZPR1 |
161 children and adolescents with SCA (92 HbSS and 69 HbSC) in a stable state |
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TC
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HDL-C
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Non-HDL
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TG
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CT/HDL
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TG/HDL
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Decreased HDL-C levels were associated with elevated markers of hemolysis and inflammation.
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Elevated TG levels were correlated with lower concentrations of Hb and HDL-C, in addition to an increase in leukocytes, LDH, and bilirubin.
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14 |
Darbari DS et al. (2013) |
USA |
Severe painful vaso-occlusive crises and mortality in a contemporary adult sickle cell anemia cohort study |
264 HbSS adults |
HDL-C |
Elevated HDL was associated with a higher frequency of vaso-occlusive crises. |
15 |
Emokpae A, Kuliya-Gwarzo A (2014) |
Nigeria |
The influence of decreased levels of high density lipoprotein cholesterol on hematological indices in sickle cell disease patients |
84 patients with SCA in a stable state (all from 15 years old) |
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Patients with reduced HDL-C levels had more severe anemia and a greater need for blood transfusions compared to those with normal HDL. |