Chalothorn et al.,2121- Chalothorn LA, Beeman CS, Ebersole JL, Kluemper GT, Hicks EP, Kryscio RJ, et al. Hypodontia as a risk marker for epithelial ovarian cancer: a case-controlled study. J Am Dent Assoc. 2008;139(2):163-9. doi: 10.14219/jada.archive.2008.0132 https://doi.org/10.14219/jada.archive.20...
(2008), USA, Case-control |
Epithelial Ovarian cancer (EOC) |
127 (30) |
23 (20) |
– |
U2, U5 |
– |
– |
– |
Fisher exact, OR |
Possible association between EOC and agenesis. The data also showed that the crude OR was 8.1 (95 percent CI, 2.1-30.9), which implied that women with EOC are 8.1 times more likely to have hypodontia than are women without EOC. |
Fekonja et al.,2222- Fekonja A, Čretnik A, Takač I. Hypodontia prevalence and pattern in women with epithelial ovarian cancer. Angle Orthod. 2014;84(5):810-4. doi: 10.2319/112813-876.1 https://doi.org/10.2319/112813-876.1...
(2014), Slovenia, Case-Control |
Epithelial Ovarian cancer (EOC) |
209 (97) |
31 (23) |
– |
U5, U2, L5, L1 |
– |
– |
Clinical and X-rays evaluations |
t-test, X2, Fisher exact, OR |
The difference between the two groups was statistically significant (p=0.004); the crude OR was 3.30 (95% CI, 0.12–7.01). Women with ovarian cancer were 2.87 times (19.2%–6.7%) more likely to have hypodontia than healthy women. |
Paranjyothi et al.,2424- Paranjyothi MV, Kumaraswamy KL, Begum LF, Manjunath K, Basheer S. Tooth agenesis: a susceptible indicator for colorectal cancer? J Cancer Res Ther. 2018;14(3):527-31. doi: 10.4103/0973-1482.168997 https://doi.org/10.4103/0973-1482.168997...
(2018), India, Case-control |
Colorectal cancer (CRC) |
44 (21) |
6 (4) |
– |
L5, U2, U5 |
– |
– |
Self-reported questionnaire,clinical and X-rays evaluations |
X2
|
Sixteen percent of cancer patients and 8% of individuals without cancer reported having tooth agenesis, no statistical difference (p= 0.384). |
Lindor et al.,2929- Lindor NM, Win AK, Gallinger S, Daftary D, Thibodeau SN, Silva R, et al. Colorectal cancer and self-reported tooth agenesis. Hered Cancer Clin Pract. 2014;12(1):7. doi: 10.1186/1897-4287-12-7 https://doi.org/10.1186/1897-4287-12-7...
(2014), Canada, Case-control |
Colorectal cancer (CRC) |
4188 (1558) |
236 (78) |
– |
– |
– |
– |
Self-reported questionnaire |
X2, Fisher exact test |
4.8% of cases and 5.7% of controls reported having at least one missing tooth, no statistical evidence of difference (p= 0.20). |
Williams et al.,3030- Williams MA, Biguetti C, Romero-Bustillos M, Maheshwari K, Dinckan N, Cavalla F, et al. Colorectal cancer-associated genes are associated with tooth agenesis and may have a role in tooth development. Sci Rep. 2018;8(1):2979. doi: 10.1038/s41598-018-21368-z https://doi.org/10.1038/s41598-018-21368...
(2018), USA, Case-control |
Colorectal cancer (CRC) and family history of any type of cancer |
347 (39) |
93 (28) |
– |
– |
11,2%/30,1% |
ATF1, DUSP10, CASC8 |
Clinical and radiographic examinations and associated gene variants |
– |
Genome-wide significant associations were found between TA and ATF1 (P = 4.36 × 10−10) and DUSP10 (P = 1.25 × 10−9), and positive association found with CASC8 (P = 8.2 × 10−5). |
Küchler et al.,2828- Küchler EC, Lips A, Tannure PN, Ho B, Costa MC, Granjeiro JM, et al. Tooth agenesis association with self-reported family history of cancer. J Dent Res. 2013;92(2):149-55. doi: 10.1177/0022034512468750 https://doi.org/10.1177/0022034512468750...
(2013), USA/Brazil, Case-control |
Family history of any type of cancer |
328 (102) |
82 (45) |
Case:18.15 ± 10.2 Control: 20.33 ±14.9 |
U4, L4, U5, L5, U2, L1, L2 |
31,1%/54,90% |
AXIN2, FGF3, FGF10, FGFR2 |
Structured questionnaire and clinical and X-rays evaluations |
Student's t test, OR, X2, Fisher's exact tests |
Individuals with tooth agenesis had an increased prevalence of having a family history of cancer OR = 2.7; 95% C.I., 1.6-4.4). A significant association between AXIN2, FGF3, FGF10, and FGFR2 and tooth agenesis was found. |