Dental and maxillomandibular incidental findings in panoramic radiography among individuals with mucopolysaccharidosis: a cross-sectional study

CARNEIRO, Natália Cristina Ruy; ABREU, Lucas Guimarães; MILAGRES, Roselaine Moreira Coelho; AMARAL, Tania Mara Pimenta; FLORES-MIR, Carlos; PORDEUS, Isabela Almeida; BORGES-OLIVEIRA, Ana Cristina

doi:10.1590/1678-7757-2020-0978

Acessibilidade / Reportar erro

Brasil

Journal of Applied Oral Science

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

Original Article • J. Appl. Oral Sci. 29 • 2021 • https://doi.org/10.1590/1678-7757-2020-0978 copy

Dental and maxillomandibular incidental findings in panoramic radiography among individuals with mucopolysaccharidosis: a cross-sectional study

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Mucopolysaccharidosis (MPS) is a group of rare and inherited metabolic disorders caused by the accumulation of macromolecule glycosaminoglycans inside lysosomes. Affected individuals may have dental and craniofacial tissue alterations, facilitating the development of several oral diseases.

Objectives

To assess, with panoramic radiographic images, the frequency of dental and maxillomandibular incidental findings among MPS individuals and compare them with non-MPS individuals.

Methodology

A cross-sectional study evaluating a sample of 14 MPS individuals and 28 non-MPS individuals aged from 5 to 26 years was carried out. They were matched for sex and age on a 2:1 proportion. Panoramic radiographs were assessed for the presence/absence of the following dental and maxillomandibular alterations: dental anomalies of number (hypodontia/dental agenesis, supernumerary teeth); anomalies of form (microdontia, macrodontia, conoid teeth, taurodontism, and root dilaceration); anomalies of position (impacted tooth, inverted tooth, tooth migration, partially bony teeth, complete bony teeth); periapical alterations (furcation lesion, circumscribed bone rarefaction); other alterations (radiolucent bone lesions, radiopaque bone lesions, radiopacity in the maxillary sinus, condylar hypoplasia). Differences between groups were tested by the Fisher’s exact test and chi-square test (p<0.05).

Results

For intrarater agreement, Kappa values were 0.76 to 0.85. The presence of supernumerary teeth (p=0.003); conoid teeth (p=0.009); taurodontism (p<0.001); impacted teeth (p<0.001); partial bony teeth (p=0.040); complete bony teeth (p=0.013); and root dilaceration (p=0.047) were statistically more frequent in MPS individuals compared to non-MPS individuals. Bone rarefaction/furcation lesions (p=0.032), condylar hypoplasia (p<0.001), radiolucent bone lesions (p=0.001), and dentigerous cysts (p=0.002) were also more frequent in MPS individuals.

Conclusion

The presence of specific oral manifestations is more common in MPS individuals than non-MPS individuals.

Mucopolysaccharidosis; Rare diseases; Dental care for the disabled; Tooth abnormalities

	GROUP
Dental abnormalities	MPS individuals	Non-MPS individuals	Odds ratio (Confidence Interval)	p Value
	n (%)	n (%)
ANOMALIES OF NUMBER
Hypodontia (Dental Agenesis)				0.647^a
Presence	4 (28.6)	8 (28.6)	1.00 [0.24-4.13]
Absence	10 (71.4)	20 (71.4)
Supernumerary teeth				0.003^a
Presence	7 (50.0)	2 (7.1)	3.66 [1.74-7.72]
Absence	7 (50.0)	26 (92.9)
ANOMALIES OF FORM
Microdontia				0.100^a
Presence	3 (21.4)	1 (3.6)	7.36 [0.68-78.71]
Absence	11 (78.6)	27 (96.4)
Conoid teeth				0.009^a
Presence	4 (28.6)	0	3.80 [2.32-6.46]
Absence	10 (71.4)	28 (100)
Taurodontism				<0.001^a
Presence	8 (57.1)	1 (3.6)	4.88 [2.28-10.45]
Absence	6 (42.9)	27 (96.4)
ANOMALIES OF POSITION
Impacted Teeth				<0.001^a
Presence	11 (78.6)	6 (21.4)	13.44 [2.81-64.20]
Absence	3 (21.4)	22 (78.6)
Inverted teeth				0.333^a
Presence	1 (7.1)	0	3.15 [2.01-4.94]
Absence	13 (92.9)	28 (100)
Migration
Presence	1 (7.1)	0		0.500^a
Absence	13 (92.9)	28 (100)	3.15 [2.01-4.94]	0.500^a
Partial bony teeth				0.040^b
Presence	8 (57.1)	7 (46.7)	4.00 [1.02-15.59]
Absence	6 (42.9)	21 (75)
Complete bony teeth				0.013^b
Presence	9 (64.3)	7(25.0)	5.4 [1.34-21.63]
Absence	5 (35.7)	21 (75.0)
ROOT ALTERATION
Dilaceration				0.047^b
Presence	9 (64.3)	9 (31.1)	3.8 [1.02-14.66]	0.047^b

	GROUP
Maxillomandibular alterations	MPS individuals	Non-MPS individuals	Odds [Confidence Interval]	P Value
	n (%)	n (%)
PERIAPICAL ALTERATIONS
Bone rarefaction (furcation lesions)				0.032^a
Presence	3 (21.4)	0	3.54 [2.14-5.85]
Absence	11 (78.6)	28 (100)
Circumscribed bone rarefaction				0.333^a
Presence	1 (7.1)	0	3.15 [2.01-4.94]
Absence	13 (92.9)	28 (100)
OTHER
Radiolucent bone lesions				0.001^a
Presence	9 (64.3)	3 (10.7)	15.00 [2.96-75.91]
Absence	5 (35.7)	25 (89.3)
Diagnostic hypothesis for radiolucent bone lesions
Dentigerous cyst	8 (57.1)	3 (10.7)	11.11 [2.24-54.94]	0.002^a
Absence	6 (42.9)	25 (89.3)		0.002^a
Radiopacity in the maxillary sinus				0.374^b
Presence	7 (50.0)	10 (35.7)	1.80 [0.49-6.61]
Absence	7 (50.0)	18 (64.3)
Condylar Hypoplasia				<0.001^a
Presence	14 (100)	1 (3.6)	0.06 [0.01-0.44]
Absence	0	27 (96.4)

Faculdade De Odontologia De Bauru - USP Serviço de Biblioteca e Documentação FOB-USP, Al. Dr. Octávio Pinheiro Brisolla 9-75, 17012-901 Bauru SP Brasil, Tel.: +55 14 32358373 - Bauru - SP - Brazil
E-mail: jaos@usp.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Corresponding address: Natália Cristina Ruy Carneiro Universidade Federal de Minas Gerais - Faculdade de Odontologia, Departamento de Saúde Bucal da Criança e do Adolescente - Belo Horizonte, Brasil - Av. Antônio Carlos, 6627 - Campus Pampulha - 31270-901 -Belo Horizonte - MG - Brasil. e-mail: nataliacrcarneiro@hotmail.com