Chemical investigation on the cultures of the fungus Marasmiellus ramealis resulted in the first isolation of eleven compounds including two new eudesmane-type sesquiterpenoids 14(10→1)abeo-eudesmane-13-hydroxyl-11-ene, 14(10→1)abeo-eudesmane-11,13-diol, and the new mellein derivative (R)-(–)-5-ethoxycarbonyl mellein. The first two compounds were evaluated for their inhibitory activity against acetylcholinesterase (AChE), and proved to be active with a percentage inhibition of 29 and 41%, respectively, at a concentration of 100 μmol L-1.
Marasmiellus ramealis (Bull.) Singer; eudesmane; sesquiterpenoids; mellein; AChE inhibition