Anacardiaceae |
|
|
|
|
Schinus terebinthifolius Raddi |
SNI animals mechanical sensitivity cold hyperalgesia |
oral |
10-100 |
116 |
Annonaceae |
|
|
|
|
Duguetia lanceolata A. St.-Hil. |
acetic acid formalin test (phases I and II) |
intraperitoneal |
1-200 |
117,118 |
Xylopia laevigata (Mart.) R. E. Fr. |
acetic acid formalin test (phases I and II) |
intraperitoneal |
12.5-50 |
119 |
Apiaceae |
|
|
|
|
Bunium persicum (Boiss.) B. Fedtsch. |
acetic acid formalin test (phases I and II) |
oral |
100-400
|
120 |
acetic acid opioidergic and histamine H1 and H2 receptors |
oral |
100-400
|
121 |
Carum copticum (L.) Benth. & Hook. f. ex C. B. Clarke |
formalin test (phases I and II) |
intraperitoneal |
20 |
122 |
Cuminum cyminum L. |
formalin test (phases I and II) tail flick |
intraperitoneal |
0.0125-2c |
123 |
Distichoselinum tenuifolium (Lag.) F. García Mart. & Silvestre |
acetic acid hot plate formalin test (phases I and II) |
oral |
25-75 |
124 |
Heracleum persicum Desf. ex Fisch., C. A. Mey. & Avé-Lall. |
acetic acid formalin test (phase II) |
oral |
50-100 |
125 |
Pimpinella anisum L. |
tail flick formalin test (phases I and II) |
intraperitoneal |
125-250 |
126 |
Asteraceae |
|
|
|
|
Achillea aleppica DC. |
4-benzoquinona |
intraperitonal |
200 |
127 |
Ageratum fastigiatum (Gardner) R. M. King & H. Rob. |
acetic acid hot plate formalin test (phases I and II) |
intraperitonal |
100-200 |
128 |
Artemisia absinthium L. |
acetic acid formalin test hot plate |
intraperitonal |
2-8 |
129 |
Artemisia dracunculus L. |
acetic acid formalin test hot plate |
intraperitonal |
10-300 |
130 |
Vanillosmopsis arborea (Gardner) Baker |
mustard model visceral nociception |
intraperitonal |
5-50 |
131 |
|
acetic acid formalin test (phase I and II) |
intraperitonal |
5-50 |
131,132 |
Burseraceae |
|
|
|
|
Protium heptaphyllum (Aubl.) Marchand |
formalin test (phases I and II) hot plate capsaicin tail flick |
oral |
50-100 |
133 |
Cyperaceae |
|
|
|
|
Cyperus esculentus L. |
formalin test (phases I and II) |
oral |
250-500 |
134 |
Cyperus rotundus L. |
formalin test (phases I and II) |
oral |
250-500 |
134 |
Remirea maritima Aubl. |
acetic acid formalin test (phases I and II) |
oral |
50-200 |
135 |
Euphorbiaceae |
|
|
|
|
Croton adamantinus Müll. Arg. |
acetic acid formalin test |
oral |
10-100 |
136 |
Croton cordiifolius Baill. |
acetic acid formalin test (phases I and II) glutamate capsaicin evaluation of opioid involvement |
intraperitoneal |
50-100 |
137 |
Croton nepetaefolius Baill. |
acetic acid hot plate formalin test (phases I and II) capsaicin |
oral |
30-300 |
138 |
Croton sonderianus Müll. Arg. |
acetic acid capsaicin formalin test (phases I and II) opioid system potassium channels |
oral |
50-200 |
69 |
Lamiaceae |
|
|
|
|
Hyptis pectinata (L.) Poit. |
acetic acid hot plate opioid mechanism |
intraperitoneal |
10-100 |
139,140 |
Lavandula angustifolia Mill. |
acetic acid formalin test (phase I and II) |
oral |
50 and 200 |
141 |
Lavandula hybrida Balb. ex Ging. |
acetic acid hot plate opioid mechanism cholinergic system |
oral |
100 |
142 |
Melissa officinalis L. |
formalin test (phases I and II) |
oral |
0.01, 0.02 and 0.04 |
143 |
Mentha × villosa Huds. |
acetic acid formalin test (phase II) |
oral |
100-200 |
144 |
Nepeta cataria L. |
tail immersion acetic acid |
intraperitoneal |
0.0005 and 0.001
|
145 |
Nepeta crispa Willd. |
tail flick formalin test (phases I and II) |
intraperitoneal |
30-200 |
146 |
Nepeta pogonosperma Jamzad & Assadi |
tail flick formalin test (phases I and II) |
intraperitoneal |
50-200 |
147 |
|
acetic acid hot plate opioid system formalin test (phase I and II) |
subcutaneous |
50-200 |
148 |
Ocimum basilicum L. |
formalin test (phase I and II) capsaicin glutamate |
intraperitoneal |
50-200 |
149 |
Ocimum gratissimum L. |
acetic acid formalin test |
oral |
30-300 |
150 |
hot plate formalin test (phase I and II) |
oral |
10-40 |
151 |
Ocimum micranthumWilld. |
acetic acid formalin test (phase I and II) |
oral |
15-100 |
152 |
acetic acid formalin test (phase II) via NO |
oral |
1-10 |
153 |
|
PFIR (pain-induced functional impairment model) opioid and serotoninergic systems |
oral |
50-200 |
154 |
Rosmarinus officinalis L. |
acetic acid hot plate |
oral |
70-500 |
155 |
|
acetic acid formalin test (phases I and II) hot plate |
oral |
10-300 |
156 |
Satureja hortensis L. |
formalin test (phases I and II) acetic acid opioid and adenosinergic system |
oral |
50-200 |
157 |
|
acetic acid formalin test (phase II) |
intraperitoneal |
100-400
|
158 |
Teucrium polium L. |
acetic acid |
intraperitoneal |
9.37-150 |
159 |
|
tail flick |
intraperitoneal |
100-200 |
160 |
Vitex agnus-castus L. |
tail immersion test formalin test (phases I and II) acetic acid |
subcutaneous |
50-62.5 |
161 |
Vitex negundo L. |
acetic acid hot plate |
oral |
150-250 |
162 |
Zataria multiflora Boiss. |
acetic acid formalin test (phase I and II) |
intraperitoneal |
0.3
|
163 |
Myrtaceae |
|
|
|
|
Eucalyptus camaldulensis Dehnh. |
hot plate tail flick opioid system |
intraperitoneal |
0.3 |
164 |
Eucalyptus citriodora Hook. |
acetic acid hot plate |
intraperitoneal |
50 |
165 |
Eucalyptus globulus Labill. |
acetic acid hot plate |
intraperitoneal |
0.1-100 |
165 |
Eucalyptus tereticornis Sm. |
acetic acid hot plate |
intraperitoneal |
0.1-100 |
165 |
Eugenia candolleana DC. |
acetic acid formalin test (phase II) |
intraperitoneal |
25, 50 and 100 |
166 |
Eugenia uniflora L. |
acetic acid hot plate |
oral |
100 and 200 |
21 |
Myrcia ovata Cambess. |
acetic acid formalin test (phase II) tail flick |
oral |
200-300 |
167 |
Ugni myricoides (Kunth) O. Berg |
carragenan-induced mechanical hypernociception complete Freundʼs adjuvant (CFA) |
oral |
5-50 |
168 |
Piperaceae |
|
|
|
|
Peperomia serpens (Sw.) Loud. |
acetic acid hot plate formalin test (phases I and II) |
oral |
62.5-500 |
169 |
Piper aleyreanum C. DC. |
formalin test opioid mechanism studies |
oral |
10-100 |
170 |
Poaceae |
|
|
|
|
Chrysopogon zizanioides (L.) Roberty |
acetic acid formalin test (phase II) hot plate |
intraperitoneal |
50-100 |
171 |
Cymbopogon citratus (DC.) Stapf |
hot plate acetic acid formalin test (phases I and II) opioid system |
oral or intraperitoneal |
5-100 |
172 |
Cymbopogon nardus (L.) Rendle |
hot plate acetic acid tail flick |
oral |
0.5-4.0 |
173 |
Cymbopogon winterianus Jowitt |
hot plate acetic acid formalin test (phases I and II) |
oral |
50-200 |
174 |
Ranunculaceae |
|
|
|
|
Nigella sativa L. |
hot plate tail-pinch acetic acid formalin test (phase I) indirect activation of the supraspinal μ1- and k-opioid receptor |
oral |
50-400 |
175 |
Rutaceae |
|
|
|
|
Choisya ternata Kunth |
acetic acid hot plate |
oral |
3-30 |
176 |
formalin test (phases I and II) |
oral |
3-30 |
177 |
Citrus bergamia Risso & Poit. |
capsaicin opioid system |
intraplantar |
10-20 |
178 |
Citrus limon (L.) Osbeck |
acetic acid opioid system |
oral |
50-150 |
179 |
Verbenaceae |
|
|
|
|
Lippia gracilisSchauer |
acetic acid |
oral |
50-200 |
180 |
acetic acid hot plate formalin test (phases I and II) via NO and cholinergic and opioid systems |
oral |
10-300 |
181 |
Lippia grata Schauer |
formalin test (phases I and II) glutamate capsaicin |
oral |
6-24 |
182 |
Lippia sidoides Cham. |
acetic acid hot plate |
subcutaneous |
100-400 |
183 |
Zingiberaceae |
|
|
|
|
Alpinia zerumbet (Pers.) B. L. Burtt & R. M. Sm. |
acetic acid hot plate formalin test opioid system |
oral |
100-300 |
184 |
Zingiber zerumbet (L.) Roscoe ex Sm. |
acetic acid capsaicin glutamate PMA (intraperitoneal) activation of L -arginine/NO, cGMP, protein kinase C, ATP-sensitive K+ channel pathway |
intraperitoneal and oral |
50-300 |
185,186 |
|
acetic acid formalin test (phase I and II) hot plate opioid system |
intraperitoneal |
30-300 |
187,1 |