Profile of Nandrolone-Based Anabolic Steroids Confiscated by Federal Police of Foz do Iguaçu, Paraná, Brazil

Schuviecersk, Fabíola Z.; Silva, Maria Luiza R.; Baghdadi, Ala; Wöhlke, Jonathan Luiz; Freitas, Fernando A.; Toci, Aline T.

doi:10.21577/0103-5053.20240205

Brasil

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Article • J. Braz. Chem. Soc. 36 (2) • 2025 • https://doi.org/10.21577/0103-5053.20240205 linkcopy

Profile of Nandrolone-Based Anabolic Steroids Confiscated by Federal Police of Foz do Iguaçu, Paraná, Brazil

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Abstract

Abstract

Anabolic steroids are often consumed by both amateur and professional sports practitioners with the aim of improving their performance and for the rapid gain of muscle mass. Nandrolone is one of the main steroids consumed and is, frequently, acquired illegally or from dubious sources, and this raises serious concerns regarding the quality of the products. This work sought to qualitatively and quantitatively evaluates oily, nandrolone-based anabolic steroids confiscated by the Federal Police Department, in the triple border (Paraguay-Brazil-Argentina, PY-BR-AR). For the quantitative study, we conducted a methodological validation analysis based on the application of solvent extraction and GC-MS (gas chromatography-mass spectrometry). A total of 40 samples of nandrolone steroids (as described on the label) were thoroughly investigated. The results obtained showed that 90% of the samples analyzed contained the active ingredient but 67.5% of these samples exhibited concentrations below the values indicated on the label; these products are thus considered to be of low quality and their consumption may pose serious risks to the consumers. The findings of this study point to the importance of enforcing regulatory controls on the sale of anabolic steroids with a view to inhibiting the consumption of counterfeit drugs that can pose serious risks to the health of consumers.

Keywords:
nandrolone; oily anabolic steroids; smuggled drugs; GC-MS; analytical method validation

Analyte	Retention time / min	Target ion / m/z
Sibutramine (IS)	15.70	114^a a Base peak; m/z: mass/charge ratio. IS: internal standard.
Nandrolone decanoate	47.77	110,^a a Base peak; m/z: mass/charge ratio. IS: internal standard. 91, 274

Range / (µg mL^-1)	r	R²	Linear equation	LOD / (µg mL^-1)	LOQ / (µg mL^-1)	Level / (µg mL^-1)	RSD (n = 6) / %	Recovery (n = 3) / %
200-450	0.9933	0.9867	y = 0.0178x - 2.5119	50.97	72.77	200	0.31	94.6
						250	3.52	94.6
						300	1.65	90.5
						350	4.72	90.5
						400	3.95	93.6
						450	3.42	93.6

Sample	Declared origin (company/country)	Declared ester	Measured concentration^a a (± value) = standard deviation; / (mg mL^-1)	Expected concentration^b b found on the label. / (mg mL^-1)	Sample	Declared origin (company/country)	Declared ester	Measured concentration^a a (± value) = standard deviation; / (mg mL^-1)	Expected concentration^b b found on the label. / (mg mL^-1)
1	1/not declared	nandrolone decanoate	no active ingredients	250	21	7/Paraguay	nandrolone decanoate	204.2 ± 0.3	200
2	1/not declared	nandrolone decanoate	no active ingredients	200	22	7/Paraguay	nandrolone decanoate	207.3 ± 0.3	200
3	not declared/not declared	nandrolone decanoate	95.9 ± 0.3	100	23	7/Paraguay	nandrolone decanoate	116.3 ± 0.3	200
4	2/Mexico	nandrolone decanoate	136.1 ± 0.3	300	24	7/Paraguay	nandrolone decanoate	103.7 ± 0.3	200
5	2/Mexico	nandrolone decanoate	137.7 ± 0.5	300	25	7/Paraguay	nandrolone phenylpropionate	49.8 ± 0.4	100
6	2/Mexico	nandrolone decanoate	132.7 ± 0.3	300	26	7/Paraguay	nandrolone decanoate	194.2 ± 0.3	200
7	2/Mexico	nandrolone decanoate	134.1 ± 0.3	300	27	7/Paraguay	nandrolone decanoate	101.9 ± 0.3	200
8	2/Mexico	nandrolone decanoate	drostanolone	300	28	7/Paraguay	nandrolone decanoate	134.1 ± 0.3	200
9	3/India	nandrolone phenylpropionate	63.1 ± 0.3	100	29	7/Paraguay	nandrolone phenylpropionate	57.6 ± 0.3	100
10	4/India	nandrolone decanoate	93.1 ± 0.7	300	30	7/Paraguay	nandrolone decanoate	120.2 ± 0.7	200
11	4/India	nandrolone decanoate	103.7 ± 0.3	100	31	7/Paraguay	nandrolone decanoate	81.8 ± 0.3	200
12	5/India	nandrolone decanoate	142.2 ± 0.4	250	32	7/Paraguay	nandrolone decanoate	147.2 ± 0.3	200
13	5/India	nandrolone phenylpropionate	75.7 ± 0.3	100	33	7/Paraguay	nandrolone decanoate	120.1 ± 0.4	200
14	5/India	nandrolone decanoate	197.5 ± 0.3	200	34	7/Paraguay	nandrolone phenylpropionate	104.6 ± 0.3	100
15	6/Paraguay	nandrolone decanoate	103.8 ± 0.3	200	35	7/Paraguay	nandrolone decanoate	112.4 ± 0.3	200
16	7/Paraguay	nandrolone phenylpropionate	drostanolone	100	36	7/Paraguay	nandrolone decanoate	127.2 ± 0.6	200
17	7/Paraguay	nandrolone decanoate	102.7 ± 0.3	200	37	7/Paraguay	nandrolone decanoate	113.5 ± 0.3	200
18	7/Paraguay	nandrolone decanoate	100.4 ± 0.3	200	38	7/Paraguay	nandrolone decanoate	130.6 ± 0.3	200
19	7/Paraguay	nandrolone decanoate	88.3 ± 0.5	200	39	7/Paraguay	nandrolone decanoate	129.8 ± 0.3	200
20	7/Paraguay	nandrolone phenylpropionate	96.3 ± 0.3	100	40	7/Paraguay	nandrolone phenylpropionate	105.8 ± 0.3	100

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[TFN1] ^a
Base peak; m/z: mass/charge ratio. IS: internal standard.