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Articles • J. Braz. Chem. Soc. 9 (4) • Aug 1998 • https://doi.org/10.1590/S0103-50531998000400010   copy

Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones

Authorship SCIMAGO INSTITUTIONS RANKINGS

The preparation of 3-substituted 1,4-benzodiazepines by benzodiazepine enolate alkylation has been explored. Employing this approach, multigram quantities of benzodiazepine 1 have been prepared for animal studies to evaluate a new approach for the treatment of the autoimmune disease systemic lupus erythematosus (SLE).

benzodiazepine enolate-alkylation; systemic lupus erythematosus

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