Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127^®

Binary mixtures of block copolymers E₁₁₄CL₂₀ and E₉₇P₆₉E₉₇ (F127(^®)) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic drug solubility in F127/E₁₁₄CL₂₀ mixtures (30-50 wt.%) were observed by addition of the diblock E₁₁₄CL₂₀, also reaching the best enhancement of drug solubility for mangiferin and carbamazepine.

Keywords:
poly(ε-caprolactone)-poly(ethylene oxide); binary mixtures; synergistic effect; drug solubility