Figure 1
Fourier transform infrared spectra (ATR) of azathioprine. The colors indicate the assignments corresponding to the functions in the molecule.
Figure 2
Fourier transform infrared spectra (ATR) of azathioprine (AZA), starch (ST), AZA + ST binary, colloidal silicon dioxide (SiO2c), AZA + SiO2c binary, talc (TA), AZA + TA binary, mannitol (MA), AZA + MA binary, stearic acid (SA), AZA + SA binary, magnesium stearate (MS) and AZA + MS binary. The broken x-axis at 2700-1780 cm-1 stands for better viewing.
Figure 3
(a) Diffraction pattern of azathioprine fitted by the Rietveld analysis. The green sticks correspond to the permitted Bragg reflections for the angular range of 5 up to 50º 2θ, black dots correspond to the experimental data points, the red line corresponds to the Rietveld fitting, and the blue line corresponds to the difference between experimental and fitted point; (b) azathioprine crystal habit showing the Miller index identification in each face.
Figure 4
Diffraction pattern of azathioprine (AZA), starch (ST), AZA + ST binary, colloidal silicon dioxide (SiO2c), AZA + SiO2c binary, talc (TA), AZA + TA binary, mannitol (MA), AZA + MA binary, stearic acid (SA), AZA + SA binary, magnesium stearate (MS) and AZA + MS binary.
Figure 5
Thermogravimetry (red)/derivative thermogravimetry (pink) with simultaneous differential thermal analysis (dark cyan) curves of azathioprine under a dynamic atmosphere in nitrogen (left) and air (right) at 50 mL min-1.
Figure 6
Differential scanning calorimetry curves of azathioprine (AZA) at heating rates of 2, 6, 10, 20, and 50 °C min-1.
Figure 7
Differential scanning calorimetry curves of azathioprine (AZA), starch (ST), AZA + ST binary, colloidal silicon dioxide (SiO2c), AZA + SiO2c binary, talc (TA), AZA + TA binary, mannitol (MA), AZA + MA binary, stearic acid (SA), AZA + SA binary, magnesium stearate (MS), AZA + MS binary.
Figure 8
Thermogravimetry curves of azathioprine (AZA), AZA + mannitol (AZA + MA) binary, AZA + stearic acid (AZA + SA) binary, AZA + magnesium stearate (AZA + MS) binary, under a dynamic atmosphere at 50 mL min-1, rate heating 10 °C min-1.
Figure 9
Experimental data of the decomposition fraction, α, for azathioprine showing the (a) complete phenomenon (0 < α < 1) and the two steps of the phenomenon between (b) 0 < α < 0.5 and (c) 0.5 < α < 1.
Figure 10
Experimental data of the decomposition fraction, α, for azathioprine and mannitol (AZA + MA).
Figure 11
Experimental data of the decomposition fraction, α, for azathioprine and stearic acid (AZA + SA) showing the (a) complete phenomenon (0 < α < 1) and the two parts of the phenomenon between (b) 0 < α < 0.75 and (c) 0.75 < α < 1.
Figure 12
Experimental data of the decomposition fraction, α, for azathioprine and magnesium stearate (AZA + MS) showing the (a) complete phenomenon (0 < α < 1) and the two parts of the phenomenon between (b) 0 < α < 0.25 and (c) 0.25 < α < 1.
Figure 13
Activation energy (Ea) of the thermal decomposition process, initial temperature and the correponding degree of conversion (α) for azathioprine (AZA, green), AZA + mannitol (AZA + MA, blue) binary, AZA + stearic acid (AZA + SA, yellow) binary, AZA + magnesium stearate (AZA + MS, pink) binary.
Figure 14
Kenichi Fukui functions for azathioprine, f(0) standing for a probability surface of reactivity with a radical attack (a); probability surface of responsiveness with an electrophilic attack (b); probability surface of reactivity with a nucleophilic attack (c); and the total electron density surface as numerical integration from the Hirshfeld surface analysis (d).
Figure 15
Kenichi Fukui functions for mannitol, f(0) standing for a probability surface of reactivity with a radical attack (a); probability surface of responsiveness with an electrophilic attack (b); probability surface of reactivity with a nucleophilic attack (c); and the total electron density surface as numerical integration from the Hirshfeld surface analysis (d).