Chemical Constituents from Cultures of the Fungus <i>Marasmiellus
                  ramealis</i> (Bull.) Singer

Yang, Ningning; Ma, Qingyun; Huang, Shengzhuo; Dai, Haofu; Guo, Zhikai; Lu, Xuehua; Wang, Yuguang; Yu, Zhifang; Zhao, Youxing

doi:10.5935/0103-5053.20140206

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Articles • J. Braz. Chem. Soc. 26 (1) • Jan 2015 • https://doi.org/10.5935/0103-5053.20140206 copy

Chemical Constituents from Cultures of the Fungus Marasmiellus ramealis (Bull.) Singer

Authorship SCIMAGO INSTITUTIONS RANKINGS

Chemical investigation on the cultures of the fungus Marasmiellus ramealis resulted in the first isolation of eleven compounds including two new eudesmane-type sesquiterpenoids 14(10→1)abeo-eudesmane-13-hydroxyl-11-ene, 14(10→1)abeo-eudesmane-11,13-diol, and the new mellein derivative (R)-(–)-5-ethoxycarbonyl mellein. The first two compounds were evaluated for their inhibitory activity against acetylcholinesterase (AChE), and proved to be active with a percentage inhibition of 29 and 41%, respectively, at a concentration of 100 μmol L^-1.

Marasmiellus ramealis (Bull.) Singer; eudesmane; sesquiterpenoids; mellein; AChE inhibition

No.	1		2
No.	δ ¹H	δ ¹³C	δ ¹H	δ ¹³C
1	-	75.1	-	75.3
2	1.54 (ß-H), 1.89 (α-H), m, 2H	36.9	1.23, 1.90, m, 2H	31.7
3	1.28, 1.68, m, 2H	31.7	1.23, 1.46, m, 2H	30.7
4	2.00, m, 1H	39.5	2.00, m, 1H	39.2
5	2.03, m, 1H	46.4	2.06, m, 1H	47.4
6	1.13, 1.45, m, 2H	30.1	1.45, 1.90, m, 2H	26.3
7	2.26, m, 1H	42.3	1.88, m, 1H	43.1
8	1.87, m, 2H	29.9	1.73 (ß-H), 1.47 (α-H), m, 2H	24.5
9	1.53, 1.70, m, 2H	26.7	1.79, 1.73, m, 2H	21.1
10	2.11, m, 1H	55.4	2.08, m, 1H	55.8
11	-	156.9	-	76.2
12	4.93, dd, 1H, J 1.5, 2.1 Hz;	106.7	0.98, s, 3H	17.9
	4.81, dd, 1H, J 1.5, 2.1 Hz
13	4.02, s, 2H	64.6	3.33, d, 1H, J 11.4 Hz;	68.4
			3.58, d, 1H, J 11.4 Hz
14	1.16, s, 3H	29.2	1.15, s, 3H	32.2
15	0.86, s, 3H	16.4	0.95, s, 3H	16.5

No.	δ ¹H	δ ¹³C
1	-	170.2
3	4.66, m, 1H	75.8
4	3.88, dd, 1H, J 3.1, 17.9 Hz;	32.7
	3.04, dd, 1H, J 11.9, 17.9 Hz
4a	-	143.5
5	-	119.1
6	8.13, d, 1H, J 9.0 Hz	138.6
7	6.93, d, 1H, J 9.0 Hz	116.3
8	-	165.5
8a	-	109.0
9	1.55, d, 3H, J 6.4 Hz	20.9
10	-	165.9
11	4.32, q, 2H, J 7.1 Hz	61.1
12	1.38, t, 3H, J 7.1 Hz	14.4

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