Figure 1
Published documents involving the terms “multicomponent” and “asymmetric” since 1970 (source Scopus database, accessed on March 06, 2023).
Scheme 1
The Strecker reaction.
Scheme 2
L-Alanine synthesis through a Strecker diastereoisomeric reaction.
Scheme 3
Diasteroselective Strecker reaction using a chiral auxiliary.
Scheme 4
Diasteroselective Strecker reaction using a bulky chiral auxiliary.
Scheme 5
Diasteroselective Strecker reaction using chiral amine as chirality inducer.
Scheme 6
Enantioselective two-component Strecker-type reaction.
Scheme 7
Enantioselective synthesis of α-aminonitriles using a chiral zirconium catalyst.
Scheme 8
Titanium(IV) catalyzed enantioselective Strecker-type reaction.
Scheme 9
Oxazaborolidinium catalyzed enantioselective Strecker-type reaction.
Scheme 10
Chiral phosphoric acid catalyzed asymmetric Strecker reaction.
Scheme 11
Chiral phosphoric acid catalyzed enantioselective Strecker-type reaction using hydrazones.
Scheme 12
Catalytic asymmetric acyl-Strecker reaction by chiral thiourea inductor.
Scheme 13
Enantioselective Strecker-type reaction of cyclic N-acyl trifluoromethylketimines.
Scheme 14
The Mannich reaction.
Scheme 15
Enantioselective Mannich reaction catalyzed by a rhodium complex.
Scheme 16
Proposed catalytic cycle for the asymmetric three-component Mannich reaction using a rhodium complex.
Scheme 17
Enantioselective L-proline catalyzed Mannich reaction.
Scheme 18
Mannich reaction catalyzed by a bifunctional cinchona-thiourea organocatalyst.
Scheme 19
Enantioselective Mannich-type reaction of 3-substituted oxindoles catalyzed by a thiourea-phosphine organocatalyst.
Scheme 20
Cinchona alkaloid catalyzed enantioselective Mannich-type reaction of 3-fluorooxindoles and cyclic N-sulfamidate aldimines.
Scheme 21
Enantioselective Mannich-type reactions of pyruvates and cyclic sulfonylimines catalyzed by a cinchona-alkaloid and 2-nitrobenzoic acid.
Scheme 22
Chiral squaramide catalyzed synthesis of enantioenriched 1,3,4-thiadiazole derivatives.
Scheme 23
Phosphoric acid catalyzed Mannich-type reaction between azlactones and aldimines.
Scheme 24
Stereoselective Mannich-type reaction for the enantioselective preparation of 1,3-diamines.
Scheme 25
Proposed mechanism for the phosphoric acid catalyzed preparation of chiral 1,3-diamines.
Scheme 26
Enantioselective preparation of 2-substituted indolin-3-ones using a chiral phosphoric acid catalyst.
Scheme 27
Anti-selective asymmetric Mannich reaction using a chiral phosphoric acid catalyst.
Scheme 28
(S)-3-Pyrrolidine carboxylic acid catalyzed anti-selective Mannich-type reaction.
Scheme 29
Asymmetric decarboxylative Mannich-type reaction between N-unprotected ketimines and β-keto acids.
Scheme 30
The Passerini reaction.
Scheme 31
Enantioselective Passerini reaction catalyzed by a titanium complex.
Scheme 32
Enantioselective Passerini reaction catalyzed by a chiral cooper complex.
Scheme 33
Enantioselective Passerini reaction catalyzed by a chiral aluminum complex.
Scheme 34
Phosphoric acid catalyzed enantioselective Passerini reaction.
Scheme 35
Diastereoselective Passerini reaction using chiral aldehydes.
Scheme 36
Diastereoselective Passerini reaction using cyrene.
Scheme 37
Diastereoselective Passerini Reaction using sugar-based aldehydes.
Scheme 38
The Ugi reaction.
Scheme 39
Asymmetric four-center three-component Ugi reaction.
Scheme 40
Chiral dicarboxylic acid catalyzed asymmetric Ugi-type reaction.
Scheme 41
Organocatalytic enantioselective three- and four-component Ugi-type reaction.
Scheme 42
Diastereoselective Ugi three-component reaction employing chiral ketimines.
Scheme 43
Organocatalyzed enantioselective three-component Ugi-type reaction.
Scheme 44
Enantioselective four-center three-component Ugi reaction.
Scheme 45
Possible reaction pathway for the four-center three-component Ugi reaction.
Scheme 46
Enantioselective Ugi four-component reaction using chiral phosphoric acids.
Scheme 47
Phosphoric acid catalyzed preparation of enantioenriched α-aminoamides.
Scheme 48
Proposed mechanism for the three-component asymmetric Ugi-type reaction.
Scheme 49
Bifunctional cinchona alkaloid squaramide catalyzed two-component Ugi-Type reaction.
Scheme 50
Dimers obtained by CPA catalysis in double-Ugi reactions.
Scheme 51
Chiral cobalt(III) catalyzed Ugi and Ugi-azide reactions.
Scheme 52
Proposed catalytic cycle (and favored transition state) for Ugi and Ugi-azide reactions catalyzed by a chiral cobalt(III) complex.