Liposome |
iminosugars/polyunsaturated ER-targeting liposomes |
improvement in the effective dose of antiviral and enhancement of the drug retention (blood) |
2727 Miller, J. L.; Lachica, R.; Sayce, A. C.; Williams, J. P.; Bapat, M.; Dwek, R.; Zitzmann, N.; Antimicrob. Agents Chemother.
2012, 56, 6379.
|
Solid lipid nanoparticle |
baicalein (flavonoid)/lipidic matrix |
controlled release of the antiviral |
3131 Yumei, L.; Kun, Z.; Haiming, M.; Pract. Pharm. Clin. Remedies
2009, 12, 104.
|
Nanostructured lipid carriers |
baicalein (flavonoid)/tocol |
increase the half-life than administration of free antiviral |
3232 Tsai, M. J.; Wu, P. C.; Huang, Y. B.; Chang, J. S.; Lin, C. L.; Tsai, Y. H.; Fang, J. Y.; Int. J. Pharm.
2012, 423, 461.
|
Nanoemulsion |
essential oils (from Rosmarinus officinalis, Ocimum basilicum L.)/surfactants (polysorbate 20; Tween 20) |
kill the mosquito larva of Aedes aegypti
|
3434 Ghosh, V.; Mukherjee, A.; Chandrasekaran, N.; Asian J. Chem.
2013, 25, S321.
,
3535 Duarte, J. L.; Amado, J. R.; Oliveira, A. E.; Cruz, R. A.; Ferreira, A. M.; Souto, R. N.; Fernandes, C. P.; Rev. Brasil. Farmacogn.
2015, 25, 189.
|
Polymeric NP |
poly(lactide-co-glycolide) (PLGA), poly(D,L-lactic acid) (PLA), polyglycolide, polycaprolactone (PCL), poly(D,L-lactide), PLGA-polyethylene glycol (PEG) |
NPs may inhibit the viral attachment to cells |
3636 Prabhu, R. H.; Patravale, V. B.; Joshi, M. D.; Int. J. Nanomed.
2015, 10, 1001.
37 Jhaveri, A.; Torchilin, V.; Expert Opin. Drug Delivery
2016, 13, 49.
-
3838 Lembo, D.; Cavalli R.; Antiviral Chem. Chemother.
2010, 21, 53.
|
Biopolymeric NP |
NPs composed of chitosan/Mycobacterium bovis Bacillus Calmette-Guerin cell wall components |
development of a dengue nanovaccine (produced by UV inactivation of DENV-2) |
4040 Hunsawonga, T.; Sunintaboon, P.; Warit, S.; Thaisomboonsuk, B.; Jarmane, R. G.; Yoon, I.-K.; Ubol, S.; Fernandez, S.; Vaccine
2015, 33, 1702.
|
Protein NP |
bovine serum albumin (BSA) NPs containing the four serotypes of dengue in their inactive form |
vaccine: after administration an induction of anti-DENV IgG antibodies is produced |
3939 Silva, E. F.; Orsi, M.; Andrade, A. L.; Domingues, R. Z.; Silva, B. M.; de Araújo, H. R.; Pimenta, P. F. P.; Diamond, M. S.; Rocha, E. S. O.; Kroon, E. G.; Malaquias, L. C. C.; Coelho, L. F.; J. Nanobiotechnol.
2012, 10, 13.
|
Nanocrystal |
quercetin |
enhance the anti-dengue virus activity of the drug by increasing bioavailability |
5151 Shegokar, R.; Müller, R H.; Int. J. Pharm.
2010, 399, 129.
,
5353 Smith, A. J.; Kavuru, P.; Wojtas, L.; Zaworotko, M. J.; Shytle, R. D.; Mol. Pharmacol.
2011, 8, 1867.
|
|
cellulose |
act as viral inhibitors |
5454 Serizawa, T.; Sawada, T.; Okura, H.; Wada M.; Biomacromolecules
2013, 14, 613.
,
5555 Zoppe, J. O.; Ruottinen, V.; Ruotsalainen, J.; Rönkkö, S.; Johansson, L.-S.; Hinkkanen, A.; Jarvinen, K.; Seppala, J.; Biomacromolecules
2014, 15, 1534.
|
Carbon quantum dot (CQD) |
only CQD or complexed with dsRNA |
cause gene silencing of dengue virus genes and mortality in Aedes aegypti. Inhibition of growth in mosquitoes beyond the larval stage |
1212 Saxena, M.; Sonkar, S. K.; Sarkar, S.; RSC Adv.
2013, 3, 22504.
,
8888 Das, S.; Debnath, N.; Cui, Y.; Unrine, J.; Palli, S. R.; ACS Appl. Mater. Interfaces
2015, 7, 19530.
|
Metallic NP (chemical synthesis) |
gold NPs |
antiviral effect after conjugation of NPs with fragments of proteins |
88 Idrees, S.; Ashfaq, U. A.; Asian Pac. J. Trop. Biomed.
2013, 3, 232.
|
silver NPs |
prevention of the viral binding to host cells by interacting with virus structure |
5959 Elechiguerra, J. L.; Burt, J. L.; Morones, J. R.; Camacho-Bragado, A.; Gao, X.-X.; Lara, H. H.; Yacaman, M. J.; J. Nanobiotechnol.
2005, 3, 6.
|
Metallic NP (green synthesis) |
silver and gold NPs produced by leaf extracts from plants or fungi |
efficacy against mosquito larvae |
6060 Salunkhe, R. B.; Patil, S. V.; Patil, C. D.; Salunke, B. K.; Parasitol. Res.
2011, 109, 823.
61 Soni, N.; Prakash, S.; Parasitol. Res.
2012a, 110, 175.
62 Soni, N.; Prakash, S.; Rep. Parasitol.
2012b, 2, 1.
63 Soni, N.; Prakash, S.; Parasitol. Res.
2012c, 111, 2091.
64 Soni, N.; Prakash, S.; Asian Pacific J. Trop. Dis.
2012d, 2, S356.
65 Soni, N.; Prakash, S.; Adv. Nanopart.
2013, 2, 125.
66 Suganya, A.; Murugan, K.; Kovendan, K.; Kumar, P. M.; Hwang, J. S.; Parasitol. Res.
2013, 112, 1385.
67 Veerakumar, K.; Govindarajan, M.; Hoti, S. L.; Parasitol. Res.
2014, 113, 4567.
68 Veerakumar, K.; Govindarajan, M.; Rajeswary, M.; Muthukumaran, U.; Parasitol. Res.
2014, 113, 1775.
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6969 Veerakumar, K.; Govindarajan, M.; Rajeswary, M.; Muthukumaram, U.; Parasitol. Res.
2014, 113, 2663.
|