AH |
condition |
12.5 mg mL-1 AMX in DMSO, 0.05 M HCl, 25 °C, 1 h |
0.75 mg mL-1 AMX in 0.05 M phosphate buffer pH 5, 1 M HCl, 25 °C, 30 min |
0.2 mg mL-1 AMX in water, 0.5 M HCl, 25 °C, 2 h |
0.5 µg mL-1 AMX in formic acid pH 2, 5 days |
5 µg mL-1 AMX in MeOH/0.02 M phosphate buffer pH 3.5/water 0.5:0.5:1 v/v/v, 0.5 M HCl under reflux, 70 °C, 2 h |
NP |
85.7 µg mL-1 AMX in diluent (not mentioned), 0.014 M HCl under reflux, 60-70 °C, 90 min |
2 mg mL-1 AMX in 0.01 M HCl/ MeCN/KH2PO4 pH 5/MeOH 10:3.75:9.6:1.65 v/v/v/v, 0.1 M HCl, 25 °C, 4 h |
0.5 mg mL-1 AMX in water, 0.5 M HCl, 25 °C, 7 min |
degradation / % |
NI |
9.5 |
7 |
residues of AMX |
20-25 |
|
NI |
26 |
6 |
detected RS |
C, D, E1, E2, G |
D1, D2, C2, I |
NI |
E1, E2 |
NI |
|
1 unknown |
2 unknowns |
D, 5 unknowns |
NH or Me |
condition |
NP |
NP |
0.2 mg mL-1 AMX in water, 50 °C, 3 h |
0.5 µg mL-1 AMX in water, 10 days |
NP |
AMX in MeOH heated for a few minutes |
NP |
NP |
0.5 mg mL-1 AMX in water, 50 °C, 5 min |
degradation / % |
|
13.12 |
NI |
|
NI |
|
5 |
detected RS |
|
NI |
at pH 7: D1, D2; at pH 8: C1, C2, E1, E2; MeOH/water 1:9 v/v: P |
|
P |
|
B, C, D, G, H, J, K, 6 unknowns |
BH |
condition |
NP |
0.75 mg mL-1 AMX in 0.05 M phosphate buffer pH 5, 0.5 M NaOH (time and temperature were not informed) |
0.2 mg mL-1 AMX in water, 0.1 M NaOH, instantly |
0.5 µg mL-1 AMX in NH4OH pH 10, 24 h |
5 µg mL-1 AMX in MeOH/0.02 M phosphate buffer pH 3.5/water 0.5:0.5:1 v/v/v, 0.025 M NaOH under reflux, 70 °C, 2 h |
AMX in aqueous KOH pH 10 heated for a few hours |
85.7 µg mL-1 AMX in 0.014 M NaOH under reflux, 60-70 ºC, 90 min |
2 mg mL-1 AMX in 0.01 M HCl/MeCN/KH2PO4 pH 5 MeOH 10:3.75:9.6:1.65 v/v/v/v, 0.1 M NaOH, 25 °C, 7 days |
0.5 mg mL-1 AMX in water, 0.1 M NaOH, 25 °C, 20 min |
degradation / % |
9.5 |
6.21 |
complete degradation |
15-20 |
NI |
NI |
none |
7 |
detected RS |
C2, D1, D2, I, J1, N-pivaloyl amoxicillin |
NI |
C1, C2 |
NI |
D |
1 unknown |
none |
C, D, G, J, 2 unknowns |
HP |
condition |
NP |
0.75 mg mL-1 AMX in 0.05 M phosphate buffer pH 5, 10% H2O2, 85 °C, 2 min |
0.2 mg mL-1 AMX in water, 0.1% H2O2 instantly |
NP |
5 µg mL-1 AMX in MeOH/0.02 M phosphate buffer pH 3.5/water 0.5:0.5:1 v/v/v, 10% H2O2 under reflux, 70 °C, 2 h |
NP |
85.7 µg mL-1 AMX in 0.4% H2O2 under reflux, 60-70 °C, 90 min |
2 mg mL-1 AMX in 0.01 M HCl/MeCN/KH2PO4 pH 5 MeOH 10:3.75:9.6:1.65 v/v/v/v, 0.3% H2O2, 25 °C, protected from light, 7 days |
0.5 mg mL-1 AMX in water, 0.05% H2O2, 25 °C, 10 min |
degradation / % |
10.8 |
5.01 |
5 |
NI |
none |
14 |
detected RS |
A, B, D1, D2, I |
NI |
NI |
1 unknown |
none |
C, D, I, P, 6 unknowns |
DT |
condition |
NP |
105 °C, 3 h |
NP |
NP |
NP |
NP |
NP |
70 °C, 21 days |
105 °C, 7 days |
degradation / % |
21.3 |
none |
3 |
detected RS |
A, B, C2, D1, D2, E1, E2, G, J1, L, N-pivaloyl amoxicillin |
none |
B, C, D, H, K, 4 unknowns |
WT |
condition |
NP |
92% RH, 25 °C, 144 h |
NP |
NP |
NP |
NP |
6 mL of 0.1 mg mL-1 AMX in volumetric flask, 60-70 °C, hot air oven, 90 min |
NP |
NP |
degradation / % |
0.1 |
NI |
detected RS |
C2, D2, I |
2 unknowns |
PhD |
condition |
NP |
1.2 million lx h, 144 h (temperature was not mentioned) |
0.2 mg mL-1 AMX in water, UV light, 3 h |
NP |
15 mL 10 µg mL-1 AMX in MeOH/0.02 M phosphate buffer pH 3.5 1:1 v/v, 1.2 million lx h, 25 °C, 144 h, and UV light, 254 nm, 3 h |
NP |
6 mL of 0.1 mg mL-1 AMX in petri dish, photostability chamber: 1.2 million lx h, 200 W h per m2 or daylight, 5 h |
UV light, 3 days |
photostability chamber: 1.2 million lx h and 200 W h per m2, 25 °C, 26 days |
degradation / % |
0.1 |
8.59 |
5 and 7, respectively |
NI |
none |
7 and 4, respectively |
detected RS |
C2, D2, I |
NI |
NI |
2 unknowns |
none |
C, D, F, I, J, K, P, 3 unknowns |