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Articles • J. Braz. Chem. Soc. 15 (1) • Feb 2004 • https://doi.org/10.1590/S0103-50532004000100005   copy

Evaluation of lipases in the desymmetrization of meso-exo-3,5-dihydroxymethylenetricyclo[5.2.1.0(2,6)]decane and the synthesis of chiral derivatives

Authorship SCIMAGO INSTITUTIONS RANKINGS

meso-exo-3,5-dihydroxymethylenetricyclo[5.2.1.0(2,6)]decane was efficiently desymmetrized by the lipase from Pseudomonas cepacia (PS-C 'Amano' II) in vinyl acetate in high yields (93%) and with excellent enantiomeric excesses (ee > 99% by chiral GC). Chiral synthons for asymmetric synthesis were synthesized from this enantiopure compound.

lipases; enzymatic catalysis; desymmetrization; chiral compounds

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