Melonal is a relatively unexplored ingredient in the field of chemistry with excellent sensory properties. The synthesis and characterization of novel transition 3d metal complexes of copper(II), nickel(II), cobalt(II) and chromium(III) involving the Schiff base of melonal were explored to examine their biological activity. Characterization of the complexes was carried out using matrix-assisted laser desorption/ionization-time-of-flight (MALDI-TOF), gas chromatography-mass spectrometry (GC-MS), thermogravimetric analysis (TGA), UV-Visible and infrared (IR) spectrophotometry. The antimicrobial studies were conducted against six bacterial strains and six fungi. The minimum inhibition concentration observed was compared against the standard antibiotic gentamycin and the anti-fungal drug amphotericin. The activity studies indicated that cobalt(II) complex exhibited activity better than standard drug amphotericin against Penicillium chrysogenum. Molecular docking study confirms the protein binding and supports the experimental finding. Binuclear cobalt(II) and chromium(III) bridging complexes of Schiff base ligand were obtained.
Keywords:
azomethine; chromium(III) complex; melonal; bridging complex; docking; DFT
